AR090970A1 - Diferenciacion de celulas madre humanas embrionarias en endodermo pancreatico - Google Patents
Diferenciacion de celulas madre humanas embrionarias en endodermo pancreaticoInfo
- Publication number
- AR090970A1 AR090970A1 ARP130101563A ARP130101563A AR090970A1 AR 090970 A1 AR090970 A1 AR 090970A1 AR P130101563 A ARP130101563 A AR P130101563A AR P130101563 A ARP130101563 A AR P130101563A AR 090970 A1 AR090970 A1 AR 090970A1
- Authority
- AR
- Argentina
- Prior art keywords
- cells
- pancreatic endoderm
- differentiation
- embryous
- markers indicative
- Prior art date
Links
- 210000001900 endoderm Anatomy 0.000 title abstract 5
- 210000000130 stem cell Anatomy 0.000 title abstract 5
- 230000004069 differentiation Effects 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 5
- 238000010899 nucleation Methods 0.000 abstract 2
- 210000004039 endoderm cell Anatomy 0.000 abstract 1
- 238000009331 sowing Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/005—Protein-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
- C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/065—Modulators of histone acetylation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/19—Growth and differentiation factors [GDF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261643684P | 2012-05-07 | 2012-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR090970A1 true AR090970A1 (es) | 2014-12-17 |
Family
ID=49551213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130101563A AR090970A1 (es) | 2012-05-07 | 2013-05-07 | Diferenciacion de celulas madre humanas embrionarias en endodermo pancreatico |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20140162359A1 (enExample) |
| EP (1) | EP2847319A4 (enExample) |
| JP (1) | JP6450674B2 (enExample) |
| KR (1) | KR20150014478A (enExample) |
| CN (1) | CN104284977A (enExample) |
| AR (1) | AR090970A1 (enExample) |
| AU (1) | AU2013259706A1 (enExample) |
| BR (1) | BR112014027783A2 (enExample) |
| CA (1) | CA2872770A1 (enExample) |
| HK (1) | HK1207885A1 (enExample) |
| IL (1) | IL235132A0 (enExample) |
| IN (1) | IN2014DN08561A (enExample) |
| MX (1) | MX2014013524A (enExample) |
| PH (1) | PH12014502686A1 (enExample) |
| RU (1) | RU2668814C2 (enExample) |
| SG (1) | SG11201406884SA (enExample) |
| WO (1) | WO2013169769A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102341674B1 (ko) | 2013-06-11 | 2021-12-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | SC-β 세포 및 조성물 그리고 그 생성 방법 |
| CN113234661A (zh) | 2014-12-18 | 2021-08-10 | 哈佛学院校长同事会 | 干细胞来源的β细胞的产生方法及其使用方法 |
| US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
| WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
| CN106467918B (zh) * | 2015-08-18 | 2020-07-31 | 中国科学技术大学先进技术研究院 | 一种基于人皮肤细胞的胰岛素分泌细胞的诱导方法及应用 |
| US20210147807A1 (en) * | 2017-06-14 | 2021-05-20 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| KR102789149B1 (ko) | 2017-11-15 | 2025-03-31 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
| AU2019320072A1 (en) | 2018-08-10 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| US12378572B2 (en) | 2018-09-07 | 2025-08-05 | Crispr Therapeutics Ag | Universal donor cells |
| AU2020283056B2 (en) | 2019-05-31 | 2023-06-08 | Viacyte, Inc. | A biocompatible membrane composite |
| WO2020243666A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
| EP3976237A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | Cell encapsulation devices with controlled oxygen diffusion distances |
| EP3976236A1 (en) | 2019-05-31 | 2022-04-06 | W.L. Gore & Associates Inc. | A biocompatible membrane composite |
| WO2021044377A1 (en) | 2019-09-05 | 2021-03-11 | Crispr Therapeutics Ag | Universal donor cells |
| US11118196B2 (en) | 2019-09-05 | 2021-09-14 | Crispr Therapeutics Ag | Universal donor cells |
| WO2022144856A1 (en) | 2020-12-31 | 2022-07-07 | Crispr Therapeutics Ag | Universal donor cells |
| CN113046306B (zh) * | 2021-03-12 | 2022-10-18 | 广东东阳光药业有限公司 | 一种多能干细胞的培养方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| KR101008868B1 (ko) | 2001-12-07 | 2011-01-17 | 제론 코포레이션 | 인간 배아 줄기세포 유래의 섬세포 |
| CN103898045B (zh) | 2003-12-23 | 2019-02-01 | 维亚希特公司 | 定形内胚层 |
| US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
| US7695965B2 (en) | 2006-03-02 | 2010-04-13 | Cythera, Inc. | Methods of producing pancreatic hormones |
| US8741643B2 (en) * | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| WO2008013664A2 (en) | 2006-07-26 | 2008-01-31 | Cythera, Inc. | Methods of producing pancreatic hormones |
| MX2010000348A (es) * | 2007-07-01 | 2010-04-12 | Lifescan Inc | Cultivo de celulas madre pluripotentes individuales. |
| ES2537578T3 (es) * | 2007-07-18 | 2015-06-09 | Lifescan, Inc. | Diferenciación de las células madre de embriones humanos |
| CA2695225C (en) * | 2007-07-31 | 2021-06-01 | Lifescan, Inc. | Differentiation of human embryonic stem cells to pancreatic endocrine |
| US7939322B2 (en) * | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| BRPI0914116A2 (pt) * | 2008-06-30 | 2019-09-17 | Centocor Ortho Biotech Inc | diferenciação de células-tronco pluripotentes |
| US20100028307A1 (en) * | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
| EP2346988B1 (en) * | 2008-10-31 | 2017-05-31 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| AU2010276402B2 (en) * | 2009-07-20 | 2014-07-03 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| WO2011058558A2 (en) * | 2009-11-12 | 2011-05-19 | Technion Research & Development Foundation Ltd. | Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state |
| EP2542666A4 (en) * | 2010-03-02 | 2014-05-07 | Univ Singapore | CULTURE ADDITIVES FOR PROMOTING A STEM CELL PROGRAMMING AND DIFFERENTIATION REACTION |
| CA2793971A1 (en) * | 2010-03-23 | 2011-09-29 | Kuraray Co., Ltd. | Culture method for causing differentiation of pluripotent mammalian cells |
| RU2673946C1 (ru) * | 2010-08-31 | 2018-12-03 | Янссен Байотек, Инк. | Дифференцирование плюрипотентных стволовых клеток |
-
2013
- 2013-05-07 CN CN201380024226.9A patent/CN104284977A/zh active Pending
- 2013-05-07 EP EP13786955.8A patent/EP2847319A4/en not_active Withdrawn
- 2013-05-07 CA CA2872770A patent/CA2872770A1/en not_active Abandoned
- 2013-05-07 HK HK15108511.6A patent/HK1207885A1/xx unknown
- 2013-05-07 BR BR112014027783A patent/BR112014027783A2/pt not_active Application Discontinuation
- 2013-05-07 RU RU2014149185A patent/RU2668814C2/ru not_active IP Right Cessation
- 2013-05-07 SG SG11201406884SA patent/SG11201406884SA/en unknown
- 2013-05-07 US US13/888,968 patent/US20140162359A1/en not_active Abandoned
- 2013-05-07 JP JP2015511622A patent/JP6450674B2/ja not_active Expired - Fee Related
- 2013-05-07 AR ARP130101563A patent/AR090970A1/es unknown
- 2013-05-07 AU AU2013259706A patent/AU2013259706A1/en not_active Abandoned
- 2013-05-07 KR KR1020147033897A patent/KR20150014478A/ko not_active Ceased
- 2013-05-07 WO PCT/US2013/039940 patent/WO2013169769A1/en not_active Ceased
- 2013-05-07 MX MX2014013524A patent/MX2014013524A/es unknown
-
2014
- 2014-10-14 IN IN8561DEN2014 patent/IN2014DN08561A/en unknown
- 2014-10-19 IL IL235132A patent/IL235132A0/en unknown
- 2014-12-02 PH PH12014502686A patent/PH12014502686A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013169769A1 (en) | 2013-11-14 |
| CA2872770A1 (en) | 2013-11-14 |
| PH12014502686A1 (en) | 2015-01-26 |
| RU2668814C2 (ru) | 2018-10-02 |
| EP2847319A1 (en) | 2015-03-18 |
| JP6450674B2 (ja) | 2019-01-09 |
| CN104284977A (zh) | 2015-01-14 |
| RU2014149185A (ru) | 2016-06-27 |
| IN2014DN08561A (enExample) | 2015-05-22 |
| JP2015516161A (ja) | 2015-06-11 |
| SG11201406884SA (en) | 2014-11-27 |
| IL235132A0 (en) | 2014-12-31 |
| BR112014027783A2 (pt) | 2017-06-27 |
| MX2014013524A (es) | 2015-02-10 |
| KR20150014478A (ko) | 2015-02-06 |
| HK1207885A1 (en) | 2016-02-12 |
| EP2847319A4 (en) | 2015-12-16 |
| US20140162359A1 (en) | 2014-06-12 |
| AU2013259706A1 (en) | 2014-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |