AR080188A1 - Tratamiento con un anticuerpo anti-egfr de la clase igg humanizada y con un anticuerpo contra el receptor del factor 1 de crecimiento similar a insulina - Google Patents

Tratamiento con un anticuerpo anti-egfr de la clase igg humanizada y con un anticuerpo contra el receptor del factor 1 de crecimiento similar a insulina

Info

Publication number
AR080188A1
AR080188A1 ARP110100465A ARP110100465A AR080188A1 AR 080188 A1 AR080188 A1 AR 080188A1 AR P110100465 A ARP110100465 A AR P110100465A AR P110100465 A ARP110100465 A AR P110100465A AR 080188 A1 AR080188 A1 AR 080188A1
Authority
AR
Argentina
Prior art keywords
antibody
sequence seq
treatment
egfr
growth factor
Prior art date
Application number
ARP110100465A
Other languages
English (en)
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of AR080188A1 publication Critical patent/AR080188A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente solicitud proporciona un anticuerpo anti-EGFR (Receptor del Factor de Crecimiento Epidérmico) de clase lgG humanizada y un anticuerpo anti-IGF-1R para el uso combinado en el tratamiento del cáncer, con o sin agentes o tratamientos adicionales, tales como otros fármacos anticáncer o terapia de radiacion. La solicitud también comprende una composicion farmacéutica que comprende una combinacion de un anticuerpo anti-EGFR de clase lgG humanizada y un anticuerpo anti-IGF-1R en un portador farmacéuticamente aceptable. Reivindicacion 1: Anticuerpo anti-EGFR de clase IgG humanizada y anticuerpo anti-IGF-1R para el uso combinado en el tratamiento del cáncer, en el que dicho anticuerpo anti-EGFR de clase TgG comprende: a) en el dominio variable de cadena pesada, una CDR1 de secuencia SEC ID n° 1, una CDR2 de secuencia SEC ID n° 16, y una CDR3 de secuencia SEC ID n° 31, y b) en el dominio variable de cadena ligera, una CDR1 de secuencia SEC ID n° 33, una CDR2 de secuencia SEC ID n° 34, y una CDR3 de secuencia SEC ID n° 35.
ARP110100465A 2010-02-18 2011-02-16 Tratamiento con un anticuerpo anti-egfr de la clase igg humanizada y con un anticuerpo contra el receptor del factor 1 de crecimiento similar a insulina AR080188A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10153991 2010-02-18

Publications (1)

Publication Number Publication Date
AR080188A1 true AR080188A1 (es) 2012-03-21

Family

ID=44369794

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100465A AR080188A1 (es) 2010-02-18 2011-02-16 Tratamiento con un anticuerpo anti-egfr de la clase igg humanizada y con un anticuerpo contra el receptor del factor 1 de crecimiento similar a insulina

Country Status (4)

Country Link
US (1) US20110200595A1 (es)
AR (1) AR080188A1 (es)
TW (1) TW201134486A (es)
WO (1) WO2011101328A2 (es)

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WO2013078223A1 (en) * 2011-11-23 2013-05-30 Children's Hospital & Research Center Oakland Anti-factor h binding protein antibodies and methods of use thereof
SG10201800535XA (en) * 2012-08-07 2018-02-27 Roche Glycart Ag Composition comprising two antibodies engineered to have reduced and increased effector function
KR20150144804A (ko) * 2013-04-22 2015-12-28 글리코토페 게엠베하 낮은 푸코실화를 갖는 항­ｅｇｆｒ 항체를 이용한 항암 치료
KR101799557B1 (ko) * 2014-07-22 2017-11-20 주식회사 레모넥스 생리활성 물질 또는 단백질 전달용 조성물 및 이의 용도
WO2016137947A1 (en) * 2015-02-24 2016-09-01 Rpeptide, Llc Anti-amyloid-beta antibodies
SG11201907260PA (en) 2017-02-06 2019-09-27 Lemonex Inc Physiologically active substance carrier
KR102152348B1 (ko) 2017-09-05 2020-09-08 주식회사 레모넥스 세포 운명 조절용 조성물
US11781248B2 (en) 2019-06-13 2023-10-10 Allogene Therapeutics, Inc. Anti-TALEN antibodies and uses thereof
US20210236667A1 (en) * 2020-01-31 2021-08-05 University Of Saskatchewan Methods and compositions for targeting disease related cell surface receptors using radiolabeled and/or cytotoxin labelled antibodies
TW202411256A (zh) * 2022-08-31 2024-03-16 中國醫藥大學 抗meEGFR抗體、其抗原結合片段及其用途

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Also Published As

Publication number Publication date
TW201134486A (en) 2011-10-16
WO2011101328A2 (en) 2011-08-25
WO2011101328A3 (en) 2011-12-22
US20110200595A1 (en) 2011-08-18

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