DOP2010000124A - Derivados 1,2,4-triazol amino como moduladores de mglur5 - Google Patents

Derivados 1,2,4-triazol amino como moduladores de mglur5

Info

Publication number
DOP2010000124A
DOP2010000124A DO2010000124A DO2010000124A DOP2010000124A DO P2010000124 A DOP2010000124 A DO P2010000124A DO 2010000124 A DO2010000124 A DO 2010000124A DO 2010000124 A DO2010000124 A DO 2010000124A DO P2010000124 A DOP2010000124 A DO P2010000124A
Authority
DO
Dominican Republic
Prior art keywords
modulators
compounds
mglur5
triazol
amino derivatives
Prior art date
Application number
DO2010000124A
Other languages
English (en)
Inventor
Methvin Isaac
Andreas Wallberg
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of DOP2010000124A publication Critical patent/DOP2010000124A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se relaciona con novedosos compuestos amino triazol 1,2,4, el metodo para su preparacion, composiciones farmaceuticas conteniendo dichos compuestos y su uso en terapia. Los compuestos actuan como moduladores de receptores de glutamato metabotropicos (mGluR) y son en consecuencias utiles en el tratamiento de las relajaciones transitorias del esfinter esofagico inferior, la enfermedad de reflujo gastroesofagico, dolor, ansiedad y sindrome del intestino irritable.
DO2010000124A 2007-10-26 2010-04-26 Derivados 1,2,4-triazol amino como moduladores de mglur5 DOP2010000124A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98295607P 2007-10-26 2007-10-26

Publications (1)

Publication Number Publication Date
DOP2010000124A true DOP2010000124A (es) 2010-10-15

Family

ID=40579779

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2010000124A DOP2010000124A (es) 2007-10-26 2010-04-26 Derivados 1,2,4-triazol amino como moduladores de mglur5

Country Status (21)

Country Link
US (1) US20090111821A1 (es)
EP (1) EP2212316A4 (es)
JP (1) JP2011500798A (es)
KR (1) KR20100089091A (es)
CN (1) CN101918399A (es)
AR (1) AR069030A1 (es)
AU (1) AU2008317544A1 (es)
BR (1) BRPI0818679A2 (es)
CA (1) CA2702974A1 (es)
CL (1) CL2008003182A1 (es)
CR (1) CR11391A (es)
DO (1) DOP2010000124A (es)
EA (1) EA201000656A1 (es)
IL (1) IL205289A0 (es)
MX (1) MX2010004362A (es)
NI (1) NI201000072A (es)
PE (1) PE20091348A1 (es)
TW (1) TW200922585A (es)
UY (1) UY31427A1 (es)
WO (1) WO2009054794A1 (es)
ZA (1) ZA201002854B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2438052A1 (en) * 2009-06-05 2012-04-11 Oslo University Hospital HF Azole derivatives as wtn pathway inhibitors
CN103429583A (zh) 2010-12-08 2013-12-04 奥斯陆大学医院公司 作为wnt信号通路抑制剂的三唑衍生物
RU2495687C1 (ru) * 2012-06-19 2013-10-20 Государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Минздравсоцразвития Российской Федерации Способ лечения больных гастроэзофагеальной рефлюксной болезнью
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини
EP2857387A1 (en) 2013-10-07 2015-04-08 Boehringer Ingelheim International Gmbh Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid
US9745308B2 (en) 2014-09-12 2017-08-29 Chiesi Farmaceutici S.P.A. Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420355D0 (en) * 1994-10-10 1994-11-23 Univ Nottingham Preparation of protein microspheres, films and coatings
WO1997007794A1 (fr) * 1995-08-28 1997-03-06 Showa Yakuhin Kako Co., Ltd. Composition pour anesthesie locale
US5962536A (en) * 1998-07-31 1999-10-05 Komer; Gene Injectable propofol formulations
WO2005077345A1 (en) * 2004-02-03 2005-08-25 Astrazeneca Ab Compounds for the treatment of gastro-esophageal reflux disease
KR20070027504A (ko) * 2004-02-18 2007-03-09 아스트라제네카 아베 테트라졸 화합물 및 대사성 글루타메이트 수용체길항제로서 이들의 용도
EA200601266A1 (ru) * 2004-02-18 2007-02-27 Астразенека Аб Соединения триазола и их применение в качестве антагонистов метаботропного рецептора глутамата
AR058807A1 (es) * 2005-09-29 2008-02-27 Astrazeneca Ab 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
WO2007061923A2 (en) * 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
ATE557010T1 (de) * 2006-03-24 2012-05-15 Eisai R&D Man Co Ltd Triazolonderivat
TW200808777A (en) * 2006-05-05 2008-02-16 Astrazeneca Ab MGLUR5 modulators III
TW200811179A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators VI
TW200811137A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators II
TW200811156A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators IV
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I
TW200808800A (en) * 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200821305A (en) * 2006-10-05 2008-05-16 Astrazeneca Ab MGluR5 modulators
CN101918395B (zh) * 2007-12-21 2014-04-16 默克雪兰诺有限公司 三唑联噁二唑衍生物
US20110039695A1 (en) * 2008-04-10 2011-02-17 Basf Se Substituted Pyridazinylmethyl Sulfonamides

Also Published As

Publication number Publication date
BRPI0818679A2 (pt) 2015-04-14
ZA201002854B (en) 2011-10-26
CN101918399A (zh) 2010-12-15
IL205289A0 (en) 2010-12-30
EP2212316A1 (en) 2010-08-04
KR20100089091A (ko) 2010-08-11
AR069030A1 (es) 2009-12-23
US20090111821A1 (en) 2009-04-30
EP2212316A4 (en) 2012-06-27
NI201000072A (es) 2011-03-24
CR11391A (es) 2010-08-05
AU2008317544A1 (en) 2009-04-30
CL2008003182A1 (es) 2009-11-27
MX2010004362A (es) 2010-04-30
EA201000656A1 (ru) 2010-12-30
PE20091348A1 (es) 2009-10-04
JP2011500798A (ja) 2011-01-06
UY31427A1 (es) 2009-05-29
TW200922585A (en) 2009-06-01
WO2009054794A1 (en) 2009-04-30
CA2702974A1 (en) 2009-04-30

Similar Documents

Publication Publication Date Title
DOP2010000124A (es) Derivados 1,2,4-triazol amino como moduladores de mglur5
CO6561821A2 (es) Compuesto n-(1h-indazol-4-il)imidazol[1.2-a]piridin -3-carboxamida sustituidos como inhibidores de cfms
CL2012000925A1 (es) Compuestos derivados de tetrahidrociclohepta[b]piridinilo, antagonista del receptor de cgrp; composicion farmaceutica que lo comprende; y su uso en el tratamiento de migraña, cefalea, diabetes, cancer, entre otras.
ECSP099370A (es) Derivados de hidantoína usados como inhibidores de mmp
UY29639A1 (es) Amidas sustituidas con heteroarilo que comprenden un grupo enlazador insaturado o cíclico, y su uso como productos farmacéuticos
ECSP088747A (es) Pirazoles como inhibidores de la 11-beta-hsd1
PA8785801A1 (es) Compuestos heterocìclicos
UY29735A1 (es) Piperazinas sustituidas como antagonistas de receptores de glutamato metabotrópicos
EA201100079A1 (ru) Производные триазоло[4,5-d]пирамидина и их применение в качестве антагонистов пуринового рецептора
SV2008001369A (es) Benzimidazoles
EA200901133A1 (ru) Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
CR20170070A (es) Composición, método y preparación del ácido biliar sintético
EA200901138A1 (ru) Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение
UY28726A1 (es) N-ciclohexilimidazolinonas sustituidas.procedimientos para su preparación y su uso como medicamentos.
AR057222A1 (es) Agonistas del receptor del neuropeprtido -2
CL2011003160A1 (es) Compuestos derivados de heterociclicos, moduladores cb2; composicion farmaceutica que los comprende; y uso en el tratamiento de enfermedades reumaticas, autoinmune, inflamatorias, dolor, entre otras.
CL2008003811A1 (es) Compuestos derivados de 4-aminopirimidina-2,6-disustituidos, antagonistas del receptor de histamina h4; proceso de preparacion; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de una enfermedad alergica, inmunologica o inflamatoria, o dolor.
SV2011003916A (es) Nuevas lactamas como inhibidores de beta secretasa
UY30393A1 (es) Derivados sustituidos de la 1-piperidin-1-il-1,3-dihidro-2h-benzimidazol-2-ona, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones
CL2007001175A1 (es) Compuestos derivados de triazol-pirrolidina sustituidos, moduladores de receptores de glutamato metabotropicos (mglur5); compuestos intermediarios; composicion y combinacion farmaceutica que los comprende; y uso de los compuestos en la preparacion de medicamentos para tratar enfermedades gastroesofagicas, la ansiedad y dolores.
UY31672A1 (es) "agonistas de receptores muscarínicos composiciones farmacéuticas métodos de tratamiento de los mismos, y procedimientos para su preparación"
CL2008002545A1 (es) Compuestos derivados de fenoxi-bencil-carbamoilo; composicion farmaceutica; procedimiento para preparar la composicion farmaceutica; y su uso en el tratamiento del dolor.
DOP2010000317A (es) Nueva clase de espiro piperidinas para el tratamiento de enfermedades neurodegenerativas
UY30363A1 (es) Derivados sustituidos de la n-(3-oxo-2,3-dihidro-1h-isoindol-4-il)-1-naftamida, procesos de preparacion, composiciones farmacéuticas y aplicaciones
CL2011002946A1 (es) Compuestos derivados de tiazoltiadiazol aminopirazol, inhibidores de proteina quinasa c-met; composicion farmaceutica que los comprende y su uso en el tratamiento de diferentes tipos de cancer.