AR079102A1 - Un metodo para preparar un producto intermedio de sitagliptina utilizando un oxirano quiral - Google Patents

Un metodo para preparar un producto intermedio de sitagliptina utilizando un oxirano quiral

Info

Publication number
AR079102A1
AR079102A1 ARP100103536A ARP100103536A AR079102A1 AR 079102 A1 AR079102 A1 AR 079102A1 AR P100103536 A ARP100103536 A AR P100103536A AR P100103536 A ARP100103536 A AR P100103536A AR 079102 A1 AR079102 A1 AR 079102A1
Authority
AR
Argentina
Prior art keywords
trifluorophenyl
prepare
intermediate product
hydroxy
formula
Prior art date
Application number
ARP100103536A
Other languages
English (en)
Spanish (es)
Inventor
Gwan Sun Lee
Nam Du Kim
Young Kil Chang
Dong Jun Kim
Hyun Seung Lee
Ji Yeon Chang
Jae Hyuk Jung
Original Assignee
Hanmi Holdings Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Holdings Co Ltd filed Critical Hanmi Holdings Co Ltd
Publication of AR079102A1 publication Critical patent/AR079102A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ARP100103536A 2009-10-01 2010-09-29 Un metodo para preparar un producto intermedio de sitagliptina utilizando un oxirano quiral AR079102A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020090093894A KR101253106B1 (ko) 2009-10-01 2009-10-01 키랄 옥실레인을 이용한 시타글립틴 중간체의 제조방법

Publications (1)

Publication Number Publication Date
AR079102A1 true AR079102A1 (es) 2011-12-28

Family

ID=43826758

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100103536A AR079102A1 (es) 2009-10-01 2010-09-29 Un metodo para preparar un producto intermedio de sitagliptina utilizando un oxirano quiral

Country Status (4)

Country Link
KR (1) KR101253106B1 (fr)
AR (1) AR079102A1 (fr)
TW (1) TW201118101A (fr)
WO (1) WO2011040717A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102838511A (zh) * 2011-06-24 2012-12-26 浙江海翔药业股份有限公司 一种西他列汀的中间体及其制备方法和应用
CN113979853A (zh) * 2021-11-24 2022-01-28 上海科利生物医药有限公司 一种(s)-3-羟基-4-(2,4,5-三氟苯基)丁酸的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2108767A2 (en) * 1970-10-02 1972-05-26 Synthelabo 2-carbamyloxy-3-phenylbutyronitriles - with hypnotic activity
WO2004087650A2 (fr) * 2003-03-27 2004-10-14 Merck & Co. Inc. Procede et intermediaires pour la preparation d'inhibiteurs d'amide d'acide beta-amino de dipeptidyle peptidase-iv
WO2009045507A2 (fr) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Procédés d'élaboration d'intermédiaire de sitagliptine via une réduction enzymatique
US20090192326A1 (en) 2007-11-13 2009-07-30 Nurit Perlman Preparation of sitagliptin intermediate

Also Published As

Publication number Publication date
KR20110036308A (ko) 2011-04-07
TW201118101A (en) 2011-06-01
WO2011040717A3 (fr) 2011-10-13
KR101253106B1 (ko) 2013-04-10
WO2011040717A2 (fr) 2011-04-07

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