AR241657A1 - Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos. - Google Patents

Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos.

Info

Publication number
AR241657A1
AR241657A1 AR88312367A AR31236788A AR241657A1 AR 241657 A1 AR241657 A1 AR 241657A1 AR 88312367 A AR88312367 A AR 88312367A AR 31236788 A AR31236788 A AR 31236788A AR 241657 A1 AR241657 A1 AR 241657A1
Authority
AR
Argentina
Prior art keywords
benanomycin
temperature
acid
medium
products
Prior art date
Application number
AR88312367A
Other languages
English (en)
Original Assignee
Zaidan Hojin Biseibutsu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP62277692A external-priority patent/JP2592468B2/ja
Priority claimed from JP32716387A external-priority patent/JP2512050B2/ja
Application filed by Zaidan Hojin Biseibutsu filed Critical Zaidan Hojin Biseibutsu
Application granted granted Critical
Publication of AR241657A1 publication Critical patent/AR241657A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/826—Actinomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PREAPARACION DE BENANOMICINA A Y BENANOMICINA B Y/O DEXILOSILBENANOMICINA B DE FORMULA (I) O SUS SALES Y ALQUIL ESTERES , SIENDO R -OH O AMINO Y R1 ES H O XILOXILO, A CONDICION DE QUE CUANDO R ES-OH, R1 NO ES H, Y UNA SAL O UN ESTER DE (I). CULTIVAR UNA CEPA PRODUCTORA DE BENAOMICINA A Y BENANOMICINA B, MH193-16F4 (FER1BP-2051) DE ACTINOMICETES EN UN MEDIO DE CULTIVO QUE TIENE FUENTESRBONO NITROGENO ASIMILABLES, BAJO CONDICIONES AEROBICAS, PARA PRODUCIR BENANOMICINA A Y/O BENANOMICINA B EN EL CUTILVO, Y LUEGO RECUPERAR ESTOS PRODUCTOS O UNO DE ELLOS DEL CULTIVO. SI SE DESEA HIDROLIZAR LA BENANOMICINA B EN UN MEDIO ACIDO, O CON UN ALCOHOL QUE CONTIENE UN ACIDO INORGANICO PARA LA ALCOHOLISIS, NEUTRALIZANDO LUEGO CON UN MEDIO ALCALINO, PARA OBTENER DEXILOSILBENANOMICINAB. TAMBIEN SE PUEDE HACERLOS REACCIONAR CON UN ALCOHOL PARA OBTENER LOS ALQUIL ESTERES, HACIENDO LA HIDROLISIS EN MEDIO ACIDO A UNA TEMPERATURA ENTRE 60° Y 110°C Y LA ALCOHOLISIS DE LA BANANOMICINA B CON ALCOHOLES A UN A TEMPERATURA ENTRE 60° Y 120°C, SEGUIDA DE LA SUBSIGUIENTE HIDROLISIS DE LOS ALQUIL CARBOXILATOS DE LA DEXILOXILBENANOMICINA B, CON HIDROXIDOS O CARBONATOS DE METILO ALCALINOS EN MEDIO ACUOSO, PARA OBTENER DESILOXILBENANOMICINA B. ESTOS PRODUCTOS SON ANTIBIOTICOS CON PROPIEDADES ANTIFUNGICIDAS.
AR88312367A 1987-11-02 1988-11-02 Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos. AR241657A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62277692A JP2592468B2 (ja) 1987-11-02 1987-11-02 新規抗生物質ベナノマイシンａおよびｂならびにその製造法
JP32716387A JP2512050B2 (ja) 1987-12-25 1987-12-25 新規抗かび性抗生物質デキシロシルベナノマイシンｂならびにその製造法

Publications (1)

Publication Number Publication Date
AR241657A1 true AR241657A1 (es) 1992-10-30

Family

ID=26552521

Family Applications (1)

Application Number Title Priority Date Filing Date
AR88312367A AR241657A1 (es) 1987-11-02 1988-11-02 Un procedimiento para la preparacion de benanomicina a y benanomicina b y/o dexilosilbenanomicina b, sus sales y alquil(c1-c4) esteres de los mismos.

Country Status (10)

Country Link
US (2) US5055453A (es)
EP (1) EP0315147B1 (es)
AR (1) AR241657A1 (es)
AU (1) AU612189B2 (es)
CA (1) CA1339016C (es)
DE (1) DE3887820T2 (es)
DK (1) DK170029B1 (es)
ES (1) ES2063015T3 (es)
FI (1) FI98739C (es)
MX (1) MX9201563A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5110960A (en) * 1987-02-02 1992-05-05 Bristol-Myers Company Antifungal antibiotics
US4990497A (en) * 1987-02-02 1991-02-05 Toshikazu Oki Antifungal antibiotics
US5109122A (en) * 1987-11-02 1992-04-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antibiotics, dexylosylbenanomicin B
US4992425A (en) * 1988-06-07 1991-02-12 Bristol-Myers Company Antibiotics BU-3608D and BU-3608E
US4960755A (en) * 1988-07-19 1990-10-02 Bristol-Myers Company BU-3608 derivatives
JP2643340B2 (ja) 1988-08-22 1997-08-20 財団法人微生物化学研究会 ヒト後天性免疫不全症候群ウイルス感染阻害剤
JP2643404B2 (ja) * 1989-01-13 1997-08-20 財団法人微生物化学研究会 新抗生物質ｎ―アセチルベナノマイシンｂならびにその製造法
DE69009923T2 (de) * 1989-09-26 1994-11-03 Zaidan Hojin Biseibutsu Antifungales Antibiotikum und seine Herstellung und Verwendung.
FI92207C (fi) * 1989-11-14 1994-10-10 Squibb Bristol Myers Co Menetelmä terapeuttisesti käyttökelpoisten pradimisiinijohdannaisten valmistamiseksi
US5227370A (en) * 1989-11-14 1993-07-13 Bristol-Myers Squibb Company Pradimicin derivatives
CA2162186C (en) * 1989-11-22 1998-12-15 Shimpei Aburaki Pradimicin derivatives
US5091418A (en) * 1990-09-28 1992-02-25 Bristol-Myers Squibb Company Novel alpha-glucosidase inhibitor, pradimicin Q
US5696096A (en) * 1990-09-28 1997-12-09 Bristol-Myers Squibb Company Pradimicin derivatives
US5217877A (en) * 1990-09-28 1993-06-08 Bristol-Myers Squibb Company Process for the preparation of α-glucosidase inhibitor, pradimicin Q
JP3134010B2 (ja) * 1991-11-26 2001-02-13 財団法人微生物化学研究会 デスアラニンベナノマイシンａ誘導体およびそれらの製造法
US5837828A (en) * 1992-04-08 1998-11-17 Bristol-Myers Squibb Co. Pradimicin derivatives
US5326867A (en) * 1992-07-16 1994-07-05 Bristol-Myers Squibb Company Pradimic acids, amides, and pradimicin derivatives
JP5020244B2 (ja) * 2005-09-13 2012-09-05 ビーエーエスエフ ソシエタス・ヨーロピア 腋窩の悪臭の生成を抑制する微生物
CA2633657A1 (en) * 2005-09-19 2007-04-12 Basf Aktiengesellschaft Microorganisms inhibiting the formation of foot malodor
US9877494B2 (en) * 2014-08-21 2018-01-30 Shantung HSU Active fermentation process and fermented liquid and drinks made by using the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4870165A (en) * 1987-02-02 1989-09-26 Bristol-Myers Company Antifungal antibiotics

Also Published As

Publication number Publication date
AU612189B2 (en) 1991-07-04
DK608288D0 (da) 1988-11-01
FI98739B (fi) 1997-04-30
DE3887820T2 (de) 1994-05-19
CA1339016C (en) 1997-03-25
DE3887820D1 (de) 1994-03-24
FI98739C (fi) 1997-08-11
AU2457988A (en) 1989-05-25
DK608288A (da) 1989-05-03
EP0315147A2 (en) 1989-05-10
DK170029B1 (da) 1995-05-01
US5278052A (en) 1994-01-11
ES2063015T3 (es) 1995-01-01
EP0315147B1 (en) 1994-02-16
EP0315147A3 (en) 1991-05-15
FI885039A0 (fi) 1988-11-01
US5055453A (en) 1991-10-08
FI885039A (fi) 1989-05-03
MX9201563A (es) 1993-10-01

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