AR209457A1 - Procedimiento para la preparacion de nuevas sales de biguanidas - Google Patents
Procedimiento para la preparacion de nuevas sales de biguanidasInfo
- Publication number
- AR209457A1 AR209457A1 AR260639A AR26063975A AR209457A1 AR 209457 A1 AR209457 A1 AR 209457A1 AR 260639 A AR260639 A AR 260639A AR 26063975 A AR26063975 A AR 26063975A AR 209457 A1 AR209457 A1 AR 209457A1
- Authority
- AR
- Argentina
- Prior art keywords
- biguanidas
- salts
- procedure
- preparation
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1369774A CH602612A5 (cs) | 1974-10-11 | 1974-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR209457A1 true AR209457A1 (es) | 1977-04-29 |
Family
ID=4394567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR260639A AR209457A1 (es) | 1974-10-11 | 1975-10-11 | Procedimiento para la preparacion de nuevas sales de biguanidas |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4028402A (cs) |
| JP (1) | JPS51125718A (cs) |
| AR (1) | AR209457A1 (cs) |
| AT (1) | AT343676B (cs) |
| BE (1) | BE834369A (cs) |
| BR (1) | BR7506595A (cs) |
| CA (1) | CA1053258A (cs) |
| CH (1) | CH602612A5 (cs) |
| CU (1) | CU34371A (cs) |
| DD (1) | DD123322A5 (cs) |
| DE (1) | DE2542598A1 (cs) |
| DK (1) | DK140834B (cs) |
| ES (1) | ES441673A1 (cs) |
| FI (1) | FI752626A7 (cs) |
| FR (1) | FR2287221A1 (cs) |
| GB (1) | GB1473256A (cs) |
| IE (1) | IE41807B1 (cs) |
| IL (1) | IL48116A (cs) |
| LU (1) | LU73557A1 (cs) |
| NL (1) | NL7511890A (cs) |
| NO (1) | NO753447L (cs) |
| PH (1) | PH12279A (cs) |
| PL (1) | PL95259B1 (cs) |
| SE (1) | SE7511357L (cs) |
| SU (1) | SU572200A3 (cs) |
| ZA (1) | ZA755861B (cs) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2401898A1 (fr) * | 1977-09-05 | 1979-03-30 | Aec Chim Organ Biolog | Nouveau sel de l'acide patoique |
| DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| US20020006899A1 (en) * | 1998-10-06 | 2002-01-17 | Pospisilik Andrew J. | Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals |
| EP1004304A4 (en) | 1996-12-24 | 2002-10-16 | Sumitomo Pharma | COMPOSITION CONTAINING ASCORBIC ACID |
| DE19823831A1 (de) * | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
| US20030176357A1 (en) * | 1998-10-06 | 2003-09-18 | Pospisilik Andrew J. | Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels |
| DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
| DE19940130A1 (de) * | 1999-08-24 | 2001-03-01 | Probiodrug Ges Fuer Arzneim | Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung |
| EP1228756A4 (en) | 1999-10-06 | 2004-06-09 | Kurokawa Kiyoshi | ACTIVE AGENTS AGAINST CARBONYL STRESS |
| US20080076811A1 (en) * | 2000-01-21 | 2008-03-27 | Bork Balkan | Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents |
| CN101690815A (zh) * | 2000-03-31 | 2010-04-07 | 普罗西迪恩有限公司 | 二肽基肽酶iv酶活性抑制剂的新用途 |
| FR2809310B1 (fr) | 2000-05-26 | 2004-02-13 | Centre Nat Rech Scient | Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant |
| JP2005097117A (ja) * | 2000-06-30 | 2005-04-14 | Chugai Pharmaceut Co Ltd | 糖尿病治療剤 |
| AU2177302A (en) * | 2000-10-27 | 2002-05-06 | Probiodrug Ag | Method for the treatment of neurological and neuropsychological disorders |
| US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
| US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
| US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
| EP1492525A2 (en) * | 2001-08-16 | 2005-01-05 | Probiodrug AG | Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades |
| US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
| DK1480961T3 (da) | 2002-02-28 | 2007-05-07 | Prosidion Ltd | Glutaminylbaserede DPIV-inhibitorer |
| US20030232761A1 (en) * | 2002-03-28 | 2003-12-18 | Hinke Simon A. | Novel analogues of glucose-dependent insulinotropic polypeptide |
| US20040033051A1 (en) * | 2002-08-16 | 2004-02-19 | Ip Kiril Kun Wan | Method and system for producing and displaying visual presentations which inhibit off-screen duplication |
| US20040058876A1 (en) * | 2002-09-18 | 2004-03-25 | Torsten Hoffmann | Secondary binding site of dipeptidyl peptidase IV (DP IV) |
| AU2003293311A1 (en) * | 2002-09-18 | 2004-04-23 | Prosidion Ltd. | Secondary binding site of dipeptidyl peptidase iv (dp iv) |
| ATE462432T1 (de) | 2003-05-05 | 2010-04-15 | Probiodrug Ag | Glutaminylcyclase-hemmer |
| KR20120035203A (ko) | 2003-05-05 | 2012-04-13 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| WO2005039548A2 (en) * | 2003-10-15 | 2005-05-06 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US20100099721A1 (en) * | 2003-11-03 | 2010-04-22 | Probiodrug Ag | Novel compounds for the treatment of neurological disorders |
| WO2005075436A2 (en) | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| KR100926417B1 (ko) | 2007-01-29 | 2009-11-12 | 한올제약주식회사 | Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 초산염,그의 제조방법 및 그를 포함하는 약제학적 조성물 |
| US20080188457A1 (en) * | 2007-02-02 | 2008-08-07 | Braincells, Inc. | Modulation of Neurogenesis with Biguanides and GSK3-beta Agents |
| US8076377B2 (en) * | 2007-09-21 | 2011-12-13 | Hanall Pharmaceutical Company, Ltd. | N,N-dimethyl imidodicarbonimidic diamide dicarboxylate, method for producing the same and pharmaceutical compositions comprising the same |
| KR101104912B1 (ko) | 2008-01-08 | 2012-01-12 | 한올바이오파마주식회사 | Ｎ,ｎ―디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물 |
| BRPI0822909B8 (pt) * | 2008-06-26 | 2021-05-25 | Laboratorios Silanes S A De C V | sal de glicinato de metformina para o controle da glicose sanguínea |
| US20110021634A1 (en) | 2009-06-18 | 2011-01-27 | Patel Pranav Dushyant | Processes for preparing metformin hydrochloride |
| WO2011049400A2 (ko) * | 2009-10-23 | 2011-04-28 | 한올바이오파마주식회사 | N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물 |
| KR101324283B1 (ko) | 2010-04-27 | 2013-11-01 | 한올바이오파마주식회사 | 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물 |
| WO2018060962A2 (en) | 2016-09-30 | 2018-04-05 | Laboratorios Silanes S.A. De C.V. | Metformin amino acid compounds and methods of using the same |
| US11185516B2 (en) | 2016-09-30 | 2021-11-30 | Laboratorios Silanes S.A. De C.V. | Metformin glycinate, pharmaceutical compositions comprising the same, and methods of using the same |
