AR240803A2 - Procedimiento para la preparacion de esteres - Google Patents
Procedimiento para la preparacion de esteresInfo
- Publication number
- AR240803A2 AR240803A2 AR30041685A AR30041685A AR240803A2 AR 240803 A2 AR240803 A2 AR 240803A2 AR 30041685 A AR30041685 A AR 30041685A AR 30041685 A AR30041685 A AR 30041685A AR 240803 A2 AR240803 A2 AR 240803A2
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- esters
- dimethyl
- substituted phenyl
- group
- Prior art date
Links
- 150000002148 esters Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE ESTERES DE ACIDO 1,4-DIHIDRO-2,6-DIMETIL-3-(ALCOXICARBONIL O ALCOXI-ALCOXICARBONIL)-4-(FENIL SUSTITUIDO)-PIRIDIN-5-CARBOXILICO, SUS ISOMEROS ESTEREOQUIMICOS Y SUS SALES FARMACEUTICAS ACEPTABLES, QUE TIENE LA FORMULA GENERAL (I), DONDE AR REPRESENTA UN GRUPO 3-NITROFENILO O 2, 3-DICLOROFENILO, A REPRESENTA UN GRUPO ALQUILENO, R REPRESENTA UN GRUPO ALQUILO, R1 REPRESENTA UN GRUPO ALQUILO. SE HACE REACCIONAR UN COMPUESTO DE FORMULA (II): AR-CHO, DONDE AR ES EL DEFINIDO ANTERIORMENTE, CON UN COMPUESTO DE FORMULA GENERAL (III) DONDE A Y R1 SON LOS DEFINIDOS ANTERIORMENTE, EN UN HIDROCARBURO HALOGENADO EN PRESENCIA DE CLORURO DE HIDROGENO ANHIDRO A UNA TEMPERATURA ENTRE 0 C Y 80 C DURANTE UNA HORA A VARIOS DIAS Y DESPUES HACER REACCIONAR EL CONDENSADO AISLADO DE (III)+(II) CON UN COMPUESTO DE FORMULA GENERAL (IV): CH-C(NH2)=CH-COOR DONDE R ES LO YA DEFINIDO EN UN DISOLVENTE APROPIADO A UNA TEMPERATURA COMPRENDIDA ENTRE LA TEMPERATURA AMBIENTE Y 105 C, DESDE UNA HORA A VARIOS DIAS, PARA PRODUCIR EL COMPUESTO DE LA FORMULA (I).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848413385A GB8413385D0 (en) | 1984-05-24 | 1984-05-24 | Carboxylic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240803A1 AR240803A1 (es) | 1991-02-28 |
| AR240803A2 true AR240803A2 (es) | 1991-02-28 |
Family
ID=10561493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR300416A AR240803A1 (es) | 1984-05-24 | 1985-05-17 | Procedimiento para la preparacion de esteres |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4634712A (es) |
| EP (1) | EP0164213B1 (es) |
| JP (1) | JPS6170A (es) |
| KR (1) | KR890004128B1 (es) |
| CN (1) | CN85104268A (es) |
| AR (1) | AR240803A1 (es) |
| AT (1) | ATE35258T1 (es) |
| AU (1) | AU575946B2 (es) |
| CA (1) | CA1261338A (es) |
| DE (1) | DE3563439D1 (es) |
| DK (1) | DK226685A (es) |
| EG (1) | EG17343A (es) |
| ES (1) | ES8703425A1 (es) |
| FI (1) | FI80678C (es) |
| GB (1) | GB8413385D0 (es) |
| GR (1) | GR851264B (es) |
| HU (1) | HU193763B (es) |
| IL (1) | IL75196A (es) |
| MX (1) | MX156875A (es) |
| NO (1) | NO165396C (es) |
| NZ (1) | NZ212111A (es) |
| PH (1) | PH21946A (es) |
| PT (1) | PT80521B (es) |
| SG (1) | SG64488G (es) |
| ZA (1) | ZA853394B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58197775A (ja) * | 1982-05-13 | 1983-11-17 | Canon Inc | 薄膜トランジスタ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| JPS5762257A (en) * | 1980-10-03 | 1982-04-15 | Yoshitomi Pharmaceut Ind Ltd | 1,4-dihydropyridine-3,5-dicarboxylic acid ester or its salt |
| JPS57175165A (en) * | 1981-04-21 | 1982-10-28 | Tokyo Tanabe Co Ltd | Novel 1,4-dihydropyridine-3,5-dicarboxylic diester derivative and its salt |
| DE3377352D1 (en) * | 1982-06-03 | 1988-08-18 | Pierrel Spa | Dihydropyridines with an antagonistic activity to calcium, process for their preparation, and pharmaceutical compositions containing them |
-
1984
- 1984-05-24 GB GB848413385A patent/GB8413385D0/en active Pending
-
1985
- 1985-04-30 DE DE8585303051T patent/DE3563439D1/de not_active Expired
- 1985-04-30 AT AT85303051T patent/ATE35258T1/de not_active IP Right Cessation
- 1985-04-30 EP EP85303051A patent/EP0164213B1/en not_active Expired
- 1985-05-06 ZA ZA853394A patent/ZA853394B/xx unknown
- 1985-05-10 KR KR1019850003193A patent/KR890004128B1/ko not_active IP Right Cessation
- 1985-05-14 US US06/734,024 patent/US4634712A/en not_active Expired - Fee Related
- 1985-05-15 IL IL75196A patent/IL75196A/xx unknown
- 1985-05-17 NZ NZ212111A patent/NZ212111A/xx unknown
- 1985-05-17 AR AR300416A patent/AR240803A1/es active
- 1985-05-20 EG EG309/85A patent/EG17343A/xx active
- 1985-05-20 FI FI852002A patent/FI80678C/fi not_active IP Right Cessation
- 1985-05-21 CA CA000481951A patent/CA1261338A/en not_active Expired
- 1985-05-22 NO NO852049A patent/NO165396C/no unknown
- 1985-05-22 GR GR851264A patent/GR851264B/el unknown
- 1985-05-22 DK DK226685A patent/DK226685A/da not_active Application Discontinuation
- 1985-05-23 PH PH32306A patent/PH21946A/en unknown
- 1985-05-23 MX MX205379A patent/MX156875A/es unknown
- 1985-05-23 JP JP60111270A patent/JPS6170A/ja active Granted
- 1985-05-23 ES ES543441A patent/ES8703425A1/es not_active Expired
- 1985-05-23 AU AU42811/85A patent/AU575946B2/en not_active Ceased
- 1985-05-23 PT PT80521A patent/PT80521B/pt not_active IP Right Cessation
- 1985-05-24 HU HU851995A patent/HU193763B/hu not_active IP Right Cessation
- 1985-06-05 CN CN198585104268A patent/CN85104268A/zh active Pending
-
1988
- 1988-09-29 SG SG64488A patent/SG64488G/en unknown
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