AR108526A1 - Variantes de quimosina con propiedades mejoradas de coagulación de la leche - Google Patents

Variantes de quimosina con propiedades mejoradas de coagulación de la leche

Info

Publication number
AR108526A1
AR108526A1 ARP170101351A ARP170101351A AR108526A1 AR 108526 A1 AR108526 A1 AR 108526A1 AR P170101351 A ARP170101351 A AR P170101351A AR P170101351 A ARP170101351 A AR P170101351A AR 108526 A1 AR108526 A1 AR 108526A1
Authority
AR
Argentina
Prior art keywords
chymosin
polypeptide variant
feed
isolated
polypeptide
Prior art date
Application number
ARP170101351A
Other languages
English (en)
Inventor
Den Brink Johannes Maarten Van
Martin Lund
Christian Jaeckel
Original Assignee
Chr Hansen As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chr Hansen As filed Critical Chr Hansen As
Publication of AR108526A1 publication Critical patent/AR108526A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1209—Proteolytic or milk coagulating enzymes, e.g. trypsine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/02—Making cheese curd
    • A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/0684—Soft uncured Italian cheeses, e.g. Mozarella, Ricotta, Pasta filata cheese; Other similar stretched cheeses
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/072—Cheddar type or similar hard cheeses without eyes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C19/00—Cheese; Cheese preparations; Making thereof
    • A23C19/06—Treating cheese curd after whey separation; Products obtained thereby
    • A23C19/068—Particular types of cheese
    • A23C19/076—Soft unripened cheese, e.g. cottage or cream cheese
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/23—Aspartic endopeptidases (3.4.23)
    • C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Dairy Products (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Fodder In General (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Detergent Compositions (AREA)

Abstract

Reivindicación 1: Una variante de polipéptido aislado de quimosina, caracterizada porque: (a) la variante de polipéptido aislado de quimosina tiene una actividad de coagulación específica (IMCU/mg de proteína total) que representa al menos el 110% de la actividad de coagulación específica de su polipéptido original y/o (b) la variante de polipéptido aislado de quimosina tiene una relación C/P que representa al menos el 200% de la relación C/P de su polipéptido original. Reivindicación 9: Un método para fabricar una variante de polipéptido aislado de quimosina de acuerdo con cualquiera de las reivindicaciones 1 a 8, que comprende los siguientes pasos: (a): realizar una alteración en una o más posiciones en la secuencia de ADN que codifica al polipéptido que tiene al menos 80% de identidad de secuencia de ID. DE SEC. Nº 2, donde la alteración comprende una sustitución, un eliminación o una inserción en al menos una posición de los aminoácidos; (b): producir y aislar la variante de polipéptido del paso (a). Reivindicación 13: Un método para fabricar un producto alimenticio o pienso, que comprende agregar una cantidad efectiva de la variante de polipéptido aislado de quimosina de acuerdo con cualquiera de las reivindicaciones 1 a 8, al o a los ingredientes del alimento o pienso y llevar a cabo otros pasos de fabricación, para obtener el producto alimenticio o pienso. Reivindicación 15: Un producto alimenticio o pienso que comprende una variante de polipéptido de la quimosina de acuerdo con cualquiera de las reivindicaciones 1 a 8. Reivindicación 17: El uso de una variante de polipéptido de la quimosina de acuerdo con la reivindicación 16, en un proceso para preparar pasta filata, cheddar, quesos del tipo continental, queso blando o queso blanco madurado en salmuera.
ARP170101351A 2016-05-19 2017-05-19 Variantes de quimosina con propiedades mejoradas de coagulación de la leche AR108526A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16170409 2016-05-19

Publications (1)

Publication Number Publication Date
AR108526A1 true AR108526A1 (es) 2018-08-29

Family

ID=56026710

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101351A AR108526A1 (es) 2016-05-19 2017-05-19 Variantes de quimosina con propiedades mejoradas de coagulación de la leche

Country Status (11)

Country Link
US (1) US10961524B2 (es)
EP (1) EP3457860A1 (es)
JP (1) JP7084317B2 (es)
KR (1) KR102448390B1 (es)
CN (1) CN109640677A (es)
AR (1) AR108526A1 (es)
AU (1) AU2017266397B2 (es)
CA (1) CA3024211A1 (es)
EA (1) EA201892531A1 (es)
MX (1) MX2018013924A (es)
WO (1) WO2017198829A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3100606C (en) 2012-05-25 2023-08-01 Chr. Hansen A/S Variants of chymosin with improved milk-clotting properties
UA121380C2 (uk) 2014-02-26 2020-05-25 Кр. Гансен А/С Поліпептид хімозину з удосконаленими властивостями щодо згортання молока
EP4079849A1 (en) * 2015-06-22 2022-10-26 Chr. Hansen A/S Variants of chymosin with improved properties
AR108527A1 (es) * 2016-05-19 2018-08-29 Chr Hansen As Variantes de quimosina con propiedades mejoradas de coagulación de leche
WO2019137983A1 (en) * 2018-01-11 2019-07-18 Chr. Hansen A/S Interactions between cultures, coagulants and technology to increase cheese yields
WO2023001832A1 (en) 2021-07-20 2023-01-26 Chr. Hansen A/S Composition for clotting milk, methods and uses thereof
WO2023194285A2 (en) * 2022-04-06 2023-10-12 Chr. Hansen A/S Aspartic protease, methods and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO841276L (no) 1983-03-31 1984-10-01 Codon Genetic Eng Lab Rekombinant dna-koding for et polypeptid som utviser melkesammenloepende aktivitet
US7390936B1 (en) 1999-08-23 2008-06-24 Sembiosys Genetics Inc. Commercial production of chymosin in plants
RU2192137C2 (ru) 2000-08-07 2002-11-10 Открытое акционерное общество "Уфамолагропром" Способ производства сыра
DE60143406D1 (de) 2000-11-06 2010-12-16 Chr Hansen As Verfahren zur herstellung von nicht aus dem rind stammendem chymosin und dessen anwendung
WO2003013514A1 (en) * 2001-08-08 2003-02-20 Carn-Aware Llc Improving neurological functions
KR101132555B1 (ko) 2002-10-02 2012-04-02 리전츠 오브 더 유니버시티 오브 캘리포니아 변경된 특이성을 갖는 프로테아제의 제조 및 선별 방법
ES2609102T3 (es) 2003-06-27 2017-04-18 Bioren, LLC Mutagénesis por revisión
EP1745068A4 (en) 2004-03-30 2009-11-04 Sudershan Biotech Ltd RECOMBINANT CALM CHYMOSIN AND PROCESS FOR PRODUCING THE SAME
EP2117331A1 (en) 2007-02-13 2009-11-18 Chr. Hansen A/S Coagulation of milk
JP2010046034A (ja) 2008-08-22 2010-03-04 Toyota Central R&D Labs Inc 変異体のスクリーニング方法
WO2010110464A1 (en) 2009-03-24 2010-09-30 Meito Sangyo Co., Ltd. Improved type milk-clotting protease derived from a microorganism
US9822352B2 (en) * 2012-05-03 2017-11-21 Dsm Ip Assets B.V. Chymosine enzyme variants
CA3100606C (en) 2012-05-25 2023-08-01 Chr. Hansen A/S Variants of chymosin with improved milk-clotting properties
UA121380C2 (uk) 2014-02-26 2020-05-25 Кр. Гансен А/С Поліпептид хімозину з удосконаленими властивостями щодо згортання молока
UA125925C2 (uk) 2015-02-10 2022-07-13 Кр. Гансен А/С Композиція для згортання молока, що містить суміш хімозинів, харчова та кормова композиції, що містять суміш хімозинів, застосування композиції для згортання молока, спосіб одержання продукту на основі молока та спосіб одержання ферментованого молочного продукту з використанням композиції для згортання молока
EP4079849A1 (en) 2015-06-22 2022-10-26 Chr. Hansen A/S Variants of chymosin with improved properties
BR112018003493A2 (pt) 2015-08-31 2018-09-18 Chr Hansen As variantes de quimosina com propriedades aperfeiçoadas
AR108527A1 (es) 2016-05-19 2018-08-29 Chr Hansen As Variantes de quimosina con propiedades mejoradas de coagulación de leche

Also Published As

Publication number Publication date
AU2017266397A1 (en) 2018-11-29
BR112018073274A2 (pt) 2019-03-19
US10961524B2 (en) 2021-03-30
CA3024211A1 (en) 2017-11-23
AU2017266397B2 (en) 2021-03-11
CN109640677A (zh) 2019-04-16
JP2019526226A (ja) 2019-09-19
EP3457860A1 (en) 2019-03-27
KR102448390B1 (ko) 2022-09-28
MX2018013924A (es) 2019-03-28
EA201892531A1 (ru) 2019-06-28
US20190174783A1 (en) 2019-06-13
JP7084317B2 (ja) 2022-06-14
KR20190010602A (ko) 2019-01-30
WO2017198829A1 (en) 2017-11-23

Similar Documents

Publication Publication Date Title
AR108526A1 (es) Variantes de quimosina con propiedades mejoradas de coagulación de la leche
MX2020011211A (es) Metodos y composiciones para materiales de semillas oleaginosas.
RU2016132974A (ru) Варианты химозина с улучшенными молокосвертывающими свойствами
MX2021012972A (es) Proteinas de leche recombinantes y composiciones que comprenden las mismas.
AR105867A1 (es) VARIANTES DE QUIMOSINA CON PROPIEDADES MEJORADAS DE a-S1-CASEÍNA
AR108527A1 (es) Variantes de quimosina con propiedades mejoradas de coagulación de leche
WO2016174651A3 (en) Liquid nutritional composition comprising micellar casein and hydrolysed whey protein
PH12021551148A1 (en) Dairy product and process
RU2017125923A (ru) Концентрат белка молочной сыворотки, кисломолочный продукт, содержащий концентрат, и способы
PH12019500263A1 (en) Process for producing infant formula products and dairy products
BR112017015224A2 (pt) queijo fresco de iogurte de consistência densa com flora bacteriana viva e sobremesas de iogurte com cobertura de chocolate feitas desse queijo e método para a produção dos mesmos.
AR105620A1 (es) Variantes de quimosina
FI20115607L (fi) Juusto ja sen valmistus
EP4223137A4 (en) WHEY PROTEIN COMPOSITION, ASSOCIATED PREPARATION METHOD AND CORRESPONDING USE
GB2618758A8 (en) Colloidal food products comprising filamentous fungal particles
IL246249B (en) Non-dairy cottage cheese and a method for its production
O'Mahony et al. Proteolysis in miniature Cheddar‐type cheeses made using blends of chymosin and Cynara cardunculus proteinases as coagulant
AR096701A1 (es) Productos de queso crema para untar ricos en proteínas y métodos para elaborar los mismos
WO2023197002A3 (en) Modified casein proteins
MX2017008800A (es) Queso untable de la cuajada.
AR046707A1 (es) Producto lacteo y procedimiento
LT2014017A (lt) Tepamas 14 % riebumo sūris iš rekombinuoto pieno ir jo gamybos būdas
KR101708008B1 (ko) 허브 성분을 포함하는 치즈 제조방법
Mohamed et al. CHEMICAL CHARACTERISTIES OF ITALIAN RICOTTA CHEESE AS INFLUENCED BY THE PROTEOLYSIS DURING RIPENING.
RU2014132908A (ru) Способ получения сыра творожного "виолетта" сливочный методом сепарирования и двойной пастеризации