AR084099A1 - Procedimiento mejorado para la preparacion de 2-trifluorometil-5-(1-substituido)-alquilpiridinas - Google Patents
Procedimiento mejorado para la preparacion de 2-trifluorometil-5-(1-substituido)-alquilpiridinasInfo
- Publication number
- AR084099A1 AR084099A1 ARP110104520A ARP110104520A AR084099A1 AR 084099 A1 AR084099 A1 AR 084099A1 AR P110104520 A ARP110104520 A AR P110104520A AR P110104520 A ARP110104520 A AR P110104520A AR 084099 A1 AR084099 A1 AR 084099A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- alkyl
- taken together
- members
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/32—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/08—Preparation by ring-closure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/08—Preparation by ring-closure
- C07D213/09—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles
- C07D213/12—Preparation by ring-closure involving the use of ammonia, amines, amine salts, or nitriles from unsaturated compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Reivindicación 1: Un procedimiento para la preparación de 2-trifluorometil-5-(1-sustituido)-alquilpiridina de fórmula (1), en donde R1 y R2 independientemente representan H, alquilo C1-4, o cualquiera entre R1 o R2 tomados conjuntamente con R3 representan un anillo saturado de 4 a 6 miembros, o R1 tomado conjuntamente con R2 representa un anillo saturado de 3 a 6 miembros opcionalmente sustituido con un átomo O ó N; R3 representa alquilo C1-4 o R3 tomados conjuntamente con R1 o R2 representan un anillo saturado de 4 a 6 miembros; y X representa CH2, O ó S, en donde: i) un 4-alcoxi-1,1,1-trifluorobut-3-en-2-ona de la fórmula (2) en donde R representa a alquilo C1-4 es condensado con una enamina de fórmula (3) en donde R1, R2, R3 y X son tal como se definen previamente, y R4 y R5 independientemente representan alquilo C1-8, alquenilo C2-8, arilalquilo C1-8, haloalquilo C1-8, alcoxialquilo C1-8, alquilaminoalquilo C1-8, arilo o heteroarilo o R4 y R5 tomados conjuntamente con N representan un anillo saturado o insaturado de 5 ó 6 miembros, para proveer un intermedio de la fórmula (4) en donde R1, R2, R3, R4, R5 y X son tal como se definen previamente, y ii) el intermedio de la fórmula (4) es ciclizado en presencia de amoníaco o un reactivo capaz de generar amoníaco, en donde la mejora comprende llevar a cabo los dos pasos en un solvente no polar sin aislamiento o purificación del intermedio de condensación de fórmula (4).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41927910P | 2010-12-03 | 2010-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084099A1 true AR084099A1 (es) | 2013-04-17 |
Family
ID=46162833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104520A AR084099A1 (es) | 2010-12-03 | 2011-12-02 | Procedimiento mejorado para la preparacion de 2-trifluorometil-5-(1-substituido)-alquilpiridinas |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8742125B2 (es) |
| EP (1) | EP2646416B9 (es) |
| JP (1) | JP5828004B2 (es) |
| KR (1) | KR20130124330A (es) |
| CN (1) | CN103814031B (es) |
| AR (1) | AR084099A1 (es) |
| AU (1) | AU2011336870B2 (es) |
| BR (1) | BR112013013290B1 (es) |
| CA (1) | CA2818513C (es) |
| CO (1) | CO6700894A2 (es) |
| IL (1) | IL226660A (es) |
| MX (1) | MX2013006190A (es) |
| PL (1) | PL2646416T3 (es) |
| RU (1) | RU2608317C2 (es) |
| UA (1) | UA113281C2 (es) |
| WO (1) | WO2012074857A2 (es) |
| ZA (1) | ZA201303872B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5828004B2 (ja) | 2010-12-03 | 2015-12-02 | ダウ アグロサイエンシィズ エルエルシー | ２−トリフルオロメチル−５−（１−置換）アルキルピリジンの調製のための改良された方法 |
| NZ702411A (en) * | 2012-06-30 | 2016-07-29 | Dow Agrosciences Llc | Pyridine n-oxides and processes for their preparation |
| CN102977005A (zh) * | 2012-11-08 | 2013-03-20 | 安徽国星生物化学有限公司 | 2，3，5-三甲基吡啶的提纯方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO912475L (no) * | 1990-06-27 | 1991-12-30 | Sankyo Co | Tiazolidinkarboksylsyreamidderivater med antiallergisk aktivitet, og fremgangsmaate til fremstilling derav. |
| RU2083562C1 (ru) * | 1993-02-05 | 1997-07-10 | Исихара Сангио Кайся Лтд. | Производные пиридина, способ их получения, инсектицидная композиция |
| DE69638035D1 (de) * | 1995-05-26 | 2009-11-05 | Ishihara Sangyo Kaisha | Verfahren zur Herstellung substituierter 1,1,1-Trifluoro-3-buten-2-one |
| WO2006060029A2 (en) | 2004-04-08 | 2006-06-08 | Dow Agrosciences Llc | Insecticidal n-substituted sulfoximines |
| TWI398433B (zh) | 2006-02-10 | 2013-06-11 | Dow Agrosciences Llc | 殺蟲性之ｎ-取代（６-鹵烷基吡啶-３-基）烷基磺醯亞胺 |
| TWI383973B (zh) * | 2006-08-07 | 2013-02-01 | Dow Agrosciences Llc | 用於製備２-取代-５-（１-烷硫基）烷基吡啶之方法 |
| TWI387585B (zh) * | 2006-09-01 | 2013-03-01 | Dow Agrosciences Llc | 殺蟲性之ｎ-取代（雜芳基）烷基烴基硫亞胺 |
| MX2010000593A (es) * | 2007-07-20 | 2010-08-04 | Dow Agrosciences Llc | Aumentador del vigor de una planta. |
| CN102137845B (zh) * | 2008-07-01 | 2013-09-04 | 陶氏益农公司 | 制备2-三氟甲基-5-(1-取代)烷基吡啶的改进方法 |
| JP5828004B2 (ja) | 2010-12-03 | 2015-12-02 | ダウ アグロサイエンシィズ エルエルシー | ２−トリフルオロメチル−５−（１−置換）アルキルピリジンの調製のための改良された方法 |
-
2011
- 2011-11-23 JP JP2013542059A patent/JP5828004B2/ja active Active
- 2011-11-23 WO PCT/US2011/061980 patent/WO2012074857A2/en active Application Filing
- 2011-11-23 BR BR112013013290-6A patent/BR112013013290B1/pt active IP Right Grant
- 2011-11-23 UA UAA201308355A patent/UA113281C2/uk unknown
- 2011-11-23 US US13/303,182 patent/US8742125B2/en active Active
- 2011-11-23 MX MX2013006190A patent/MX2013006190A/es active IP Right Grant
- 2011-11-23 RU RU2013130244A patent/RU2608317C2/ru active
- 2011-11-23 EP EP11844184.9A patent/EP2646416B9/en active Active
- 2011-11-23 CN CN201180058142.8A patent/CN103814031B/zh active Active
- 2011-11-23 PL PL11844184T patent/PL2646416T3/pl unknown
- 2011-11-23 CA CA2818513A patent/CA2818513C/en active Active
- 2011-11-23 AU AU2011336870A patent/AU2011336870B2/en active Active
- 2011-11-23 KR KR1020137014014A patent/KR20130124330A/ko not_active Application Discontinuation
- 2011-12-02 AR ARP110104520A patent/AR084099A1/es active IP Right Grant
-
2013
- 2013-05-28 ZA ZA2013/03872A patent/ZA201303872B/en unknown
- 2013-05-29 CO CO13131752A patent/CO6700894A2/es unknown
- 2013-05-30 IL IL226660A patent/IL226660A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CO6700894A2 (es) | 2013-06-28 |
| ZA201303872B (en) | 2014-08-27 |
| MX2013006190A (es) | 2013-07-29 |
| RU2013130244A (ru) | 2015-01-10 |
| CN103814031B (zh) | 2016-10-19 |
| JP2014514241A (ja) | 2014-06-19 |
| CA2818513C (en) | 2018-07-17 |
| WO2012074857A3 (en) | 2014-03-13 |
| CA2818513A1 (en) | 2012-06-07 |
| BR112013013290A2 (pt) | 2016-07-12 |
| IL226660A (en) | 2017-05-29 |
| EP2646416B9 (en) | 2016-12-21 |
| RU2608317C2 (ru) | 2017-01-17 |
