AR086204A1 - Cefalosporinas como agentes antibacteriales - Google Patents
Cefalosporinas como agentes antibacterialesInfo
- Publication number
- AR086204A1 AR086204A1 ARP120101502A ARP120101502A AR086204A1 AR 086204 A1 AR086204 A1 AR 086204A1 AR P120101502 A ARP120101502 A AR P120101502A AR P120101502 A ARP120101502 A AR P120101502A AR 086204 A1 AR086204 A1 AR 086204A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- so2r6
- nhr4
- nr4r5
- cephalosporins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
La presente proporciona derivados de cefalosporinas de la fórmula (1), su uso para el tratamiento de infecciones en mamíferos, composición farmacéutica que contiene estos compuestos y métodos para la preparación de estos compuestos.Reivindicación 1: Un compuesto de la fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: R1 es -NR4R5, -SO2R6, -C(=O)NR4R4, -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, SC(=O)NHR4, -SP(=O)(OR4)2; o R1 es -alquilo C1-8 sustituido con -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, -SC(=O)NHR4, -SP(=O)(OR4)2, -C(=O)NR4R5, -SO2R6; o R1 es -O-alquilo C1-8 sustituido con -SR4, -S(C=O)R4, -S(C=S)R4, -SC(=O)OR4, -SC(=O)NHR4, -SP(=O)(OR4)2, -C(=O)NR4R5, o -SO2R6; R2 y R3 son de manera independiente -H, -OH, -CN, halo, -NO2, -alquilo C1-10, -O-alquilo C1-10, -N(R4)2; o R1 y R3 tomados juntos con los carbonos a los cuales se unen forman un arilo o heteroarilo; R4 es -H o -alquilo C1-10; R5 es -SO2R4, -C(=O)alquilo C1-10; R6 es H, alquilo C1-6, o NR4R4; en cada presencia, alquilo C1-10 es opcionalmente sustituido con -OH, -CN, halo, -NO2, -O-alquilo C1-6, -SH, -S-alquilo C1-4, -S(C=O)alquilo C1-4, o -O(C=O)alquilo C1-4; y n es 1, 2, ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161481407P | 2011-05-02 | 2011-05-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086204A1 true AR086204A1 (es) | 2013-11-27 |
Family
ID=46062670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101502A AR086204A1 (es) | 2011-05-02 | 2012-04-27 | Cefalosporinas como agentes antibacteriales |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8722656B2 (es) |
| EP (1) | EP2705044A1 (es) |
| JP (1) | JP2014513116A (es) |
| CN (1) | CN103649097A (es) |
| AR (1) | AR086204A1 (es) |
| AU (1) | AU2012251438A1 (es) |
| CA (1) | CA2834999A1 (es) |
| MX (1) | MX2013012820A (es) |
| TW (1) | TW201311699A (es) |
| UY (1) | UY34047A (es) |
| WO (1) | WO2012150520A1 (es) |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2776992A (en) | 1956-03-14 | 1957-01-08 | Du Pont | Trifluoromethylsulfonylphenyldichloracetamidopropandiol |
| US3294818A (en) | 1964-04-06 | 1966-12-27 | Warner Lambert Pharmaceutical | Substituted dioxolanes and process for their production |
| US4235892A (en) | 1979-02-05 | 1980-11-25 | Schering Corporation, Patent Dept. | 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor |
| ES8104203A1 (es) | 1979-02-05 | 1981-04-16 | Schering Corp | Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol |
| US4361557A (en) | 1980-01-28 | 1982-11-30 | Schering Corporation | 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor |
| EP0061234A3 (en) * | 1981-03-05 | 1983-11-16 | Beecham Group Plc | Cephalosporin derivatives, process for their preparation and pharmaceutical preparations containing them |
| JPH064643B2 (ja) * | 1985-12-20 | 1994-01-19 | ファイザー製薬株式会社 | セフアロスポリン化合物 |
| DE3750673T2 (de) * | 1986-11-21 | 1995-03-16 | Ici Pharma | Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate. |
| US4977288A (en) | 1988-01-29 | 1990-12-11 | President And Fellows Of Harvard College | M-aminophenyltrialkylstannane |
| US5143910A (en) | 1989-09-07 | 1992-09-01 | Shionogi & Co., Ltd. | Piperaziniocephalosporins |
| SK283674B6 (sk) * | 1993-03-12 | 2003-11-04 | Pharmacia & Upjohn Company | Kryštalická voľná kyselina ceftiofuru a spôsob jej prípravy a farmaceutická kompozícia, ktorá ju obsahuje |
| IL163749A0 (en) | 2002-03-08 | 2005-12-18 | Schering Plough Ltd | Novel florfenicol-type antibiotics |
| TWI262181B (en) | 2003-12-23 | 2006-09-21 | Schering Plough Ltd | Florfenicol prodrug having improved water solubility |
| WO2005066119A2 (en) | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Antibacterial 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols and preparation thereof |
| WO2005073244A1 (en) | 2004-01-22 | 2005-08-11 | Eli Lilly And Company | Selective estrogen receptor modulators |
| GB0417709D0 (en) | 2004-08-09 | 2004-09-08 | Glaxo Group Ltd | Compounds |
| RU2008112952A (ru) | 2005-09-07 | 2009-10-20 | Шеринг-Плоу Лтд. (CH) | Способ получения соединений сложного эфира оксазолидина и их превращение до флорфеникола |
| US20080318919A1 (en) * | 2005-10-29 | 2008-12-25 | Intervet International B.V. | Cefquinome Compositions and Methods of Their Use |
| US8119667B2 (en) | 2005-12-29 | 2012-02-21 | Schering-Plough Animal Health Corporation | Carbonates of fenicol antibiotics |
| US7518017B2 (en) | 2006-02-17 | 2009-04-14 | Idexx Laboratories | Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds |
| WO2007124435A2 (en) | 2006-04-21 | 2007-11-01 | Board Of Regents, The University Of Texas System | Detection of histone deacetylase inhibition |
| EP2077998B1 (en) | 2006-09-05 | 2011-03-09 | Amgen Inc. | Phthalazine, aza- and diaza-phthalazine compounds and methods of use |
| CA2672795A1 (en) | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof |
| CA2672586A1 (en) | 2006-12-13 | 2008-06-26 | Schering-Plough Ltd. | Water-soluble prodrugs of florfenicol and its analogs |
| US20080153906A1 (en) | 2006-12-13 | 2008-06-26 | Celly Chander S | Water-Soluble Phenicol Prodrugs in a Lipophilic Vehicle System |
| JP2010529016A (ja) | 2007-05-30 | 2010-08-26 | シェーリング−プラウ リミテッド | フロルフェニコールへの中間体として有用なオキサゾリン保護アミノジオール化合物を調製するための方法 |
| WO2008151288A2 (en) | 2007-06-05 | 2008-12-11 | Xenon Pharmaceuticals Inc. | Aromatic and heteroaromatic compounds useful in treating iron disorders |
| CN101796037A (zh) | 2007-07-25 | 2010-08-04 | 英特威国际有限公司 | 制备噁唑烷-氨基二醇和噁唑烷酮-氨基二醇及相关中间体的方法 |
| EP2229149B1 (en) | 2007-12-14 | 2012-03-07 | Intervet International B.V. | Process for recovering flunixin from pharmaceutical compositions |
| PE20091171A1 (es) | 2007-12-14 | 2009-08-03 | Schering Plough Ltd | Proceso para recuperar florfenicol y analogos de florfenicol |
| US8673920B2 (en) | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
-
2012
- 2012-04-19 CN CN201280033080.XA patent/CN103649097A/zh active Pending
- 2012-04-19 JP JP2014508893A patent/JP2014513116A/ja not_active Withdrawn
- 2012-04-19 MX MX2013012820A patent/MX2013012820A/es unknown
- 2012-04-19 EP EP12720640.7A patent/EP2705044A1/en not_active Withdrawn
- 2012-04-19 WO PCT/IB2012/051973 patent/WO2012150520A1/en active Application Filing
- 2012-04-19 CA CA2834999A patent/CA2834999A1/en not_active Abandoned
- 2012-04-19 AU AU2012251438A patent/AU2012251438A1/en not_active Abandoned
- 2012-04-27 AR ARP120101502A patent/AR086204A1/es not_active Application Discontinuation
- 2012-04-30 UY UY0001034047A patent/UY34047A/es not_active Application Discontinuation
- 2012-04-30 TW TW101115372A patent/TW201311699A/zh unknown
- 2012-04-30 US US13/459,851 patent/US8722656B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2834999A1 (en) | 2012-11-08 |
| CN103649097A (zh) | 2014-03-19 |
| WO2012150520A1 (en) | 2012-11-08 |
| US8722656B2 (en) | 2014-05-13 |
| AU2012251438A1 (en) | 2013-11-14 |
| US20120283237A1 (en) | 2012-11-08 |
| EP2705044A1 (en) | 2014-03-12 |
| JP2014513116A (ja) | 2014-05-29 |
| MX2013012820A (es) | 2014-02-10 |
| UY34047A (es) | 2013-01-03 |
| TW201311699A (zh) | 2013-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |