IN2015DN00202A - - Google Patents
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- Publication number
- IN2015DN00202A IN2015DN00202A IN202DEN2015A IN2015DN00202A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A IN 202DEN2015 A IN202DEN2015 A IN 202DEN2015A IN 2015DN00202 A IN2015DN00202 A IN 2015DN00202A
- Authority
- IN
- India
- Prior art keywords
- mula
- inhibitors
- compounds
- formula
- neutrophil elastase
- Prior art date
Links
- 235000013350 formula milk Nutrition 0.000 abstract 2
- 108010028275 Leukocyte Elastase Proteins 0.000 abstract 1
- 102000016799 Leukocyte elastase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176079 | 2012-07-12 | ||
| EP13158756 | 2013-03-12 | ||
| PCT/EP2013/064603 WO2014009425A1 (en) | 2012-07-12 | 2013-07-10 | Inhibition of enzymes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2015DN00202A true IN2015DN00202A (OSRAM) | 2015-06-12 |
Family
ID=48953361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN202DEN2015 IN2015DN00202A (OSRAM) | 2012-07-12 | 2013-07-10 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9199984B2 (OSRAM) |
| EP (1) | EP2872509B1 (OSRAM) |
| KR (1) | KR20150031318A (OSRAM) |
| CN (1) | CN104428300B (OSRAM) |
| AR (1) | AR091737A1 (OSRAM) |
| BR (1) | BR112015000507A2 (OSRAM) |
| CA (1) | CA2878792A1 (OSRAM) |
| IN (1) | IN2015DN00202A (OSRAM) |
| RU (1) | RU2638537C2 (OSRAM) |
| WO (1) | WO2014009425A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015091281A1 (en) | 2013-12-16 | 2015-06-25 | Chiesi Farmaceutici S.P.A. | Tetrahydrotriazolopyrimidine derivatives as human neutrophil elastase inhibitors |
| US9487528B2 (en) | 2014-06-09 | 2016-11-08 | Chiesi Farmaceutici S.P.A. | Compounds |
| US9475779B2 (en) | 2014-07-31 | 2016-10-25 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9440930B2 (en) | 2014-07-31 | 2016-09-13 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9657015B2 (en) | 2014-07-31 | 2017-05-23 | Boehringer Ingelheim International Gmbh | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity |
| US9409870B2 (en) * | 2014-12-15 | 2016-08-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| US9862706B2 (en) | 2016-05-31 | 2018-01-09 | Chiesi Farmaceutici S.P.A. | Compounds |
| WO2017207432A1 (en) * | 2016-05-31 | 2017-12-07 | Chiesi Farmaceutici S.P.A. | Novel compounds |
| KR102404031B1 (ko) | 2016-05-31 | 2022-06-02 | 키에시 파르마슈티시 엣스. 피. 에이. | 인간 호중구 엘라스타제 억제제로서 이미다졸론 화합물 |
| JP7245167B2 (ja) | 2017-02-27 | 2023-03-23 | バーリント ゲーザ | 表示情報及び／又はデータの同時多機能操作を可能とするディスプレイを備えたスマートデバイス |
| MX2022000954A (es) | 2019-07-23 | 2022-02-14 | Bayer Ag | Novedosos compuestos de heteroaril-triazol como plaguicidas. |
| TWI874423B (zh) | 2019-07-23 | 2025-03-01 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基三唑化合物（一） |
| US20220354833A1 (en) | 2019-09-17 | 2022-11-10 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| PH12022550874A1 (en) | 2019-10-09 | 2023-03-27 | Bayer Ag | Novel heteroaryl-triazole compounds as pesticides |
| WO2021069569A1 (en) | 2019-10-09 | 2021-04-15 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
| US20230117470A1 (en) * | 2019-11-01 | 2023-04-20 | Bristol-Myers Squibb Company | Substituted pyrazole compounds as toll receptor inhibitors |
| TW202134226A (zh) | 2019-11-18 | 2021-09-16 | 德商拜耳廠股份有限公司 | 作為殺蟲劑之新穎雜芳基-三唑化合物 |
| LT4106757T (lt) | 2020-04-16 | 2023-11-10 | Mereo Biopharma 4 Limited | Neutrofilų elastazės inhibitoriaus alvelestato panaudojimas kvėpavimo sistemos ligų, nulemtų alfa-1 antitripsino nepakankamumo, gydymui |
| JP2023542789A (ja) * | 2020-09-28 | 2023-10-12 | シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド | ピラゾール化合物並びにその調製方法及び使用 |
| CN113480486B (zh) * | 2021-07-30 | 2022-05-24 | 赣南师范大学 | 一种3-胺基-1,2,4-三唑类衍生物及其制备方法和应用 |
| AU2022373971A1 (en) | 2021-10-20 | 2024-04-04 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259504A (en) | 1979-08-27 | 1981-03-31 | American Cyanamid Company | Substituted 1H-1,2,4-triazoles |
| US4451471A (en) | 1981-03-18 | 1984-05-29 | Ciba-Geigy Corporation | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same |
| US4576958A (en) | 1984-01-23 | 1986-03-18 | E. I. Du Pont De Nemours And Company | Antihypertensive 4,5-diaryl-1H-imidazole-2-methanol derivatives |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| ES2184633B1 (es) | 2001-08-07 | 2004-08-01 | J. URIACH & CIA, S.A. | Procedimiento para la preparacion de derivados de 4-(imidazol-1-il) bencenosulfonamida. |
| US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
| WO2006038116A2 (en) | 2004-10-07 | 2006-04-13 | Warner-Lambert Company Llc | Triazolopyridine derivatives as antibacterial agents |
| US7902374B2 (en) | 2005-05-06 | 2011-03-08 | Universal Display Corporation | Stability OLED materials and devices |
| US20080125587A1 (en) | 2006-05-25 | 2008-05-29 | Chimmanamada Dinesh U | Synthesis of triazole compounds that modulate HSP90 activity |
| EA017297B1 (ru) * | 2007-11-06 | 2012-11-30 | Астразенека Аб | Некоторые производные 2-пиразинона и их применение в качестве ингибиторов нейтрофильной эластазы |
| PE20091953A1 (es) | 2008-05-08 | 2010-01-09 | Du Pont | Azoles sustituidos como fungicidas |
| JP2011525183A (ja) * | 2008-06-20 | 2011-09-15 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なイミダゾピリジンおよびイミダゾピラジン化合物 |
| US8410128B2 (en) * | 2008-06-20 | 2013-04-02 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as kinase inhibitors |
| DE102009004197A1 (de) * | 2009-01-09 | 2010-07-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch anellierte Diaryldihydropyrimidin-Derivate und ihre Verwendung |
| KR20120099639A (ko) * | 2009-10-02 | 2012-09-11 | 아스트라제네카 아베 | 호중구 엘라스타제의 억제제로서 사용되는 2-피리돈 화합물 |
-
2013
- 2013-07-10 RU RU2015104644A patent/RU2638537C2/ru not_active IP Right Cessation
- 2013-07-10 EP EP13747801.2A patent/EP2872509B1/en active Active
- 2013-07-10 CA CA2878792A patent/CA2878792A1/en not_active Abandoned
- 2013-07-10 IN IN202DEN2015 patent/IN2015DN00202A/en unknown
- 2013-07-10 KR KR20157002129A patent/KR20150031318A/ko not_active Withdrawn
- 2013-07-10 CN CN201380036973.4A patent/CN104428300B/zh not_active Expired - Fee Related
- 2013-07-10 BR BR112015000507A patent/BR112015000507A2/pt not_active IP Right Cessation
- 2013-07-10 WO PCT/EP2013/064603 patent/WO2014009425A1/en not_active Ceased
- 2013-07-11 AR ARP130102470 patent/AR091737A1/es unknown
- 2013-07-12 US US13/940,555 patent/US9199984B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2878792A1 (en) | 2014-01-16 |
| US9199984B2 (en) | 2015-12-01 |
| US20140018345A1 (en) | 2014-01-16 |
| HK1207078A1 (en) | 2016-01-22 |
| WO2014009425A1 (en) | 2014-01-16 |
| EP2872509B1 (en) | 2016-09-14 |
| AR091737A1 (es) | 2015-02-25 |
| BR112015000507A2 (pt) | 2017-06-27 |
| KR20150031318A (ko) | 2015-03-23 |
| RU2015104644A (ru) | 2016-08-27 |
| CN104428300B (zh) | 2016-11-09 |
| CN104428300A (zh) | 2015-03-18 |
| EP2872509A1 (en) | 2015-05-20 |
| RU2638537C2 (ru) | 2017-12-14 |
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