AR070919A1 - (pirazolilcarbonil) imidazolidinonas sustituidas y su uso - Google Patents
(pirazolilcarbonil) imidazolidinonas sustituidas y su usoInfo
- Publication number
- AR070919A1 AR070919A1 ARP090100947A ARP090100947A AR070919A1 AR 070919 A1 AR070919 A1 AR 070919A1 AR P090100947 A ARP090100947 A AR P090100947A AR P090100947 A ARP090100947 A AR P090100947A AR 070919 A1 AR070919 A1 AR 070919A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- cyano
- halogen
- hydroxy
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuesto de formula (1) en donde R1 representa fenilo, estando dicho fenilo sustituido con entre 1 y 3 sustituyentes, los sustituyentes se seleccionan en forma independiente entre sí del grupo formado por halogeno, hidroxi, ciano, nitro, trifluoro metilo trifluorometoxi, trifluorometiltio, alquilo C1-4 y alcoxi C1-4, en donde alquilo C1-4 y alcoxi C1-4 pueden a su vez estar sustituidos entre una y tres veces, de manera idéntica o diferente, con radicales seleccionados entre la serie halogeno, ciano, hidroxi, alcoxi C1-4, amino, monoalquilamino C1-4, di-alquilamino C1-4, cicloalquilo C3-7 y heterociclilo de 4 a 7 miembros, pudiendo los radicales cicloalquilo y heterociclilo mencionados en ultimo término estar cada uno a su vez sustituido hasta tres veces, de manera idéntica o diferente, con halogeno, ciano, alquilo C1-4, trifluorometilo, hidroxi, alcoxi C1-4, trifluorometoxi, oxo, amino, monoalquilamino C1-4 y di-alquilamino C1-4, R2 representa fenilo, estando dicho fenilo sustituido con entre 1 y 3 sustituyentes, y los sustituyentes se seleccionan en forma independiente entre sí del grupo formado por halogeno, hidroxi, ciano, nitro, trifluorometilo, trifluorometoxi, trifluorometiltio, alquilo C1-4 y alcoxi C1-4, en donde alquilo C1-4 y alcoxi C1-4 pueden a su vez estar sustituidos entre una y tres veces, de manera idéntica o diferente, con radicales seleccionados entre la serie halogeno, ciano, hidroxi, alcoxi C1-4, amino, monoalquilamino C1-4, di-alquilamino C1-4, cicloalquilo C3-7 y heterociclilo de 4 a 7 miembros, pudiendo los radicales cicloalquilo y heterociclilo mencionados en ultimo término estar cada uno a su vez sustituido hasta tres veces, de manera idéntica o diferente, con halogeno, ciano, alquilo C1-4, trifluorometilo, hidroxi, alcoxi C1-4, trifluorometoxi, oxo, amino, monoalquilamino C1-4 y di-alquilamino C1-4, o una de las sales del mismo, los solvatos del mismo o los solvatos de las sales del mismo. Métodos para su preparacion, su uso para el tratamiento y/o la profilaxis de enfermedades, así como su uso para la preparacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades, especialmente de enfermedades retrovirales, en humanos y/o animales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008015033A DE102008015033A1 (de) | 2008-03-17 | 2008-03-17 | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070919A1 true AR070919A1 (es) | 2010-05-12 |
Family
ID=40565083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090100947A AR070919A1 (es) | 2008-03-17 | 2009-03-17 | (pirazolilcarbonil) imidazolidinonas sustituidas y su uso |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8399682B2 (es) |
| EP (1) | EP2254885B1 (es) |
| JP (1) | JP5576853B2 (es) |
| KR (1) | KR20100124337A (es) |
| CN (1) | CN101977908B (es) |
| AP (1) | AP2774A (es) |
| AR (1) | AR070919A1 (es) |
| AU (1) | AU2009226656A1 (es) |
| CA (1) | CA2718685C (es) |
| CL (1) | CL2009000636A1 (es) |
| DE (1) | DE102008015033A1 (es) |
| IL (1) | IL207649A0 (es) |
| MA (1) | MA32224B1 (es) |
| MX (1) | MX2010010230A (es) |
| NZ (1) | NZ588141A (es) |
| PE (1) | PE20091718A1 (es) |
| RU (1) | RU2010141578A (es) |
| TW (1) | TW200951125A (es) |
| UA (1) | UA102390C2 (es) |
| UY (1) | UY31717A1 (es) |
| WO (1) | WO2009115213A1 (es) |
| ZA (1) | ZA201007361B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008015032A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062863A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung |
| DE102008062878A1 (de) | 2008-12-17 | 2010-06-24 | Aicuris Gmbh & Co. Kg | Substituierte Furancarboxamide und ihre Verwendung |
| EP2295038B1 (en) * | 2009-09-11 | 2013-05-29 | AiCuris GmbH & Co. KG | Solid dispersion comprising an anti-HIV agent |
| DE102011055815A1 (de) | 2011-11-29 | 2013-05-29 | Aicuris Gmbh & Co. Kg | Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung |
| DE102012016908A1 (de) | 2012-08-17 | 2014-02-20 | Aicuris Gmbh & Co. Kg | Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung |
Family Cites Families (50)
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|---|---|---|---|---|
| GB453061A (en) | 1935-03-23 | 1936-09-04 | Charles Howard Twigg | Improvements in and relating to gas heated geysers and water heaters |
| US3806506A (en) | 1971-08-05 | 1974-04-23 | Uniroyal Inc | Furan derivatives,compositions thereof and methods for using same |
| DE3119796A1 (de) | 1981-05-19 | 1982-12-23 | Hoechst Ag, 6000 Frankfurt | Substituierte tryptaminderivate von thienyloxpropanolaminen, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen sowie ihre verwendung |
| FR2538388B1 (fr) | 1982-12-24 | 1985-06-21 | Pharmuka Lab | Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments |
| US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| PH27357A (en) | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
| US5571810A (en) | 1990-06-11 | 1996-11-05 | Fujisawa Pharmaceutical Co., Ltd. | Thiophene derivatives |
| GB9012936D0 (en) | 1990-06-11 | 1990-08-01 | Fujisawa Pharmaceutical Co | Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same |
| IL104311A (en) | 1992-02-05 | 1997-07-13 | Fujisawa Pharmaceutical Co | Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same |
| FR2692575B1 (fr) | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| JPH084281B2 (ja) | 1992-09-30 | 1996-01-17 | 橋本コーポレイション株式会社 | オンフック後相手の声を拡声する電話装置 |
| FR2728571B1 (fr) | 1994-12-22 | 1997-01-31 | Adir | Nouveaux ethers d'oximes tricycliques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US5696151A (en) | 1995-11-30 | 1997-12-09 | Uniroyal Chemical Company, Inc. | Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants |
| US6143780A (en) | 1999-09-17 | 2000-11-07 | Uniroyal Chemical Company, Inc. | N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV |
| SK18102002A3 (sk) | 2000-06-28 | 2003-07-01 | Astrazeneca Ab | Substituované chinazolínové deriváty, ich použitie a kompozícia obsahujúca tieto deriváty |
| GB0113524D0 (en) * | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
| US6930190B2 (en) | 2001-08-01 | 2005-08-16 | Basell Polyolefine Gmbh | Process for the preparation of heterocyclic pentalene derivatives |
| US7223782B2 (en) | 2001-11-01 | 2007-05-29 | Icagen, Inc. | Pyrazole-amides and -sulfonamides |
| US7005432B2 (en) | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| US7166619B2 (en) | 2002-08-14 | 2007-01-23 | Ppd Discovery , Inc. | Prenylation inhibitors and methods of their synthesis and use |
| GB0221477D0 (en) * | 2002-09-16 | 2002-10-23 | Pfizer Ltd | Chemical compounds |
| GB0223232D0 (en) * | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| ATE538097T1 (de) | 2002-12-02 | 2012-01-15 | Astellas Pharma Inc | Als cox-i-inhibitoren geeignete pyrazolderivate |
| CA2515119A1 (en) | 2003-02-07 | 2004-08-19 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivative |
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| US7678788B2 (en) | 2003-02-27 | 2010-03-16 | Neurosearch A/S | Diazabicyclic aryl derivatives |
| FR2856683A1 (fr) | 2003-06-25 | 2004-12-31 | Sanofi Synthelabo | Derives de 4-cyanopyrazole-3-carboxamide, leur preparation et leur application en therapeutique |
| PL1641764T3 (pl) * | 2003-06-26 | 2011-12-30 | Novartis Ag | Inhibitory kinazy P38 na bazie 5-członowych heterocykli |
| GB0315657D0 (en) * | 2003-07-03 | 2003-08-13 | Astex Technology Ltd | Pharmaceutical compounds |
| WO2005007625A2 (en) | 2003-07-14 | 2005-01-27 | The University Of Tennessee Research Foundation | Heterocyclic amides with anti-tuberculosis activity |
| US7220772B2 (en) * | 2003-09-05 | 2007-05-22 | Pfizer, Inc. | Pyrazole derivatives |
| FR2860792B1 (fr) | 2003-10-10 | 2006-02-24 | Sanofi Synthelabo | Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique |
| JP4208925B2 (ja) | 2004-02-20 | 2009-01-14 | アストラゼネカ アクチボラグ | 治療薬 |
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| GB0417910D0 (en) | 2004-08-11 | 2004-09-15 | Novartis Ag | Organic compounds |
| JP4942654B2 (ja) | 2004-08-23 | 2012-05-30 | イーライ リリー アンド カンパニー | ヒスタミンｈ３受容体薬剤、製剤及び治療的使用 |
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| EP1743637A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Use of substituted pyrazole compounds and combinations thereof for the treatment of the metabolic syndrome |
| GB0516661D0 (en) | 2005-08-13 | 2005-09-21 | Astrazeneca Ab | Therapeutic agents |
| RU2009117653A (ru) | 2006-10-12 | 2010-11-20 | Янссен Фармацевтика Нв (Be) | Применение производных замещенного пиразинона в качестве лекарственного средства |
| US20100210649A1 (en) | 2006-12-21 | 2010-08-19 | Sloan-Kettering Institute For Cancer Research | Pyridazinones and furan-containing compounds |
| GB0701426D0 (en) | 2007-01-25 | 2007-03-07 | Univ Sheffield | Compounds and their use |
| DE102008015032A1 (de) * | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte Pyrazolamide und ihre Verwendung |
| DE102008015033A1 (de) | 2008-03-17 | 2009-09-24 | Aicuris Gmbh & Co. Kg | Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung |
-
2008
- 2008-03-17 DE DE102008015033A patent/DE102008015033A1/de not_active Ceased
-
2009
- 2009-03-10 RU RU2010141578/04A patent/RU2010141578A/ru not_active Application Discontinuation
- 2009-03-10 AU AU2009226656A patent/AU2009226656A1/en not_active Abandoned
- 2009-03-10 JP JP2011500075A patent/JP5576853B2/ja not_active Expired - Fee Related
- 2009-03-10 CA CA2718685A patent/CA2718685C/en not_active Expired - Fee Related
- 2009-03-10 EP EP09721416.7A patent/EP2254885B1/de active Active
- 2009-03-10 KR KR1020107023291A patent/KR20100124337A/ko not_active Application Discontinuation
- 2009-03-10 UA UAA201012130A patent/UA102390C2/ru unknown
- 2009-03-10 NZ NZ588141A patent/NZ588141A/en not_active IP Right Cessation
- 2009-03-10 CN CN200980109500.6A patent/CN101977908B/zh not_active Expired - Fee Related
- 2009-03-10 AP AP2010005422A patent/AP2774A/xx active
- 2009-03-10 MX MX2010010230A patent/MX2010010230A/es active IP Right Grant
- 2009-03-10 WO PCT/EP2009/001714 patent/WO2009115213A1/de active Application Filing
- 2009-03-16 TW TW098108355A patent/TW200951125A/zh unknown
- 2009-03-17 PE PE2009000388A patent/PE20091718A1/es not_active Application Discontinuation
- 2009-03-17 AR ARP090100947A patent/AR070919A1/es not_active Application Discontinuation
- 2009-03-17 CL CL2009000636A patent/CL2009000636A1/es unknown
- 2009-03-17 UY UY031717A patent/UY31717A1/es not_active Application Discontinuation
-
2010
- 2010-08-17 IL IL207649A patent/IL207649A0/en unknown
- 2010-09-17 US US12/885,340 patent/US8399682B2/en not_active Expired - Fee Related
- 2010-10-11 MA MA33241A patent/MA32224B1/fr unknown
- 2010-10-14 ZA ZA2010/07361A patent/ZA201007361B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2254885A1 (de) | 2010-12-01 |
| JP2011514366A (ja) | 2011-05-06 |
| WO2009115213A1 (de) | 2009-09-24 |
| CA2718685A1 (en) | 2009-09-24 |
| RU2010141578A (ru) | 2012-04-27 |
| CN101977908A (zh) | 2011-02-16 |
| AP2774A (en) | 2013-09-30 |
| AU2009226656A1 (en) | 2009-09-24 |
| MX2010010230A (es) | 2010-11-09 |
| CN101977908B (zh) | 2014-04-23 |
| IL207649A0 (en) | 2010-12-30 |
| JP5576853B2 (ja) | 2014-08-20 |
| US20110124618A1 (en) | 2011-05-26 |
| UA102390C2 (ru) | 2013-07-10 |
| TW200951125A (en) | 2009-12-16 |
| UY31717A1 (es) | 2009-08-31 |
| DE102008015033A1 (de) | 2009-09-24 |
| KR20100124337A (ko) | 2010-11-26 |
| CA2718685C (en) | 2016-11-29 |
| EP2254885B1 (de) | 2013-12-04 |
| ZA201007361B (en) | 2011-12-28 |
| AP2010005422A0 (en) | 2010-10-31 |
| PE20091718A1 (es) | 2009-12-11 |
| NZ588141A (en) | 2012-05-25 |
| CL2009000636A1 (es) | 2010-05-07 |
| US8399682B2 (en) | 2013-03-19 |
| MA32224B1 (fr) | 2011-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |