AR091737A1 - Inhibicion de enzimas - Google Patents
Inhibicion de enzimasInfo
- Publication number
- AR091737A1 AR091737A1 ARP130102470A AR091737A1 AR 091737 A1 AR091737 A1 AR 091737A1 AR P130102470 A ARP130102470 A AR P130102470A AR 091737 A1 AR091737 A1 AR 091737A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- alkylene
- hydrogen
- heterocycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176079 | 2012-07-12 | ||
| EP13158756 | 2013-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR091737A1 true AR091737A1 (es) | 2015-02-25 |
Family
ID=48953361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130102470 AR091737A1 (es) | 2012-07-12 | 2013-07-11 | Inhibicion de enzimas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9199984B2 (OSRAM) |
| EP (1) | EP2872509B1 (OSRAM) |
| KR (1) | KR20150031318A (OSRAM) |
| CN (1) | CN104428300B (OSRAM) |
| AR (1) | AR091737A1 (OSRAM) |
| BR (1) | BR112015000507A2 (OSRAM) |
| CA (1) | CA2878792A1 (OSRAM) |
| IN (1) | IN2015DN00202A (OSRAM) |
| RU (1) | RU2638537C2 (OSRAM) |
| WO (1) | WO2014009425A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160097227A (ko) | 2013-12-16 | 2016-08-17 | 키에시 파르마슈티시 엣스. 피. 에이. | 인간 호중구 엘라스타제 억제제로서 테트라하이드로트리아졸로피리미딘 유도체 |
| US9487528B2 (en) | 2014-06-09 | 2016-11-08 | Chiesi Farmaceutici S.P.A. | Compounds |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| AR108609A1 (es) * | 2016-05-31 | 2018-09-05 | Chiesi Farm Spa | Derivados de imidazolona y pirazolona como inhibidores de la elastasa de neutrófilos humana (hne) |
| WO2017207432A1 (en) * | 2016-05-31 | 2017-12-07 | Chiesi Farmaceutici S.P.A. | Novel compounds |
| CN109311850B (zh) * | 2016-05-31 | 2021-11-19 | 奇斯药制品公司 | 作为人嗜中性粒细胞弹性蛋白酶抑制剂的咪唑酮化合物 |
| KR20210002380A (ko) | 2017-02-27 | 2021-01-08 | 게저 발린트 | 디스플레이된 정보 및/또는 데이터의 동시 다기능 핸들링을 가능하게 하는 디스플레이를 구비한 스마트 장치 |
| MX2022000951A (es) | 2019-07-23 | 2022-02-14 | Bayer Ag | Novedosos compuestos de heteroaril-triazol como plaguicidas. |
| EP4003973B1 (en) | 2019-07-23 | 2024-11-20 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| BR112022006791A2 (pt) | 2019-10-09 | 2022-06-28 | Bayer Ag | Novos compostos heteroaril-triazol como pesticidas |
| UY38910A (es) | 2019-10-09 | 2021-05-31 | Bayer Ag | Compuestos de heteroarilo-triazol como pesticidas, formulaciones, usos y métodos de uso de los mismos |
| JP7652772B2 (ja) * | 2019-11-01 | 2025-03-27 | ブリストル－マイヤーズ スクイブ カンパニー | 置換ピラゾール化合物 |
| TW202134226A (zh) | 2019-11-18 | 2021-09-16 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| DK4106757T3 (da) | 2020-04-16 | 2023-10-23 | Mereo Biopharma 4 Ltd | Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel |
| CN116249692B (zh) * | 2020-09-28 | 2024-08-23 | 四川科伦博泰生物医药股份有限公司 | 吡唑类化合物及其制备方法和用途 |
| CN113480486B (zh) * | 2021-07-30 | 2022-05-24 | 赣南师范大学 | 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用 |
| CN118265527A (zh) | 2021-10-20 | 2024-06-28 | 美莱奥生物制药第四有限公司 | 用于治疗纤维化的中性粒细胞弹性蛋白酶抑制剂 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259504A (en) | 1979-08-27 | 1981-03-31 | American Cyanamid Company | Substituted 1H-1,2,4-triazoles |
| US4451471A (en) | 1981-03-18 | 1984-05-29 | Ciba-Geigy Corporation | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same |
| US4576958A (en) | 1984-01-23 | 1986-03-18 | E. I. Du Pont De Nemours And Company | Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| ES2184633B1 (es) | 2001-08-07 | 2004-08-01 | J. URIACH & CIA, S.A. | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
| US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| CA2582482A1 (en) | 2004-10-07 | 2006-04-13 | Warner-Lambert Company Llc | Triazolopyridine derivatives as antibacterial agents |
| US7902374B2 (en) | 2005-05-06 | 2011-03-08 | Universal Display Corporation | Stability OLED materials and devices |
| TW200806637A (en) | 2006-05-25 | 2008-02-01 | Synta Pharmaceuticals Corp | Synthesis of triazole compounds that modulate HSP90 activity |
| JP2011502982A (ja) * | 2007-11-06 | 2011-01-27 | アストラゼネカ・アクチエボラーグ | 好中球エラスターゼの阻害剤としてのある種の２−ピラジノン誘導体およびその使用 |
| PE20091953A1 (es) | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| WO2009155389A1 (en) * | 2008-06-20 | 2009-12-23 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as kinase inhibitors |
| EP2300466B1 (en) * | 2008-06-20 | 2014-08-06 | Bristol-Myers Squibb Company | Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors |
| DE102009004197A1 (de) * | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| MX2012003644A (es) * | 2009-10-02 | 2012-04-30 | Astrazeneca Ab | Compuestos de 2-piridona empleados como inhibidores de la elastasa neutrofila. |
-
2013
- 2013-07-10 IN IN202DEN2015 patent/IN2015DN00202A/en unknown
- 2013-07-10 CA CA2878792A patent/CA2878792A1/en not_active Abandoned
- 2013-07-10 CN CN201380036973.4A patent/CN104428300B/zh not_active Expired - Fee Related
- 2013-07-10 EP EP13747801.2A patent/EP2872509B1/en active Active
- 2013-07-10 KR KR20157002129A patent/KR20150031318A/ko not_active Withdrawn
- 2013-07-10 BR BR112015000507A patent/BR112015000507A2/pt not_active IP Right Cessation
- 2013-07-10 RU RU2015104644A patent/RU2638537C2/ru not_active IP Right Cessation
- 2013-07-10 WO PCT/EP2013/064603 patent/WO2014009425A1/en not_active Ceased
- 2013-07-11 AR ARP130102470 patent/AR091737A1/es unknown
- 2013-07-12 US US13/940,555 patent/US9199984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1207078A1 (en) | 2016-01-22 |
| US20140018345A1 (en) | 2014-01-16 |
| US9199984B2 (en) | 2015-12-01 |
| EP2872509A1 (en) | 2015-05-20 |
| RU2638537C2 (ru) | 2017-12-14 |
| WO2014009425A1 (en) | 2014-01-16 |
| CN104428300B (zh) | 2016-11-09 |
| RU2015104644A (ru) | 2016-08-27 |
| CA2878792A1 (en) | 2014-01-16 |
| KR20150031318A (ko) | 2015-03-23 |
| IN2015DN00202A (OSRAM) | 2015-06-12 |
| EP2872509B1 (en) | 2016-09-14 |
| CN104428300A (zh) | 2015-03-18 |
| BR112015000507A2 (pt) | 2017-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR091737A1 (es) | Inhibicion de enzimas | |
| AR098136A1 (es) | Compuestos de heteroarilo como inhibidores de btk y usos de los mismos | |
| AR093020A1 (es) | Compuestos antiviricos para el vsr | |
| AR092869A1 (es) | Alcoxipirazoles como activadores de guanilato ciclasa soluble | |
| AR129635A2 (es) | Moduladores de tetrahidropiridopirazina de gpr6 | |
| AR102492A1 (es) | Cromanos sustituidos y métodos para su uso | |
| AR098721A1 (es) | Inhibidores de biarilo de tirosina quinasa de bruton | |
| AR093404A1 (es) | Compuestos macrociclicos que modulan la actividad de los inhibidores de la apoptosis | |
| AR098492A1 (es) | Derivados de purina | |
| AR109805A1 (es) | Derivados de oxadiazol microbiocidas | |
| AR096757A1 (es) | Inhibidores de bromodominios | |
| AR100886A1 (es) | 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas | |
| AR090868A1 (es) | Composiciones plaguicidas y procesos relacionados con ellas | |
| AR109905A1 (es) | Pirrolidinas sustituidas como moduladores de cftr | |
| AR103561A1 (es) | Fenilpiridinas herbicidas | |
| AR094557A1 (es) | Tiadiazol, análogos del mismo, y métodos para el tratamiento de condiciones relacionadas con deficiencia de smn | |
| AR087901A1 (es) | Derivados dihidroquinolina-2-ona como inhibidores de la aldosterona sintasa y procedimiento para su obtencion | |
| AR094299A1 (es) | Derivados de ftalazin-1(2h)-ona sustituidos | |
| AR086817A1 (es) | Compuestos inhibidores de la fosfodiesterasa tipo 10a | |
| AR110089A1 (es) | Inhibidores de magl | |
| AR096052A1 (es) | Compuestos y sus usos para la modulación de hemoglobina | |
| AR106301A1 (es) | Composiciones de pirrolpirimidina como inhibidores de quinasas | |
| AR104555A1 (es) | SULFONAS TRICÍCLICAS COMO MODULARES DE RORg | |
| AR118706A2 (es) | Compuesto para el control de plagas y vegetación no deseada, procedimiento para prepararlo, composición que lo comprende, y compuesto intermediario relacionado | |
| AR088886A1 (es) | Compuestos de 1,2,5-oxadiazol sustituido y su uso como herbicidas ii |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |