AT370427B - Verfahren zur herstellung von submikroskopischen teilchen - Google Patents

Verfahren zur herstellung von submikroskopischen teilchen

Info

Publication number
AT370427B
AT370427B AT0496279A AT496279A AT370427B AT 370427 B AT370427 B AT 370427B AT 0496279 A AT0496279 A AT 0496279A AT 496279 A AT496279 A AT 496279A AT 370427 B AT370427 B AT 370427B
Authority
AT
Austria
Prior art keywords
producing
submicroscopic particles
submicroscopic
particles
producing submicroscopic
Prior art date
Application number
AT0496279A
Other languages
English (en)
Other versions
ATA496279A (de
Original Assignee
Couvreur Patrick
Roland Michel
Speiser Peter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE189366A external-priority patent/BE869107A/xx
Application filed by Couvreur Patrick, Roland Michel, Speiser Peter filed Critical Couvreur Patrick
Publication of ATA496279A publication Critical patent/ATA496279A/de
Application granted granted Critical
Publication of AT370427B publication Critical patent/AT370427B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
    • C08F22/30—Nitriles
    • C08F22/32—Alpha-cyano-acrylic acid; Esters thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
AT0496279A 1978-07-19 1979-07-18 Verfahren zur herstellung von submikroskopischen teilchen AT370427B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE189366A BE869107A (fr) 1978-07-19 1978-07-19 Particules submicroscopiques biodegradables contenant une substance biologiquement active, leur preparation et leur application

Publications (2)

Publication Number Publication Date
ATA496279A ATA496279A (de) 1982-08-15
AT370427B true AT370427B (de) 1983-03-25

Family

ID=3843131

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0496279A AT370427B (de) 1978-07-19 1979-07-18 Verfahren zur herstellung von submikroskopischen teilchen

Country Status (5)

Country Link
US (1) US4329332A (de)
EP (1) EP0007895B1 (de)
AT (1) AT370427B (de)
CA (1) CA1132069A (de)
DE (1) DE2965725D1 (de)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4489055A (en) * 1978-07-19 1984-12-18 N.V. Sopar S.A. Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use
FR2504408B1 (fr) * 1981-04-24 1986-02-14 Couvreur Patrick Procede de preparation de particules submicroscopiques, particules ainsi obtenues et compositions pharmaceutiques les contenant
US4452861A (en) * 1982-05-20 1984-06-05 Rca Corporation Solid particles encapsulated with cyanoacrylate polymer
US4919929A (en) * 1984-02-01 1990-04-24 Stolle Research & Development Corporation Mammal immunization
JPS59163313A (ja) * 1983-03-09 1984-09-14 Teijin Ltd 経鼻投与用ペプチドホルモン類組成物
GB8310038D0 (en) * 1983-04-13 1983-05-18 Amersham Int Plc Technetium-99 labelled tin colloid
DE3336583A1 (de) * 1983-09-26 1985-04-25 Udo Dr. 8400 Regensburg Ehrenfeld Erzeugnis zur diagnose und therapie von malignen tumoren
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
FR2604903B1 (fr) * 1986-10-08 1989-01-13 Sopar Sa Nv Agents therapeutiques sous forme de particules submicroscopiques contre des parasitoses et compositions pharmaceutiques les contenant
JP2664906B2 (ja) * 1987-08-13 1997-10-22 ストール・リサーチ・アンド・デイベロップメント・コーポレーション 改良された哺乳類の免疫法
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
FR2659554B1 (fr) 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5178882A (en) * 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
US5219577A (en) * 1990-06-22 1993-06-15 The Regents Of The University Of California Biologically active composition having a nanocrystalline core
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5686092A (en) * 1992-11-24 1997-11-11 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
AU6289794A (en) * 1994-03-28 1995-10-17 Patrique Limited Intermediates for the preparation of poly(cyanoacrylates) and applications of the poly(cyanoacrylates) so prepared
US6165988A (en) * 1995-02-10 2000-12-26 Christian Noe Medicament in particulate form
US8333996B2 (en) 1995-05-19 2012-12-18 Etex Corporation Calcium phosphate delivery vehicle and adjuvant
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
KR100508910B1 (ko) 1995-10-17 2006-04-20 알티피 파마 코포레이션 불용성약물방출
US6247995B1 (en) 1996-02-06 2001-06-19 Bruce Bryan Bioluminescent novelty items
US5876995A (en) * 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
AU3585397A (en) * 1996-06-27 1998-01-14 G.D. Searle & Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
US6416960B1 (en) 1996-08-08 2002-07-09 Prolume, Ltd. Detection and visualization of neoplastic tissues and other tissues
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US8728536B2 (en) * 1996-10-16 2014-05-20 Etex Corporation Chemotherapeutic composition using nanocrystalline calcium phosphate paste
FR2755136B1 (fr) * 1996-10-25 1999-01-22 Virsol Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant
EP1015872B1 (de) 1996-12-12 2005-03-02 Prolume, Ltd. Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
US5874111A (en) * 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
US6120806A (en) * 1997-06-25 2000-09-19 Whitmire; David R. Oral formulations for controlled release of alcohol deterrents
EP1023050B1 (de) * 1997-06-27 2013-09-25 Abraxis BioScience, LLC Zusammensetzungen von pharmakologischen wirkstoffen, verfahren zu deren herstellung und deren verwendung
FR2766368B1 (fr) * 1997-07-24 2000-03-31 Univ Claude Bernard Lyon Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres
IL137734A0 (en) * 1998-02-11 2001-10-31 Res Triangle Pharm Ltd Method and composition for treatment of inflammatory conditions
ES2359973T3 (es) * 1998-03-19 2011-05-30 MERCK SHARP & DOHME CORP. Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas.
EP1484033B1 (de) * 1998-03-19 2011-02-23 Merck Sharp & Dohme Corp. Flüssige Polymerlosung zur Kontrollierten freisetzung von bioaktiven substanzen
EP1925320A3 (de) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
US6162766A (en) * 1998-05-29 2000-12-19 3M Innovative Properties Company Encapsulated breakers, compositions and methods of use
ES2216517T3 (es) 1998-05-29 2004-10-16 Skyepharma Canada Inc. Composiciones de microcapsulas termoprotegidas y procedimiento para su esterilizacion terminal con vapor.
AU759641B2 (en) 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
BR9915738A (pt) 1998-11-20 2001-10-02 Rtp Pharma Inc Micropartìculas estabilizadas em fosfolipìdeos dispersìveis
IL148685A0 (en) * 1999-09-21 2002-09-12 Rtp Pharma Inc Surface modified particulate compositions of biologically active substances
US6207193B1 (en) * 1999-12-27 2001-03-27 Stephen E. Feldman Transdermal drug delivery system
EP1276465B1 (de) 2000-04-20 2014-03-12 Jagotec AG Verbessertes verfahren zur herstellung wasserunlöslicher arzneistoffpartikel
CA2309575A1 (en) * 2000-05-26 2001-11-26 James E. Guillet Internally cross-linked macromolecules
ATE424811T1 (de) 2000-08-31 2009-03-15 Jagotec Ag Gemahlene partikel
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
ATE522211T1 (de) * 2000-09-20 2011-09-15 Jagotec Ag Stabilisierte fibrat-mikropartikel
FR2816949B1 (fr) * 2000-11-17 2003-11-28 Centre Nat Rech Scient Copolymere a structure sequencee compose d'un segment saccharidique lie a au moins un segment hydrophobe bioerodable, et particules correspondantes
WO2002067901A1 (en) * 2001-02-22 2002-09-06 Skyepharma Canada Inc. Fibrate-statin combinations with reduced fed-fasted effects
AU2002346424A1 (en) * 2001-11-19 2003-06-10 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
FR2839517A1 (fr) * 2002-05-07 2003-11-14 Centre Nat Rech Scient Nouveaux agents tensioactifs biodegradables de type copolymeres amphiphiles constitues de segments hydrophobes et d'oligo et/ou polysaccharides
EP1530482B9 (de) 2002-07-18 2014-04-16 Helix Biopharma Corp. Verwendung von urease zur hemmung des krebszellenwachstums
DE10315538A1 (de) * 2003-04-04 2004-10-21 Siemens Ag Teilchen mit einer Membran
EP1615596B1 (de) * 2003-04-11 2016-11-02 Etex Corporation Osteoinduktives knochenmaterial
WO2005095950A1 (en) * 2004-03-30 2005-10-13 Pfizer Products Inc. Method and device for evaluation of pharmaceutical compositions
WO2005117919A2 (en) * 2004-04-15 2005-12-15 Etex Corporation Delayed-setting calcium phosphate pastes
FR2872703B1 (fr) * 2004-07-07 2006-10-06 Ethypharm Sa Nanoparticules polymeriques composites
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material
EP1973552B1 (de) * 2005-12-23 2017-04-12 Ajay Gupta Eisenhaltige parenterale ernährungszusammensetzung
WO2007124372A2 (en) * 2006-04-20 2007-11-01 Transport Pharmaceuticals, Inc. Pharmaceutical formulations for iontophoretic methotrexate delivery
BRPI0713409A2 (pt) * 2006-06-13 2012-03-27 Phibro Animal Health Corporation método de controle de metabolismo de lactobacilos em pasta em uma instalação de produção de etanol; método de erradicação de lactobacilos em pasta em uma instalação de produção de etanol; e método de controle de microorganismos indesejados na pasta em uma instalação de produção de etanol
US20100062073A1 (en) * 2006-11-29 2010-03-11 Ronald Arthur Beyerinck Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein
US9289196B2 (en) 2006-12-12 2016-03-22 Cook Medical Technologies Llc Hemostatic substance with a coating
WO2008125940A2 (en) * 2007-04-17 2008-10-23 Pfizer Products Inc. Nanoparticles comprising non-crystalline drug
EP2146695A4 (de) * 2007-04-23 2010-05-19 Sun Pharmaceuticals Ind Ltd Pharmazeutische zusammensetzungen
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
US8309129B2 (en) * 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
EP2162120B1 (de) * 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
WO2009010842A2 (en) * 2007-07-13 2009-01-22 Pfizer Products Inc. Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
US20090061009A1 (en) * 2007-08-29 2009-03-05 Joseph Schwarz Composition and Method of Treatment of Bacterial Infections
FR2921660B1 (fr) 2007-10-01 2015-09-25 Centre Nat Rech Scient Nanoparticules hybrides organiques inorganiques a base de carboxylates de fer.
FR2921661B1 (fr) * 2007-10-01 2013-05-31 Centre Nat Rech Scient Solide hybride organique inorganique a surface modifiee.
EP2742875B1 (de) * 2007-11-14 2016-02-24 Adhezion Biomedical, LLC Cyanoacrylgewebehaftstoffe
EP2231169B1 (de) * 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
MX2011000629A (es) 2008-07-17 2011-04-26 Merial Ltd Formulaciones analgesicas inyectables de larga duracion para animales.
FR2991325B1 (fr) 2012-05-31 2015-01-16 Centre Nat Rech Scient Solide hybride organique inorganique ameliore a surface externe modifiee
SG11201705982PA (en) 2015-01-23 2017-08-30 Helix Biopharma Corp Antibody-urease conjugates for therapeutic purposes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776232A (en) * 1954-06-02 1957-01-01 Eastman Kodak Co Mixed alpha-cyanoacrylate adhesive compositions
US2912454A (en) * 1957-05-06 1959-11-10 Rohm & Haas Preparation of alkyl alpha-cyanoacrylates
US3415758A (en) * 1960-03-09 1968-12-10 Ncr Co Process of forming minute capsules en masse
US3185625A (en) * 1961-11-08 1965-05-25 Brown Ethan Allan Injectionable substances
GB1172513A (en) * 1965-11-11 1969-12-03 Ici Ltd Polymer Coated Particles
JPS5212150B1 (de) * 1968-06-04 1977-04-05
JPS5322839B2 (de) * 1972-07-27 1978-07-11
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same

Also Published As

Publication number Publication date
CA1132069A (en) 1982-09-21
US4329332A (en) 1982-05-11
DE2965725D1 (en) 1983-07-28
ATA496279A (de) 1982-08-15
EP0007895B1 (de) 1983-06-22
EP0007895A1 (de) 1980-02-06

Similar Documents

Publication Publication Date Title
AT370427B (de) Verfahren zur herstellung von submikroskopischen teilchen
AT386550B (de) Verfahren zur herstellung von submikroskopischen teilchen
ATA729079A (de) Verfahren zur herstellung von monaldehyden
AT371097B (de) Verfahren zur herstellung von o-methallyloxyphenol
AT367080B (de) Verfahren zur herstellung von spanplatten
AT384229B (de) Verfahren zur herstellung von viskosen
ATA311179A (de) Verfahren zur herstellung von 6alpha-halogen -pregnadien-derivates
AT374486B (de) Verfahren zur herstellung von 17beta-hydroxy-17
AT371431B (de) Verfahren zur herstellung von aldehyden
AT380701B (de) Verfahren zur herstellung von monofilen
ATA663779A (de) Verfahren zur herstellung von 3-exomethyl- encephamsulfoxidestern
AT370132B (de) Verfahren zur herstellung von interferon
AT367017B (de) Verfahren zur herstellung von p-amino-diphenylamin
AT369728B (de) Verfahren zur herstellung von trichloraethylen
AT374399B (de) Verfahren zur herstellung von ziehsteinbohrungen
AT368508B (de) Verfahren zur herstellung von 3-carbamoyloxymethylcephalosporinverbindungen
DD137591A1 (de) Verfahren zur herstellung von aethylenhomo-und-kopolymerisaten
AT370422B (de) Verfahren zur herstellung von vindesinmonosulfat
AT376439B (de) Verfahren zur herstellung von ergotalkaloiden
DD136833A1 (de) Verfahren zur herstellung von polyaetheralkoholen
ATA254579A (de) Verfahren zur herstellung von 2-mercaptobenzthiazol
AT357547B (de) Verfahren zur herstellung von 3-phenyl- pyridazon-(6)
AT373244B (de) Verfahren zur herstellung von n-tritylimidazolverbindungen
AT366661B (de) Verfahren zur herstellung von cisbicyclooctylaminen
DD134270A1 (de) Verfahren zur herstellung von diazomaterialien

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee