AR065521A1 - Heterociclos sulfonilados utiles para la modulacion del receptor de progesterona - Google Patents
Heterociclos sulfonilados utiles para la modulacion del receptor de progesteronaInfo
- Publication number
- AR065521A1 AR065521A1 ARP080100833A ARP080100833A AR065521A1 AR 065521 A1 AR065521 A1 AR 065521A1 AR P080100833 A ARP080100833 A AR P080100833A AR P080100833 A ARP080100833 A AR P080100833A AR 065521 A1 AR065521 A1 AR 065521A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- heterocycle
- heteroaryl
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Métodos para preparar y usar estos compuestos para anticoncepcion; para tratar o prevenir fibroides, leiomiomata uterino, endometriosis, hemorragia disfuncional, síndrome del ovario poliquístico, y carcinomas dependientes de hormona; proporcionarterapia de reemplazo hormonal; estimular la ingesta de alimentos; de sincronizacion del estro y para tratar síntomas relacionados con el ciclo. Reivindicacion 1: Un compuesto de la estructura (1) donde: n es 1 2, o 3; Z es CR4R5, NR4 u O, con lacondicion de que Z es CR4R5 cuando n es 1; R1 se selecciona del grupo que consiste en alquilo C1-6, cicloalquilo C3-8, alquilo C1-6 sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, heterociclo sustituido,alquenilo C3-6, alquenilo C3-6 sustituido, alquinilo C3-6 y alquinilo C3-6 sustituido; R2, R3, R4, y R5 se seleccionan independientemente del grupo que consiste en H, halogeno, CN, alquilo C1-6, alquilo C1-6 sustituido, -(CHmXn)zCHpXq, cicloalquiloC3-6, O-alquilo C1-6, O-alquilo C1-6 sustituido, O-(CHmXn)zCHpXq, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, y heterociclo sustituido; o R2 y R4 o R2 y R5 o R3 y R4 o R3 y R5 se unen para formar un anillo carbocíclicoo heterocíclico que contiene de 3 a 8 átomos; R6, R7 y R8 se seleccionan independientemente del grupo que consiste en H, halogeno, CN, alquilo C1-6, alquilo C1-6 sustituido, -(CHmXn)zCHpXq, cicloalquilo C3-6, O-alquilo C1-6, O-alquilo C1-6sustituido, O-(CHmXn)zCHpXq, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, y heterociclo sustituido; X es halogeno; m y n son independientemente 0 a 2, con la condicion de que rn +- n = 2: p y q son independientemente 0 a3, con la condicion de que p + q = 3; z es 0 a 10; y R9 se selecciona del grupo que consiste en H, alquilo C1-6, C(O)O-alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alquilo C1-6 sustituido, cicloalquilo C3-6 y cicloalquilo C3-6 sustituido; o unasal, profármaco, tautomero o metabolito de éste, aceptables para uso farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90519907P | 2007-03-06 | 2007-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065521A1 true AR065521A1 (es) | 2009-06-10 |
Family
ID=39524346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100833A AR065521A1 (es) | 2007-03-06 | 2008-02-28 | Heterociclos sulfonilados utiles para la modulacion del receptor de progesterona |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7750038B2 (es) |
| EP (1) | EP2121657A1 (es) |
| JP (1) | JP2010520283A (es) |
| AR (1) | AR065521A1 (es) |
| CA (1) | CA2679380A1 (es) |
| CL (1) | CL2008000675A1 (es) |
| MX (1) | MX2009009514A (es) |
| PA (1) | PA8771801A1 (es) |
| TW (1) | TW200848021A (es) |
| WO (1) | WO2008109056A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200848019A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Aryl sulfonamides useful for modulation of the progesterone receptor |
