AR248140A1 - Composicion de 1, 4, 7, 10-tetraazaciclododecano como la fraccion macrolitica, o sales fisiologicamente aceptables del mismo y radionuclidos como agente terapeuticamente activo. - Google Patents

Composicion de 1, 4, 7, 10-tetraazaciclododecano como la fraccion macrolitica, o sales fisiologicamente aceptables del mismo y radionuclidos como agente terapeuticamente activo.

Info

Publication number
AR248140A1
AR248140A1 AR89315722A AR31572289A AR248140A1 AR 248140 A1 AR248140 A1 AR 248140A1 AR 89315722 A AR89315722 A AR 89315722A AR 31572289 A AR31572289 A AR 31572289A AR 248140 A1 AR248140 A1 AR 248140A1
Authority
AR
Argentina
Prior art keywords
treatment
acid complexes
aminophosphonic acid
macrocyclic aminophosphonic
calcific tumors
Prior art date
Application number
AR89315722A
Other languages
English (en)
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of AR248140A1 publication Critical patent/AR248140A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PREPARACION DE UN COMPLEJO TERAPEUTICO QUE TIENE: (1) ACIDO 1, 4, 7, 10- TETRAAZACICLODODECANO-1, 4, 7, 10-TETRAMETILENFOSFONICO DE FORMULA (II) Y SALES FISIOLOGICAMENTE ACEPTABLES DE LOS ACIDOS DONDE CADA A ES UN GRUPO (I), (2) UN RADIONUCLIDO DE SM-153, GD-159, HO-166, LU-177, YB-175 QUE COMPRENDE HACER REACCIONAR, ACIDO 1, 4, 7, 10-TETRAAZACICLODODECANO DE FORMULA (II) EN MEDIO ACUOSO, CON UN RADIONUCLIDO ELEGIDO ENTRE LOS ANTERIORES A PH CONTROLADO.
AR89315722A 1988-12-19 1989-12-19 Composicion de 1, 4, 7, 10-tetraazaciclododecano como la fraccion macrolitica, o sales fisiologicamente aceptables del mismo y radionuclidos como agente terapeuticamente activo. AR248140A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/284,876 US5059412A (en) 1984-06-04 1988-12-19 Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors

Publications (1)

Publication Number Publication Date
AR248140A1 true AR248140A1 (es) 1995-06-30

Family

ID=23091854

Family Applications (1)

Application Number Title Priority Date Filing Date
AR89315722A AR248140A1 (es) 1988-12-19 1989-12-19 Composicion de 1, 4, 7, 10-tetraazaciclododecano como la fraccion macrolitica, o sales fisiologicamente aceptables del mismo y radionuclidos como agente terapeuticamente activo.

Country Status (26)

Country Link
US (1) US5059412A (es)
EP (2) EP0408701B1 (es)
JP (1) JP2515929B2 (es)
KR (1) KR0178966B1 (es)
CN (1) CN1025983C (es)
AR (1) AR248140A1 (es)
AT (1) ATE112689T1 (es)
AU (3) AU639899B2 (es)
BR (1) BR8907255A (es)
CA (1) CA2005880C (es)
CY (1) CY1902A (es)
DE (1) DE68918852T2 (es)
DK (1) DK175479B1 (es)
ES (1) ES2061010T3 (es)
FI (1) FI101857B1 (es)
HK (1) HK146795A (es)
HU (1) HU207454B (es)
IE (2) IE940833L (es)
IL (1) IL92784A (es)
MX (1) MX18786A (es)
NO (1) NO180434C (es)
NZ (1) NZ231818A (es)
PT (1) PT92619B (es)
SA (1) SA91120234B1 (es)
WO (1) WO1990006776A1 (es)
ZA (1) ZA899734B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
JPH06340556A (ja) * 1990-06-18 1994-12-13 Dow Chem Co:The イメージング剤としての大環状アミノホスホン酸錯体の使用
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
WO1997001360A2 (en) * 1995-06-26 1997-01-16 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements and their use in medical therapy and diagnosis
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6005083A (en) * 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
CA2434302A1 (en) * 2001-01-08 2002-08-15 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
US20020094316A1 (en) * 2001-01-09 2002-07-18 Shuang Liu Polypodal chelants for metallopharmaceuticals
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
US20030228256A1 (en) * 2002-06-11 2003-12-11 Inverardi Luca A. Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2007008232A2 (en) 2004-09-03 2007-01-18 Board Of Regents, The University Of Texas System Locoregional internal radionuclide ablation of abnormal tissues.
WO2011149844A1 (en) * 2010-05-24 2011-12-01 Iso Therapeutics Group Llc Delivery of high dose therapeutic radioisotopes to bone
EP3054996B1 (en) 2013-10-07 2023-06-21 IGL Pharma, Inc. Process for preparing high purity therapeutic bone agents
JP6930922B2 (ja) * 2015-05-25 2021-09-01 アイジーエル ファーマ，インコーポレイティド 放射性同位体用ｄｏｔｍｐキット製剤
US11369700B2 (en) 2015-05-25 2022-06-28 IGL Pharma Inc. DOTMP kit formulations for radioisotopes
IL265536B (en) 2016-09-27 2022-07-01 Bayer Pharma AG A method for the production of a crystalline form of the a modification of calcobuterol
US11813339B2 (en) 2017-02-08 2023-11-14 Igl Pharma, Inc. Method of use for therapeutic bone agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965254A (en) * 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
US4017595A (en) * 1975-08-28 1977-04-12 Research Corporation Bone-seeking indium-113m or indium-111 organic phosphonate complexes
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
AU563671B2 (en) * 1984-06-04 1987-07-16 Dow Chemical Company, The Organic amine phosphonic acid complexes
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents

Also Published As

Publication number Publication date
AU657641B2 (en) 1995-03-16
CN1025983C (zh) 1994-09-28
BR8907255A (pt) 1991-03-12
AU5068593A (en) 1994-02-24
DE68918852T2 (de) 1995-05-11
FI101857B (fi) 1998-09-15
EP0408701A4 (en) 1991-07-31
US5059412A (en) 1991-10-22
HU901163D0 (en) 1991-03-28
NO903632L (no) 1990-10-17
EP0375376A2 (en) 1990-06-27
AU639899B2 (en) 1993-08-12
NO903632D0 (no) 1990-08-17
FI101857B1 (fi) 1998-09-15
MX18786A (es) 1993-12-01
DK175479B1 (da) 2004-11-08
PT92619B (pt) 1995-09-12
HUT54897A (en) 1991-04-29
IL92784A (en) 1994-08-26
CN1046739A (zh) 1990-11-07
EP0408701B1 (en) 1994-10-12
IE940833L (en) 1990-06-19
SA91120234B1 (ar) 2004-09-04
JP2515929B2 (ja) 1996-07-10
NO180434C (no) 1997-04-23
ATE112689T1 (de) 1994-10-15
KR910700073A (ko) 1991-03-13
DK195990D0 (da) 1990-08-16
CA2005880A1 (en) 1990-06-19
IE66391B1 (en) 1995-12-27
AU4828290A (en) 1990-07-10
IL92784A0 (en) 1990-09-17
CA2005880C (en) 1999-01-05
FI904084A0 (fi) 1990-08-17
NO180434B (no) 1997-01-13
EP0375376A3 (en) 1991-06-12
KR0178966B1 (ko) 1999-03-20
NZ231818A (en) 1992-05-26
ES2061010T3 (es) 1994-12-01
IE894063L (en) 1990-06-19
PT92619A (pt) 1990-06-29
DK195990A (da) 1990-08-16
EP0408701A1 (en) 1991-01-23
HK146795A (en) 1995-09-22
ZA899734B (en) 1991-08-28
WO1990006776A1 (en) 1990-06-28
HU207454B (en) 1993-04-28
AU4700989A (en) 1990-06-21
JPH03502936A (ja) 1991-07-04
DE68918852D1 (de) 1994-11-17
CY1902A (en) 1989-12-15

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