AR114533A1 - Oligonucleótidos antisentido de metaloproteinasa-1 de matriz - Google Patents

Oligonucleótidos antisentido de metaloproteinasa-1 de matriz

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Publication number
AR114533A1
AR114533A1 ARP190101321A ARP190101321A AR114533A1 AR 114533 A1 AR114533 A1 AR 114533A1 AR P190101321 A ARP190101321 A AR P190101321A AR P190101321 A ARP190101321 A AR P190101321A AR 114533 A1 AR114533 A1 AR 114533A1
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AR
Argentina
Prior art keywords
substituted
unsubstituted
human mmp
mrna
nucleic acid
Prior art date
Application number
ARP190101321A
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English (en)
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Olipass Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Olipass Corp filed Critical Olipass Corp
Publication of AR114533A1 publication Critical patent/AR114533A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/33—Alteration of splicing

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
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  • Biotechnology (AREA)
  • Birds (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método para tratar enfermedades o afecciones asociadas con la transcripción del gen de MMP-1 humana que implica la administración del derivado de ácido nucleico peptídico de acuerdo con la reivindicación 1 a un sujeto. La presente proporciona el derivado de ácido nucleico peptídico de acuerdo con la reivindicación 1, que se dirige al sitio de empalme 5’ del pre-ARNm de MMP-1 humana “exón 5”. Los derivados de ácido nucleico peptídicos en la presente inducen fuertemente variantes de corte y empalme del ARNm de MMP-1 humana en células y son muy útiles para tratar afecciones o enfermedades de envejecimiento de la piel asociadas con la proteína MMP-1 humana. Reivindicación 1: Un derivado de ácido nucleico peptídico representado por la fórmula (1), o una sal farmacéuticamente aceptable del mismo, en donde, n es un número entero entre 10 y 21; el compuesto de fórmula (1) posee al menos una superposición complementaria de 10 mer con la secuencia de pre-ARNm de 16 mer de [(5’®3’) CAUAUAUGGUGAGUAU] en el pre-ARNm de MMP-1 humana; el compuesto de fórmula (1) es completamente complementario al pre-ARNm de MMP-1 humana, o parcialmente complementario al pre-ARNm de MMP-1 humana con uno o dos emparejamientos erróneos; S₁, S₂, Sₙ₋₁, Sₙ, T₁, T₂, ···, Tₙ₋₁, y Tₙ representan independientemente radical hibrido, deuterio, alquilo sustituido o no sustituido, o arilo sustituido o no sustituido; X e Y representan independientemente radical hibrido, deuterio, formil [H-C(=O)-], aminocarbonil [NH₂-C(=O)-], aminotiocarbonil [NH₂-C(=S)-], alquilo sustituido o no sustituido, arilo sustituido o no sustituido, alquiloxi sustituido o no sustituido, ariloxi sustituido o no sustituido, alquilacilo sustituido o no sustituido, arilacilo sustituido o no sustituido, alquiloxicarbonilo sustituido o no sustituido, ariloxicarbonilo sustituido o no sustituido, alquilaminocarbonilo sustituido o no sustituido, arilaminocarbonilo sustituido o no sustituido, alquilaminotiocarbonilo sustituido o no sustituido, arilaminotiocarbonilo sustituido o no sustituido, alquiloxitiocarbonilo sustituido o no sustituido, ariloxitiocarbonilo sustituido o no sustituido, alquilsulfonilo sustituido o no sustituido, arilsulfonilo sustituido o no sustituido, alquilfosfonilo sustituido o no sustituido, o arilfosfonilo sustituido o no sustituido; Z representa radical hibrido, deuterio, hidroxi, alquiloxi sustituido o no sustituido, ariloxi sustituido o no sustituido, amino sustituido o no sustituido, alquilo sustituido o no sustituido, o arilo sustituido o no sustituido; B₁, B₂, ···, Bₙ₋₁, y Bₙ se seleccionan independientemente de nucleobases naturales que incluyen adenina, timina, guanina, citosina y uracilo, y nucleobases no naturales; y, al menos cuatro de B₁, B₂, ···, Bₙ₋₁, y Bₙ se seleccionan independientemente de nucleobases no naturales con un radical amino sustituido o no sustituido unido covalentemente al resto de nucleobase.
ARP190101321A 2018-05-18 2019-05-17 Oligonucleótidos antisentido de metaloproteinasa-1 de matriz AR114533A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20180057352 2018-05-18