| US8038364B2 (en) | 2007-08-07 | 2011-10-18 | Saint-Gobain Technical Fabrics America, Inc. | Reinforcement for asphaltic paving, method of paving, and process for making a grid with the coating for asphaltic paving |
| JP2009286773A (ja) * | 2008-03-14 | 2009-12-10 | Bayer Cropscience Ag | 殺虫性縮環式アリール類 |
| CA2888221C (en) | 2012-10-19 | 2017-09-19 | Saint-Gobain Adfors Canada, Ltd. | Composite tack film |
| CN105934246B (zh) | 2013-11-18 | 2019-10-22 | 福马疗法公司 | 作为bet溴域抑制剂的四氢喹啉组成物 |
| CN106029076B (zh) | 2013-11-18 | 2019-06-07 | 福马疗法公司 | 作为bet溴域抑制剂的苯并哌嗪组合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW263508B (es) | 1991-02-12 | 1995-11-21 | Pfizer | |
| DE19633751A1 (de) | 1996-08-22 | 1998-02-26 | Basf Ag | Substituierte 2-Arylpyridine |
| US6417214B1 (en) | 1999-05-04 | 2002-07-09 | Wyeth | 3,3-substituted indoline derivatives |
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US6358948B1 (en) | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| AU5570900A (en) | 1999-07-01 | 2001-01-22 | Sankyo Company Limited | Indoline or tetrahydroquinoline derivatives |
| US20020049223A1 (en) | 1999-11-05 | 2002-04-25 | Elmore Steven W. | Quinoline and naphthyridine carboxylic acid antibacterials |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| AU2001278755A1 (en) | 2000-08-18 | 2002-03-04 | Takeda Chemical Industries Ltd. | Injections |
| AU2005102A (en) | 2000-11-02 | 2002-05-15 | Wyeth Corp | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
| WO2003004028A1 (en) | 2001-07-02 | 2003-01-16 | Akzo Nobel N.V. | Tetrahydroquinoline derivatives |
| US7071210B2 (en) | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
| DE10229777A1 (de) | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
| US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| DE10300099A1 (de) | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Indol-Phenylsulfonamid-Derivate |
| WO2005007628A1 (en) | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| CA2532800C (en) | 2003-07-23 | 2013-06-18 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
| DE10335450A1 (de) | 2003-08-02 | 2005-02-17 | Bayer Ag | Indolin-Sulfanilsäureamide |
| GT200500183A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| GT200500185A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| PE20070404A1 (es) | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
| PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
-
2008
- 2008-02-26 TW TW097106592A patent/TW200848021A/zh unknown
- 2008-02-28 AR ARP080100833A patent/AR065521A1/es unknown
- 2008-03-04 EP EP08742010A patent/EP2121657A1/en not_active Withdrawn
- 2008-03-04 WO PCT/US2008/002830 patent/WO2008109056A1/en active Application Filing
- 2008-03-04 CA CA002679380A patent/CA2679380A1/en not_active Abandoned
- 2008-03-04 MX MX2009009514A patent/MX2009009514A/es unknown
- 2008-03-04 US US12/041,707 patent/US7750038B2/en not_active Expired - Fee Related
- 2008-03-04 JP JP2009552708A patent/JP2010520283A/ja active Pending
- 2008-03-06 PA PA20088771801A patent/PA8771801A1/es unknown
- 2008-03-06 CL CL200800675A patent/CL2008000675A1/es unknown
-
2010
- 2010-05-26 US US12/787,803 patent/US20100234422A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200848021A (en) | 2008-12-16 |
| EP2121657A1 (en) | 2009-11-25 |
| JP2010520283A (ja) | 2010-06-10 |
| CL2008000675A1 (es) | 2008-07-18 |
| PA8771801A1 (es) | 2009-02-09 |
| US20080221160A1 (en) | 2008-09-11 |
| MX2009009514A (es) | 2009-09-16 |
| US7750038B2 (en) | 2010-07-06 |
| US20100234422A1 (en) | 2010-09-16 |
| WO2008109056A1 (en) | 2008-09-12 |
| CA2679380A1 (en) | 2008-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |