ATA655474A - Verfahren zur herstellung eines oral zu verabreichenden pharmazeutischen, dispergierbaren pulvers - Google Patents

Verfahren zur herstellung eines oral zu verabreichenden pharmazeutischen, dispergierbaren pulvers

Info

Publication number
ATA655474A
ATA655474A AT655474A AT655474A ATA655474A AT A655474 A ATA655474 A AT A655474A AT 655474 A AT655474 A AT 655474A AT 655474 A AT655474 A AT 655474A AT A655474 A ATA655474 A AT A655474A
Authority
AT
Austria
Prior art keywords
manufacturing
dispersible powder
pharmaceutical
oral administrative
oral
Prior art date
Application number
AT655474A
Other languages
German (de)
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ATA655474A publication Critical patent/ATA655474A/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT655474A 1973-08-13 1974-08-09 Verfahren zur herstellung eines oral zu verabreichenden pharmazeutischen, dispergierbaren pulvers ATA655474A (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US387999A US3881005A (en) 1973-08-13 1973-08-13 Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof

Publications (1)

Publication Number Publication Date
ATA655474A true ATA655474A (de) 1977-02-15

Family

ID=23532208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT655474A ATA655474A (de) 1973-08-13 1974-08-09 Verfahren zur herstellung eines oral zu verabreichenden pharmazeutischen, dispergierbaren pulvers

Country Status (14)

Country Link
US (1) US3881005A (forum.php)
JP (1) JPS5048115A (forum.php)
AR (1) AR202034A1 (forum.php)
AT (1) ATA655474A (forum.php)
AU (1) AU7155674A (forum.php)
BE (1) BE818729A (forum.php)
DD (1) DD112899A5 (forum.php)
DE (1) DE2437845A1 (forum.php)
DK (1) DK427674A (forum.php)
FR (1) FR2240717B1 (forum.php)
IL (1) IL45311A0 (forum.php)
NL (1) NL7410862A (forum.php)
SE (1) SE7410331L (forum.php)
ZA (1) ZA744587B (forum.php)

Families Citing this family (68)

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JPS51118817A (en) * 1975-04-08 1976-10-19 Nippon Shinyaku Co Ltd A process for preparing absorbable steroid glycoside pharmaceutical
JPS51139613A (en) * 1975-05-24 1976-12-02 Nippon Shinyaku Co Ltd An absorbable non-crystalline sterol glycoside monopalmitate ester and a method for preparing its pharmaceutical
JPS5266616A (en) * 1975-11-29 1977-06-02 Sawai Seiyaku Kk Manufacturing of solidified oily liquid substance
WO1991001139A1 (de) * 1989-07-21 1991-02-07 Marigen S.A. Sterole, deren fettsäureester und glucoside; verfahren zu ihrer herstellung; spontan dispergierbare mittel mit diesen verbindungen, sowie ihre verwendung zur behandlung von tumoren
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
WO1995000158A1 (en) * 1993-06-25 1995-01-05 Bio-Sphere Technology Dietary supplement incorporating beta-sitosterol and pectin
US6936277B2 (en) * 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US20030104035A1 (en) 1996-08-09 2003-06-05 Raisio Benecol Ltd. Stanol composition and the use thereof
FI105887B (fi) * 1996-09-27 2000-10-31 Suomen Sokeri Oy Elintarvike- ja terapeuttisiin sovelluksiin käyttökelpoiset, kasvisterolia sisältävät tuotteet, menetelmä niiden valmistamiseksi ja niiden käyttö
FI108110B (fi) * 1997-06-13 2001-11-30 Danisco Finland Oy Elintarvike- ja eläinravitsemusalalla käyttökelpoinen esiseos, menetelmä sen valmistamiseksi ja sen käyttö
US6423363B1 (en) † 1997-08-22 2002-07-23 Lipton, Division Of Conopco, Inc. Aqueous dispersion
IN185730B (forum.php) * 1998-02-19 2001-04-14 Mcneil Ppc Inc
US6110502A (en) * 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
FR2775620B1 (fr) 1998-03-05 2002-04-19 Gervais Danone Sa Suspension homogene stable depourvue d'emulsifiant, son procede de preparation et son utilisation dans des compositions alimentaires
SE512958C2 (sv) 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
US5932562A (en) * 1998-05-26 1999-08-03 Washington University Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
US6123978A (en) * 1998-08-31 2000-09-26 Mcneil-Ppc, Inc. Stable salad dressings
US6376481B2 (en) * 1998-09-02 2002-04-23 Mcneil-Ppc, Inc. Sterol esters in tableted solid dosage forms
US6242001B1 (en) 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds
US6113972A (en) * 1998-12-03 2000-09-05 Monsanto Co. Phytosterol protein complex
WO2000041491A2 (en) * 1999-01-15 2000-07-20 Nutrahealth Ltd (Uk) Modified food products and beverages, and additives for food and beverages
JP2002535975A (ja) * 1999-02-03 2002-10-29 フォーブス メディ−テック インコーポレーテッド フィトステロールまたはフィトスタノールの微粒子を製造する方法
US6190720B1 (en) * 1999-06-15 2001-02-20 Opta Food Ingredients, Inc. Dispersible sterol compositions
AU5405200A (en) * 1999-06-25 2001-01-31 Cognis Deutschland Gmbh & Co. Kg Use of nanoscale sterols and sterol esters
US6391370B1 (en) * 1999-11-12 2002-05-21 Kraft Foods, Inc. Micromilling plant sterols and emulsifiers
US6677327B1 (en) * 1999-11-24 2004-01-13 Archer-Daniels-Midland Company Phytosterol and phytostanol compositions
US7232574B1 (en) 1999-12-15 2007-06-19 Mcneil-Ppc, Inc. Long chain alcohols provided in edible oils
US6355274B1 (en) 1999-12-15 2002-03-12 Mcneil-Ppc, Inc. Encapsulated long chain alcohols
US20030165572A1 (en) * 2000-09-01 2003-09-04 Nicolas Auriou Water-dispersible encapsulated sterols
GB0021498D0 (en) * 2000-09-01 2000-10-18 Novartis Nutrition Ag New formulation
AU2005234649B2 (en) * 2000-09-01 2008-01-17 Forbes Medi-Tech, Inc. Water-dispersible encapsulated sterols
KR20020026053A (ko) 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
US6773733B2 (en) * 2001-03-26 2004-08-10 Loders Croklaan Usa Llc Structured particulate systems
US20030003131A1 (en) * 2001-06-22 2003-01-02 Matthew Dyer Method for manufacture of free-flowing powder containing water-dispersible sterols
WO2003043433A1 (en) * 2001-11-16 2003-05-30 Brandeis University Prepared foods containing triglyceride-recrystallized non-esterified phytosterols
US7144595B2 (en) * 2001-11-16 2006-12-05 Brandeis University Prepared foods containing triglyceride-recrystallized non-esterified phytosterols
FI117082B (fi) * 2002-02-08 2006-06-15 Raisio Yhtymae Oyj Esteröityjä kasvisteroleita sisältävä pastatuote
JP2005520507A (ja) * 2002-03-20 2005-07-14 ユージーン サイエンス インコーポレイテッド 植物ステロール含有食品、及びその調製方法
JP2005520508A (ja) * 2002-03-20 2005-07-14 ユージーン サイエンス インコーポレイテッド 植物ステロールと乳化剤の混合粉末及びその製造方法
CA2481384A1 (en) * 2002-04-10 2003-10-23 Cargill, Incorporated Aqueous dispersible steryl ester compositions
DE60324695D1 (de) * 2002-06-12 2008-12-24 Coca Cola Co Pflanzliches sterol enthaltende getränke
US7732000B2 (en) * 2002-06-20 2010-06-08 General Mills, Inc. Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix
ES2414091T3 (es) 2003-07-17 2013-07-18 Unilever N.V. Procedimiento de estabilización de una dispersión comestible que comprende aceite
EP1708579B1 (en) * 2004-01-30 2008-11-12 Unilever N.V. Particulate comprising phytosterols and food compositions comprising said creamer
US8968768B2 (en) * 2004-03-29 2015-03-03 Wyeth Llc Phytosterol nutritional supplements
CN1956734B (zh) 2004-03-29 2012-10-10 惠氏公司 复合维生素和矿物质的营养补充剂
US20060035009A1 (en) * 2004-08-10 2006-02-16 Kraft Foods Holdings, Inc. Compositions and processes for water-dispersible phytosterols and phytostanols
US20060034934A1 (en) * 2004-08-13 2006-02-16 Deguise Matthew L Agglomeration of sterol particles
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DE102005008445A1 (de) * 2005-02-24 2006-08-31 Cognis Ip Management Gmbh Zuckerhaltige Sterolfeststoffdispersionen
DE102005039836A1 (de) * 2005-08-23 2007-03-01 Cognis Ip Management Gmbh Sterolesterpulver
US7575768B2 (en) * 2005-09-07 2009-08-18 Brandeis University Dietary supplements and prepared foods containing triglyceride-recrystallized non-esterified phytosterols
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DE102006010663A1 (de) * 2006-03-08 2007-09-13 Cognis Ip Management Gmbh Verfahren zur Herstellung sterolhaltiger Pulver
EP1929884A1 (de) * 2006-12-04 2008-06-11 Cognis IP Management GmbH Verfahren zur Herstellung von Sterolformulierungen
US20090092727A1 (en) * 2007-10-04 2009-04-09 Daniel Perlman Water-dispersible phytosterol-surfactant conglomerate particles
US7790495B2 (en) * 2007-10-26 2010-09-07 International Business Machines Corporation Optoelectronic device with germanium photodetector
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US20110223312A1 (en) * 2009-11-30 2011-09-15 Daniel Perlman Triglyceride-encapsulated phytosterol microparticles dispersed in beverages
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CA2820354C (en) 2010-12-17 2019-06-11 Unilever Plc Process of compacting a microporous fat powder and compacted fat powder so obtained
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KR102063558B1 (ko) 2015-03-11 2020-02-11 티유비아이티에이케이 총 콜레스테롤 및 ldl 콜레스테롤 수준 저하용 수성 또는 분말 형태의 수 분산형 스테롤/스타놀이 강화된 폴리페놀이 풍부한 허브 차
IT201700066508A1 (it) * 2017-06-15 2018-12-15 Isagro Spa Sospensioni concentrate di fitosteroli e relativo processo di preparazione

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DE1228029C2 (de) * 1964-05-09 1973-05-17 Merck Ag E Verfahren zur Herstellung von Tabletten durch Pressen von Pulvergemischen ohne vorhergehende Granulation
US3800038A (en) * 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier

Also Published As

Publication number Publication date
DK427674A (forum.php) 1975-04-21
AR202034A1 (es) 1975-05-09
IL45311A0 (en) 1974-10-22
AU7155674A (en) 1976-01-29
SE7410331L (forum.php) 1975-02-14
DE2437845A1 (de) 1975-02-27
NL7410862A (nl) 1975-02-17
DD112899A5 (forum.php) 1975-05-12
JPS5048115A (forum.php) 1975-04-30
BE818729A (fr) 1975-02-12
FR2240717A1 (forum.php) 1975-03-14
ZA744587B (en) 1976-02-25
US3881005A (en) 1975-04-29
FR2240717B1 (forum.php) 1977-11-04

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