AR110778A1 - Compuestos de pirimidina y su uso farmacéutico - Google Patents
Compuestos de pirimidina y su uso farmacéuticoInfo
- Publication number
- AR110778A1 AR110778A1 ARP180100179A ARP180100179A AR110778A1 AR 110778 A1 AR110778 A1 AR 110778A1 AR P180100179 A ARP180100179 A AR P180100179A AR P180100179 A ARP180100179 A AR P180100179A AR 110778 A1 AR110778 A1 AR 110778A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- alkyl group
- hydroxy
- linear
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 20
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 7
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 7
- 150000002431 hydrogen Chemical group 0.000 abstract 7
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229910003827 NRaRb Inorganic materials 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005392 carboxamide group Chemical group NC(=O)* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
- -1 where Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto seleccionado de una sustancia de la fórmula (1) y una de sus sales aceptables desde el punto de vista farmacéutico, caracterizado porque, en la fórmula (1) R¹ es hidrógeno, halógeno, un grupo hidroxi o un grupo C₁₋₄ alcoxi; R² es hidrógeno, halógeno un grupo ciano, un grupo nitro, un grupo amino, un grupo carboxamida, un grupo formilo, un grupo halo-C₁₋₄ alquilo o un grupo C₁₋₄ alquilo; R³ es hidrógeno, un grupo halo-C₁₋₄ alquilo, un grupo C₁₋₄ alquilo, un grupo C₂₋₄ alquenilo o un grupo C₂₋₄ alquinilo; R⁴(s) son cada uno independientemente un halógeno, un grupo hidroxi, un grupo ciano, un grupo nitro, un grupo amino, -SRᶜ, -S(=O)Rᶜ, -S(=O)₂Rᶜ, un grupo halo-C₁₋₄ alquilo, un grupo C₁₋₄ alcoxi, un grupo C₁₋₄ alquilo, un grupo C₁₋₄ alquilo, un grupo C₂₋₄ alquenilo, un grupo C₂₋₄ alquinilo, -NRᵃRᵇ, -CO₂Rᵇ, o -CO-NRᵃRᵇ, donde, Rᵃ y Rᵇ son cada uno independientemente hidrógeno o un grupo C₁₋₆ alquilo, y Rᶜ es un grupo C₁₋₄ alquilo o -NRᵃRᵇ; k es un número entero de 0 a 4; R⁵ y R⁶ son cada uno independientemente halógeno, un grupo hidroxi, un grupo nitro, un grupo amino, un grupo C₁₋₄ alcoxi, un grupo hidroxi-C₁₋₄ alquilo, un grupo C₁₋₄ alquilo, un grupo C₂₋₄ alquenilo, un grupo C₂₋₄ alquinilo, un grupo C₃₋₁₀ cicloalquilo o un grupo C₃₋₉ heterocicloalquilo, donde, el grupo C₃₋₁₀ cicloalquilo y el grupo C₃₋₉ heterocicloalquilo son cada uno independientemente no sustituidos o sustituidos con un halógeno, un grupo C₁₋₄ alquilo o un grupo halo-C₁₋₄ alquilo; R⁷ es hidrógeno, un grupo C₁₋₆ alquilo lineal o ramificado, un grupo C₃₋₇ cicloalquilo, un grupo C₃₋₈ heterocicloalquilo o un grupo C₁₋₄ alcoxi; Y es una unión directa, -(CH₂)ₘ-, -O-, -O(CH₂)ₘ-, -(CH₂)ₘO-, -C(=O)-, -NR⁹-, -SO₂-, -(CH₂)ₘ-O-(CH₂)ₙ-, -CO(CH₂)ₘ-, -(CH₂)ₘCO-, -(CH₂)ₘ-CO-(CH₂)ₙ-, -(CH₂)ₘNR⁹-, -NR⁹(CH₂)ₘ-, -(CH₂)ₘ-NR⁹-(CH₂)ₙ-, -(CH₂)ₘSO₂-, -SO₂(CH₂)ₘ-, o -(CH₂)ₘ-SO₂-(CH₂)ₙ-, donde R⁹ es hidrógeno, un grupo C₁₋₄ alquilo, un grupo C₃₋₁₀ cicloalquilo o un grupo C₃₋₉ heterocicloalquilo; y m y n son cada uno independientemente un número entero de 1 a 3; Z está representada por la fórmula (2) caracterizado porque, en la fórmula (2) el anillo A es un grupo C₃₋₁₀ cicloalquilo o un grupo C₂₋₁₁ heterocicloalquilo; R¹⁰(s) son cada uno independientemente un halógeno, un grupo alquilo, un grupo ciano, un grupo nitro, un grupo amino, un grupo tiol, un grupo formilo, un grupo halo-C₁₋₄ alquilo lineal o ramificado, un grupo C₁₋₄ alcoxi lineal o ramificado, un grupo hidroxi-C₁₋₄ alquilo lineal o ramificado, un grupo C₁₋₄ alquilo lineal o