AR088378A1 - DERIVADOS DE N-CICLOPROPIL-N-(4,5,6,7-TETRAHIDRO-1H-INDAZOL-5-IL)-BENZAMIDA COMO INHIBIDOR DE LA 11b-HSD1 - Google Patents
DERIVADOS DE N-CICLOPROPIL-N-(4,5,6,7-TETRAHIDRO-1H-INDAZOL-5-IL)-BENZAMIDA COMO INHIBIDOR DE LA 11b-HSD1Info
- Publication number
- AR088378A1 AR088378A1 ARP120103883A ARP120103883A AR088378A1 AR 088378 A1 AR088378 A1 AR 088378A1 AR P120103883 A ARP120103883 A AR P120103883A AR P120103883 A ARP120103883 A AR P120103883A AR 088378 A1 AR088378 A1 AR 088378A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- ring
- heteroaryl
- lower alkyl
- pain
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/28—Cinnolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Dar a conocer un compuesto ventajoso como ingrediente activo de una composición farmacéutica para el tratamiento de enfermedades relacionadas con la 11b-hidroxiesteroide deshidrogenasa tipo 1 tales como demencia, esquizofrenia, depresión, dolor (en particular, dolor neuropático o fibromialgia), diabetes (en particular, diabetes mellitus tipo II), la resistencia a la insulina y demás. Se descubrió que un compuesto heterocíclico bicíclico (el heterociclo bicíclico se forma cuando un anillo de ciclohexano se fusiona a un heterociclo monocíclico de 5 a 6 miembros que tiene sólo un átomo de nitrógeno como heteroátomo) sustituido con un grupo acilamino tal como un grupo (hetero)aroilamino similar o una sal farmacéuticamente aceptable del mismo tiene una excelente acción de inhibición contra la 11b-HSD1. En consecuencia, este compuesto heterocíclico bicíclico se puede utilizar para el tratamiento de la demencia, esquizofrenia, depresión, dolor (en particular, dolor neuropático o fibromialgia), diabetes (en particular, diabetes mellitus tipo II), la resistencia a la insulina y demás. Reivindicación 1: Un compuesto representado por la fórmula (1) o una sal farmacéuticamente aceptable del mismo, [los símbolos que aparecen en la fórmula representan lo siguiente: anillo A: un heterociclo monocíclico de 5 a 6 miembros que puede estar sustituido y tiene sólo el o los átomos de nitrógeno como heteroátomos; donde los átomos presentes en la posición en que el anillo se fusiona al anillo adyacente son átomos de carbono, R¹: alquilo inferior, halógeno-alquilo inferior, o cicloalquilo que puede estar sustituido, R²: halógeno o alquilo inferior, R³: arilo, heteroarilo o alquileno inferior-heteroarilo; donde cada uno del arilo y heteroarilo representados por R³ puede estar sustituido, n: un entero de 0 a 3 y una línea de puntos representa un enlace simple o un enlace doble].
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011228822 | 2011-10-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088378A1 true AR088378A1 (es) | 2014-05-28 |
Family
ID=48140904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120103883A AR088378A1 (es) | 2011-10-18 | 2012-10-18 | DERIVADOS DE N-CICLOPROPIL-N-(4,5,6,7-TETRAHIDRO-1H-INDAZOL-5-IL)-BENZAMIDA COMO INHIBIDOR DE LA 11b-HSD1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9266840B2 (es) |
| EP (1) | EP2772484B1 (es) |
| JP (1) | JP6020459B2 (es) |
| KR (1) | KR101987514B1 (es) |
| CN (1) | CN103917524B (es) |
| AR (1) | AR088378A1 (es) |
| AU (1) | AU2012327076B2 (es) |
| BR (1) | BR112014009524A2 (es) |
| CA (1) | CA2851589C (es) |
| CY (1) | CY1119181T1 (es) |
| DK (1) | DK2772484T3 (es) |
| EA (1) | EA024846B1 (es) |
| ES (1) | ES2641258T3 (es) |
| HR (1) | HRP20171125T1 (es) |
| IL (1) | IL232061A (es) |
| IN (1) | IN2014CN02949A (es) |
| LT (1) | LT2772484T (es) |
| ME (1) | ME02733B (es) |
| MX (1) | MX344014B (es) |
| PL (1) | PL2772484T3 (es) |
| PT (1) | PT2772484T (es) |
| RS (1) | RS56288B1 (es) |
| SI (1) | SI2772484T1 (es) |
| TW (1) | TWI545113B (es) |
| UA (1) | UA112327C2 (es) |
| WO (1) | WO2013058258A1 (es) |
| ZA (1) | ZA201403513B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2844259A4 (en) | 2012-04-30 | 2015-11-11 | Anderson Gaweco | MMR MODULATORS AND USES THEREOF |
| US9045477B2 (en) | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| EP2970306A4 (en) * | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS CONDENSED IN 6.5 |
| AU2016284398C1 (en) * | 2015-06-22 | 2021-01-07 | Sumitomo Dainippon Pharma Co., Ltd. | 1,4-disubstituted imidazole derivative |
| CN108129430A (zh) * | 2016-11-30 | 2018-06-08 | 重庆圣华曦药业股份有限公司 | 一种立他司特中间体的合成方法 |
| CN115925692A (zh) * | 2022-11-28 | 2023-04-07 | 浙江理工大学 | 一种三氟甲基取代的烯胺化合物的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2044964T3 (es) * | 1986-08-12 | 1994-01-16 | Roussel Uclaf | Procedimiento para preparar derivados de decahidroquinolina. |
| GB8907865D0 (en) | 1989-04-07 | 1989-05-24 | Wyeth John & Brother Ltd | Tetrahydroquinoline derivatives |
| US5194439A (en) * | 1990-04-06 | 1993-03-16 | John Wyeth & Brother Limited | N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes |
| DE69602248T4 (de) * | 1995-07-20 | 2000-10-26 | Toray Industries | 4a-aryldecahydroisochinolin-verbindungen und ihre medizinische verwendungen |
| JP2003527395A (ja) | 2000-03-17 | 2003-09-16 | ノボ ノルディスク アクティーゼルスカブ | ヒスタミンｈ３受容体リガンドとしての縮環イミダゾール |
| CA2479928A1 (en) | 2002-03-28 | 2003-10-09 | Neurogen Corporation | Substituted biaryl amides as c5a receptor modulators |
| ATE482747T1 (de) | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
| CA2540843A1 (en) * | 2003-10-23 | 2005-05-12 | Sterix Limited | Phenyl carboxamide and sulfonamide derivatives for use as 11-beta-hydroxysteroid dehydrogenase |
| AU2006230364B2 (en) | 2005-03-31 | 2012-09-13 | Janssen Pharmaceutica N.V. | Bicyclic pyrazole compounds as antibacterial agents |
| WO2006104280A1 (ja) * | 2005-03-31 | 2006-10-05 | Takeda Pharmaceutical Company Limited | 糖尿病の予防・治療剤 |
| WO2007050124A1 (en) | 2005-05-19 | 2007-05-03 | Xenon Pharmaceuticals Inc. | Fused piperidine derivatives and their uses as therapeutic agents |
| TW200716576A (en) | 2005-06-07 | 2007-05-01 | Shionogi & Co | Heterocyclic derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US7605289B2 (en) | 2005-06-17 | 2009-10-20 | Amgen, Inc. | Benzamide derivatives and uses related thereto |
