AR067335A1 - Factor vii/viia humano modificado y composicion farmaceutica que lo contiene - Google Patents

Factor vii/viia humano modificado y composicion farmaceutica que lo contiene

Info

Publication number
AR067335A1
AR067335A1 ARP080102572A ARP080102572A AR067335A1 AR 067335 A1 AR067335 A1 AR 067335A1 AR P080102572 A ARP080102572 A AR P080102572A AR P080102572 A ARP080102572 A AR P080102572A AR 067335 A1 AR067335 A1 AR 067335A1
Authority
AR
Argentina
Prior art keywords
arginine
isoleucine
valine
tryptophan
phenylalanine
Prior art date
Application number
ARP080102572A
Other languages
English (en)
Inventor
Emmanuel Nony
Sami Chtourou
Nicolas Bihoreau
Original Assignee
Lab Francais Du Fractionnement
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lab Francais Du Fractionnement filed Critical Lab Francais Du Fractionnement
Publication of AR067335A1 publication Critical patent/AR067335A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

Ácidos nucleicos que codifican dichos factores VII/VIIa modificados, organismos modificados que los contienen y métodos para su fabricacion. Reivindicacion 1: Un factor VII/VIla humano modificado en comparacion con la secuencie peptídica del factor VII/VIla humano nativo, que tiene al menos dos aminoácidos seleccionados entre usina 38, arginina 290 y arginina 315, que son sustituidos o eliminados, donde: dicha lisina 38 es reemplazada por un aminoácido seleccionado entre glutamina, alanina, ácido glutámico, glicina, isoleucina, leucina, metionina, histidina, fenilalanina, prolina, serina, treonina, triptofano, tirosina o valina; dicha arginina 290 es reemplazada por un aminoácido seleccionado entre glutamina, alanina, ácido glutámico, asparagina, glicina, isoleucina, leucina, metionina, histidina, fenilalanina, prolina, serina, treonina, triptofano, tirosina o valina; y/o dicha arginina 315 es reemplazada por un aminoácido seleccionado entre glutamina, alanina, ácido glutámico, asparagina, glicina, isoleucina, leucina, metionina, histidina, fenilalanina, prolina, serina, treonina, triptofano, tirosina o valina.
ARP080102572A 2007-06-15 2008-06-17 Factor vii/viia humano modificado y composicion farmaceutica que lo contiene AR067335A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0755775A FR2917414B1 (fr) 2007-06-15 2007-06-15 Facteur vii/viia humain modifie et composition pharmaceutique contenant celui-ci

Publications (1)

Publication Number Publication Date
AR067335A1 true AR067335A1 (es) 2009-10-07

Family

ID=38702010

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102572A AR067335A1 (es) 2007-06-15 2008-06-17 Factor vii/viia humano modificado y composicion farmaceutica que lo contiene

Country Status (12)

Country Link
US (1) US20110162094A1 (es)
EP (1) EP2162147A2 (es)
JP (1) JP2010529848A (es)
KR (1) KR20100039281A (es)
CN (1) CN101743017A (es)
AR (1) AR067335A1 (es)
AU (1) AU2008265021A1 (es)
BR (1) BRPI0813372A2 (es)
CA (1) CA2691110A1 (es)
FR (1) FR2917414B1 (es)
TW (1) TW200906851A (es)
WO (1) WO2008155509A2 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2554161A1 (en) 2011-08-02 2013-02-06 LFB Biotechnologies Pharmaceutical composition comprising factor VII encapsulated in micelles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE141646T1 (de) * 1986-04-09 1996-09-15 Genzyme Corp Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern
DK323587D0 (da) * 1987-06-25 1987-06-25 Novo Industri As Protein
US5580560A (en) * 1989-11-13 1996-12-03 Novo Nordisk A/S Modified factor VII/VIIa
FR2684999A1 (fr) * 1991-12-16 1993-06-18 Aquitaine Dev Transf Sanguine Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.
AU2002218029A1 (en) * 2000-11-09 2002-05-21 The Scripps Research Institute Modified factor viia

Also Published As

Publication number Publication date
WO2008155509A3 (fr) 2009-02-19
EP2162147A2 (fr) 2010-03-17
FR2917414A1 (fr) 2008-12-19
WO2008155509A2 (fr) 2008-12-24
FR2917414B1 (fr) 2012-07-13
CN101743017A (zh) 2010-06-16
CA2691110A1 (fr) 2008-12-24
TW200906851A (en) 2009-02-16
KR20100039281A (ko) 2010-04-15
US20110162094A1 (en) 2011-06-30
WO2008155509A9 (fr) 2010-04-08
BRPI0813372A2 (pt) 2014-12-30
JP2010529848A (ja) 2010-09-02
AU2008265021A1 (en) 2008-12-24

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