AT387025B - Verfahren zur herstellung des l-alpha-aspartyll-phenylalaninmethylesters (aspartam) - Google Patents

Verfahren zur herstellung des l-alpha-aspartyll-phenylalaninmethylesters (aspartam)

Info

Publication number
AT387025B
AT387025B AT0253784A AT253784A AT387025B AT 387025 B AT387025 B AT 387025B AT 0253784 A AT0253784 A AT 0253784A AT 253784 A AT253784 A AT 253784A AT 387025 B AT387025 B AT 387025B
Authority
AT
Austria
Prior art keywords
aspartyll
aspartam
alpha
producing
methyl ester
Prior art date
Application number
AT0253784A
Other languages
English (en)
Other versions
ATA253784A (de
Inventor
Franco Dallatomasina
Roberto Ortica
Pietro Giardino
Ernesto Oppici
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of ATA253784A publication Critical patent/ATA253784A/de
Application granted granted Critical
Publication of AT387025B publication Critical patent/AT387025B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • C07K5/06121Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
AT0253784A 1983-08-12 1984-08-06 Verfahren zur herstellung des l-alpha-aspartyll-phenylalaninmethylesters (aspartam) AT387025B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838321802A GB8321802D0 (en) 1983-08-12 1983-08-12 Aspartame synthesis

Publications (2)

Publication Number Publication Date
ATA253784A ATA253784A (de) 1988-04-15
AT387025B true AT387025B (de) 1988-11-25

Family

ID=10547240

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0253784A AT387025B (de) 1983-08-12 1984-08-06 Verfahren zur herstellung des l-alpha-aspartyll-phenylalaninmethylesters (aspartam)

Country Status (19)

Country Link
US (1) US4549987A (de)
JP (1) JPH0676435B2 (de)
AT (1) AT387025B (de)
AU (1) AU561635B2 (de)
BE (1) BE900317A (de)
CA (1) CA1243668A (de)
CH (1) CH660013A5 (de)
DE (1) DE3428979A1 (de)
DK (1) DK163929C (de)
FI (1) FI81364C (de)
FR (1) FR2550538B1 (de)
GB (2) GB8321802D0 (de)
GR (1) GR80045B (de)
IL (1) IL72621A (de)
IT (1) IT1209577B (de)
NL (1) NL8402480A (de)
SE (1) SE466258B (de)
SU (1) SU1299515A3 (de)
ZA (1) ZA846148B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8616873D0 (en) * 1986-07-10 1986-08-20 British Telecomm Optical telecommunications system
DE3635582A1 (de) * 1986-10-20 1988-04-21 Hoechst Ag Verfahren zur reinigung von n-acyl-aspartam
US4992272A (en) * 1987-03-09 1991-02-12 Diamond Scientific Canine distemper virus vaccine
NL8701035A (nl) * 1987-05-01 1988-12-01 Stamicarbon Werkwijze voor de bereiding van aspartylfenylalaninemethylester uit n-formylaspartylfenylalaninemethylester.
JP2662287B2 (ja) * 1988-03-14 1997-10-08 三井東圧化学株式会社 α―L―アスパルチル―L―フェニルアラニンメチルエステルの分離方法
US5283357A (en) * 1988-03-14 1994-02-01 Mitsui Toatsu Chemicals, Incorporated Separation method of α-l-aspartyl-l-phenylalanine methyl ester
JP2979761B2 (ja) * 1991-05-23 1999-11-15 味の素株式会社 α−L−アスパルチル−L−フェニルアラニンメチルエステル塩酸塩の製造法
US20080314872A1 (en) * 2007-06-19 2008-12-25 Ferro Corporation Chemical-Mechanical Polishing Compositions Containing Aspartame And Methods Of Making And Using The Same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1117134B (de) * 1960-06-04 1961-11-16 Berlin Chemie Veb Verfahren zur Herstellung von Peptiden unter Verwendung einer oxydativ entfernbaren Schutzgruppe
DE2107411A1 (de) * 1970-02-21 1971-08-26 Beecham Group Ltd , Brentford, Middlesex (Großbritannien) Verfahren zur Herstellung von alpha Asparagmylrest enthaltenden Dipeptiden

