AR101704A1 - Compuestos heterocíclicos fusionados - Google Patents
Compuestos heterocíclicos fusionadosInfo
- Publication number
- AR101704A1 AR101704A1 ARP150102746A ARP150102746A AR101704A1 AR 101704 A1 AR101704 A1 AR 101704A1 AR P150102746 A ARP150102746 A AR P150102746A AR P150102746 A ARP150102746 A AR P150102746A AR 101704 A1 AR101704 A1 AR 101704A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- different
- amino
- same
- lower alkyl
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 201000008827 tuberculosis Diseases 0.000 abstract 2
- -1 (5) pyrazinyl Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014174528 | 2014-08-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR101704A1 true AR101704A1 (es) | 2017-01-04 |
Family
ID=54105947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150102746A AR101704A1 (es) | 2014-08-28 | 2015-08-27 | Compuestos heterocíclicos fusionados |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US10053446B2 (enExample) |
| EP (1) | EP3186240B9 (enExample) |
| JP (1) | JP6625612B2 (enExample) |
| KR (1) | KR102418413B1 (enExample) |
| CN (1) | CN106795117B (enExample) |
| AP (1) | AP2017009788A0 (enExample) |
| AR (1) | AR101704A1 (enExample) |
| AU (1) | AU2015307873B2 (enExample) |
| BR (1) | BR112017003231B1 (enExample) |
| CA (1) | CA2959478C (enExample) |
| CY (1) | CY1122286T1 (enExample) |
| DK (1) | DK3186240T3 (enExample) |
| EA (1) | EA038414B1 (enExample) |
| ES (1) | ES2743788T3 (enExample) |
| HR (1) | HRP20191486T2 (enExample) |
| HU (1) | HUE045025T2 (enExample) |
| IL (1) | IL250484B (enExample) |
| LT (1) | LT3186240T (enExample) |
| MX (1) | MX2017002312A (enExample) |
| MY (1) | MY189098A (enExample) |
| NZ (1) | NZ729064A (enExample) |
| PH (1) | PH12017500290B1 (enExample) |
| PL (1) | PL3186240T3 (enExample) |
| PT (1) | PT3186240T (enExample) |
| SG (1) | SG11201700882XA (enExample) |
| SI (1) | SI3186240T1 (enExample) |
| TW (1) | TWI687409B (enExample) |
| WO (1) | WO2016031255A1 (enExample) |
| ZA (1) | ZA201700916B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI687409B (zh) * | 2014-08-28 | 2020-03-11 | 日商大塚製藥股份有限公司 | 稠合雜環化合物 |
| CN108884044B (zh) * | 2016-02-26 | 2023-01-31 | 大塚制药株式会社 | 哌啶衍生物 |
| CN112543757A (zh) | 2018-06-15 | 2021-03-23 | 卡迪拉保健有限公司 | 对结核菌具有抗菌活性的缩合氮杂杂芳基化合物 |
| JP2023085582A (ja) * | 2020-05-11 | 2023-06-21 | 大塚製薬株式会社 | ジヒドロキノリノン化合物の共結晶 |
| WO2022039506A1 (ko) * | 2020-08-19 | 2022-02-24 | 주식회사 미토이뮨테라퓨틱스 | Ｍabc-r 감염에 의한 병적 염증 치료제로서의 미토콘드리아 표적 항산화제 |
| CN116102537B (zh) * | 2021-11-10 | 2024-10-01 | 四川大学 | 一种喹啉酮类衍生物及其制备方法和用途 |
| CN116589448B (zh) * | 2023-04-24 | 2025-10-28 | 西南交通大学 | 一种3,4-二氢喹啉酮衍生物及其应用 |
| WO2025183016A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
| WO2025183017A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
| US5668127A (en) | 1995-06-26 | 1997-09-16 | Pathogenesis Corporation | Nitroimidazole antibacterial compounds and methods of use thereof |
| AR041198A1 (es) | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| CN100497345C (zh) * | 2003-10-31 | 2009-06-10 | 大塚制药株式会社 | 治疗结核病的2,3-二氢-6-硝基咪唑并[2,1-b]唑化合物 |
| PL1678185T3 (pl) | 2003-10-31 | 2009-04-30 | Otsuka Pharma Co Ltd | Związki 2,3-dihydro-6-nitroimidazo[2,1-B]oksazolu do leczenia gruźlicy |
| JP4761756B2 (ja) | 2003-10-31 | 2011-08-31 | 大塚製薬株式会社 | ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物 |
| PL2502911T3 (pl) * | 2004-06-24 | 2017-09-29 | Vertex Pharma | Modulatory transporterów kasety wiążącej ATP |
| JPWO2007099828A1 (ja) | 2006-02-23 | 2009-07-16 | 塩野義製薬株式会社 | 環式基で置換された含窒素複素環誘導体 |
| GB0812648D0 (en) * | 2008-07-10 | 2008-08-20 | Prosidion Ltd | Compounds |
| WO2010045987A1 (en) * | 2008-10-23 | 2010-04-29 | Glaxo Group Limited | Substituted (aza) -1-methyl-1h-quin0lin-2-0nes as antibacterials |
| ES2530266T3 (es) | 2009-07-31 | 2015-02-27 | Global Alliance For Tb Drug Development | Análogos de nitroimidazooxazina y sus usos |
| EP2697232B1 (en) | 2011-04-15 | 2016-05-18 | Otsuka Pharmaceutical Co., Ltd. | 6,7-dihydroimidazo[2,1-b][1,3]oxazine bactericides |
| TWI687409B (zh) * | 2014-08-28 | 2020-03-11 | 日商大塚製藥股份有限公司 | 稠合雜環化合物 |
| CN108884044B (zh) * | 2016-02-26 | 2023-01-31 | 大塚制药株式会社 | 哌啶衍生物 |
-
2015
- 2015-08-27 TW TW104128109A patent/TWI687409B/zh active
- 2015-08-27 AR ARP150102746A patent/AR101704A1/es active IP Right Grant
- 2015-08-28 NZ NZ729064A patent/NZ729064A/en unknown
- 2015-08-28 CA CA2959478A patent/CA2959478C/en active Active
- 2015-08-28 MY MYPI2017700649A patent/MY189098A/en unknown
- 2015-08-28 PH PH1/2017/500290A patent/PH12017500290B1/en unknown
- 2015-08-28 MX MX2017002312A patent/MX2017002312A/es active IP Right Grant
- 2015-08-28 JP JP2017507903A patent/JP6625612B2/ja active Active
- 2015-08-28 CN CN201580045974.4A patent/CN106795117B/zh active Active
- 2015-08-28 HU HUE15763096A patent/HUE045025T2/hu unknown
- 2015-08-28 PT PT15763096T patent/PT3186240T/pt unknown
- 2015-08-28 PL PL15763096T patent/PL3186240T3/pl unknown
- 2015-08-28 ES ES15763096T patent/ES2743788T3/es active Active
- 2015-08-28 US US15/506,887 patent/US10053446B2/en active Active
- 2015-08-28 SG SG11201700882XA patent/SG11201700882XA/en unknown
- 2015-08-28 EP EP15763096.3A patent/EP3186240B9/en active Active
- 2015-08-28 DK DK15763096.3T patent/DK3186240T3/da active
- 2015-08-28 AU AU2015307873A patent/AU2015307873B2/en active Active
- 2015-08-28 AP AP2017009788A patent/AP2017009788A0/en unknown
- 2015-08-28 HR HRP20191486TT patent/HRP20191486T2/hr unknown
- 2015-08-28 KR KR1020177007855A patent/KR102418413B1/ko active Active
- 2015-08-28 WO PCT/JP2015/004371 patent/WO2016031255A1/en not_active Ceased
- 2015-08-28 SI SI201530868T patent/SI3186240T1/sl unknown
- 2015-08-28 EA EA201790464A patent/EA038414B1/ru unknown
- 2015-08-28 LT LTEP15763096.3T patent/LT3186240T/lt unknown
- 2015-08-28 BR BR112017003231-7A patent/BR112017003231B1/pt active IP Right Grant
-
2017
- 2017-02-06 ZA ZA2017/00916A patent/ZA201700916B/en unknown
- 2017-02-07 IL IL250484A patent/IL250484B/en active IP Right Grant
-
2018
- 2018-07-09 US US16/029,850 patent/US10464926B2/en active Active
-
2019
- 2019-08-26 CY CY20191100906T patent/CY1122286T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |