AR129307A1 - Compuestos inhibidores alostéricos selectivos de t790m / l858r, t790m / l858r / c797s, l858r y/o l858r / c797s que contienen mutantes de egfr - Google Patents

Compuestos inhibidores alostéricos selectivos de t790m / l858r, t790m / l858r / c797s, l858r y/o l858r / c797s que contienen mutantes de egfr

Info

Publication number
AR129307A1
AR129307A1 ARP230101177A ARP230101177A AR129307A1 AR 129307 A1 AR129307 A1 AR 129307A1 AR P230101177 A ARP230101177 A AR P230101177A AR P230101177 A ARP230101177 A AR P230101177A AR 129307 A1 AR129307 A1 AR 129307A1
Authority
AR
Argentina
Prior art keywords
compound
formula
dihydropyrrolo
indazol
morpholinophenyl
Prior art date
Application number
ARP230101177A
Other languages
English (en)
Spanish (es)
Inventor
Georg Jaeschke
Bruno Martoglio
Yvonne Alice Nagel
Christa Ulrike Obst-Sander
Antonio Ricci
Sandra Steiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR129307A1 publication Critical patent/AR129307A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ARP230101177A 2022-05-13 2023-05-12 Compuestos inhibidores alostéricos selectivos de t790m / l858r, t790m / l858r / c797s, l858r y/o l858r / c797s que contienen mutantes de egfr AR129307A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP22173211 2022-05-13
EP22175324 2022-05-25

Publications (1)

Publication Number Publication Date
AR129307A1 true AR129307A1 (es) 2024-08-07

Family

ID=86604076

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP230101177A AR129307A1 (es) 2022-05-13 2023-05-12 Compuestos inhibidores alostéricos selectivos de t790m / l858r, t790m / l858r / c797s, l858r y/o l858r / c797s que contienen mutantes de egfr

Country Status (10)

Country Link
US (1) US20250313565A1 (enExample)
EP (1) EP4522617A1 (enExample)
JP (1) JP2025515833A (enExample)
KR (1) KR20250012058A (enExample)
CN (1) CN119173518A (enExample)
AR (1) AR129307A1 (enExample)
AU (1) AU2023269227A1 (enExample)
CA (1) CA3256325A1 (enExample)
TW (1) TW202402276A (enExample)
WO (1) WO2023217923A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer
WO2022117475A1 (en) 2020-12-01 2022-06-09 F. Hoffmann-La Roche Ag New indazole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) * 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer

Also Published As

Publication number Publication date
CA3256325A1 (en) 2023-11-16
AU2023269227A1 (en) 2024-10-03
JP2025515833A (ja) 2025-05-20
EP4522617A1 (en) 2025-03-19
TW202402276A (zh) 2024-01-16
KR20250012058A (ko) 2025-01-23
WO2023217923A1 (en) 2023-11-16
CN119173518A (zh) 2024-12-20
US20250313565A1 (en) 2025-10-09

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