AR072810A1 - Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor. - Google Patents
Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor.Info
- Publication number
- AR072810A1 AR072810A1 ARP090102693A ARP090102693A AR072810A1 AR 072810 A1 AR072810 A1 AR 072810A1 AR P090102693 A ARP090102693 A AR P090102693A AR P090102693 A ARP090102693 A AR P090102693A AR 072810 A1 AR072810 A1 AR 072810A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- pyrimidine
- manufacture
- pharmaceutical composition
- piperazinil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un Compuesto de 3-[4-fenilsulfonil-1-piperazinil)carbonil]pirazolo[1,5-a]pirimidina que es de la formula (1), o una sal del mismo: R1 es alquilo C1-4, halogeno o ciano; m y n se seleccionan de 0, 1 y 2; R2 es alquilo C1-4 R3 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; R4 es hidrogeno o alquilo C1-4; R5 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; R6 es hidrogeno, ciano, haloalquilo C1-4, haloalcoxi C1-4 o halogeno; de modo que al menos 1 de R3, R4, R5 y R6 es un grupo diferente de hidrogeno; R7 es hidrogeno o alquilo C1-4; de manera que cuando R7 es alquilo C1-4, n es 0. Composicion farmacéutica que lo contienen y uso del mismo para la fabricacion de un medicamento para tratar enfermedades en las que es beneficioso el bloqueo de los canales de calcio Cav2.2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0813144.3A GB0813144D0 (en) | 2008-07-17 | 2008-07-17 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072810A1 true AR072810A1 (es) | 2010-09-22 |
Family
ID=39737241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102693A AR072810A1 (es) | 2008-07-17 | 2009-07-15 | Compuesto de 3-( 4 fenilsulfonil-1-piperazinil) carbonil) pirazolo(1,5 -a) pirimidina , composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento del dolor. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8093249B2 (es) |
| EP (1) | EP2313413B1 (es) |
| JP (1) | JP5611201B2 (es) |
| AR (1) | AR072810A1 (es) |
| ES (1) | ES2387733T3 (es) |
| GB (1) | GB0813144D0 (es) |
| TW (1) | TW201016699A (es) |
| UY (1) | UY31989A (es) |
| WO (1) | WO2010007074A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201000685D0 (en) | 2010-01-15 | 2010-03-03 | Glaxo Group Ltd | Novel compounds |
| EP3156405A1 (en) | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| KR20230017828A (ko) * | 2020-05-27 | 2023-02-06 | 에스테베 파마슈티칼스 에스에이 | 통증에 대한 다중모드 활성을 갖는 피라졸로[1,5-a]피리미딘 유도체 |
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-
2008
- 2008-07-17 GB GBGB0813144.3A patent/GB0813144D0/en not_active Ceased
-
2009
- 2009-07-15 TW TW098123841A patent/TW201016699A/zh unknown
- 2009-07-15 UY UY0001031989A patent/UY31989A/es unknown
- 2009-07-15 JP JP2011517912A patent/JP5611201B2/ja not_active Expired - Fee Related
- 2009-07-15 WO PCT/EP2009/059013 patent/WO2010007074A1/en active Application Filing
- 2009-07-15 US US12/503,135 patent/US8093249B2/en not_active Expired - Fee Related
- 2009-07-15 ES ES09780588T patent/ES2387733T3/es active Active
- 2009-07-15 AR ARP090102693A patent/AR072810A1/es not_active Application Discontinuation
- 2009-07-15 EP EP09780588A patent/EP2313413B1/en not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| GB0813144D0 (en) | 2008-08-27 |
| TW201016699A (en) | 2010-05-01 |
| US8093249B2 (en) | 2012-01-10 |
| EP2313413A1 (en) | 2011-04-27 |
| JP2011528021A (ja) | 2011-11-10 |
| US20100016330A1 (en) | 2010-01-21 |
| WO2010007074A1 (en) | 2010-01-21 |
| ES2387733T3 (es) | 2012-10-01 |
| UY31989A (es) | 2010-01-05 |
| JP5611201B2 (ja) | 2014-10-22 |
| EP2313413B1 (en) | 2012-05-16 |
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Legal Events
| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |