CN119173518A - 新的吲唑衍生物 - Google Patents

新的吲唑衍生物 Download PDF

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Publication number
CN119173518A
CN119173518A CN202380039816.2A CN202380039816A CN119173518A CN 119173518 A CN119173518 A CN 119173518A CN 202380039816 A CN202380039816 A CN 202380039816A CN 119173518 A CN119173518 A CN 119173518A
Authority
CN
China
Prior art keywords
compound
methyl
formula
compound according
indazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380039816.2A
Other languages
English (en)
Chinese (zh)
Inventor
G·耶施克
B·马尔托利奥
Y·A·纳吉尔
C·U·奥布斯特-桑德尔
A·里奇
S·斯坦纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN119173518A publication Critical patent/CN119173518A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202380039816.2A 2022-05-13 2023-05-11 新的吲唑衍生物 Pending CN119173518A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22173211.8 2022-05-13
EP22173211 2022-05-13
EP22175324 2022-05-25
EP22175324.7 2022-05-25
PCT/EP2023/062529 WO2023217923A1 (en) 2022-05-13 2023-05-11 New indazole derivatives

Publications (1)

Publication Number Publication Date
CN119173518A true CN119173518A (zh) 2024-12-20

Family

ID=86604076

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380039816.2A Pending CN119173518A (zh) 2022-05-13 2023-05-11 新的吲唑衍生物

Country Status (10)

Country Link
US (1) US20250313565A1 (enExample)
EP (1) EP4522617A1 (enExample)
JP (1) JP2025515833A (enExample)
KR (1) KR20250012058A (enExample)
CN (1) CN119173518A (enExample)
AR (1) AR129307A1 (enExample)
AU (1) AU2023269227A1 (enExample)
CA (1) CA3256325A1 (enExample)
TW (1) TW202402276A (enExample)
WO (1) WO2023217923A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer
WO2022117475A1 (en) 2020-12-01 2022-06-09 F. Hoffmann-La Roche Ag New indazole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020254565A1 (en) * 2019-06-21 2020-12-24 F. Hoffmann-La Roche Ag Egfr inhibitors for the treatment of cancer

Also Published As

Publication number Publication date
CA3256325A1 (en) 2023-11-16
AU2023269227A1 (en) 2024-10-03
JP2025515833A (ja) 2025-05-20
EP4522617A1 (en) 2025-03-19
AR129307A1 (es) 2024-08-07
TW202402276A (zh) 2024-01-16
KR20250012058A (ko) 2025-01-23
WO2023217923A1 (en) 2023-11-16
US20250313565A1 (en) 2025-10-09

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