AR102283A1 - Conjugados de prostaglandina y derivados para tratar el glaucoma y la hipertensión ocular - Google Patents

Conjugados de prostaglandina y derivados para tratar el glaucoma y la hipertensión ocular

Info

Publication number
AR102283A1
AR102283A1 ARP150103338A ARP150103338A AR102283A1 AR 102283 A1 AR102283 A1 AR 102283A1 AR P150103338 A ARP150103338 A AR P150103338A AR P150103338 A ARP150103338 A AR P150103338A AR 102283 A1 AR102283 A1 AR 102283A1
Authority
AR
Argentina
Prior art keywords
glaucoma
derivatives
conjugates
intraocular pressure
treatment
Prior art date
Application number
ARP150103338A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54478216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR102283(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR102283A1 publication Critical patent/AR102283A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/08—Esters of nitric acid having nitrate groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Conjugados de prostaglandina y derivados, y métodos para su uso, para tratar el glaucoma y/o reducir la presión intraocular. Composiciones farmacéuticas oftálmicas útiles en el tratamiento de enfermedades oculares como el glaucoma y la presión intraocular elevada. Dichas composiciones comprenden una cantidad eficaz de conjugados de prostaglandina o derivados de la presente. Reivindicación 1: Una composición farmacéutica oftálmica útil en el tratamiento del glaucoma y en el control de la presión intraocular, que comprende una cantidad eficaz de un compuesto de la fórmula (1), donde A se selecciona de los compuestos del grupo de fórmula (2), imina, sidnonimina, oxima, hidroxilamina, N-hidroxiguanidina o hidroxiurea; y un vehículo farmacéuticamente aceptable para ello. Reivindicación 11: El método de la .reivindicación. 9, donde dicha composición comprende múltiples agentes de tratamiento del glaucoma. Reivindicación 12: El método de la reivindicación 11, donde al menos un agente de tratamiento del glaucoma se selecciona del grupo que consiste en: bloqueadores b, análogos de prostaglandina, inhibidores de anhidrasa carbónica, agonistas de a₂, mióticos, inhibidores de rho cinasa, agonistas serotoninérgicos y neuroprotectores. Reivindicación 15: El compuesto de la reivindicación 11, que se selecciona de: (Z)-7-((1R,2R,3R,5S)-3,5-bis(nitrooxi)-2-((R,E)-3-(nitrooxi)-4-(3-(trifluorometil)fenoxi)but-1-en-1-il)ciclopentil)hept-5-enoato de isopropilo y 1-óxido de (Z)-2-((((Z)-7-((1R,2R,3R,5S)-3,5-dihidroxi-2-((R,E)-3-hidroxi-4-(3-(trifluorometil)fenoxi)but-1-en-1-il)ciclopentil)hept-5-enoil)oxi)metoxi)-1-(pirrolidin-1-il)diazeno.
ARP150103338A 2014-10-15 2015-10-15 Conjugados de prostaglandina y derivados para tratar el glaucoma y la hipertensión ocular AR102283A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462064193P 2014-10-15 2014-10-15

Publications (1)

Publication Number Publication Date
AR102283A1 true AR102283A1 (es) 2017-02-15

Family

ID=54478216

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103338A AR102283A1 (es) 2014-10-15 2015-10-15 Conjugados de prostaglandina y derivados para tratar el glaucoma y la hipertensión ocular

Country Status (12)

Country Link
US (2) US9604949B2 (es)
EP (1) EP3206693B1 (es)
JP (2) JP6654757B2 (es)
KR (1) KR20170066427A (es)
CN (2) CN112022856A (es)
AR (1) AR102283A1 (es)
AU (1) AU2015332447B2 (es)
BR (1) BR112017007095B1 (es)
CA (1) CA2964364A1 (es)
MX (5) MX2020012011A (es)
RU (1) RU2712221C2 (es)
WO (1) WO2016061370A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019288296B2 (en) * 2018-06-19 2022-11-24 Cella Therapeutics, Llc Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a CNP compound, an NPR-B compound, a Tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension
KR102282716B1 (ko) * 2020-02-07 2021-07-29 포항공과대학교 산학협력단 일산화질소 공여체를 포함하는 뇌-혈관 장벽 투과성을 증가시키는데 사용하기 위한 조성물 및 그의 용도
EP4146664A2 (en) 2020-05-01 2023-03-15 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR900701270A (ko) * 1988-08-23 1990-12-01 안데르스 베딘 피리디닐메틸(술피닐 또는 티오)벤즈이미다졸을 사용한 인체 눈의 녹내장 및 관련 장해의 치료 방법
US5510383A (en) * 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US6417228B1 (en) * 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2000051978A1 (en) * 1999-03-01 2000-09-08 Nitromed, Inc. Nitrosated and nitrosylated prostaglandins, compositions and metods of use
JP3984283B2 (ja) * 2004-01-05 2007-10-03 ニコックス，ソシエテ アノニム プロスタグランヂンニトロオキシ誘導体
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
EP1934872A2 (en) * 2005-10-13 2008-06-25 Novokin Biotech Inc. Development of prodrugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety using in vitro/in silico predictions
AU2009236356A1 (en) * 2008-04-16 2009-10-22 Allergan, Inc. Combination therapy for glaucoma
CA2777352A1 (en) * 2009-11-05 2011-05-12 Biocon Limited A novel process for the preparation of prostaglandins and intermediates thereof
EP2567689A1 (en) * 2011-09-12 2013-03-13 Visiotact Pharma Ophthtalmic compositions comprising prostaglandin F2 alpha derivatives and hyaluronic acid
WO2013163219A1 (en) * 2012-04-24 2013-10-31 Allergan, Inc. Prostaglandin and vasoconstrictor pharmaceutical compositions and methods of use

Also Published As

Publication number Publication date
RU2017116230A3 (es) 2019-05-22
CA2964364A1 (en) 2016-04-21
US20160108012A1 (en) 2016-04-21
CN112022856A (zh) 2020-12-04
JP6830991B2 (ja) 2021-02-17
MX2017004809A (es) 2017-07-26
MX2020012012A (es) 2022-04-19
KR20170066427A (ko) 2017-06-14
CN107106573A (zh) 2017-08-29
BR112017007095B1 (pt) 2023-03-14
JP2020023556A (ja) 2020-02-13
WO2016061370A1 (en) 2016-04-21
US9604949B2 (en) 2017-03-28
MX2020012014A (es) 2022-04-19
JP2017531018A (ja) 2017-10-19
US10016441B2 (en) 2018-07-10
AU2015332447B2 (en) 2018-10-25
US20170239268A1 (en) 2017-08-24
MX2020012011A (es) 2022-04-19
JP6654757B2 (ja) 2020-02-26
MX2019011925A (es) 2019-11-18
RU2017116230A (ru) 2018-11-15
RU2712221C2 (ru) 2020-01-27
AU2015332447A1 (en) 2017-04-27
EP3206693B1 (en) 2022-08-03
BR112017007095A2 (pt) 2017-12-26
EP3206693A1 (en) 2017-08-23

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