AR104110A1 - Composiciones y métodos para detectar un contaminante biológico - Google Patents
Composiciones y métodos para detectar un contaminante biológicoInfo
- Publication number
- AR104110A1 AR104110A1 ARP160100814A ARP160100814A AR104110A1 AR 104110 A1 AR104110 A1 AR 104110A1 AR P160100814 A ARP160100814 A AR P160100814A AR P160100814 A ARP160100814 A AR P160100814A AR 104110 A1 AR104110 A1 AR 104110A1
- Authority
- AR
- Argentina
- Prior art keywords
- specific
- oligonucleotide
- detection probe
- artificial
- oligonucleotide primer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
Abstract
Se proveen composiciones y métodos útiles para la determinación de si un contaminante microbiano está presente en un proceso de producción de agentes terapéuticos biológicos. Específicamente, se proveen un plásmido control de amplificación positivo artificial y una sonda de detección de PCR cuantitativa única, lo cual posibilita la detección rápida y en tiempo real de un resultado falso positivo. Reivindicación 1: Una composición que comprende una secuencia nucleotídica artificial, un fluoróforo, y un desactivador, donde la secuencia nucleotídica artificial comprende en su extremo 3 no más de cinco ácidos nucleicos consecutivos que son idénticos a una secuencia de cualquiera de SEC ID Nº 9 y 12 - 37. Reivindicación 9: Una composición que comprende: a) un cebador oligonucleotídico delantero especifico para parvovirus de roedor; b) una sonda de detección de oligonucleótidos específica para parvovirus de roedor; c) una sonda de detección de oligonucleótidos artificial; d) un cebador oligonucleotídico inverso específico para un parvovirus de roedor; e) un cebador oligonucleotídico delantero específico para M13; f) una sonda de detección de oligonucleótidos específica para M13; y g) un cebador oligonucleotídico inverso específico para M13.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562139321P | 2015-03-27 | 2015-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104110A1 true AR104110A1 (es) | 2017-06-28 |
Family
ID=56297073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160100814A AR104110A1 (es) | 2015-03-27 | 2016-03-28 | Composiciones y métodos para detectar un contaminante biológico |
| ARP200102452A AR119878A2 (es) | 2015-03-27 | 2020-09-01 | Composiciones y métodos para detectar un contaminante biológico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP200102452A AR119878A2 (es) | 2015-03-27 | 2020-09-01 | Composiciones y métodos para detectar un contaminante biológico |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10669594B2 (es) |
| EP (3) | EP3699298B1 (es) |
| JP (4) | JP6670847B2 (es) |
| CN (2) | CN107960108B (es) |
| AR (2) | AR104110A1 (es) |
| AU (2) | AU2016243498B2 (es) |
| BR (1) | BR112017020582A2 (es) |
| CA (2) | CA3226784A1 (es) |
| DK (1) | DK3274469T3 (es) |
| EA (2) | EA202190319A1 (es) |
| ES (1) | ES2804845T3 (es) |
| IL (4) | IL302434A (es) |
| MX (2) | MX2017012437A (es) |
| PL (1) | PL3274469T3 (es) |
| PT (1) | PT3274469T (es) |
| SG (2) | SG10202006108RA (es) |
| TW (3) | TWI735433B (es) |
| WO (1) | WO2016160572A1 (es) |
| ZA (2) | ZA201706797B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI735433B (zh) | 2015-03-27 | 2021-08-11 | 美商再生元醫藥公司 | 偵測生物污染物之組成物及方法 |
| EP3638697A4 (en) | 2017-06-12 | 2021-07-07 | Bluefin Biomedicine, Inc. | ANTI-IL1RAP ANTIBODIES AND ANTIBODY INGREDIENT CONJUGATES |
| US20190093149A1 (en) * | 2017-09-27 | 2019-03-28 | The United States Of America, As Represented By The Secretary Of Agriculture | Assays for detecting multiple tick-borne pathogens |
| CN112105747A (zh) * | 2018-01-30 | 2020-12-18 | 拜奥法尔防护有限责任公司 | 用于验证核酸扩增测定的方法和系统 |
| TW201945732A (zh) * | 2018-03-20 | 2019-12-01 | 美商路瑪賽特有限責任公司 | 使用雷射力細胞學之先進生理及生化細胞監測與定量 |
| US11702653B2 (en) | 2018-05-21 | 2023-07-18 | Battelle Memorial Institute | Control compositions and methods for sequencing |
| EP3894553A4 (en) * | 2018-12-13 | 2022-06-29 | Battelle Memorial Institute | Methods and control compositions for a quantitative polymerase chain reaction |
| KR102278112B1 (ko) * | 2020-07-10 | 2021-07-15 | (주)하임바이오텍 | 특정 인공 뉴클레오타이드 서열을 이용한 위양성 판단용 조성물 및 이를 이용한 위양성 판단 방법 |
| WO2022133005A1 (en) * | 2020-12-17 | 2022-06-23 | Amgen Inc. | Real time pcr method to detect bovine parvovirus 3 |
| KR20230011040A (ko) * | 2021-07-13 | 2023-01-20 | 재단법인 바이오나노헬스가드연구단 | 미생물 현장 오염 검출용 조성물 및 이의 용도 |
| CN114561492A (zh) * | 2022-02-28 | 2022-05-31 | 宁夏回族自治区疾病预防控制中心(宁夏回族自治区性病艾滋病防治中心) | 一种新冠病毒核酸检测阳性质控品及其制备方法和用途 |
| CN116814848B (zh) * | 2023-04-12 | 2024-03-19 | 中国医学科学院医学实验动物研究所 | 基于荧光raa检测小鼠微小病毒的引物和探针及方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5585254A (en) * | 1987-08-21 | 1996-12-17 | University Of Colorado Foundation, Inc. | Autonomous parvovirus gene delivery vehicles and expression vectors |
| US5371241A (en) | 1991-07-19 | 1994-12-06 | Pharmacia P-L Biochemicals Inc. | Fluorescein labelled phosphoramidites |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| ES2343394T3 (es) * | 1999-08-13 | 2010-07-29 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Variantes de ns1 de parvovirus. |
| AT409383B (de) * | 1999-12-22 | 2002-07-25 | Baxter Ag | Verfahren zur detektion und quantifizierung von nukleinsäuren in einer probe |
| US20020177222A1 (en) * | 2000-08-10 | 2002-11-28 | Sikun Li | Replication competent AAV helper functions |
| BRPI0211191B8 (pt) * | 2001-06-28 | 2021-07-27 | Chiron Corp | ensaios baseados em ácido nucléico para se diagnosticar precisamente infecção por parvovírus b19 e inciadores e marcadores para uso nesses ensaios |
| DE60309238T2 (de) | 2002-03-08 | 2007-06-06 | Asml Netherlands B.V. | Lithographische Maske, lithographischer Apparat und Verfahren zur Herstellung einer Vorrichtung |
| WO2004044247A2 (en) | 2002-11-12 | 2004-05-27 | Genolife | One step real-time rt pcr kits for the universal detection of organisms in industrial products |
| JP4805158B2 (ja) * | 2003-05-16 | 2011-11-02 | アメリカ合衆国 | 核酸増幅系に用いる内部コントロール核酸分子 |
| DE102006034844B3 (de) * | 2006-07-27 | 2007-12-06 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Zusammensetzungen und Verfahren zur Amplifikation von Hepatitis A-Viren (HAV) und/oder Parvoviren B19 (PB19) mittels Multiplex-PCR |
| US7771997B2 (en) | 2007-06-04 | 2010-08-10 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| EP2098599A1 (en) * | 2008-03-05 | 2009-09-09 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Composition comprising an oligonucleotide mixture for the detection of contaminations in cell cultures |
| WO2010111509A1 (en) * | 2009-03-25 | 2010-09-30 | Life Technologies Corporation | Discriminatory positive/extraction control dna |
| WO2010151792A1 (en) | 2009-06-26 | 2010-12-29 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
| WO2012052158A2 (en) * | 2010-10-21 | 2012-04-26 | Deutsches Krebsforschungszentrum | Retargeting of rat parvovirus h-1pv to cancer cells through genetic engineering of its capsid |
| US9580761B2 (en) * | 2011-02-25 | 2017-02-28 | Novartis Ag | Exogenous internal positive control |
| CN102206713B (zh) * | 2011-04-06 | 2013-01-02 | 浙江大学 | 三重荧光定量rt-pcr检测试剂盒及用途 |
