AR246527A1 - Procedimiento para la preparacion de n-acil-n,n'-di-lisogangliosidos, n'-acil-n,n'-di-lisogangliosidos y n,n'-diacil-n,n'-di-lisogangliosidos. - Google Patents
Procedimiento para la preparacion de n-acil-n,n'-di-lisogangliosidos, n'-acil-n,n'-di-lisogangliosidos y n,n'-diacil-n,n'-di-lisogangliosidos.Info
- Publication number
- AR246527A1 AR246527A1 AR90318382A AR31838290A AR246527A1 AR 246527 A1 AR246527 A1 AR 246527A1 AR 90318382 A AR90318382 A AR 90318382A AR 31838290 A AR31838290 A AR 31838290A AR 246527 A1 AR246527 A1 AR 246527A1
- Authority
- AR
- Argentina
- Prior art keywords
- lisogangliosidos
- acil
- groups
- diacil
- aliphatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G99/00—Subject matter not provided for in other groups of this subclass
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
PREPARACION DE N-ACIL-N,N'-DI-LISOGANGLIOSIDOS, N'-ACIL-N,N'-DI- LISOGANGLIOSIDOS Y N,N'-DIACIL-N,N'-DI-LISOGANGLIOSIDOS, DONDE LOS GRUPOS ACILO DERIVAN DE UN ACIDO ORGANICO ALIFATICO, AROMATICO,ARALIFATICO, ALICICLICO O HETEROCICLICO Y EN DONDE UNO DE LOS DOS GRUPOS ACILO NO ES ALIFATICO, ESTERES Y/O AMIDAS DE LOS GRUPOS CARBOXI SIALICOS DE LOS MISMOS, Y/O ESTERES INTERNOS Y/O DERIVADOS PERACILADOS DE LOS MISMOS, QUE COMPRENDE ACILAR N,N'-DI-LISOGANGLIOSIDOS, N-ACIL-N,N'-DI-LISOGANGLIOSIDOS O N'-ACIL- N,N'-DI-LISOGANGLIOSIDOS CON LOS ACIDOS CORRESPONDIENTES O DESACILAR LOS N,N'-DIACIL-N,N'-DI-LISOGANGLIOSIDOS APROPIADOS SELECTIVAMENTE EN EL NITROGENO DE ESFINGOSINA O EN EL NITROGENO NEURAMINICO, O MEZCLAS DE ESTOS COMPUESTOS Y, OPCIONALMENTE CONVERTIR LOS ACIL-DI-LISOGANGLIOSIDOS RESULTANTES EN ESTER, AMIDA, ESTER INTERNO Y/O HIDROXI PERACILADOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT04855489A IT1238346B (it) | 1989-11-14 | 1989-11-14 | Gangliosidi modificati e loro derivati funzionali. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR246527A1 true AR246527A1 (es) | 1994-08-31 |
Family
ID=11267289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90318382A AR246527A1 (es) | 1989-11-14 | 1990-11-14 | Procedimiento para la preparacion de n-acil-n,n'-di-lisogangliosidos, n'-acil-n,n'-di-lisogangliosidos y n,n'-diacil-n,n'-di-lisogangliosidos. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5264424A (es) |
| EP (1) | EP0433112B1 (es) |
| JP (1) | JPH03170491A (es) |
| KR (1) | KR910009716A (es) |
| CN (1) | CN1033031C (es) |
| AR (1) | AR246527A1 (es) |
| AT (1) | ATE172737T1 (es) |
| AU (1) | AU645766B2 (es) |
| BR (1) | BR9005758A (es) |
| CA (1) | CA2029974A1 (es) |
| DE (1) | DE69032722T2 (es) |
| ES (1) | ES2124214T3 (es) |
| FI (1) | FI905628A0 (es) |
| HU (1) | HU210744B (es) |
| IL (1) | IL96344A0 (es) |
| IT (1) | IT1238346B (es) |
| NO (1) | NO174775C (es) |
| NZ (1) | NZ236057A (es) |
| PL (1) | PL287756A1 (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407072B1 (en) * | 1988-12-02 | 2002-06-18 | Fidia S.P.A. | Lysoganglioside derivatives |
| IT1232176B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Derivati di-lisogangliosidi |
| IT1239060B (it) * | 1990-05-04 | 1993-09-20 | Fidia Spa | Processo per la modulazione selettiva dell'espressione e della funzione di un determinante sulla superficie cellulare attraverso appropriati agenti chimici |
| IT1253832B (it) * | 1991-08-01 | 1995-08-29 | Fidia Spa | Derivati di gangliosidi |
| US5849717A (en) * | 1993-03-04 | 1998-12-15 | Fidia S.P.A. | O-sulfated gangliosides and lyso-ganglioside derivatives |
| IT1267955B1 (it) * | 1993-03-04 | 1997-02-18 | Fidia S P A In Amministrazione | Derivati solfatati dei lisogangliosidi |
| IT1267956B1 (it) * | 1993-03-04 | 1997-02-18 | Fidia S P A In Amministrazione | Derivati o-solfatati di gangliosidi e lisogangliosidi |
| US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
| US5824662A (en) | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| CZ60499A3 (cs) | 1996-09-27 | 1999-08-11 | Guilford Pharmaceuticals Inc. | Prostředky s účinkem na NAALADázy, způsoby léčení glutamátové abnormality a způsoby ovlivňování neuronální aktivity u živočichů |
| US5973128A (en) * | 1996-11-22 | 1999-10-26 | The Hospital For Sick Children Research And Development Lp | Glycolipid mimics and methods of use thereof |
| US7314953B2 (en) | 2001-03-27 | 2008-01-01 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
| AU2002326805B2 (en) * | 2001-08-29 | 2009-01-22 | Seneb Biosciences, Inc. | Novel synthetic ganglioside derivatives and compositions thereof |
| CA2486303C (en) | 2002-05-22 | 2013-04-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
| NZ542148A (en) | 2003-03-06 | 2008-05-30 | Neose Technologies Inc | Methods and compositions for the enzymatic synthesis of gangliosides |
| WO2005033700A1 (ja) * | 2003-10-03 | 2005-04-14 | Takeda Pharmaceutical Company Limited | インスリン抵抗性改善剤のスクリーニング方法 |
| CN1960828B (zh) * | 2004-04-15 | 2011-04-27 | 密尔沃基电动工具公司 | 动力工具 |
| WO2006052841A2 (en) * | 2004-11-09 | 2006-05-18 | Neose Technologies, Inc. | Glycolipids |
| EP2173166A4 (en) | 2007-07-03 | 2010-08-11 | Childrens Hosp & Res Ct Oak | POLYSIALIC ACID DE-N-ACETYLASE HEMMER AND METHOD OF USE THEREOF |
| CA2690440A1 (en) * | 2007-07-03 | 2009-01-08 | Children's Hospital & Research Center At Oakland | Oligosialic acid derivatives, methods of manufacture, and immunological uses |
| AU2008272785B2 (en) | 2007-07-03 | 2014-06-12 | Children's Hospital & Research Center At Oakland | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting |
| US20120035120A1 (en) | 2009-03-25 | 2012-02-09 | Seneb Biosciences, Inc. | Glycolipids as treatment for disease |
| CN109721632B (zh) * | 2017-10-27 | 2023-10-31 | 齐鲁制药有限公司 | 一种高纯度神经节苷脂gm1及其制备方法 |
| US20210353659A1 (en) * | 2018-08-24 | 2021-11-18 | Industry-Academic Cooperation Foundation, Yonsei University | Composition for preventing or treating muscular diseases, or for improving muscular functions, containing gagnlioside |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1046051B (it) * | 1975-08-13 | 1980-06-30 | Fidia Spa | Nuova applicazione terapeutica dei gangliosidi e procedimento per la loro estrazione |
| IT1171432B (it) * | 1981-08-03 | 1987-06-10 | Fidia Farmaceutici | Amidi organiche derivate da lipidi azotati utilizzabili come farmaci |
| US4476119A (en) * | 1981-08-04 | 1984-10-09 | Fidia S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
| US4716223A (en) * | 1981-08-04 | 1987-12-29 | Fidia, S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
| US4593091A (en) * | 1981-08-04 | 1986-06-03 | Fidia, S.P.A. | Method for preparing ganglioside derivatives and use thereof in pharmaceutical compositions |
| IT1199116B (it) * | 1984-07-03 | 1988-12-30 | Fidia Farmaceutici | Derivati di gangliosidi |
| IT1182209B (it) * | 1985-02-18 | 1987-09-30 | Fidia Farmaceutici | Uso terapeutico del monosialoganglioside gm1 e dei suoi derivati in gravi patologie di infarti cerebrali |
| IT1235161B (it) * | 1988-12-02 | 1992-06-22 | Fidia Farmaceutici | Derivati di lisogangliosidi |
| IT1232176B (it) * | 1989-07-27 | 1992-01-25 | Fidia Farmaceutici | Derivati di-lisogangliosidi |
-
1989
- 1989-11-14 IT IT04855489A patent/IT1238346B/it active IP Right Grant
-
1990
- 1990-11-13 US US07/611,700 patent/US5264424A/en not_active Expired - Fee Related
- 1990-11-13 NZ NZ236057A patent/NZ236057A/en unknown
- 1990-11-13 BR BR909005758A patent/BR9005758A/pt not_active Application Discontinuation
- 1990-11-13 NO NO904921A patent/NO174775C/no unknown
- 1990-11-14 EP EP90403220A patent/EP0433112B1/en not_active Expired - Lifetime
- 1990-11-14 ES ES90403220T patent/ES2124214T3/es not_active Expired - Lifetime
- 1990-11-14 DE DE69032722T patent/DE69032722T2/de not_active Expired - Fee Related
- 1990-11-14 AT AT90403220T patent/ATE172737T1/de not_active IP Right Cessation
- 1990-11-14 KR KR1019900018389A patent/KR910009716A/ko not_active Application Discontinuation
- 1990-11-14 AU AU66624/90A patent/AU645766B2/en not_active Ceased
- 1990-11-14 CN CN90109290A patent/CN1033031C/zh not_active Expired - Fee Related
- 1990-11-14 CA CA002029974A patent/CA2029974A1/en not_active Abandoned
- 1990-11-14 AR AR90318382A patent/AR246527A1/es active
- 1990-11-14 FI FI905628A patent/FI905628A0/fi not_active Application Discontinuation
- 1990-11-14 IL IL96344A patent/IL96344A0/xx unknown
- 1990-11-14 JP JP2310149A patent/JPH03170491A/ja active Pending
- 1990-11-14 PL PL28775690A patent/PL287756A1/xx unknown
- 1990-11-14 HU HU907124A patent/HU210744B/hu not_active IP Right Cessation
-
1993
- 1993-10-20 US US08/138,184 patent/US5424294A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2124214T3 (es) | 1999-02-01 |
| US5424294A (en) | 1995-06-13 |
| EP0433112A1 (en) | 1991-06-19 |
| CA2029974A1 (en) | 1991-05-15 |
| EP0433112B1 (en) | 1998-10-28 |
| IL96344A0 (en) | 1991-08-16 |
| IT8948554A0 (it) | 1989-11-14 |
| NO174775B (no) | 1994-03-28 |
| IT1238346B (it) | 1993-07-13 |
| CN1033031C (zh) | 1996-10-16 |
| KR910009716A (ko) | 1991-06-28 |
| NO904921D0 (no) | 1990-11-13 |
| BR9005758A (pt) | 1991-09-24 |
| JPH03170491A (ja) | 1991-07-24 |
| DE69032722T2 (de) | 1999-07-08 |
| IT8948554A1 (it) | 1991-05-14 |
| CN1051912A (zh) | 1991-06-05 |
| NZ236057A (en) | 1994-09-27 |
| NO904921L (no) | 1991-05-15 |
| HUT55403A (en) | 1991-05-28 |
| FI905628A0 (fi) | 1990-11-14 |
| PL287756A1 (en) | 1991-12-02 |
| AU6662490A (en) | 1991-05-23 |
| ATE172737T1 (de) | 1998-11-15 |
| DE69032722D1 (de) | 1998-12-03 |
| US5264424A (en) | 1993-11-23 |
| AU645766B2 (en) | 1994-01-27 |
| NO174775C (no) | 1994-07-06 |
| HU210744B (en) | 1995-07-28 |
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