ATE112689T1 - Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung. - Google Patents

Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.

Info

Publication number
ATE112689T1
ATE112689T1 AT90901464T AT90901464T ATE112689T1 AT E112689 T1 ATE112689 T1 AT E112689T1 AT 90901464 T AT90901464 T AT 90901464T AT 90901464 T AT90901464 T AT 90901464T AT E112689 T1 ATE112689 T1 AT E112689T1
Authority
AT
Austria
Prior art keywords
macrocylic
formulations
manufacture
methods
acid complexes
Prior art date
Application number
AT90901464T
Other languages
English (en)
Inventor
Jaime Simon
David A Wilson
Joseph R Garlich
David E Troutner
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ATE112689T1 publication Critical patent/ATE112689T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817—Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/06—Chelate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT90901464T 1988-12-19 1989-12-15 Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung. ATE112689T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/284,876 US5059412A (en) 1984-06-04 1988-12-19 Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors

Publications (1)

Publication Number Publication Date
ATE112689T1 true ATE112689T1 (de) 1994-10-15

Family

ID=23091854

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90901464T ATE112689T1 (de) 1988-12-19 1989-12-15 Makrocylische aminophosphonsäurekomplexe, verfahren zur herstellung und formulierungen sowie verwendung.

Country Status (26)

Country Link
US (1) US5059412A (de)
EP (2) EP0408701B1 (de)
JP (1) JP2515929B2 (de)
KR (1) KR0178966B1 (de)
CN (1) CN1025983C (de)
AR (1) AR248140A1 (de)
AT (1) ATE112689T1 (de)
AU (3) AU639899B2 (de)
BR (1) BR8907255A (de)
CA (1) CA2005880C (de)
CY (1) CY1902A (de)
DE (1) DE68918852T2 (de)
DK (1) DK175479B1 (de)
ES (1) ES2061010T3 (de)
FI (1) FI101857B1 (de)
HK (1) HK146795A (de)
HU (1) HU207454B (de)
IE (2) IE940833L (de)
IL (1) IL92784A (de)
MX (1) MX18786A (de)
NO (1) NO180434C (de)
NZ (1) NZ231818A (de)
PT (1) PT92619B (de)
SA (1) SA91120234B1 (de)
WO (1) WO1990006776A1 (de)
ZA (1) ZA899734B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US5645818A (en) * 1989-03-24 1997-07-08 Guerbet S.A. Diagnostic compositions comprising a complex formed by a nitrogenous macrocyclic ligand with metal ions
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
WO1991016075A1 (en) * 1990-04-20 1991-10-31 Australian Nuclear Science & Technology Organisation Bone marrow treatments
MC2260A1 (fr) * 1990-06-18 1993-04-26 Dow Chemical Co Formulations de produits radiopharmaceutiques,leur methode d'administration et leur procede de preparation
ZA914616B (en) * 1990-06-18 1993-02-24 Dow Chemical Co The use of macrocyclic aminophosphonic acid complexes as imaging agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5320829A (en) * 1991-12-10 1994-06-14 The Dow Chemical Company Oral compositions for inhibiting plaque formation
EP0955044B1 (de) * 1995-06-26 2005-11-16 Chelator LLC Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
EP1191948A2 (de) * 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
AU2002249935A1 (en) * 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
WO2002055112A2 (en) * 2001-01-09 2002-07-18 Bristol Myers Squibb Co Polypodal chelants for metallopharmaceuticals
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
US20030228256A1 (en) * 2002-06-11 2003-12-11 Inverardi Luca A. Methods of achieving transplantation tolerance through radioablation of hemolymphopoietic cell populations
WO2007008232A2 (en) 2004-09-03 2007-01-18 Board Of Regents, The University Of Texas System Locoregional internal radionuclide ablation of abnormal tissues.
WO2011149844A1 (en) * 2010-05-24 2011-12-01 Iso Therapeutics Group Llc Delivery of high dose therapeutic radioisotopes to bone
CA2926652C (en) 2013-10-07 2021-07-20 Isotherapeutics Group, Llc High purity therapeutic bone agents
US11369700B2 (en) 2015-05-25 2022-06-28 IGL Pharma Inc. DOTMP kit formulations for radioisotopes
EP3302496B1 (de) * 2015-05-25 2021-01-06 IGL Pharma, Inc. Dotmp-kitformulierungen für radioisotope
US10793532B2 (en) 2016-09-27 2020-10-06 Bayer Pharma Aktiengesellschaft Method for producing the crystalline form of modification a of calcobutrol
EP3579886A4 (de) * 2017-02-08 2020-11-25 IGL Pharma, Inc. Verfahren zur verwendung für therapeutische knochenmittel

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965254A (en) * 1973-05-23 1976-06-22 The Procter & Gamble Company Compositions for the treatment of calcific tumors
US4017595A (en) * 1975-08-28 1977-04-12 Research Corporation Bone-seeking indium-113m or indium-111 organic phosphonate complexes
CA1078731A (en) * 1976-12-16 1980-06-03 Charles E. Frosst And Co. Skeletal imaging kit utilizing triethylene tetramine hexa (methylene phosphonic acid)
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
ZA852799B (en) * 1984-06-04 1986-12-30 Dow Chemical Co Organic amine phosphonic acid complexes for the treatment of calcific tumors
US5064633A (en) * 1984-06-04 1991-11-12 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes, their formulations and use
US5059412A (en) * 1984-06-04 1991-10-22 The Dow Chemical Company Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors
US4898724A (en) * 1984-06-04 1990-02-06 The Dow Chemical Company Organis amine phosphonic acid complexes for the treatment of calcific tumors
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US4853209A (en) * 1987-05-18 1989-08-01 The Dow Chemical Company Bone marrow suppressing agents
US4976950A (en) * 1988-12-19 1990-12-11 The Dow Chemical Company Bone marrow suppressing agents
US4882142A (en) * 1988-12-19 1989-11-21 The Dow Chemical Company Bone marrow suppressing agents

Also Published As

Publication number Publication date
IE66391B1 (en) 1995-12-27
CY1902A (en) 1989-12-15
DE68918852T2 (de) 1995-05-11
SA91120234B1 (ar) 2004-09-04
HK146795A (en) 1995-09-22
US5059412A (en) 1991-10-22
JPH03502936A (ja) 1991-07-04
DE68918852D1 (de) 1994-11-17
NO903632L (no) 1990-10-17
EP0408701A4 (en) 1991-07-31
CA2005880A1 (en) 1990-06-19
NO180434C (no) 1997-04-23
AU657641B2 (en) 1995-03-16
WO1990006776A1 (en) 1990-06-28
KR0178966B1 (ko) 1999-03-20
AU4828290A (en) 1990-07-10
PT92619A (pt) 1990-06-29
IE894063L (en) 1990-06-19
IL92784A0 (en) 1990-09-17
EP0375376A2 (de) 1990-06-27
DK195990A (da) 1990-08-16
AU4700989A (en) 1990-06-21
EP0408701A1 (de) 1991-01-23
FI101857B (fi) 1998-09-15
ZA899734B (en) 1991-08-28
MX18786A (es) 1993-12-01
EP0375376A3 (de) 1991-06-12
KR910700073A (ko) 1991-03-13
AU5068593A (en) 1994-02-24
AR248140A1 (es) 1995-06-30
DK175479B1 (da) 2004-11-08
CA2005880C (en) 1999-01-05
CN1046739A (zh) 1990-11-07
BR8907255A (pt) 1991-03-12
IE940833L (en) 1990-06-19
HUT54897A (en) 1991-04-29
CN1025983C (zh) 1994-09-28
PT92619B (pt) 1995-09-12
JP2515929B2 (ja) 1996-07-10
IL92784A (en) 1994-08-26
HU901163D0 (en) 1991-03-28
EP0408701B1 (de) 1994-10-12
AU639899B2 (en) 1993-08-12
FI101857B1 (fi) 1998-09-15
FI904084A0 (fi) 1990-08-17
ES2061010T3 (es) 1994-12-01
NO903632D0 (no) 1990-08-17
DK195990D0 (da) 1990-08-16
NO180434B (no) 1997-01-13
HU207454B (en) 1993-04-28
NZ231818A (en) 1992-05-26

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Legal Events

Date Code Title Description
EELA Cancelled due to lapse of time