AR115955A1 - Oligonucleótidos antisentido de acetil-coa carboxilasa2 - Google Patents
Oligonucleótidos antisentido de acetil-coa carboxilasa2Info
- Publication number
- AR115955A1 AR115955A1 ARP190102319A ARP190102319A AR115955A1 AR 115955 A1 AR115955 A1 AR 115955A1 AR P190102319 A ARP190102319 A AR P190102319A AR P190102319 A ARP190102319 A AR P190102319A AR 115955 A1 AR115955 A1 AR 115955A1
- Authority
- AR
- Argentina
- Prior art keywords
- coa
- acetyl
- human acc2
- mrna
- nucleic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente proporciona el derivado de ácido nucleico peptídico que se dirige al sitio de empalme 5 del pre-ARNm humano ACC2 exón 12. Los derivados de ácido nucleico peptídico en la presente inducen fuertemente variantes de empalme del ARNm de ACC2 humano en la célula y son muy útiles para tratar afecciones o trastornos del envejecimiento de la piel asociados con la proteína ACC2 humana.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020180095124A KR102304280B1 (ko) | 2018-08-14 | 2018-08-14 | 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115955A1 true AR115955A1 (es) | 2021-03-17 |
Family
ID=69525636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190102319A AR115955A1 (es) | 2018-08-14 | 2019-08-14 | Oligonucleótidos antisentido de acetil-coa carboxilasa2 |
Country Status (13)
Country | Link |
---|---|
US (1) | US11739124B2 (es) |
EP (1) | EP3837274A4 (es) |
JP (2) | JP2021534146A (es) |
KR (1) | KR102304280B1 (es) |
CN (1) | CN112566922A (es) |
AR (1) | AR115955A1 (es) |
AU (1) | AU2019320670B2 (es) |
BR (1) | BR112020026541A2 (es) |
CA (1) | CA3104658A1 (es) |
MX (1) | MX2021000998A (es) |
SG (1) | SG11202012829RA (es) |
TW (1) | TWI826490B (es) |
WO (1) | WO2020036353A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102304280B1 (ko) | 2018-08-14 | 2021-09-23 | 올리패스 주식회사 | 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133444A (en) | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
US6617422B1 (en) | 1997-05-23 | 2003-09-09 | Peter Nielsen | Peptide nucleic acid monomers and oligomers |
US20030105044A1 (en) | 2001-10-17 | 2003-06-05 | Isis Pharmaceuticals Inc. | Antisense modulation of matrix metalloproteinase 1 expression |
US20040215006A1 (en) | 2003-04-25 | 2004-10-28 | Isis Pharmaceuticals Inc. | Modulation of tyrosinase expression |
GB0415196D0 (en) * | 2004-07-07 | 2004-08-11 | Astrazeneca Ab | Polypeptide |
US7211423B2 (en) * | 2004-07-23 | 2007-05-01 | Bristol-Myers Squibb Co. | Acetyl CoA carboxylase 2 sequences and methods |
US8299041B2 (en) * | 2005-04-08 | 2012-10-30 | Isis Pharmaceuticals, Inc. | Compositions and their uses directed to acetyl-CoA carboxylases |
BE1017127A6 (nl) | 2006-03-24 | 2008-03-04 | Hyfte Luc J R Van | Scharnierende bevestiging van een paddelroerwerk. |
JP2010075639A (ja) * | 2007-10-19 | 2010-04-08 | Shiseido Co Ltd | 顔面及び頸部の皮膚状態を改善する美容方法及び装置 |
KR20090098710A (ko) * | 2008-03-14 | 2009-09-17 | 주식회사 씨티아이바이오 | 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체 |
US20100166689A1 (en) | 2008-12-31 | 2010-07-01 | Revance Therapeutics, Inc. | Compositions and Methods for Treating Hyperpigmentation |
WO2010123983A1 (en) | 2009-04-21 | 2010-10-28 | Yale University | Compostions and methods for targeted gene therapy |
KR20120073536A (ko) | 2010-12-27 | 2012-07-05 | 주식회사 파나진 | 다중전하를 갖는 pna |
US9499587B2 (en) | 2012-01-23 | 2016-11-22 | University Of South Florida | Gamma-AApeptides with potent and broad-spectrum antimicrobial activity |
US20140314697A1 (en) | 2013-04-18 | 2014-10-23 | Corum Inc. | Method for Inhibiting Inflammation and Reducing Melanophilin Expression with Glycine Derivatives And the Composition Thereof |
KR101809209B1 (ko) | 2016-05-31 | 2017-12-15 | 주식회사 올리패스코스메슈티컬즈 | 두피의 건강 개선을 위한 화장료 조성물 및 이의 제조방법 |
JP7407592B2 (ja) | 2016-08-08 | 2024-01-04 | オリパス コーポレーション | アンドロゲン受容体アンチセンスオリゴヌクレオチド |
EP3512870B1 (en) | 2016-09-16 | 2022-08-03 | Olipass Corporation | Scn9a antisense oligonucleotides |
JP7089511B2 (ja) | 2016-10-11 | 2022-06-22 | オリパス コーポレーション | HIF1-αアンチセンスオリゴヌクレオチド |
AU2017385962B2 (en) * | 2016-12-30 | 2021-09-02 | Olipass Corporation | Exon skipping by peptide nucleic acid derivatives |
JP7503903B2 (ja) | 2017-01-06 | 2024-06-21 | オリパス コーポレーション | Snap25アンチセンスオリゴヌクレオチド |
WO2018138585A1 (en) | 2017-01-24 | 2018-08-02 | Olipass Corporation | Scn9a antisense pain killer |
KR102236495B1 (ko) | 2017-07-24 | 2021-04-06 | 올리패스 주식회사 | 티로시나아제 안티센스 올리고뉴클레오티드 |
TWI832851B (zh) | 2018-05-18 | 2024-02-21 | 韓商奧利通公司 | 基質金屬蛋白酶-1之反義寡核苷酸 |
KR102304280B1 (ko) | 2018-08-14 | 2021-09-23 | 올리패스 주식회사 | 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드 |
JP2022541896A (ja) | 2019-07-18 | 2022-09-28 | オリパス コーポレーション | メラノフィリンアンチセンスオリゴヌクレオチド |
-
2018
- 2018-08-14 KR KR1020180095124A patent/KR102304280B1/ko active IP Right Grant
-
2019
- 2019-07-23 TW TW108126009A patent/TWI826490B/zh active
- 2019-08-05 WO PCT/KR2019/009697 patent/WO2020036353A1/en unknown
- 2019-08-05 EP EP19850610.7A patent/EP3837274A4/en active Pending
- 2019-08-05 AU AU2019320670A patent/AU2019320670B2/en active Active
- 2019-08-05 CA CA3104658A patent/CA3104658A1/en active Pending
- 2019-08-05 SG SG11202012829RA patent/SG11202012829RA/en unknown
- 2019-08-05 CN CN201980053079.5A patent/CN112566922A/zh active Pending
- 2019-08-05 BR BR112020026541-1A patent/BR112020026541A2/pt unknown
- 2019-08-05 JP JP2021507611A patent/JP2021534146A/ja active Pending
- 2019-08-05 MX MX2021000998A patent/MX2021000998A/es unknown
- 2019-08-05 US US17/266,763 patent/US11739124B2/en active Active
- 2019-08-14 AR ARP190102319A patent/AR115955A1/es unknown
-
2023
- 2023-12-26 JP JP2023218786A patent/JP2024038106A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TWI826490B (zh) | 2023-12-21 |
EP3837274A1 (en) | 2021-06-23 |
AU2019320670A1 (en) | 2021-02-11 |
US11739124B2 (en) | 2023-08-29 |
AU2019320670B2 (en) | 2024-04-11 |
KR20200019509A (ko) | 2020-02-24 |
JP2024038106A (ja) | 2024-03-19 |
SG11202012829RA (en) | 2021-02-25 |
CA3104658A1 (en) | 2020-02-20 |
CN112566922A (zh) | 2021-03-26 |
TW202022115A (zh) | 2020-06-16 |
BR112020026541A2 (pt) | 2021-04-06 |
KR102304280B1 (ko) | 2021-09-23 |
WO2020036353A1 (en) | 2020-02-20 |
MX2021000998A (es) | 2021-06-23 |
US20210363190A1 (en) | 2021-11-25 |
EP3837274A4 (en) | 2022-05-18 |
JP2021534146A (ja) | 2021-12-09 |
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