| WO2007069773A1 (en) | 2005-12-15 | 2007-06-21 | Shionogi & Co., Ltd. | A pharmaceutical composition comprising an amide derivative |
| EA014717B1 (ru) | 2006-04-21 | 2011-02-28 | Эли Лилли Энд Компани | ПРОИЗВОДНЫЕ ЛАКТАМА ЦИКЛОГЕКСИЛИМИДАЗОЛА В КАЧЕСТВЕ ИНГИБИТОРОВ 11-β-ГИДРОКСИСТЕРОИД ДЕГИДРОГЕНАЗЫ 1 |
| MX2008013484A (es) | 2006-04-21 | 2008-10-30 | Lilly Co Eli | Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1. |
| PL2021337T3 (pl) | 2006-04-25 | 2010-06-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| CA2654699A1 (en) | 2006-06-08 | 2007-12-21 | Amgen Inc. | Benzamide derivatives and uses related thereto |
| TW200808695A (en) | 2006-06-08 | 2008-02-16 | Amgen Inc | Benzamide derivatives and uses related thereto |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| US7932421B2 (en) | 2006-12-26 | 2011-04-26 | Amgen Inc. | N-cyclohexyl benzamides and benzeneacetamides as inhibitors of 11-beta-hydroxysteroid dehydrogenases |
| EP2519517B1 (en) | 2009-12-29 | 2015-03-25 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| UA112418C2 (uk) | 2010-09-07 | 2016-09-12 | Астеллас Фарма Інк. | Терапевтичний болезаспокійливий засіб |
| US20140018540A1 (en) | 2010-12-14 | 2014-01-16 | Electrophoretics Limited | Casein kinase 1delta (ck 1delta) inhibitors |
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2012
- 2012-10-17 LT LTEP12840990.1T patent/LT2772484T/lt unknown
- 2012-10-17 ES ES12840990.1T patent/ES2641258T3/es active Active
- 2012-10-17 UA UAA201405224A patent/UA112327C2/uk unknown
- 2012-10-17 CN CN201280051414.6A patent/CN103917524B/zh active Active
- 2012-10-17 EA EA201490811A patent/EA024846B1/ru not_active IP Right Cessation
- 2012-10-17 CA CA2851589A patent/CA2851589C/en active Active
- 2012-10-17 RS RS20170733A patent/RS56288B1/sr unknown
- 2012-10-17 AU AU2012327076A patent/AU2012327076B2/en active Active
- 2012-10-17 JP JP2013539653A patent/JP6020459B2/ja active Active
- 2012-10-17 SI SI201231017T patent/SI2772484T1/sl unknown
- 2012-10-17 KR KR1020147012520A patent/KR101987514B1/ko active IP Right Grant
- 2012-10-17 IN IN2949CHN2014 patent/IN2014CN02949A/en unknown
- 2012-10-17 WO PCT/JP2012/076771 patent/WO2013058258A1/ja active Application Filing
- 2012-10-17 PT PT128409901T patent/PT2772484T/pt unknown
- 2012-10-17 MX MX2014004701A patent/MX344014B/es active IP Right Grant
- 2012-10-17 ME MEP-2017-145A patent/ME02733B/me unknown
- 2012-10-17 BR BR112014009524A patent/BR112014009524A2/pt not_active Application Discontinuation
- 2012-10-17 EP EP12840990.1A patent/EP2772484B1/en active Active
- 2012-10-17 US US14/351,965 patent/US9266840B2/en active Active
- 2012-10-17 PL PL12840990T patent/PL2772484T3/pl unknown
- 2012-10-17 DK DK12840990.1T patent/DK2772484T3/en active
- 2012-10-17 TW TW101138258A patent/TWI545113B/zh active
- 2012-10-18 AR ARP120103883A patent/AR088378A1/es active IP Right Grant
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2014
- 2014-04-10 IL IL232061A patent/IL232061A/en active IP Right Grant
- 2014-05-15 ZA ZA2014/03513A patent/ZA201403513B/en unknown
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2017
- 2017-07-21 HR HRP20171125TT patent/HRP20171125T1/hr unknown
- 2017-07-31 CY CY20171100826T patent/CY1119181T1/el unknown
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