GB735731A - Improvements in or relating to the n-acylation of 1-phenyl-2-aminopropan-1:3-diol and its derivatives - Google Patents

Improvements in or relating to the n-acylation of 1-phenyl-2-aminopropan-1:3-diol and its derivatives

Info

Publication number
GB735731A
GB735731A GB3999/53A GB399953A GB735731A GB 735731 A GB735731 A GB 735731A GB 3999/53 A GB3999/53 A GB 3999/53A GB 399953 A GB399953 A GB 399953A GB 735731 A GB735731 A GB 735731A
Authority
GB
United Kingdom
Prior art keywords
diol
phenyl
dichloracetate
aminopropane
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3999/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB735731A publication Critical patent/GB735731A/en
Expired legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1 - Phenol - 2 - aminopropane - 1 : 3 - diol and its p-nitro derivative are N-acylated by treatment with an aliphatic carboxylic acid ester in aqueous alkaline medium, preferably in the presence of an alcohol. The starting material may be used as a mineral acid salt. The product may be purified by conversion in acid medium to the O-acylated isomer and subsequent re-formation of the N-acyl compound in alkaline solution. In the examples dl-cis-1-phenyl - 2 - amino - propane - 1 : 3 - diol is N-acetylated with ethyl acetate or N-dichloracetylated with methyl dichloracetate. The latter product is isomerized to 1-phenyl-2-amino-1-dichloracetoxypropan - 3 - ol with alcoholic hydrochloric acid and reconverted to the N-acyl compound with potassium carbonate. A further example shows the production of chloramphenicol from l - cis - 1 - (p - nitrophenyl)-2 - aminopropane - 1 : 3 - diol and methyl dichloracetate. Specification 652,273 is referred to.
GB3999/53A 1952-02-16 1953-02-12 Improvements in or relating to the n-acylation of 1-phenyl-2-aminopropan-1:3-diol and its derivatives Expired GB735731A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU735731X 1952-02-16

Publications (1)

Publication Number Publication Date
GB735731A true GB735731A (en) 1955-08-24

Family

ID=10980169

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3999/53A Expired GB735731A (en) 1952-02-16 1953-02-12 Improvements in or relating to the n-acylation of 1-phenyl-2-aminopropan-1:3-diol and its derivatives

Country Status (1)

Country Link
GB (1) GB735731A (en)

Similar Documents

Publication Publication Date Title
AR241657A1 (en) New antibiotics, benanomicins a and b and dexylosylbenanomicin b, and production and uses thereof
GB1042631A (en) New fused polycyclic hydrocarbon derivatives and processes for the preparation thereof
SE7506455L (en) ANTIBACTERIAL AGENTS
GB735731A (en) Improvements in or relating to the n-acylation of 1-phenyl-2-aminopropan-1:3-diol and its derivatives
GB1292170A (en) A method of preparing aeruginoic acid and esters thereof
GB562267A (en) Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid
ES421098A1 (en) Fluoro-substituted thiaxanthene derivatives
FR1190615A (en) Process for the purification of esters of dicarboxylic acids
GB707709A (en) Process for the production of n-[-a:-g-dihydroxy--a:-a-dimethyl-butyryl]--a-alanine--a-mercaptoethylamide
NL296871A (en)
GB848410A (en) Improvements in or relating to dipeptide derivatives
GB860321A (en) Preparing beta-hydromuconic seminitrile and esters thereof
GB630712A (en) Process of preparing intermediates useful in the preparation of penicill amine
ES416936A1 (en) Procedure for preparing beta- (3,4-dialcanyloxyphenyl) -l-alamines esters. (Machine-translation by Google Translate, not legally binding)
US2769837A (en) 3,5-diisopropylsalicylamide
GB799272A (en) Production of intermediates for the synthesis of reserpine and analogous compounds
MX3089E (en) PROCEDURE FOR THE PREPARATION OF A BIS (BENZAMIDE) - BENZOIC ACID DERIVATIVE
GB914503A (en) Aromatic compounds and methods for their production
GB975045A (en) A process for the production of fibres of polypeptides of glutamic acid
GB874152A (en) Process for the production of alpha-amino-beta-hydroxy-carboxylic acids
FR1211946A (en) Process for the production of alkyl esters of unsaturated aliphatic acids
GB857653A (en) Substituted anilides
GB977961A (en) Monocarboxylic acids containing a pentafluorophenyl nucleus and methods for preparing them
GB606194A (en) Improvements in or relating to thiophene compounds and processes of preparing the same
GB695741A (en) Optically active -a-phenyl-serine compounds and process for the manufacture thereof