PE20091348A1 - Derivados de 1,2,4-triazol amino como moduladores de mglur5 - Google Patents
Derivados de 1,2,4-triazol amino como moduladores de mglur5Info
- Publication number
- PE20091348A1 PE20091348A1 PE2008001830A PE2008001830A PE20091348A1 PE 20091348 A1 PE20091348 A1 PE 20091348A1 PE 2008001830 A PE2008001830 A PE 2008001830A PE 2008001830 A PE2008001830 A PE 2008001830A PE 20091348 A1 PE20091348 A1 PE 20091348A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- amino
- triazole
- isoxazol
- mglur5
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDO A UN COMPUESTO DERIVADO DE 1,2,4-TRIAZOL AMINO DE FORMULA I, DONDE X ES (a), (b), ENTRE OTROS, R1 ES METIL, HALOGENO O CIANO, R2 ES H O FLUORO, R3 Y R4 SON CADA UNO C1-C3 ALQUIL O CICLOPROPIL, R5 ES H, ALQUIL C1-C3 O CICLOPROPIL, Z ES (c), (d), ENTRE OTROS, R6 Y R7 SON CADA UNO H, FLUORO, ALQUIL C1-C3 O ALCOXI C1-C3. SON COMPUESTOS PREFERIDOS: 5-{5-[{[5-(3-CLOROFENIL)ISOXAZOL-3-IL]METIL}(CICLOPROPIL)AMINO]-4-METIL-4H-1,2,4-TRIAZOL-3-IL}PIRIDAZIN-3(2H)-ONA, 6-[4-ETIL-5-(METIL{[5-(3-METILFENIL)ISOXAZOL-3-IL]METIL}AMINO)-4H-1,2,4-TRIAZOL-3-IL]PIRIMIDIN-4(3H)-ONA; 2-METIL-5-[4-METIL-5-(METIL{(1S)-1-[5-(3-METILFENIL)ISOXAZOL-3-IL]ETIL}AMINO)-4H-1,2,4-TRIAZOL-3-IL]PIRIDAZIN-3(2H)-ONA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES DE GLUTAMATO METABOTROPICOS mGLUR5, SIENDO UTILES PARA EL TRATAMIENTO DE DEMENCIA SENIL, ENFERMEDAD DE PARKINSON, ESQUIZOFRENIA, RETINOPATIAS, EPILEPSIA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98295607P | 2007-10-26 | 2007-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091348A1 true PE20091348A1 (es) | 2009-10-04 |
Family
ID=40579779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001830A PE20091348A1 (es) | 2007-10-26 | 2008-10-24 | Derivados de 1,2,4-triazol amino como moduladores de mglur5 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20090111821A1 (es) |
| EP (1) | EP2212316A4 (es) |
| JP (1) | JP2011500798A (es) |
| KR (1) | KR20100089091A (es) |
| CN (1) | CN101918399A (es) |
| AR (1) | AR069030A1 (es) |
| AU (1) | AU2008317544A1 (es) |
| BR (1) | BRPI0818679A2 (es) |
| CA (1) | CA2702974A1 (es) |
| CL (1) | CL2008003182A1 (es) |
| CR (1) | CR11391A (es) |
| DO (1) | DOP2010000124A (es) |
| EA (1) | EA201000656A1 (es) |
| IL (1) | IL205289A0 (es) |
| MX (1) | MX2010004362A (es) |
| NI (1) | NI201000072A (es) |
| PE (1) | PE20091348A1 (es) |
| TW (1) | TW200922585A (es) |
| UY (1) | UY31427A1 (es) |
| WO (1) | WO2009054794A1 (es) |
| ZA (1) | ZA201002854B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010139966A1 (en) * | 2009-06-05 | 2010-12-09 | Oslo University Hospital Hf | Azole derivatives as wtn pathway inhibitors |
| WO2012076898A1 (en) | 2010-12-08 | 2012-06-14 | Oslo University Hospital Hf | Triazole derivatives as wnt signaling pathway inhibitors |
| RU2495687C1 (ru) * | 2012-06-19 | 2013-10-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Северо-Осетинская государственная медицинская академия" Минздравсоцразвития Российской Федерации | Способ лечения больных гастроэзофагеальной рефлюксной болезнью |
| UA113223C2 (xx) * | 2012-08-13 | 2016-12-26 | Арилетинілпіримідини | |
| EP2857387A1 (en) | 2013-10-07 | 2015-04-08 | Boehringer Ingelheim International Gmbh | Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid |
| US9745308B2 (en) | 2014-09-12 | 2017-08-29 | Chiesi Farmaceutici S.P.A. | Pyridazinone derivatives as phoshoinositide 3-kinases inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9420355D0 (en) * | 1994-10-10 | 1994-11-23 | Univ Nottingham | Preparation of protein microspheres, films and coatings |
| EP0858803A4 (en) * | 1995-08-28 | 2000-02-09 | Showa Pharm Chem Ind | COMPOSITION FOR LOCAL ANESTHESIA |