| CN106986791A (zh) * | 2017-05-11 | 2017-07-28 | 杜剑平 | 一种治疗肿瘤的药物化合物及其制备方法和应用 |
| CN107118130A (zh) * | 2017-05-11 | 2017-09-01 | 杜剑平 | 一类治疗肿瘤的药物化合物及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3179562A (en) * | 1961-08-23 | 1965-04-20 | Du Pont | Treatment of diabetes with alpha, alpha substituted acetic acid derivatives |
-
1974
- 1974-10-11 CH CH1369774A patent/CH602612A5/xx not_active IP Right Cessation
-
1975
- 1975-09-15 ZA ZA00755861A patent/ZA755861B/xx unknown
- 1975-09-17 IL IL48116A patent/IL48116A/xx unknown
- 1975-09-19 FI FI752626A patent/FI752626A7/fi not_active Application Discontinuation
- 1975-09-24 DE DE19752542598 patent/DE2542598A1/de not_active Withdrawn
- 1975-10-06 IE IE2184/75A patent/IE41807B1/en unknown
- 1975-10-08 PH PH17640A patent/PH12279A/en unknown
- 1975-10-08 CU CU7534371A patent/CU34371A/es unknown
- 1975-10-08 US US05/620,525 patent/US4028402A/en not_active Expired - Lifetime
- 1975-10-09 SU SU7502178502A patent/SU572200A3/ru active
- 1975-10-09 SE SE7511357A patent/SE7511357L/xx unknown
- 1975-10-09 CA CA237,343A patent/CA1053258A/en not_active Expired
- 1975-10-09 JP JP50121432A patent/JPS51125718A/ja active Pending
- 1975-10-09 LU LU73557A patent/LU73557A1/xx unknown
- 1975-10-09 BR BR7506595*A patent/BR7506595A/pt unknown
- 1975-10-09 NL NL7511890A patent/NL7511890A/xx not_active Application Discontinuation
- 1975-10-09 FR FR7530907A patent/FR2287221A1/fr not_active Withdrawn
- 1975-10-10 ES ES441673A patent/ES441673A1/es not_active Expired
- 1975-10-10 DK DK457475AA patent/DK140834B/da unknown
- 1975-10-10 AT AT776375A patent/AT343676B/de active
- 1975-10-10 GB GB4161175A patent/GB1473256A/en not_active Expired
- 1975-10-10 PL PL1975183923A patent/PL95259B1/pl unknown
- 1975-10-10 BE BE160823A patent/BE834369A/xx unknown
- 1975-10-10 NO NO753447A patent/NO753447L/no unknown
- 1975-10-10 DD DD188797A patent/DD123322A5/xx unknown
- 1975-10-11 AR AR260639A patent/AR209457A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| DK457475A (cs) | 1976-04-12 |
| AT343676B (de) | 1978-06-12 |
| DD123322A5 (cs) | 1976-12-12 |
| LU73557A1 (cs) | 1977-05-24 |
| IL48116A (en) | 1979-07-25 |
| IE41807B1 (en) | 1980-03-26 |
| AU8497775A (en) | 1977-03-24 |
| BR7506595A (pt) | 1976-08-17 |
| FI752626A7 (cs) | 1976-04-12 |
| US4028402A (en) | 1977-06-07 |
| ATA776375A (de) | 1977-10-15 |
| JPS51125718A (en) | 1976-11-02 |
| FR2287221A1 (fr) | 1976-05-07 |
| SU572200A3 (ru) | 1977-09-05 |
| PL95259B1 (pl) | 1977-10-31 |
| SE7511357L (sv) | 1976-04-12 |
| IE41807L (en) | 1976-04-11 |
| BE834369A (fr) | 1976-04-12 |
| IL48116A0 (en) | 1975-11-25 |
| GB1473256A (en) | 1977-05-11 |
| DE2542598A1 (de) | 1976-04-22 |
| ES441673A1 (es) | 1977-04-01 |
| CA1053258A (en) | 1979-04-24 |
| PH12279A (en) | 1978-12-12 |
| CH602612A5 (cs) | 1978-07-31 |
| NL7511890A (nl) | 1976-04-13 |
| ZA755861B (en) | 1976-08-25 |
| NO753447L (cs) | 1976-04-13 |
| CU34371A (es) | 1979-06-01 |
| DK140834B (da) | 1979-11-26 |
| DK140834C (cs) | 1980-04-28 |
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