ramificado, un grupo hidroxi-C₁₋₄ alquilcarbonilo lineal o ramificado, un grupo C₂₋₄ alquenilo, un grupo C₂₋₄ alquinilo, un grupo C₃₋₁₀ cicloalquilo, un grupo C₂₋₉ heterocicloalquilo, un grupo hidroxi-C₂₋₉ heterocicloalquilo, -NR¹¹R¹², -COR¹³, -COOR¹³, o -SO₂R¹⁴; R¹¹ y R¹² son cada uno independientemente hidrógeno, un grupo hidroxi-C₁₋₄ alquilo lineal o ramificado, un grupo halo-C₁₋₄ alquilo lineal o ramificado, un grupo C₁₋₄ alquilo lineal o ramificado, un grupo C₂₋₄ alquenilo o un grupo C₂₋₄ alquinilo; R¹³ es hidrógeno, un grupo hidroxi, un grupo hidroxi-C₁₋₄ alquilo, un grupo halo-C₁₋₄ alquilo, un grupo C₁₋₄ alquilo, un grupo C₂₋₄ alquenilo, un grupo C₂₋₄ alquinilo, un grupo C₃₋₁₀ cicloalquilo o un grupo C₂₋₉ heterocicloalquilo; R¹⁴ es un grupo hidroxi, un grupo halo-C₁₋₄ alquilo, un grupo C₁₋₄ alquilo, un grupo C₂₋₄ alquenilo, un grupo C₂₋₄ alquinilo, un grupo C₃₋₁₀ cicloalquilo, un grupo C₂₋₉ heterocicloalquilo, un grupo arilo, o -NRᵃRᵇ; y q es un número entero de 0 a 5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170012766 | 2017-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110778A1 true AR110778A1 (es) | 2019-05-02 |
Family
ID=62979563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100179A AR110778A1 (es) | 2017-01-26 | 2018-01-26 | Compuestos de pirimidina y su uso farmacéutico |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10280154B2 (es) |
| EP (2) | EP3514153B1 (es) |
| JP (3) | JP6608565B2 (es) |
| KR (1) | KR101954369B1 (es) |
| CN (1) | CN110214138A (es) |
| AR (1) | AR110778A1 (es) |
| AU (1) | AU2018211880B2 (es) |
| BR (1) | BR112019015256A2 (es) |
| CA (1) | CA3050239A1 (es) |
| DK (1) | DK3514153T3 (es) |
| EA (1) | EA039868B1 (es) |
| ES (1) | ES2890668T3 (es) |
| HU (1) | HUE056472T2 (es) |
| IL (2) | IL290745B2 (es) |
| MX (1) | MX2019008808A (es) |
| PH (1) | PH12019501690A1 (es) |
| PL (1) | PL3514153T3 (es) |
| PT (1) | PT3514153T (es) |
| SA (1) | SA519402288B1 (es) |
| SG (1) | SG11201906435SA (es) |
| TW (1) | TWI810172B (es) |
| WO (1) | WO2018139903A1 (es) |
| ZA (1) | ZA201905020B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019015256A2 (pt) * | 2017-01-26 | 2020-04-14 | Hanmi Pharm Ind Co Ltd | composto selecionado de uma substância de fórmula 1 e um sal farmaceuticamente aceitável da mesma, e composicão farmacêutica |
| AU2019203034B1 (en) | 2018-07-25 | 2019-09-26 | Hanmi Pharm. Co., Ltd. | Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same |
| KR101954370B1 (ko) * | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
| WO2020171646A1 (ko) | 2019-02-22 | 2020-08-27 | 한미약품 주식회사 | Flt3 저해제 및 저메틸화제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조성물 |
| CA3130244A1 (en) * | 2019-02-22 | 2020-08-27 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia |
| WO2020171649A1 (ko) * | 2019-02-22 | 2020-08-27 | 한미약품 주식회사 | Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물 |
| CN111606889B (zh) * | 2019-02-25 | 2023-03-07 | 上海翰森生物医药科技有限公司 | 4-(1-环丙基-1h-吲哚-3-基)-n-苯基嘧啶-2-胺衍生物的制备方法 |
| EP3991733A4 (en) | 2019-06-27 | 2023-07-05 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ACUTE MYELOIC LEUKEMIA CONTAINING FLT3 INHIBITOR AND CHEMOTHERAPEUTICS |
| EP4277902A1 (en) * | 2021-01-07 | 2023-11-22 | Ontario Institute for Cancer Research (OICR) | Isoindolinone aminopyrimidine compounds as inhibitors of nuak kinases, compositions and uses thereof |
| WO2023082052A1 (zh) * | 2021-11-09 | 2023-05-19 | 暨南大学 | 环状2-氨基嘧啶类化合物及其用途 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0500492D0 (en) * | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
| US20110183975A1 (en) * | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
| CN101723936B (zh) * | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
| UY32203A (es) * | 2008-10-29 | 2010-05-31 | Astrazeneca Ab | Amino pirimidinas y su uso en terapia |
| US20110005173A1 (en) * | 2009-07-08 | 2011-01-13 | Kraft Foods Global Brands Llc | Method and Apparatus to Create a Contoured Flow Wrap Package |
| US8435980B2 (en) * | 2009-07-15 | 2013-05-07 | Abbvie Inc. | Pyrrolopyridine inhibitors of kinases |
| UY33539A (es) * | 2010-08-02 | 2012-02-29 | Astrazeneca Ab | Compuestos químicos alk |
| SG10201910984XA (en) | 2011-07-27 | 2020-01-30 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer |
| EP2832734A4 (en) * | 2012-03-28 | 2015-08-26 | Takeda Pharmaceutical | HETEROCYCLIC CONNECTION |
| WO2014155300A2 (en) * | 2013-03-28 | 2014-10-02 | Aurigene Discovery Technologies Limited | Substitued pyrimidine amine derivatives as tak-1 inhibitors |
| RS58175B1 (sr) * | 2014-04-04 | 2019-03-29 | Syros Pharmaceuticals Inc | Inhibitori ciklin-zavisne kinaze 7 (cdk7) |
| WO2016029839A1 (zh) * | 2014-08-25 | 2016-03-03 | 四川海思科制药有限公司 | 一种（取代的苯基）（取代的嘧啶）胺基衍生物及其制备方法和药物用途 |
| LT3571192T (lt) * | 2017-01-17 | 2023-02-27 | Astrazeneca Ab | Jak1 atžvilgiu selektyvūs inhibitoriai |
| BR112019015256A2 (pt) * | 2017-01-26 | 2020-04-14 | Hanmi Pharm Ind Co Ltd | composto selecionado de uma substância de fórmula 1 e um sal farmaceuticamente aceitável da mesma, e composicão farmacêutica |
-
2018
- 2018-01-26 BR BR112019015256A patent/BR112019015256A2/pt active Search and Examination
- 2018-01-26 WO PCT/KR2018/001193 patent/WO2018139903A1/ko unknown
- 2018-01-26 KR KR1020180010226A patent/KR101954369B1/ko active IP Right Grant
- 2018-01-26 EP EP18744290.0A patent/EP3514153B1/en active Active
- 2018-01-26 EP EP20201112.8A patent/EP3789386A1/en not_active Withdrawn
- 2018-01-26 IL IL290745A patent/IL290745B2/en unknown
- 2018-01-26 JP JP2019519419A patent/JP6608565B2/ja active Active
- 2018-01-26 AU AU2018211880A patent/AU2018211880B2/en active Active
- 2018-01-26 MX MX2019008808A patent/MX2019008808A/es unknown
- 2018-01-26 PL PL18744290T patent/PL3514153T3/pl unknown
- 2018-01-26 TW TW107102879A patent/TWI810172B/zh active
- 2018-01-26 CN CN201880008683.1A patent/CN110214138A/zh active Pending
- 2018-01-26 SG SG11201906435SA patent/SG11201906435SA/en unknown
- 2018-01-26 CA CA3050239A patent/CA3050239A1/en active Pending
- 2018-01-26 DK DK18744290.0T patent/DK3514153T3/da active
- 2018-01-26 PT PT187442900T patent/PT3514153T/pt unknown
- 2018-01-26 AR ARP180100179A patent/AR110778A1/es unknown
- 2018-01-26 ES ES18744290T patent/ES2890668T3/es active Active
- 2018-01-26 HU HUE18744290A patent/HUE056472T2/hu unknown
- 2018-01-26 EA EA201991580A patent/EA039868B1/ru unknown
- 2018-09-11 US US16/127,487 patent/US10280154B2/en active Active
- 2018-12-19 US US16/226,070 patent/US10519141B2/en active Active
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2019
- 2019-07-11 IL IL268010A patent/IL268010B/en unknown
- 2019-07-23 PH PH12019501690A patent/PH12019501690A1/en unknown
- 2019-07-24 SA SA519402288A patent/SA519402288B1/ar unknown
- 2019-07-30 ZA ZA2019/05020A patent/ZA201905020B/en unknown
- 2019-10-23 JP JP2019192510A patent/JP7191799B2/ja active Active
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2022
- 2022-12-07 JP JP2022195974A patent/JP2023027203A/ja active Pending
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