ES8405376A1 - Un procedimiento para la preparacion de 2-amino-bencimidazoles 1,5(6)-sustituidos. - Google Patents

Un procedimiento para la preparacion de 2-amino-bencimidazoles 1,5(6)-sustituidos.

Info

Publication number
ES8405376A1
ES8405376A1 ES521319A ES521319A ES8405376A1 ES 8405376 A1 ES8405376 A1 ES 8405376A1 ES 521319 A ES521319 A ES 521319A ES 521319 A ES521319 A ES 521319A ES 8405376 A1 ES8405376 A1 ES 8405376A1
Authority
ES
Spain
Prior art keywords
preparing
aminobenzimidazoles
disubstituted
amino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521319A
Other languages
English (en)
Other versions
ES521319A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES521319A0 publication Critical patent/ES521319A0/es
Publication of ES8405376A1 publication Critical patent/ES8405376A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 2-AMINO-BENCIMIDAZOLES 1,5(6)-SUSTITUIDOS.CONSISTE EN HACER REACCIONAR UN BENCIMIDAZOL TAUTOMERO DE FORMULA (II) CON UN REACTIVO DE FORMULA RSO2X O X(CH2)NNCS EN PRESENCIA DE UNA BASE ACEPTORA DE ACIDO TAL COMO TRIETILAMINO O PIRIDINA, AGUA, UN DISOLVENTE NO HIDROXILICO MISCIBLE EN AGUA TAL COMO ACETONA, EN CANTIDADES EQUIMOLARES Y A TEMPERATURA DE 0JC A 75JC, PARA OBTENER BENCIMIDAZOL TAUTOMERO DE FORMULA (I), DONDE R ES RSO2- Y OTROS; R ES ALQUILO CON C 1 A 5, CICLOALQUILO CON C 3 A 7, FENILO, FURILO O TIENILO; R ES HIDRAZINOCARBONILO,CARBOXI, CARBOXAMIDO, 1-(ALQUIL C 1 A 4) CARBOXAMIDO, HIDROXIMETILO, CIANO, NITRO Y OTROS.TIENE APLICACIONES COMO AGENTES ANTIVIRICOS AL INHIBIR EL CRECIMIENTO DE CIERTOS VIRUS TALES COMO LOS RINOVIRUS, POLIO, COXACKIE, ECOVIRUS Y MENGOVIRUS.
ES521319A 1982-04-08 1983-04-07 Un procedimiento para la preparacion de 2-amino-bencimidazoles 1,5(6)-sustituidos. Expired ES8405376A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/366,883 US4434288A (en) 1982-04-08 1982-04-08 Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles

Publications (2)

Publication Number Publication Date
ES521319A0 ES521319A0 (es) 1984-06-01
ES8405376A1 true ES8405376A1 (es) 1984-06-01

Family

ID=23444984

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521319A Expired ES8405376A1 (es) 1982-04-08 1983-04-07 Un procedimiento para la preparacion de 2-amino-bencimidazoles 1,5(6)-sustituidos.

Country Status (21)

Country Link
US (1) US4434288A (es)
EP (1) EP0091794B1 (es)
JP (1) JPS58188866A (es)
KR (1) KR860001582B1 (es)
AT (1) ATE38986T1 (es)
CA (1) CA1187874A (es)
CS (2) CS127784A2 (es)
DD (1) DD209623A5 (es)
DE (1) DE3378578D1 (es)
DK (1) DK152983A (es)
ES (1) ES8405376A1 (es)
FI (1) FI831192L (es)
GB (1) GB2118550B (es)
GR (1) GR78170B (es)
HU (1) HU193501B (es)
IE (1) IE54836B1 (es)
IL (1) IL68298A (es)
PL (1) PL241386A1 (es)
PT (1) PT76500B (es)
RO (1) RO86853B (es)
SU (1) SU1189338A3 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435418A (en) * 1982-12-13 1984-03-06 Smithkline Beckman Corporation 5-Phenylethenylbenzimidazoles
JPS62221672A (ja) * 1986-03-20 1987-09-29 Nippon Tokushu Noyaku Seizo Kk 新規スルホニルアゾ−ル
US5545653A (en) * 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
US5693661A (en) * 1995-06-07 1997-12-02 Eli Lilly And Company Anti-viral compounds
BR9709528A (pt) * 1996-06-05 1999-08-10 Lilly Co Eli Compostos antivirais
US5891874A (en) * 1996-06-05 1999-04-06 Eli Lilly And Company Anti-viral compound
US5821242A (en) * 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
JP2001513084A (ja) 1997-02-25 2001-08-28 ザ ガバメント オブ ザ ユナイテッド ステーツ オブ アメリカ，レプリゼンテッド バイ ザ セクレタリー，デパートメント オブ ヘルス アンド ヒューマン サービシズ 逆転写酵素の非ヌクレオシド阻害剤としての置換ベンズイミダゾール
CA2293508A1 (en) * 1997-06-04 1998-12-10 Louis Nickolaus Jungheim Anti-viral compounds
US10292390B2 (en) 2011-11-04 2019-05-21 Wisconsin Alumni Research Foundation Inhibition and dispersion of bacterial biofilms with 2-aminobenzimidazole derivatives
CN108997158B (zh) * 2018-07-16 2020-12-15 青岛科技大学 一种实现二取代酰胺与二苯基甲酮偶联的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018790A (en) * 1975-05-08 1977-04-19 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
US4243813A (en) * 1974-07-01 1981-01-06 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles
PT65486B (en) * 1975-08-28 1978-03-24 Lilly Co Eli Process for the preparation of carbonil-substituted 1-sulfonylbenzimidazoles
US4174454A (en) * 1975-08-28 1979-11-13 Eli Lilly And Company Alkylidenylmethyl-substituted 1-sulfonylbenzimidazoles
CA1076582A (en) * 1975-10-28 1980-04-29 Charles J. Paget Antiviral thiazolinyl or thiazinyl ketobenzimidazoles
US4008243A (en) * 1975-11-19 1977-02-15 Eli Lilly And Company Antiviral thiazolinyl or thiazinyl benzimidazole esters
US4118573A (en) * 1975-11-24 1978-10-03 Eli Lilly And Company Substituted 1-sulfonylbenzimidazoles

Also Published As

Publication number Publication date
IE54836B1 (en) 1990-02-28
FI831192A0 (fi) 1983-04-08
DK152983D0 (da) 1983-04-06
EP0091794A1 (en) 1983-10-19
GR78170B (es) 1984-09-26
PT76500B (en) 1986-02-06
KR860001582B1 (ko) 1986-10-10
US4434288A (en) 1984-02-28
IE830795L (en) 1983-10-08
PT76500A (en) 1983-05-01
EP0091794B1 (en) 1988-11-30
RO86853B (ro) 1985-05-31
FI831192L (fi) 1983-10-09
GB2118550B (en) 1985-08-29
GB2118550A (en) 1983-11-02
CS127784A2 (cs) 1984-12-14
ES521319A0 (es) 1984-06-01
CA1187874A (en) 1985-05-28
DD209623A5 (de) 1984-05-16
SU1189338A3 (ru) 1985-10-30
DE3378578D1 (en) 1989-01-05
HU193501B (en) 1987-10-28
KR840004411A (ko) 1984-10-15
PL241386A1 (en) 1983-11-21
ATE38986T1 (de) 1988-12-15
JPS58188866A (ja) 1983-11-04
DK152983A (da) 1983-10-09
IL68298A (en) 1986-09-30
RO86853A (ro) 1985-05-20
CS253983A2 (en) 1984-12-14

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