| JP5828004B2 (ja) | 2015-12-02 |
| KR20130124330A (ko) | 2013-11-13 |
| CN103814031A (zh) | 2014-05-21 |
| UA113281C2 (xx) | 2017-01-10 |
| EP2646416A2 (en) | 2013-10-09 |
| EP2646416A4 (en) | 2014-11-05 |
| BR112013013290B1 (pt) | 2018-02-14 |
| EP2646416B1 (en) | 2016-09-07 |
| AU2011336870B2 (en) | 2016-03-03 |
| WO2012074857A2 (en) | 2012-06-07 |
| PL2646416T3 (pl) | 2017-03-31 |
| AU2011336870A1 (en) | 2013-05-30 |
| US8742125B2 (en) | 2014-06-03 |
| US20120142933A1 (en) | 2012-06-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2020003007A1 (es) | Lactamas biciclicas y metodos de uso de las mismas (divisional solicitud no. 3486-2017) | |
| AR090760A1 (es) | Compuestos de benzotiazol y su uso contra el virus de hiv | |
| AR072431A1 (es) | Procedimiento mejorado para la preparacion de 2-trifluormetil-5-(1-substituido)alquilpiridina | |
| RU2015103515A (ru) | Производное соединение сложного эфира 2-аминоникотиновой кислоты и бактерицид, содержащий то же самое в качестве активного ингредиента | |
| PE20171341A1 (es) | Compuestos de pirazina para el tratamiento de enfermedades infecciosas | |
| CY1116987T1 (el) | Συμπυκνωμενα ιμιδαζολυλιμιδαζολια ως αντιϊικες ενωσεις | |
| ECSP12012292A (es) | Ciertas amino-piridazinas, composicioines de las mismas y métodos de uso de los mismos | |
| EA201490445A1 (ru) | Циклопропанаминовое соединение | |
| UY35639A (es) | Nuevos derivados de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CR20140336A (es) | Nuevos derivados de fosfatos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CL2011000917A1 (es) | Compuestos derivados de tioamida; sus metodos de preparacion y uso de los compuestos para el tratamiento de enfermedades endoparasitarias. | |
| HN2011000341A (es) | Compuestos derivados de sulfonamidas, composiciones farmaceuticos y proceso de preparacion de los mismos | |
| EA201201178A1 (ru) | Пестицидные смеси, включающие изоксазолиновые производные и инсектицид или нематоцидное биологическое средство | |
| BR112014006660A2 (pt) | novos derivados de dihidroquinolina-2-ona bicíclicos | |
| CO2017000980A2 (es) | Compuestos derivados de imidazo[1,2-b]piridazin-2-carboxamida e imidazo[1,2- b]piridazin-2-ilmetanona activos como inhibidores selectivos de la fosfodiesterasa 4a (pde4a) | |
| CO7111275A2 (es) | Inhibidores de dgat1 de éter cíclico de cabeza de puente | |
| EA201691031A1 (ru) | Синтез макроциклического трипептида, ингибирующего hcv ns3 | |
| PE20151748A1 (es) | Inhibidores de bace1 | |
| AR105774A1 (es) | Procedimiento para la preparación de (4s)-4-(4-ciano-2-metoxifenilo)-5-etoxi-2,8-dimetilo-1,4-dihidro-1,6-naftiridina-3-carboxamida y su purificación para su uso como principio activo farmacéutico | |
| CL2017002059A1 (es) | Compuestos 4- sustitutos de benzoxaborol y uso de los mismos | |
| UA114325C2 (uk) | Феноксіетилпіперидинові сполуки | |
| UY35653A (es) | Nuevos derivados de indol y de pirrol, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| CR20110703A (es) | Nuevos derivados de (6-oxo-1,6-dihidro-pirimidin-2-il)-amida, su preparacion y su utilizacion farmaceutica como inhibidores de fosforilacion de akt(pkb) | |
| EA201391267A1 (ru) | Способ получения органических соединений | |
| AR084099A1 (es) | Procedimiento mejorado para la preparacion de 2-trifluorometil-5-(1-substituido)-alquilpiridinas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |