AR069030A1 - Derivados de 1,2,4-triazol amino y de isoxazoles, composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento de trastornos gastrointestinales y del snc - Google Patents
Derivados de 1,2,4-triazol amino y de isoxazoles, composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento de trastornos gastrointestinales y del sncInfo
- Publication number
- AR069030A1 AR069030A1 ARP080104651A ARP080104651A AR069030A1 AR 069030 A1 AR069030 A1 AR 069030A1 AR P080104651 A ARP080104651 A AR P080104651A AR P080104651 A ARP080104651 A AR P080104651A AR 069030 A1 AR069030 A1 AR 069030A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxy
- alkyl
- silyl
- tert
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Los siguientes intermediarios de síntesis: 2-{[tert-butil(dimetil)silil]oxi}acetamida; [tert-butil(dimetil)silil]oxi}acetonitrilo; (1Z)-2-{[tert-butil(dimetil)silil]oxi}-N'-hidroxietanimidamida; y (1Z)-2-{[tert-butil(dimetil)silil]oxi}-N'-{[(3-metilfenil)carbonil]oxi}etanimidamida. Reivindicación 1: Un compuesto de la fórmula (1) donde: X es un resto del grupo de fórmulas (2); R¹ es metil halógeno o ciano; R² es hidrógeno o fluoro; R³ es alquil C₁₋₃ o ciclopropil; R⁴ es alquil C₁₋₃ o ciclopropil; R⁵ es hidrógeno, alquil C₁₋₃ o ciclopropil; Z es un resto del grupo de fórmulas (3) donde R⁶ es hidrógeno, fluoro, alquil C₁₋₃ o alcoxi C₁₋₃; R⁷ es hidrógeno, fluoro, alquil C₁₋₃ o alcoxi C₁₋₃; así como sales, hidratos, isoformas, tautómeros y/o enantiómeros del mismo farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98295607P | 2007-10-26 | 2007-10-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069030A1 true AR069030A1 (es) | 2009-12-23 |
Family
ID=40579779
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104651A AR069030A1 (es) | 2007-10-26 | 2008-10-24 | Derivados de 1,2,4-triazol amino y de isoxazoles, composiciones farmaceuticas que los comprenden y usos de los mismos en el tratamiento de trastornos gastrointestinales y del snc |
Country Status (21)
Country | Link |
---|---|
US (1) | US20090111821A1 (es) |
EP (1) | EP2212316A4 (es) |
JP (1) | JP2011500798A (es) |
KR (1) | KR20100089091A (es) |
CN (1) | CN101918399A (es) |
AR (1) | AR069030A1 (es) |
AU (1) | AU2008317544A1 (es) |
BR (1) | BRPI0818679A2 (es) |
CA (1) | CA2702974A1 (es) |
CL (1) | CL2008003182A1 (es) |
CR (1) | CR11391A (es) |
DO (1) | DOP2010000124A (es) |
EA (1) | EA201000656A1 (es) |
IL (1) | IL205289A0 (es) |
MX (1) | MX2010004362A (es) |
NI (1) | NI201000072A (es) |
PE (1) | PE20091348A1 (es) |
TW (1) | TW200922585A (es) |
UY (1) | UY31427A1 (es) |
WO (1) | WO2009054794A1 (es) |
ZA (1) | ZA201002854B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2438052A1 (en) * | 2009-06-05 | 2012-04-11 | Oslo University Hospital HF | Azole derivatives as wtn pathway inhibitors |
CA2820800A1 (en) | 2010-12-08 | 2012-06-14 | Oslo University Hospital Hf | Triazole derivatives as wnt signaling pathway inhibitors |
RU2495687C1 (ru) * | 2012-06-19 | 2013-10-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Минздравсоцразвития Российской Федерации | Способ лечения больных гастроэзофагеальной рефлюксной болезнью |
UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
EP2857387A1 (en) | 2013-10-07 | 2015-04-08 | Boehringer Ingelheim International Gmbh | Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid |
US9745308B2 (en) | 2014-09-12 | 2017-08-29 | Chiesi Farmaceutici S.P.A. | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9420355D0 (en) * | 1994-10-10 | 1994-11-23 | Univ Nottingham | Preparation of protein microspheres, films and coatings |
EP0858803A4 (en) * | 1995-08-28 | 2000-02-09 | Showa Pharm Chem Ind | COMPOSITION FOR LOCAL ANESTHESIA |
