TW200724688A - Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof - Google Patents

Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof

Info

Publication number
TW200724688A
TW200724688A TW095121394A TW95121394A TW200724688A TW 200724688 A TW200724688 A TW 200724688A TW 095121394 A TW095121394 A TW 095121394A TW 95121394 A TW95121394 A TW 95121394A TW 200724688 A TW200724688 A TW 200724688A
Authority
TW
Taiwan
Prior art keywords
intermediates
pharmaceutically acceptable
acceptable salts
producing
producing atorvastatin
Prior art date
Application number
TW095121394A
Other languages
Chinese (zh)
Inventor
Shang-Hui Hu
Jun-Hua Tao
Zhi-Yi Xie
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TW200724688A publication Critical patent/TW200724688A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Abstract

A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
TW095121394A 2005-06-16 2006-06-15 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof TW200724688A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69106505P 2005-06-16 2005-06-16

Publications (1)

Publication Number Publication Date
TW200724688A true TW200724688A (en) 2007-07-01

Family

ID=36928182

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095121394A TW200724688A (en) 2005-06-16 2006-06-15 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof

Country Status (6)

Country Link
EP (1) EP1893767A1 (en)
JP (1) JP2006345863A (en)
AR (1) AR055975A1 (en)
CA (1) CA2612293A1 (en)
TW (1) TW200724688A (en)
WO (1) WO2006134482A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008119810A2 (en) 2007-04-03 2008-10-09 Lek Pharmaceuticals D.D. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
EP2017267A1 (en) * 2007-07-16 2009-01-21 LEK Pharmaceuticals D.D. Synthesis of statins
EP2185713B1 (en) * 2007-08-03 2014-09-10 Pfizer Products Inc. Process for preparing chiral compounds
AU2009207721B2 (en) 2008-01-23 2014-10-23 Lek Pharmaceuticals D.D. ((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)methyl carboxylate and process for the production employing a 2-deoxyribose-5-phosphate aldolase
AU2011355209B2 (en) 2010-12-20 2015-09-17 Lek Pharmaceuticals D.D. Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof
EP2465936A1 (en) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of statins and intermediates thereof
JP5705580B2 (en) * 2011-02-21 2015-04-22 公益財団法人微生物化学研究会 Thioamide compound, method for producing thioamide compound, method for producing [(4R, 6R) -6-aminoethyl-1,3-dioxan-4-yl] acetate derivative, and method for producing atorvastatin
CN103060396B (en) * 2011-10-21 2017-09-12 武汉启瑞药业有限公司 A kind of new method for the Atorvastatin calcium for producing high chiral purity
WO2013068917A1 (en) * 2011-11-07 2013-05-16 Dr. Reddy's Laboratories Limited Processes for the production of a lactone statin intermediate by enzymatic oxidation
CN105272954B (en) * 2014-06-27 2017-10-13 上海弈柯莱生物医药科技有限公司 A kind of preparation method of the ketone of 6 substituent methyl, 4 hydroxy tetrahydro pyrans 2 and its derivative
EP3478848A4 (en) 2016-06-30 2020-01-29 Ardra Inc. Methods and microorganisms for producing flavors and fragrance chemicals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7414119B2 (en) * 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them

Also Published As

Publication number Publication date
JP2006345863A (en) 2006-12-28
WO2006134482A8 (en) 2008-03-06
EP1893767A1 (en) 2008-03-05
CA2612293A1 (en) 2006-12-21
WO2006134482A1 (en) 2006-12-21
AR055975A1 (en) 2007-09-12

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