| GB201203568D0 (en) * | 2012-02-29 | 2012-04-11 | Vela Operations Pte Ltd | Real time PCR detection of streptococcus |
| HU230463B1 (hu) * | 2012-07-02 | 2016-07-28 | Ud-Genomed Medical Genomic Technologies Kft. | Kontroll rendszer immunprecipitációs vizsgálatokhoz |
| WO2014055515A1 (en) * | 2012-10-02 | 2014-04-10 | Neurophage Pharmaceuticals, Inc. | Use of p3 of bacteriophage fusion proteins as amyloid binding agents |
| GB2525024A (en) * | 2014-04-10 | 2015-10-14 | Vela Operations Pte Ltd | Universal controls for sequencing assays |
| TWI735433B (zh) | 2015-03-27 | 2021-08-11 | 美商再生元醫藥公司 | 偵測生物污染物之組成物及方法 |
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2016
- 2016-03-24 TW TW105109119A patent/TWI735433B/zh active
- 2016-03-24 TW TW110125474A patent/TWI804917B/zh active
- 2016-03-24 TW TW112118669A patent/TW202336236A/zh unknown
- 2016-03-25 IL IL302434A patent/IL302434A/en unknown
- 2016-03-25 DK DK16734060.3T patent/DK3274469T3/da active
- 2016-03-25 EP EP20164343.4A patent/EP3699298B1/en active Active
- 2016-03-25 CA CA3226784A patent/CA3226784A1/en active Pending
- 2016-03-25 PT PT167340603T patent/PT3274469T/pt unknown
- 2016-03-25 MX MX2017012437A patent/MX2017012437A/es unknown
- 2016-03-25 JP JP2017550633A patent/JP6670847B2/ja active Active
- 2016-03-25 US US15/080,859 patent/US10669594B2/en active Active
- 2016-03-25 SG SG10202006108RA patent/SG10202006108RA/en unknown
- 2016-03-25 EP EP24161139.1A patent/EP4361290A2/en active Pending
- 2016-03-25 AU AU2016243498A patent/AU2016243498B2/en active Active
- 2016-03-25 PL PL16734060T patent/PL3274469T3/pl unknown
- 2016-03-25 CN CN201680025470.0A patent/CN107960108B/zh active Active
- 2016-03-25 EP EP16734060.3A patent/EP3274469B1/en active Active
- 2016-03-25 BR BR112017020582-3A patent/BR112017020582A2/pt unknown
- 2016-03-25 EA EA202190319A patent/EA202190319A1/ru unknown
- 2016-03-25 CN CN202210143904.4A patent/CN114875175A/zh active Pending
- 2016-03-25 WO PCT/US2016/024216 patent/WO2016160572A1/en active Application Filing
- 2016-03-25 SG SG11201707690QA patent/SG11201707690QA/en unknown
- 2016-03-25 EA EA201792155A patent/EA037740B1/ru unknown
- 2016-03-25 ES ES16734060T patent/ES2804845T3/es active Active
- 2016-03-25 CA CA2980915A patent/CA2980915C/en active Active
- 2016-03-28 AR ARP160100814A patent/AR104110A1/es unknown
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2017
- 2017-09-27 MX MX2021007667A patent/MX2021007667A/es unknown
- 2017-09-27 IL IL254731A patent/IL254731B/en active IP Right Grant
- 2017-10-09 ZA ZA2017/06797A patent/ZA201706797B/en unknown
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2018
- 2018-09-12 ZA ZA2018/06101A patent/ZA201806101B/en unknown
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2020
- 2020-03-02 JP JP2020034913A patent/JP6894026B2/ja active Active
- 2020-04-22 US US16/855,217 patent/US11549154B2/en active Active
- 2020-09-01 AR ARP200102452A patent/AR119878A2/es unknown
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2021
- 2021-03-17 IL IL281579A patent/IL281579B/en unknown
- 2021-06-02 JP JP2021092874A patent/JP7385623B2/ja active Active
- 2021-12-28 IL IL289447A patent/IL289447A/en unknown
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2022
- 2022-10-05 AU AU2022246398A patent/AU2022246398A1/en active Pending
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2023
- 2023-05-04 US US18/061,712 patent/US20230295747A1/en active Pending
- 2023-11-10 JP JP2023191978A patent/JP2023184743A/ja active Pending
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