US5962536A (en) * | 1998-07-31 | 1999-10-05 | Komer; Gene | Injectable propofol formulations |
WO2005077345A1 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
CA2556263A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists |
KR20070027503A (ko) * | 2004-02-18 | 2007-03-09 | 아스트라제네카 아베 | 트리아졸 화합물 및 대사성 글루타메이트 수용체길항제로서 이들의 용도 |
AR058807A1 (es) * | 2005-09-29 | 2008-02-27 | Astrazeneca Ab | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
WO2007061923A2 (en) * | 2005-11-18 | 2007-05-31 | Takeda San Diego, Inc. | Glucokinase activators |
ATE491694T1 (de) * | 2006-03-24 | 2011-01-15 | Eisai R&D Man Co Ltd | Triazolonderivat |
TW200811156A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators IV |
TW200811137A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators II |
TW200808777A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGLUR5 modulators III |
TW200808800A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
TW200811157A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
TW200811179A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators VI |
TW200821305A (en) * | 2006-10-05 | 2008-05-16 | Astrazeneca Ab | MGluR5 modulators |
CN101918395B (zh) * | 2007-12-21 | 2014-04-16 | 默克雪兰诺有限公司 | 三唑联噁二唑衍生物 |
EP2276746A1 (en) * | 2008-04-10 | 2011-01-26 | Basf Se | Substituted pyridazinylmethyl sulfonamides |
-
2008
- 2008-10-23 KR KR1020107011336A patent/KR20100089091A/ko not_active Application Discontinuation
- 2008-10-23 JP JP2010530962A patent/JP2011500798A/ja active Pending
- 2008-10-23 EP EP08842741A patent/EP2212316A4/en not_active Withdrawn
- 2008-10-23 AU AU2008317544A patent/AU2008317544A1/en not_active Abandoned
- 2008-10-23 CA CA2702974A patent/CA2702974A1/en not_active Abandoned
- 2008-10-23 WO PCT/SE2008/051197 patent/WO2009054794A1/en active Application Filing
- 2008-10-23 BR BRPI0818679 patent/BRPI0818679A2/pt not_active Application Discontinuation
- 2008-10-23 MX MX2010004362A patent/MX2010004362A/es unknown
- 2008-10-23 CN CN2008801236495A patent/CN101918399A/zh active Pending
- 2008-10-23 EA EA201000656A patent/EA201000656A1/ru unknown
- 2008-10-23 TW TW097140705A patent/TW200922585A/zh unknown
- 2008-10-24 UY UY31427A patent/UY31427A1/es not_active Application Discontinuation
- 2008-10-24 AR ARP080104651A patent/AR069030A1/es unknown
- 2008-10-24 PE PE2008001830A patent/PE20091348A1/es not_active Application Discontinuation
- 2008-10-24 US US12/258,114 patent/US20090111821A1/en not_active Abandoned
- 2008-10-24 CL CL2008003182A patent/CL2008003182A1/es unknown
-
2010
- 2010-04-22 ZA ZA2010/02854A patent/ZA201002854B/en unknown
- 2010-04-22 IL IL205289A patent/IL205289A0/en unknown
- 2010-04-26 DO DO2010000124A patent/DOP2010000124A/es unknown
- 2010-04-26 CR CR11391A patent/CR11391A/es not_active Application Discontinuation
- 2010-04-26 NI NI201000072A patent/NI201000072A/es unknown
Also Published As
Publication number | Publication date |
---|---|
NI201000072A (es) | 2011-03-24 |
CL2008003182A1 (es) | 2009-11-27 |
DOP2010000124A (es) | 2010-10-15 |
US20090111821A1 (en) | 2009-04-30 |
JP2011500798A (ja) | 2011-01-06 |
CN101918399A (zh) | 2010-12-15 |
EA201000656A1 (ru) | 2010-12-30 |
AU2008317544A1 (en) | 2009-04-30 |
PE20091348A1 (es) | 2009-10-04 |
UY31427A1 (es) | 2009-05-29 |
MX2010004362A (es) | 2010-04-30 |
BRPI0818679A2 (pt) | 2015-04-14 |
IL205289A0 (en) | 2010-12-30 |
EP2212316A1 (en) | 2010-08-04 |
KR20100089091A (ko) | 2010-08-11 |
EP2212316A4 (en) | 2012-06-27 |
WO2009054794A1 (en) | 2009-04-30 |
ZA201002854B (en) | 2011-10-26 |
TW200922585A (en) | 2009-06-01 |
CR11391A (es) | 2010-08-05 |
CA2702974A1 (en) | 2009-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |