AR067760A1 - Procedimiento para preparar compuestos quirales - Google Patents

Procedimiento para preparar compuestos quirales

Info

Publication number
AR067760A1
AR067760A1 ARP080103326A AR067760A1 AR 067760 A1 AR067760 A1 AR 067760A1 AR P080103326 A ARP080103326 A AR P080103326A AR 067760 A1 AR067760 A1 AR 067760A1
Authority
AR
Argentina
Prior art keywords
procedure
chiral compounds
aminopropionaldehyde
pyran
tetrahydro
Prior art date
Application number
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR067760A1 publication Critical patent/AR067760A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedimiento quimioenzimático con 2-desoxirribosa-5-fosfato aldolasa (DERA) para preparar compuestos quirales. Reivindicacion 1: Un procedimiento que comprende la etapa de hacer reaccionar acetaldehído con un sustrato de aminoaldehído N-protegido seleccionado del grupo constituido por 3-ftalimidopropionaldehído, N-formil-3-aminopropionaldehído, 3-succinimidopropionaldehído y N-diBoc-3-aminopropionaldehído en condiciones de condensacion aldolica catalizada por aldolasa para formar el correspondiente lactol. Reivindicacion 32: 2-[2-(4,6-Dihidroxi-tetrahidro-piran-2-iI]-isoindol-1,3-diona. Reivindicacion 43: Una forma cristalina de 4-fluoro-alfa-[2-metil-1-oxopropil]-gamma-oxo-N,beta-difenilbencenbutanamida caracterizada por tener picos de difraccion de rayos X de polvo de dos-theta de aproximadamente 9,0, 12,7, 20,2, 22,6 y 25,2 grados. Reivindicacion 44: Una forma cristalina de (2R-trans)-5-(4-fluorofenil)-2-(1-metiletil)-N,4-difenil-1-[2-(tetrahidro-4-hidroxi-6-oxo-2H-piran-2-il)etil]-1H-pirrol-3-carboxamida caracterizada por tener picos de difraccion de rayos X de polvo de dos-theta de aproximadamente 6,3, 12,7, 16,8, 21,1 y 25,5 grados.
ARP080103326 2007-08-03 2008-07-31 Procedimiento para preparar compuestos quirales AR067760A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95372507P 2007-08-03 2007-08-03

Publications (1)

Publication Number Publication Date
AR067760A1 true AR067760A1 (es) 2009-10-21

Family

ID=40070852

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103326 AR067760A1 (es) 2007-08-03 2008-07-31 Procedimiento para preparar compuestos quirales

Country Status (8)

Country Link
US (2) US8642783B2 (es)
EP (2) EP2185713B1 (es)
JP (2) JP5490384B2 (es)
AR (1) AR067760A1 (es)
CA (2) CA2918498A1 (es)
ES (2) ES2523404T3 (es)
TW (1) TW200914618A (es)
WO (1) WO2009019561A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2753513C (en) 2009-03-02 2017-10-10 Golf Hill Limited Compounds and methods for treating cancer and viral infections
US20130041162A1 (en) 2010-04-19 2013-02-14 Dsm Sinochem Pharmaceuticals Netherlands B.V. Production of atorvastatin low in ether impurities
WO2011131601A1 (en) 2010-04-19 2011-10-27 Dsm Ip Assets B.V. Production of atorvastatin low in lactone impurities
MX2013002809A (es) * 2010-09-16 2013-04-29 Dsm Sinochem Pharm Nl Bv Esteres de acidos hexanoicos.
CN102643223A (zh) * 2012-03-15 2012-08-22 老河口荆洪化工有限责任公司 一种3-邻苯二甲酰亚胺丙醛的制备方法
CN102766136A (zh) * 2012-08-07 2012-11-07 浙江宏元药业有限公司 一种制备阿托伐他汀钙中间体的方法
CN103159773B (zh) * 2013-03-25 2015-01-28 武汉大学 具有手性螺环内酯吡咯环结构片段的多环衍生物及其合成方法
KR101710553B1 (ko) * 2014-07-07 2017-02-28 한국생명공학연구원 헤모필루스 인플루엔자 Rd KW20 균주 유래 2-디옥시리보오스 5-포스페이트 알돌라아제 변이체
CA2992794A1 (en) * 2015-07-21 2017-01-26 Radhakrishnan Mahadevan Methods and microorganisms for the production of 1,3-butanediol
CN105693670A (zh) * 2016-04-05 2016-06-22 苏州汉酶生物技术有限公司 一种生物法制备n-(2-((2r,4r)-4,6-二羟基四氢-2h-吡喃-2-基)-乙基)-2-苯乙酰胺的方法
WO2018005806A2 (en) * 2016-06-30 2018-01-04 Ardra Bio Inc. Methods and microorganisms for producing flavors and fragrance chemicals
CN111909048B (zh) * 2020-09-07 2021-03-16 浙江宏元药业股份有限公司 一种多组分一锅法合成阿托伐他汀钙中间体的方法
CN114195670B (zh) * 2021-12-31 2024-03-15 河南豫辰药业股份有限公司 一种阿托伐他汀母核m4的精制方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01275594A (ja) * 1988-04-27 1989-11-06 Sakai Yakuhin Kk カナマイシン誘導体の製造方法
US5155251A (en) 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
DE60218678T2 (de) * 2001-07-12 2008-02-14 Dsm Ip Assets B.V. Verfahren zur herstellung von 2,4-didesoxyhexosen und 2,4,6-tridesoxyhexosen
US7414119B2 (en) * 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them
US7414141B2 (en) * 2003-07-25 2008-08-19 Avecia Pharmaceuticals, Ltd. Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin
CA2568728A1 (en) * 2004-06-04 2005-12-15 Dsm Ip Assets B.V. Improved 2-deoxy-d-ribose 5-phosphate aldolases (deras) and the uses thereof
WO2006134482A1 (en) * 2005-06-16 2006-12-21 Pfizer Inc. Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof
WO2008075165A1 (en) * 2006-12-19 2008-06-26 Pfizer Products Inc. Novel process for the synthesis of [r-(r*, r*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid or a pharmaceutically acceptable salt thereof

Also Published As

Publication number Publication date
JP5490384B2 (ja) 2014-05-14
US20140187794A1 (en) 2014-07-03
ES2523304T3 (es) 2014-11-24
CA2695357C (en) 2016-04-05
CA2695357A1 (en) 2009-02-12
EP2532660A1 (en) 2012-12-12
WO2009019561A2 (en) 2009-02-12
EP2185713A2 (en) 2010-05-19
JP2014051515A (ja) 2014-03-20
CA2918498A1 (en) 2009-02-12
JP5788457B2 (ja) 2015-09-30
US9079877B2 (en) 2015-07-14
EP2185713B1 (en) 2014-09-10
WO2009019561A3 (en) 2009-05-14
ES2523404T3 (es) 2014-11-25
TW200914618A (en) 2009-04-01
US20110118476A1 (en) 2011-05-19
US8642783B2 (en) 2014-02-04
JP2009082129A (ja) 2009-04-23
EP2532660B1 (en) 2014-09-10

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