Publications (1)

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AR114533A1 true AR114533A1 (es) 2020-09-16

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ID=68540475

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101321A AR114533A1 (es) 2018-05-18 2019-05-17 Oligonucleótidos antisentido de metaloproteinasa-1 de matriz

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Country Link
US (1) US20210292369A1 (es)
EP (1) EP3794124A4 (es)
JP (1) JP7422406B2 (es)
KR (1) KR102194594B1 (es)
CN (1) CN112041447A (es)
AR (1) AR114533A1 (es)
AU (1) AU2019268955A1 (es)
BR (1) BR112020017892A2 (es)
CA (1) CA3091911A1 (es)
MX (1) MX2020009836A (es)
SG (1) SG11202008247WA (es)
TW (1) TWI832851B (es)
WO (1) WO2019221570A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102304280B1 (ko) 2018-08-14 2021-09-23 올리패스 주식회사 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5719262A (en) * 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US6617422B1 (en) * 1997-05-23 2003-09-09 Peter Nielsen Peptide nucleic acid monomers and oligomers
US20030105044A1 (en) * 2001-10-17 2003-06-05 Isis Pharmaceuticals Inc. Antisense modulation of matrix metalloproteinase 1 expression
EP1268856A2 (de) * 2000-04-07 2003-01-02 Epigenomics AG Detektion von snp's und cytosin-methylierungen
DE10238298A1 (de) * 2002-08-21 2004-03-04 Beiersdorf Ag Verwendung von Antisense-Oligonucleotiden zur Behandlung von degenerativen Hauterscheinungen
AU2004275903B2 (en) * 2003-09-29 2012-04-12 Topigen Pharmaceutique Inc. Oligonucleotide compositions and methods for treating disease including inflammatory conditions
WO2006088483A2 (en) * 2004-06-16 2006-08-24 Trustees Of Dartmouth College Compositions and methods for inhibiting the synthesis or expression of mmp-1
KR20090098710A (ko) * 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
KR20120073536A (ko) * 2010-12-27 2012-07-05 주식회사 파나진 다중전하를 갖는 ｐｎａ
US20150240239A1 (en) * 2014-02-27 2015-08-27 Nugen Biosience (Taiwan) Co., Ltd. Methods and pharmaceutical compositions for inhibiting matrix metalloproteinases 1 by interference ribonucleic acid
US10900039B2 (en) * 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
CA3032549A1 (en) * 2016-08-08 2018-02-15 Olipass Corporation Androgen receptor antisense oligonucleotides
EP3512870B1 (en) * 2016-09-16 2022-08-03 Olipass Corporation Scn9a antisense oligonucleotides
CN110248956B (zh) * 2016-10-11 2023-02-21 奥利通公司 HIF-1α反义寡核苷酸
JP7305542B2 (ja) * 2016-12-30 2023-07-10 オリパス コーポレーション ペプチド核酸誘導体によるエクソンスキッピング

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Publication number Publication date
WO2019221570A1 (en) 2019-11-21
CA3091911A1 (en) 2019-11-21
KR102194594B1 (ko) 2020-12-23
AU2019268955A1 (en) 2020-11-26
EP3794124A4 (en) 2022-08-10
MX2020009836A (es) 2021-01-08
TWI832851B (zh) 2024-02-21
KR20190132220A (ko) 2019-11-27
JP7422406B2 (ja) 2024-01-26
EP3794124A1 (en) 2021-03-24
TW202002991A (zh) 2020-01-16
CN112041447A (zh) 2020-12-04
SG11202008247WA (en) 2020-12-30
JP2021524236A (ja) 2021-09-13
US20210292369A1 (en) 2021-09-23
BR112020017892A2 (pt) 2020-12-22

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