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
GB1309605A (en) * 1970-01-31 1973-03-14 Ajinomoto Kk Process for producing alpha-dipeptide esters of l-aspartic acid
BE791544A (fr) * 1971-11-19 1973-05-17 Stamicarbon Preparation d'esters alkyliques de dipeptide
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5223001A (en) * 1975-08-14 1977-02-21 Ajinomoto Co Inc Process for elimination of formyl group
MX4704E (es) * 1976-12-27 1982-08-04 Monsanto Co Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina
JPS57131746A (en) * 1981-02-10 1982-08-14 Ajinomoto Co Inc Removal of n-formyl group
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−L−アスパルチル−L−フエニルアラニンメチルエステルまたはその塩酸塩の製法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1117134B (de) * 1960-06-04 1961-11-16 Berlin Chemie Veb Verfahren zur Herstellung von Peptiden unter Verwendung einer oxydativ entfernbaren Schutzgruppe
DE2107411A1 (de) * 1970-02-21 1971-08-26 Beecham Group Ltd , Brentford, Middlesex (Großbritannien) Verfahren zur Herstellung von alpha Asparagmylrest enthaltenden Dipeptiden

Also Published As

Publication number Publication date
DK163929C (da) 1992-09-14
GB2144748B (en) 1987-03-04
GB2144748A (en) 1985-03-13
IL72621A (en) 1987-12-20
FR2550538A1 (fr) 1985-02-15
SU1299515A3 (ru) 1987-03-23
SE8404006L (sv) 1985-02-13
GR80045B (en) 1984-12-10
DK381984A (da) 1985-02-13
FR2550538B1 (fr) 1988-03-04
DE3428979A1 (de) 1985-02-21
AU3168484A (en) 1985-02-14
CA1243668A (en) 1988-10-25
ATA253784A (de) 1988-04-15
GB8321802D0 (en) 1983-09-14
SE466258B (sv) 1992-01-20
FI843112A (fi) 1985-02-13
JPS6067497A (ja) 1985-04-17
BE900317A (fr) 1984-12-03
US4549987A (en) 1985-10-29
DK381984D0 (da) 1984-08-08
IT1209577B (it) 1989-08-30
NL8402480A (nl) 1985-03-01
DE3428979C2 (de) 1990-09-06
SE8404006D0 (sv) 1984-08-07
IL72621A0 (en) 1984-11-30
FI81364B (fi) 1990-06-29
IT8422233A0 (it) 1984-08-06
GB8420238D0 (en) 1984-09-12
AU561635B2 (en) 1987-05-14
ZA846148B (en) 1985-03-27
FI843112A0 (fi) 1984-08-08
DK163929B (da) 1992-04-21
JPH0676435B2 (ja) 1994-09-28
CH660013A5 (it) 1987-03-13
FI81364C (fi) 1990-10-10

Similar Documents

Publication Publication Date Title
AT380476B (de) Verfahren zur herstellung von chinazolinderivaten
ATA271384A (de) Verfahren zur herstellung neuer ester
AT383808B (de) Verfahren zur herstellung von penemen
DE3485087D1 (de) Verfahren zur herstellung gekruemmter oberflaechen.
ATA224084A (de) Verfahren zur herstellung von alkoholen
AT371744B (de) Verfahren zur herstellung von foerderschnecken
AT377259B (de) Verfahren zur herstellung von dihydropyridylimidatestern
DE3880640D1 (de) Verfahren zur herstellung aliphatischer o-arylurethane.
AT387025B (de) Verfahren zur herstellung des l-alpha-aspartyll-phenylalaninmethylesters (aspartam)
AT389512B (de) Verfahren zur herstellung von 3-chlormethylchinuclidin
ATA199684A (de) Verfahren zur herstellung von 6-deoxyanthracyclinonen
AT387024B (de) Verfahren zur herstellung von aspartam
ATA160984A (de) Verfahren zur herstellung des neuen antitumor- antibiotikum-komplexes bbm-1675
ATA88387A (de) Verfahren zur herstellung des tripeptids arg-ala-arg
ATA328781A (de) Verfahren zur herstellung 5-substituierter dialursaeuren
AT381311B (de) Verfahren zur herstellung von vincaminsaeureestern
ATA146384A (de) Verfahren zur herstellung neuer acylaminophenolderivate
AT380480B (de) Verfahren zur herstellung von anthracyclinglykosiden
AT389513B (de) Verfahren zur herstellung von alkoxyapovincaminsaeureestern
AT384024B (de) Verfahren zur herstellung von azinomethylrifamycinen
ATA319282A (de) Verfahren zur herstellung von reinem 3-amino-crotonitril
AT388374B (de) Verfahren zur herstellung von n-sulfonylaryloxybenzamiden
ATA201283A (de) Verfahren zur herstellung von carboxyalkyldipeptiden
AT383128B (de) Verfahren zur herstellung des 1-aethoxycarbonyloxy-aethylesters von alpha-aminobenzylpenicillin
ATA328581A (de) Verfahren zur herstellung von 1-phenoxy-3-amino- 2-propanolen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee