JP2025515833A - 新規インダゾール誘導体 - Google Patents

新規インダゾール誘導体 Download PDF

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Publication number
JP2025515833A
JP2025515833A JP2024566738A JP2024566738A JP2025515833A JP 2025515833 A JP2025515833 A JP 2025515833A JP 2024566738 A JP2024566738 A JP 2024566738A JP 2024566738 A JP2024566738 A JP 2024566738A JP 2025515833 A JP2025515833 A JP 2025515833A
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JP
Japan
Prior art keywords
compound
methyl
formula
compound according
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024566738A
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English (en)
Japanese (ja)
Other versions
JP2025515833A5 (enExample
Inventor
ゲオルク ジェスキー，
ブルーノ マルトーリオ，
イヴォン アリス ナーゲル，
クリスタ ウルリケ オブスト－サンダー，
アントニオ リッチ，
サンドラ シュタイナー，
Original Assignee
エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト filed Critical エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト
Publication of JP2025515833A publication Critical patent/JP2025515833A/ja
Publication of JP2025515833A5 publication Critical patent/JP2025515833A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024566738A 2022-05-13 2023-05-11 新規インダゾール誘導体 Pending JP2025515833A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22173211.8 2022-05-13
EP22173211 2022-05-13
EP22175324 2022-05-25
EP22175324.7 2022-05-25
PCT/EP2023/062529 WO2023217923A1 (en) 2022-05-13 2023-05-11 New indazole derivatives

Publications (2)

Publication Number Publication Date
JP2025515833A true JP2025515833A (ja) 2025-05-20
JP2025515833A5 JP2025515833A5 (enExample) 2026-05-18

Family

ID=86604076

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024566738A Pending JP2025515833A (ja) 2022-05-13 2023-05-11 新規インダゾール誘導体

Country Status (10)

Country Link
US (1) US20250313565A1 (enExample)
EP (1) EP4522617A1 (enExample)
JP (1) JP2025515833A (enExample)
KR (1) KR20250012058A (enExample)
CN (1) CN119173518A (enExample)
AR (1) AR129307A1 (enExample)
AU (1) AU2023269227A1 (enExample)
CA (1) CA3256325A1 (enExample)
TW (1) TW202402276A (enExample)
WO (1) WO2023217923A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer
WO2022117475A1 (en) 2020-12-01 2022-06-09 F. Hoffmann-La Roche Ag New indazole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) * 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer

Also Published As

Publication number Publication date
CA3256325A1 (en) 2023-11-16
AU2023269227A1 (en) 2024-10-03
EP4522617A1 (en) 2025-03-19
AR129307A1 (es) 2024-08-07
TW202402276A (zh) 2024-01-16
KR20250012058A (ko) 2025-01-23
WO2023217923A1 (en) 2023-11-16
CN119173518A (zh) 2024-12-20
US20250313565A1 (en) 2025-10-09

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