AR088619A1 - Metodo para preparar complejos de polipeptidos fisiologicamente activos - Google Patents
Metodo para preparar complejos de polipeptidos fisiologicamente activosInfo
- Publication number
- AR088619A1 AR088619A1 ARP120104102A ARP120104102A AR088619A1 AR 088619 A1 AR088619 A1 AR 088619A1 AR P120104102 A ARP120104102 A AR P120104102A AR P120104102 A ARP120104102 A AR P120104102A AR 088619 A1 AR088619 A1 AR 088619A1
- Authority
- AR
- Argentina
- Prior art keywords
- physiologically active
- active polypeptide
- conjugate
- peptide polymer
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
Método para preparar un conjugado de un polipéptido fisiológicamente activo seleccionado del grupo de la insulina y un polímero no peptídico por unión del polipéptido fisiológicamente activo a dicho polímero no peptídico mediante un enlace covalente usando un solvente orgánico, y para preparar un complejo de un polipéptido fisiológicamente activo por unión del conjugado con un vehículo para mejorar la duración y la estabilidad in vivo de dicho polipéptido fisiológicamente activo. El método permite preparar el conjugado del polipéptido fisiológicamente activo y el polímero no peptídico con una gran pureza y rendimiento. Los complejos de polipéptidos fisiológicamente activos preparados con esta característica permiten reducir el costo de producción y extender la actividad in vivo a un nivel relativamente alto, y además aumentar significativamente la vida media en sangre. Por consiguiente, se puede emplear eficazmente en el desarrollo de una formulación de liberación sostenida de un polipéptido fisiológicamente activo que permite elevar la adaptabilidad del paciente para tomar la droga.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020110114828A KR20130049671A (ko) | 2011-11-04 | 2011-11-04 | 생리활성 폴리펩타이드 결합체 제조 방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR088619A1 true AR088619A1 (es) | 2014-06-25 |
Family
ID=48192386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120104102A AR088619A1 (es) | 2011-11-04 | 2012-11-01 | Metodo para preparar complejos de polipeptidos fisiologicamente activos |
Country Status (17)
Country | Link |
---|---|
US (1) | US11434271B2 (es) |
EP (1) | EP2773672B1 (es) |
JP (2) | JP6336394B2 (es) |
KR (1) | KR20130049671A (es) |
CN (2) | CN103930447A (es) |
AR (1) | AR088619A1 (es) |
AU (1) | AU2012331750B2 (es) |
BR (1) | BR112014010818A2 (es) |
CA (1) | CA2854078A1 (es) |
ES (1) | ES2898718T3 (es) |
IL (1) | IL232387B (es) |
MX (1) | MX369480B (es) |
RU (1) | RU2624129C2 (es) |
SG (1) | SG11201401677VA (es) |
TW (1) | TWI617569B (es) |
WO (1) | WO2013066106A1 (es) |
ZA (1) | ZA201403189B (es) |
Families Citing this family (12)
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KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
AR090281A1 (es) * | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
AR096890A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn |
AR096891A1 (es) * | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
CN117065044A (zh) * | 2014-03-31 | 2023-11-17 | 韩美药品株式会社 | 通过使用免疫球蛋白Fc片段连接改善蛋白质和肽的溶解度的方法 |
TW201718022A (zh) * | 2015-07-24 | 2017-06-01 | 韓美藥品股份有限公司 | 製備生理活性多肽接合物的方法 |
WO2017053807A2 (en) | 2015-09-23 | 2017-03-30 | Genentech, Inc. | Optimized variants of anti-vegf antibodies |
US20200283492A1 (en) * | 2017-09-29 | 2020-09-10 | Hanmi Pharm Co., Ltd. | Long acting protein complex having an enhanced efficiency |
CN113166271A (zh) * | 2018-05-18 | 2021-07-23 | 郑州晟斯生物科技有限公司 | 具有延长半衰期的融合多肽缀合物 |
CN110964116A (zh) * | 2018-09-26 | 2020-04-07 | 北京辅仁瑞辉生物医药研究院有限公司 | GLP1-Fc融合蛋白及其缀合物 |
CN109384840A (zh) * | 2018-10-23 | 2019-02-26 | 福州大学 | 蛋白质的修饰与分离纯化以及巯基蛋白酶的酶活调控方法 |
CN112521481B (zh) * | 2020-12-08 | 2022-11-04 | 武汉市工程科学技术研究院 | 表面修饰物及其制备方法和应用 |
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AR096891A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo |
AR096890A1 (es) | 2013-07-12 | 2016-02-03 | Hanmi Pharm Ind Co Ltd | Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn |
CA2925416A1 (en) | 2013-09-27 | 2015-04-02 | Hanmi Pharm. Co., Ltd. | Sustained type human growth hormone preparation |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
KR20150140177A (ko) | 2014-06-05 | 2015-12-15 | 한미약품 주식회사 | 단백질 및 펩타이드의 면역원성을 감소시키는 방법 |
EA038544B1 (ru) | 2015-12-31 | 2021-09-13 | Ханми Фарм. Ко., Лтд. | Тройной агонист рецепторов глюкагона/glp-1/gip |
IL263934B2 (en) | 2016-06-29 | 2023-10-01 | Hanmi Pharm Ind Co Ltd | A derivative of glucagon, its conjugate, a preparation containing it and its medical use |
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2011
- 2011-11-04 KR KR1020110114828A patent/KR20130049671A/ko active Application Filing
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2012
- 2012-11-01 AR ARP120104102A patent/AR088619A1/es unknown
- 2012-11-02 EP EP12845690.2A patent/EP2773672B1/en active Active
- 2012-11-02 RU RU2014117563A patent/RU2624129C2/ru active
- 2012-11-02 WO PCT/KR2012/009186 patent/WO2013066106A1/en active Application Filing
- 2012-11-02 AU AU2012331750A patent/AU2012331750B2/en not_active Ceased
- 2012-11-02 JP JP2014539876A patent/JP6336394B2/ja active Active
- 2012-11-02 TW TW101140679A patent/TWI617569B/zh not_active IP Right Cessation
- 2012-11-02 CA CA2854078A patent/CA2854078A1/en not_active Abandoned
- 2012-11-02 CN CN201280054295.XA patent/CN103930447A/zh active Pending
- 2012-11-02 US US14/356,054 patent/US11434271B2/en active Active
- 2012-11-02 CN CN201810120391.9A patent/CN108210934A/zh active Pending
- 2012-11-02 ES ES12845690T patent/ES2898718T3/es active Active
- 2012-11-02 BR BR112014010818A patent/BR112014010818A2/pt unknown
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US11434271B2 (en) | 2022-09-06 |
TWI617569B (zh) | 2018-03-11 |
CA2854078A1 (en) | 2013-05-10 |
AU2012331750A1 (en) | 2014-05-22 |
CN108210934A (zh) | 2018-06-29 |
JP2014532695A (ja) | 2014-12-08 |
RU2014117563A (ru) | 2015-12-10 |
WO2013066106A1 (en) | 2013-05-10 |
IL232387B (en) | 2019-11-28 |
BR112014010818A2 (pt) | 2017-06-13 |
US20140296475A1 (en) | 2014-10-02 |
KR20130049671A (ko) | 2013-05-14 |
CN103930447A (zh) | 2014-07-16 |
NZ624338A (en) | 2016-11-25 |
AU2012331750B2 (en) | 2017-06-15 |
EP2773672A4 (en) | 2015-03-18 |
SG11201401677VA (en) | 2014-05-29 |
RU2624129C2 (ru) | 2017-06-30 |
ZA201403189B (en) | 2015-08-26 |
JP6336394B2 (ja) | 2018-06-06 |
ES2898718T3 (es) | 2022-03-08 |
MX369480B (es) | 2019-11-08 |
IL232387A0 (en) | 2014-06-30 |
EP2773672B1 (en) | 2021-09-15 |
TW201323435A (zh) | 2013-06-16 |
JP2018150332A (ja) | 2018-09-27 |
EP2773672A1 (en) | 2014-09-10 |
MX2014005353A (es) | 2014-05-28 |
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