AT338286B - Verfahren zur herstellung von neuen 7- ((omega-1) -oxoalkyl) -1,3- dialkylxanthinen - Google Patents

Verfahren zur herstellung von neuen 7- ((omega-1) -oxoalkyl) -1,3- dialkylxanthinen

Info

Publication number
AT338286B
AT338286B AT929674A AT929674A AT338286B AT 338286 B AT338286 B AT 338286B AT 929674 A AT929674 A AT 929674A AT 929674 A AT929674 A AT 929674A AT 338286 B AT338286 B AT 338286B
Authority
AT
Austria
Prior art keywords
dialkylxanthines
oxoalkyl
omega
new
production
Prior art date
Application number
AT929674A
Other languages
English (en)
Other versions
ATA929674A (de
Inventor
Gunther Dr Brenner
Joachim Dr Goring
Eskendar Ali Khan
Oskar Dr Rothe
Manfred Dr Tauscher
Original Assignee
Wuelfing J A Fa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2402908A external-priority patent/DE2402908C2/de
Application filed by Wuelfing J A Fa filed Critical Wuelfing J A Fa
Priority to AT243276A priority Critical patent/AT338821B/de
Publication of ATA929674A publication Critical patent/ATA929674A/de
Application granted granted Critical
Publication of AT338286B publication Critical patent/AT338286B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT929674A 1974-01-22 1974-11-20 Verfahren zur herstellung von neuen 7- ((omega-1) -oxoalkyl) -1,3- dialkylxanthinen AT338286B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT243276A AT338821B (de) 1974-01-22 1976-04-05 Verfahren zur herstellung von neuen 7-(3'-oxoalkyl)-1,3-dialkylxanthinen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2402908A DE2402908C2 (de) 1974-01-22 1974-01-22 7-(3-Oxobutyl)-1,3-di-(n-butyl)-xanthin und Verfahren zu seiner Herstellung

Publications (2)

Publication Number Publication Date
ATA929674A ATA929674A (de) 1976-12-15
AT338286B true AT338286B (de) 1977-08-10

Family

ID=5905372

Family Applications (1)

Application Number Title Priority Date Filing Date
AT929674A AT338286B (de) 1974-01-22 1974-11-20 Verfahren zur herstellung von neuen 7- ((omega-1) -oxoalkyl) -1,3- dialkylxanthinen

Country Status (13)

Country Link
US (2) US4242345A (de)
JP (1) JPS5912677B2 (de)
AR (1) AR207462A1 (de)
AT (1) AT338286B (de)
BE (1) BE824665A (de)
CA (1) CA1068693A (de)
CH (1) CH608236A5 (de)
FI (1) FI59596C (de)
FR (1) FR2258183B1 (de)
GB (1) GB1441562A (de)
HU (1) HU169012B (de)
NL (1) NL184330C (de)
YU (1) YU15175A (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2507555A1 (de) * 1975-02-21 1976-09-02 Wuelfing J A Fa 7-(oxoalkyl)-1,3-dialkylxanthine, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
DE2507554A1 (de) * 1975-02-21 1976-09-02 Wuelfing J A Fa 7-(oxoalkyl)-1,3-dialkylxanthine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0005015B1 (de) * 1978-04-22 1986-10-29 BEECHAM - WUELFING GmbH & Co. KG Verwendung eines Xanthinderivats für die Herstellung eines Arzneimittels
IL59665A0 (en) * 1979-04-05 1980-06-30 Wuelfing J Kg Xanthine derivatives,process for their preparation and their use in pharmaceutical compositions
DE3173289D1 (en) * 1980-06-21 1986-02-06 Beecham Wuelfing Gmbh & Co Kg Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment
JPS63225317A (ja) * 1986-10-06 1988-09-20 Hoechst Japan Kk 抗消化性潰瘍剤
US4965271A (en) * 1986-12-31 1990-10-23 Hoechst Roussel Pharmaceuticals, Inc. Method of inhibiting the activity of leukocyte derived cytokines
US5096906A (en) * 1986-12-31 1992-03-17 University Of Virginia Alumni Patents Foundation Method of inhibiting the activity of leukocyte derived cytokines
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤
US5321029A (en) * 1988-11-14 1994-06-14 Beecham-Wuelfing Gmbh & Co.K.G. Xanthines
GB8826595D0 (en) * 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
CA2030112A1 (en) * 1989-11-24 1991-05-25 Yasuo Ito Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same
DE69119700T2 (de) * 1990-11-07 1996-11-07 Hoechst Roussel Pharma Verwendung von Xanthinen zur Herstellung von Arzneimitteln zur Hemmung der Vermehrung menschlicher Retroviren
US6420374B1 (en) 1990-11-30 2002-07-16 Fred Hutchinson Cancer Research Center Use of xanthines as immunosuppressants and to inhibit allograft reactions
MX9203323A (es) * 1991-07-11 1994-07-29 Hoechst Ag El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales.
ATE146078T1 (de) * 1992-02-22 1996-12-15 Hoechst Ag Verwendung von xanthinderivaten zur behandlung von muskelschädigungen nach vollständiger unterbrechung der blutzirkulation
EP0570831A2 (de) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
US6670334B2 (en) 2001-01-05 2003-12-30 University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
SG176313A1 (en) * 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
CA2576826C (en) * 2004-08-02 2014-09-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006023272A1 (en) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA557342A (en) 1958-05-13 Doebel Karl Process for the manufacture of novel xanthine derivatives
US2756229A (en) * 1956-07-24 Xanthine derivatives
US2761863A (en) * 1956-09-04 Lower-alkyl
FR4791E (fr) 1900-06-29 1905-10-16 Eugene Fournier Lampe à pétrole perfectionnée pour chauffage intensif dite: "la naphteuse"
GB759174A (en) * 1952-11-07 1956-10-17 Geigy Ag J R Improvements in diuretic acting xanthine derivatives
DE926788C (de) 1952-11-07 1955-04-25 Geigy Ag J R Verfahren zur Herstellung von 1, 3-dialkylierten 7-Oxyalkyl-xanthinabkoemmlingen
GB759981A (en) * 1953-09-09 1956-10-24 Roche Products Ltd Process for the manufacture of xanthine derivatives
CH325292A (de) 1953-10-21 1957-10-31 Geigy Ag J R Verfahren zur Herstellung von 7-Oxyalkyl-xanthinderivaten
US3737433A (en) * 1964-09-05 1973-06-05 Albert Ag Chem Werke Certain oxoalkyldimethylxanthines
DE2234202A1 (de) 1972-07-12 1974-01-24 Albert Ag Chem Werke Verfahren zur herstellung von oxoalkylxanthinen
DE2330742C2 (de) 1973-06-16 1982-07-29 Hoechst Ag, 6000 Frankfurt 1-(Oxoalkyl)-3-methyl-7-alkylxanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2457666A1 (de) * 1974-12-06 1976-06-10 Hoechst Ag Arzneimittel, verfahren zur herstellung von dafuer geeigneten wirkstoffen und diese oxoalkyl-dialkyl-xanthine
JPS5233120A (en) * 1975-09-10 1977-03-14 Nisshin Steel Co Ltd Double coiled automobile steel pipe covered with heat flexible plastic resin

Also Published As

Publication number Publication date
NL7414887A (nl) 1975-07-24
CH608236A5 (de) 1978-12-29
NL184330B (nl) 1989-01-16
FR2258183A1 (de) 1975-08-18
BE824665A (fr) 1975-05-15
US4291037A (en) 1981-09-22
JPS50101386A (de) 1975-08-11
US4242345A (en) 1980-12-30
JPS5912677B2 (ja) 1984-03-24
FR2258183B1 (de) 1978-07-28
FI750122A (de) 1975-07-23
ATA929674A (de) 1976-12-15
YU15175A (en) 1982-06-30
FI59596B (fi) 1981-05-29
CA1068693A (en) 1979-12-25
GB1441562A (en) 1976-07-07
NL184330C (nl) 1989-06-16
FI59596C (fi) 1981-09-10
AR207462A1 (es) 1976-10-08
HU169012B (de) 1976-08-28

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Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee