ATA293589A - Neue chinolinsulfonaminoderivate und verfahren zu deren herstellung sowie pharmazeutische zusammensetzung - Google Patents

Neue chinolinsulfonaminoderivate und verfahren zu deren herstellung sowie pharmazeutische zusammensetzung

Info

Publication number
ATA293589A
ATA293589A AT0293589A AT293589A ATA293589A AT A293589 A ATA293589 A AT A293589A AT 0293589 A AT0293589 A AT 0293589A AT 293589 A AT293589 A AT 293589A AT A293589 A ATA293589 A AT A293589A
Authority
AT
Austria
Prior art keywords
chinolin
sulphon
new
production
pharmaceutical composition
Prior art date
Application number
AT0293589A
Other languages
English (en)
Other versions
AT398201B (de
Original Assignee
Hidaka Hiroyoshi
Tobishi Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hidaka Hiroyoshi, Tobishi Pharmaceutical Co filed Critical Hidaka Hiroyoshi
Publication of ATA293589A publication Critical patent/ATA293589A/de
Application granted granted Critical
Publication of AT398201B publication Critical patent/AT398201B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
AT0293589A 1988-12-26 1989-12-22 Neue chinolinsulfonaminoderivate und verfahren zu deren herstellung sowie pharmazeutische zusammensetzung AT398201B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP32591088 1988-12-26
JP7641989 1989-03-30
JP8786889 1989-04-10

Publications (2)

Publication Number Publication Date
ATA293589A true ATA293589A (de) 1994-02-15
AT398201B AT398201B (de) 1994-10-25

Family

ID=27302151

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0293589A AT398201B (de) 1988-12-26 1989-12-22 Neue chinolinsulfonaminoderivate und verfahren zu deren herstellung sowie pharmazeutische zusammensetzung

Country Status (11)

Country Link
US (1) US5081246A (de)
KR (1) KR0183374B1 (de)
AT (1) AT398201B (de)
CA (1) CA2005741C (de)
CH (1) CH680441A5 (de)
DK (1) DK175678B1 (de)
ES (1) ES2029759A6 (de)
FR (1) FR2640973B1 (de)
GB (1) GB2228933B (de)
NL (1) NL193726C (de)
SE (1) SE503081C2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340811A (en) * 1990-03-08 1994-08-23 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinoline-or quinoline-sulfonamide derivative and a pharmaceutical composition comprising the same
JPH069402A (ja) * 1991-05-15 1994-01-18 Hiroyoshi Hidaka 抗潰瘍剤
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2084176T3 (es) * 1991-09-05 1996-05-01 Pharno Wedropharm Gmbh Derivados de sulfonamidas aromaticas, su uso como inhibidores de enzimas y composiciones farmaceuticas que los contienen.
US5378715A (en) * 1992-02-24 1995-01-03 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
US5514696A (en) * 1992-05-06 1996-05-07 Bristol-Myers Squibb Co. Phenyl sulfonamide endothelin antagonists
US5420123A (en) * 1992-12-21 1995-05-30 Bristol-Myers Squibb Company Dibenzodiazepine endothelin antagonists
US5965732A (en) * 1993-08-30 1999-10-12 Bristol-Myers Squibb Co. Sulfonamide endothelin antagonists
US5612359A (en) * 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5780473A (en) * 1995-02-06 1998-07-14 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5760038A (en) * 1995-02-06 1998-06-02 Bristol-Myers Squibb Company Substituted biphenyl sulfonamide endothelin antagonists
US5846990A (en) * 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09124620A (ja) 1995-10-11 1997-05-13 Bristol Myers Squibb Co 置換ビフェニルスルホンアミドエンドセリン拮抗剤
US5856507A (en) * 1997-01-21 1999-01-05 Bristol-Myers Squibb Co. Methods for the preparation of biphenyl isoxazole sulfonamides
SG87052A1 (en) 1996-02-20 2002-03-19 Bristol Myers Squibb Co Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides
US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
WO1998033781A1 (en) * 1997-01-30 1998-08-06 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
BR9915735A (pt) 1998-11-20 2001-09-04 Hoffmann La Roche Antagonistas receptores de ccr-3 de piperidina
HUP0201320A2 (en) 1999-03-19 2002-08-28 Bristol Myers Squibb Co Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof
US6337326B1 (en) 1999-11-08 2002-01-08 American Home Products Corporation N-aryl-(homopiperazinyl)-cyclohexyl amines
US6639082B2 (en) 2000-10-17 2003-10-28 Bristol-Myers Squibb Company Methods for the preparation of biphenyl isoxazole sulfonamides
NZ533649A (en) * 2001-12-21 2006-01-27 King Pharmaceuticals Res & Dev Tyrosyl derivatives and their use as P2X7 receptor modulators
KR101149954B1 (ko) * 2005-08-30 2012-06-01 아사히 가세이 파마 가부시키가이샤 술폰아미드 화합물
GB0617222D0 (en) * 2006-08-31 2006-10-11 Vereniging Het Nl Kanker I Antibiotics
US8415372B2 (en) * 2007-02-27 2013-04-09 Asahi Kasei Pharma Corporation Sulfonamide compound
EP2130828A4 (de) * 2007-02-28 2010-12-29 Asahi Kasei Pharma Corp Sulfonamidderivat
ES2396795T3 (es) 2007-07-02 2013-02-27 Asahi Kasei Pharma Corporation Compuesto de sulfonamida y cirstal del mismo
UA112109C2 (uk) 2012-03-20 2016-07-25 Адамед Сп. З О.О. Сульфонамідні похідні бензиламіну для лікування захворювань центральної нервової системи (цнс)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS609495B2 (ja) * 1976-02-18 1985-03-11 萬有製薬株式会社 ω−（アリ−ルスルホンアミド）−アルキルアミン
DD142804A3 (de) * 1977-11-07 1980-07-16 Wagner Guenter Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden
US4456757A (en) * 1981-03-20 1984-06-26 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonyl derivatives and process for the preparation thereof
SE8203887D0 (sv) * 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
JPS5993054A (ja) * 1982-11-18 1984-05-29 Asahi Chem Ind Co Ltd イソキノリンスルホン酸アミド誘導体
JPS6081168A (ja) * 1983-10-13 1985-05-09 Asahi Chem Ind Co Ltd アミジン誘導体
US4678783B1 (en) * 1983-11-04 1995-04-04 Asahi Chemical Ind Substituted isoquinolinesulfonyl compounds
JPS61126026A (ja) * 1984-11-26 1986-06-13 Hiroyoshi Hidaka イソキノリンスルホン酸アミドを有効成分とする抗癌剤
EP0187371B1 (de) * 1984-12-27 1991-06-19 Asahi Kasei Kogyo Kabushiki Kaisha Substituierte Isochinolinsulfonyl-Verbindungen
JPS61271221A (ja) * 1985-05-28 1986-12-01 Hiroyoshi Hidaka ５−イソキノリンスルホニルピペラジンを有効成分とする抗癌剤
JPS61293914A (ja) * 1985-06-24 1986-12-24 Hiroyoshi Hidaka イソキノリン誘導体を有効成分とする抗癌剤
JPH062741B2 (ja) * 1985-10-29 1994-01-12 旭化成工業株式会社 ２級のイソキノリンスルホンアミド誘導体
JPH0667926B2 (ja) * 1985-11-12 1994-08-31 旭化成工業株式会社 環状のイソキノリンスルホンアミド誘導体
JPS6322757A (ja) * 1986-03-05 1988-01-30 Tokyo Tatsuno Co Ltd 自動車用サ−ビス装置
JPH0676384B2 (ja) * 1986-06-20 1994-09-28 旭化成工業株式会社 １−クロル−５−イソキノリンスルホン酸
JPH07603B2 (ja) * 1987-02-27 1995-01-11 北陸製薬株式会社 イソキノリンスルホンアミド誘導体

Also Published As

Publication number Publication date
US5081246A (en) 1992-01-14
SE8904261D0 (sv) 1989-12-19
CA2005741A1 (en) 1990-06-26
NL8903143A (nl) 1990-07-16
FR2640973A1 (de) 1990-06-29
GB2228933A (en) 1990-09-12
KR900009598A (ko) 1990-07-05
GB2228933B (en) 1993-03-31
NL193726B (nl) 2000-04-03
DK666289A (da) 1990-06-27
ES2029759A6 (es) 1992-09-01
KR0183374B1 (ko) 1999-05-01
DK666289D0 (da) 1989-12-22
AT398201B (de) 1994-10-25
FR2640973B1 (de) 1992-03-27
CH680441A5 (de) 1992-08-31
GB8928895D0 (en) 1990-02-28
CA2005741C (en) 1998-06-02
NL193726C (nl) 2000-08-04
DK175678B1 (da) 2005-01-17
SE8904261L (sv) 1990-06-27
SE503081C2 (sv) 1996-03-18

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Legal Events

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ELJ Ceased due to non-payment of the annual fee