| US5962536A (en) * | 1998-07-31 | 1999-10-05 | Komer; Gene | Injectable propofol formulations |
| WO2005077345A1 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| CN101018779A (zh) * | 2004-02-18 | 2007-08-15 | 阿斯利康(瑞典)有限公司 | 三唑化合物及其作为代谢型谷氨酸受体拮抗剂的应用 |
| CA2556263A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Tetrazole compounds and their use as metabotropic glutamate receptor antagonists |
| UY29796A1 (es) * | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
| JP2009515997A (ja) * | 2005-11-18 | 2009-04-16 | タケダ サン ディエゴ インコーポレイテッド | グルコキナーゼ活性剤 |
| DE602007011231D1 (de) * | 2006-03-24 | 2011-01-27 | Eisai R&D Man Co Ltd | Triazolonderivat |
| TW200811137A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators II |
| TW200811157A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
| TW200811179A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators VI |
| TW200811156A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators IV |
| TW200808777A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGLUR5 modulators III |
| TW200808800A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
| TW200821305A (en) * | 2006-10-05 | 2008-05-16 | Astrazeneca Ab | MGluR5 modulators |
| AU2008340113B2 (en) * | 2007-12-21 | 2014-01-09 | Merck Serono S.A. | Triazole oxadiazoles derivatives |
| US20110039695A1 (en) * | 2008-04-10 | 2011-02-17 | Basf Se | Substituted Pyridazinylmethyl Sulfonamides |
-
2008
- 2008-10-23 EA EA201000656A patent/EA201000656A1/ru unknown
- 2008-10-23 AU AU2008317544A patent/AU2008317544A1/en not_active Abandoned
- 2008-10-23 WO PCT/SE2008/051197 patent/WO2009054794A1/en active Application Filing
- 2008-10-23 EP EP08842741A patent/EP2212316A4/en not_active Withdrawn
- 2008-10-23 JP JP2010530962A patent/JP2011500798A/ja active Pending
- 2008-10-23 CA CA2702974A patent/CA2702974A1/en not_active Abandoned
- 2008-10-23 MX MX2010004362A patent/MX2010004362A/es unknown
- 2008-10-23 BR BRPI0818679 patent/BRPI0818679A2/pt not_active Application Discontinuation
- 2008-10-23 KR KR1020107011336A patent/KR20100089091A/ko not_active Application Discontinuation
- 2008-10-23 CN CN2008801236495A patent/CN101918399A/zh active Pending
- 2008-10-23 TW TW097140705A patent/TW200922585A/zh unknown
- 2008-10-24 US US12/258,114 patent/US20090111821A1/en not_active Abandoned
- 2008-10-24 UY UY31427A patent/UY31427A1/es not_active Application Discontinuation
- 2008-10-24 AR ARP080104651A patent/AR069030A1/es unknown
- 2008-10-24 CL CL2008003182A patent/CL2008003182A1/es unknown
- 2008-10-24 PE PE2008001830A patent/PE20091348A1/es not_active Application Discontinuation
-
2010
- 2010-04-22 IL IL205289A patent/IL205289A0/en unknown
- 2010-04-22 ZA ZA2010/02854A patent/ZA201002854B/en unknown
- 2010-04-26 CR CR11391A patent/CR11391A/es not_active Application Discontinuation
- 2010-04-26 NI NI201000072A patent/NI201000072A/es unknown
- 2010-04-26 DO DO2010000124A patent/DOP2010000124A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200922585A (en) | 2009-06-01 |
| DOP2010000124A (es) | 2010-10-15 |
| BRPI0818679A2 (pt) | 2015-04-14 |
| CR11391A (es) | 2010-08-05 |
| WO2009054794A1 (en) | 2009-04-30 |
| CL2008003182A1 (es) | 2009-11-27 |
| EP2212316A4 (en) | 2012-06-27 |
| IL205289A0 (en) | 2010-12-30 |
| AU2008317544A1 (en) | 2009-04-30 |
| MX2010004362A (es) | 2010-04-30 |
| EP2212316A1 (en) | 2010-08-04 |
| NI201000072A (es) | 2011-03-24 |
| JP2011500798A (ja) | 2011-01-06 |
| CN101918399A (zh) | 2010-12-15 |
| AR069030A1 (es) | 2009-12-23 |
| US20090111821A1 (en) | 2009-04-30 |
| EA201000656A1 (ru) | 2010-12-30 |
| KR20100089091A (ko) | 2010-08-11 |
| UY31427A1 (es) | 2009-05-29 |
| ZA201002854B (en) | 2011-10-26 |
| CA2702974A1 (en) | 2009-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |