AT343802B - Verfahren zur herstellung von derivaten von 4,6-di-0- (aminoglycosyl)-2-deoxystreptaminen - Google Patents

Verfahren zur herstellung von derivaten von 4,6-di-0- (aminoglycosyl)-2-deoxystreptaminen

Info

Publication number
AT343802B
AT343802B AT895075A AT895075A AT343802B AT 343802 B AT343802 B AT 343802B AT 895075 A AT895075 A AT 895075A AT 895075 A AT895075 A AT 895075A AT 343802 B AT343802 B AT 343802B
Authority
AT
Austria
Prior art keywords
deoxystreptamines
aminoglycosyl
derivatives
preparation
Prior art date
Application number
AT895075A
Other languages
English (en)
Other versions
ATA895075A (de
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of ATA895075A publication Critical patent/ATA895075A/de
Application granted granted Critical
Publication of AT343802B publication Critical patent/AT343802B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT895075A 1974-11-29 1975-11-25 Verfahren zur herstellung von derivaten von 4,6-di-0- (aminoglycosyl)-2-deoxystreptaminen AT343802B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52859374A 1974-11-29 1974-11-29
US05/611,289 US4000261A (en) 1974-11-29 1975-09-08 5-epi-4,6-di-o-(aminoglycosyl)-2-deoxystreptamines, methods for their manufacture and intermediates useful therein, methods for their use as antibacterial agents and compositions useful therefor

Publications (2)

Publication Number Publication Date
ATA895075A ATA895075A (de) 1977-10-15
AT343802B true AT343802B (de) 1978-06-26

Family

ID=27062767

Family Applications (1)

Application Number Title Priority Date Filing Date
AT895075A AT343802B (de) 1974-11-29 1975-11-25 Verfahren zur herstellung von derivaten von 4,6-di-0- (aminoglycosyl)-2-deoxystreptaminen

Country Status (2)

Country Link
US (1) US4000261A (de)
AT (1) AT343802B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217446A (en) * 1974-10-26 1980-08-12 Pfizer Inc. ωAmino-2-hydroxyalkyl derivatives of aminoglycoside antibiotics
NZ184213A (en) * 1976-06-16 1980-05-27 Pfizer 2-deoxystreptamine aminoglycosides and antibacterial pharmaceutical compositions
DE2647807A1 (de) * 1976-10-22 1978-04-27 Merck Patent Gmbh Verfahren zur herstellung von garamin und garaminderivaten
DE2840907A1 (de) * 1978-09-20 1980-04-03 Bayer Ag Selektiv geschuetzte 4,6-di-o-(aminoglykosyl)-1,3-diaminocyclitole
US4272626A (en) * 1979-09-26 1981-06-09 Abbott Laboratories Method of producing 1-epi-2-deoxyfortimicin A and intermediates therefor
US4288547A (en) * 1979-11-13 1981-09-08 Haruo Yamamoto Fermentative process for preparing antibiotics of the gentamicin class
US4387219A (en) * 1979-11-13 1983-06-07 Sterling Drug Inc. 2-Hydroxy gentamicin compounds
WO2005070945A1 (ja) * 2004-01-21 2005-08-04 Meiji Seika Kaisha, Ltd. メチシリン耐性黄色ブドウ球菌（ｍｒｓａ）に有効な新規アミノグリコシド系抗生物質
KR101296099B1 (ko) 2007-11-21 2014-02-26 아카오젠, 인코포레이티드 항균성 아미노글리코사이드 동족체
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3828021A (en) * 1972-06-14 1974-08-06 Merck & Co Inc Gentamicin c1 derivatives
US3920628A (en) * 1972-10-24 1975-11-18 Schering Corp 2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein

Also Published As

Publication number Publication date
ATA895075A (de) 1977-10-15
US4000261A (en) 1976-12-28

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Legal Events

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ELJ Ceased due to non-payment of the annual fee