AR074885A1 - Metodo para purificar 4-(nitrooxi)butil (2s)-2-(6-metoxi-2-naftil)propanoato - Google Patents

Metodo para purificar 4-(nitrooxi)butil (2s)-2-(6-metoxi-2-naftil)propanoato

Info

Publication number
AR074885A1
AR074885A1 ARP090102272A ARP090102272A AR074885A1 AR 074885 A1 AR074885 A1 AR 074885A1 AR P090102272 A ARP090102272 A AR P090102272A AR P090102272 A ARP090102272 A AR P090102272A AR 074885 A1 AR074885 A1 AR 074885A1
Authority
AR
Argentina
Prior art keywords
naproxcinod
nitrooxi
naftil
metoxi
butil
Prior art date
Application number
ARP090102272A
Other languages
English (en)
Inventor
Nicoletta Toniutti
Thierry Delahaique
Pietro Allegrini
Tiziano Scubla
Romano Rivolta
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of AR074885A1 publication Critical patent/AR074885A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a un método para purificar naproxcinod que comprende los pasos de: a) disolver o dispersar una mezcla que contiene naproxcinod en una cantidad mayor que 90% en peso en un solvente; b) enfriar la solución o la dispersión de dos fases bajo agitación a una temperatura que oscila entre -20° C y 10° C; c) opcionalmente sembrar la solución con cristales de naproxcinod; d) agitar, manteniendo la temperatura en el rango de -40° C a 10° C; e) recoger el sólido formando manteniendo la temperatura por debajo de 15° C. Un objeto adicional de la invención es una forma cristalina de naproxcinod.
ARP090102272A 2008-06-20 2009-06-19 Metodo para purificar 4-(nitrooxi)butil (2s)-2-(6-metoxi-2-naftil)propanoato AR074885A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000325A ITRM20080325A1 (it) 2008-06-20 2008-06-20 Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato

Publications (1)

Publication Number Publication Date
AR074885A1 true AR074885A1 (es) 2011-02-23

Family

ID=40302064

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102272A AR074885A1 (es) 2008-06-20 2009-06-19 Metodo para purificar 4-(nitrooxi)butil (2s)-2-(6-metoxi-2-naftil)propanoato

Country Status (15)

Country Link
US (1) US8329937B2 (es)
EP (1) EP2288590A2 (es)
JP (1) JP2011524892A (es)
KR (1) KR20110037927A (es)
CN (1) CN101874014A (es)
AR (1) AR074885A1 (es)
AU (1) AU2009261666A1 (es)
BR (1) BRPI0905869A2 (es)
CA (1) CA2705634A1 (es)
IL (1) IL204701A0 (es)
IT (1) ITRM20080325A1 (es)
NZ (1) NZ584336A (es)
RU (1) RU2010120745A (es)
WO (1) WO2009153668A2 (es)
ZA (1) ZA201002316B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103058861B (zh) * 2013-01-08 2015-03-18 安徽赛诺医药化工有限公司 一种萘普西诺中间体的合成新方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
IT1313596B1 (it) * 1999-08-04 2002-09-09 Nicox Sa Processo per la preparazione di nitrossialchil esteri del naproxene
US20050234123A1 (en) * 2001-11-27 2005-10-20 Aldo Belli Process
US20040028747A1 (en) * 2002-08-06 2004-02-12 Tucker Christopher J. Crystalline drug particles prepared using a controlled precipitation process
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
CA2683488A1 (en) * 2007-04-25 2008-11-06 Nicox S.A. Use of 4-(nitrooxy)-butyl-(s)-2-(6-methoxy-2-naphtyl)-propanoate for treating pain and inflammation

Also Published As

Publication number Publication date
BRPI0905869A2 (pt) 2015-06-30
KR20110037927A (ko) 2011-04-13
CA2705634A1 (en) 2009-12-23
AU2009261666A1 (en) 2009-12-23
NZ584336A (en) 2012-08-31
ITRM20080325A1 (it) 2009-12-21
RU2010120745A (ru) 2012-07-27
WO2009153668A3 (en) 2010-02-11
IL204701A0 (en) 2010-11-30
ZA201002316B (en) 2011-06-29
US20100256411A1 (en) 2010-10-07
US8329937B2 (en) 2012-12-11
EP2288590A2 (en) 2011-03-02
JP2011524892A (ja) 2011-09-08
CN101874014A (zh) 2010-10-27
WO2009153668A2 (en) 2009-12-23

Similar Documents

Publication Publication Date Title
BR112012018902A2 (pt) solução eletrolítica não aquosa, elemento eletroquímico usando a mesma, e composto de alquinila usando para esta
AR098260A2 (es) Polimorfo cristalino de una sal de bisulfato de un antagonista del receptor de trombina, proceso para su preparación, composición y forma purificada
BR112013027300A2 (pt) solução eletrolítica não aquosa, dispositivo de armazenamento elétrico da mesma, e composto de éster de ácido sulfônico cíclico
EA201391522A1 (ru) Способ получения соединений для применения в качестве ингибиторов sglt2
BR112018012106A2 (pt) forma cristalina de inibidor de btk quinase e método de preparação da mesma
RU2010145171A (ru) Аналоги галихондрина в
JP2013515822A5 (es)
AR082601A1 (es) Formas cristalinas de compuestos de pirimido[6,1-a]isoquinolin-4-ona
BR112014021938A8 (pt) metodo para produzir composto epóxi contendo enxofre
CO6420345A2 (es) Tetrahidrobenzazepinas ariloxi- y heteroariloxi-siustituidas y su uso de la misma para bloquear reabsorcion de norepinefrina dopamina y serotonina
AR091687A1 (es) Formas solidas de inhibidores de fosfodiesterasa tipo 5
AR064116A1 (es) Sal de potasio cristalina de analogos de lipoxina a4
RU2014104994A (ru) Полиморфные формы натриевой соли 4-трет-бутил-n-[4-хлор-2-(1-окси-пиридин-4-карбонил)-фенил]-бензолсульфонамида
CR10102A (es) Acido 3-(4-{[4-(4{[3-(3,3,-dimetil-1piperidinil) propil) oxi} fenil)1-piperidinil]carbonil}-1-naftalenil)propanoico o proponeico como antagonistas del receptor h1 h3 para el tratamiento de disfunciones inflamatorias y/o alergicas
MD4391B1 (ro) Formă cristalină nouă VII a agomelatinei, procedeu de preparare şi utilizarea acesteia, şi compoziţie farmaceutică care o conţine
RU2014104991A (ru) Полиморфные формы натриевой соли 4-трет-бутил-n-[4-хлор-2-(1-окси-пиридин-4-карбонил)-фенил]-бензолсульфонамида
AR074885A1 (es) Metodo para purificar 4-(nitrooxi)butil (2s)-2-(6-metoxi-2-naftil)propanoato
MD4484C1 (ro) Forma cristalină VIII a agomelatinei, procedeu de preparare, utilizarea acesteia şi compoziţie farmaceutică care o conţine
BR112013004957A2 (pt) composição de eletrólito não aquosa e bateria secundária de eletrólito não aquosa
MD20120130A2 (en) Delta crystalline form of the L-arginine salt of perindopril, a process for its preparation and pharmaceutical compositions containing it
AR074889A1 (es) Procedimiento de obtencion de la forma cristalina v de la agomelatina
DK1940772T3 (da) Ny fremgangsmåde til fremstilling af kvaternære syre- og ammoniumsalte
BR112018003258A2 (pt) forma cristalina de inibidor de receptor de androgênio e método de preparação do mesmo
ES2530722T3 (es) Preparación de 1,7'-dimetil-2'-propil-2,5'-bis-1H-bencimidazol
PE20130043A1 (es) Proceso para preparar voriconazol utilizando nuevos intermediarios

Legal Events

Date Code Title Description
FB Suspension of granting procedure