AR065520A1 - Arilsulfonamidas utiles par la modulacion del receptor de progesterona - Google Patents
Arilsulfonamidas utiles par la modulacion del receptor de progesteronaInfo
- Publication number
- AR065520A1 AR065520A1 ARP080100832A ARP080100832A AR065520A1 AR 065520 A1 AR065520 A1 AR 065520A1 AR P080100832 A ARP080100832 A AR P080100832A AR P080100832 A ARP080100832 A AR P080100832A AR 065520 A1 AR065520 A1 AR 065520A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- zchpxq
- chmxn
- cycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
También se proporcionan métodos para preparar estos compuestos y métodos de anticoncepcion; para tratar o prevenir fibroides; tratar o prevenir leiomiomata uterino; tratar o prevenir endometriosis, hemorragia disfuncional y síndrome del ovariopoliquístico; tratar o prevenir carcinomas dependientes de hormona; proporcionar terapia de reemplazo hormonal; estimular la ingesta de alimentos; de sincronizacion del estro; y para tratar síntomas relacionados con el ciclo usando los compuestosdescriptos en la presente memoria. Reivindicacion 1: Un compuesto de la estructura (1) donde: R1 y R2 se seleccionan independientemente del grupo que consiste en H, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-8, cicloalquilo C3-8sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo, heterociclo sustituido, alquenilo C3-6, alquenilo C3-6 sustituido, alquinilo C3-6, alquinilo C3-6 sustituido, -(CHmXn)zCHpXq, O-alquilo C1-6, O-alquilo C1-6sustituido y O-(CHmXn)zCHpXq; o R1 y R2 se pueden tomar juntos para formar un anillo de 4 a 8 átomos anulares que contiene en su esqueleto átomos de carbono y 1 a 4 N, O, S o SO2, y donde cualquier átomo de C o átomo de N de dicho anillo estáopcionalmente sustituido con alquilo C1-4, F o CF3; R3, R4, R5 y R6 se seleccionan independientemente del grupo que consiste en H, halogeno, CN, alquilo C1-6, alquilo C1-6 sustituido, -(CHmXn)zCHpXq, cicloalquilo C3-6, cicloalquilo C3-6 sustituido,O-alquilo C1-6, O-alquilo C1-6 sustituido, OH, NH2, NH-(CHmXn)zCHpXq, O-(CHmXn)zCHpXq, N-{(CHmXn)zCHpXq}2, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, heterociclo y heterociclo sustituido; X es halogeno; m y n son,independientemente, 0 a 2, con la condicion que m + n = 2; p y q son independientemente, 0 a 3, con la condicion que p + q = 3; z es 0 a 10; R7 se selecciona del grupo que consiste en H, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-6,cicloalquilo C3-6 sustituido; o una sal, tautomero, metabolito o profármaco de éste, aceptables para uso farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90523907P | 2007-03-06 | 2007-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065520A1 true AR065520A1 (es) | 2009-06-10 |
Family
ID=39719009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100832A AR065520A1 (es) | 2007-03-06 | 2008-02-28 | Arilsulfonamidas utiles par la modulacion del receptor de progesterona |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7723332B2 (es) |
| EP (1) | EP2137145A2 (es) |
| JP (1) | JP2010520282A (es) |
| AR (1) | AR065520A1 (es) |
| CA (1) | CA2679564A1 (es) |
| CL (1) | CL2008000673A1 (es) |
| MX (1) | MX2009009515A (es) |
| TW (1) | TW200848019A (es) |
| WO (1) | WO2008109055A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7751863B2 (en) | 2007-02-06 | 2010-07-06 | Glumetrics, Inc. | Optical determination of ph and glucose |
| TW200848019A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Aryl sulfonamides useful for modulation of the progesterone receptor |
| AR070120A1 (es) * | 2008-01-11 | 2010-03-17 | Wyeth Corp | Derivados de aril sulfonamida que contienen o-sulfato y o-fosfato, utiles como inhibidores de beta-amiloide, proceso de preparacion de los mismos y composiciones farmaceuticas que los contienen. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0230088D0 (en) | 2002-12-24 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| US7169801B2 (en) | 2003-03-17 | 2007-01-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2005065681A1 (en) | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer |
| GT200500183A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| GB0427381D0 (en) * | 2004-12-14 | 2005-01-19 | Novartis Ag | Organic compounds |
| PE20070182A1 (es) | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
| PE20070404A1 (es) | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
| TW200848019A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Aryl sulfonamides useful for modulation of the progesterone receptor |
| TW200848021A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
-
2008
- 2008-02-26 TW TW097106595A patent/TW200848019A/zh unknown
- 2008-02-28 AR ARP080100832A patent/AR065520A1/es unknown
- 2008-03-04 US US12/041,716 patent/US7723332B2/en not_active Expired - Fee Related
- 2008-03-04 JP JP2009552707A patent/JP2010520282A/ja active Pending
- 2008-03-04 EP EP08726382A patent/EP2137145A2/en not_active Withdrawn
- 2008-03-04 MX MX2009009515A patent/MX2009009515A/es active IP Right Grant
- 2008-03-04 CA CA002679564A patent/CA2679564A1/en not_active Abandoned
- 2008-03-04 WO PCT/US2008/002829 patent/WO2008109055A2/en active Application Filing
- 2008-03-06 CL CL200800673A patent/CL2008000673A1/es unknown
-
2010
- 2010-04-15 US US12/760,666 patent/US20100204228A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7723332B2 (en) | 2010-05-25 |
| CL2008000673A1 (es) | 2008-07-18 |
| MX2009009515A (es) | 2009-09-16 |
| JP2010520282A (ja) | 2010-06-10 |
| TW200848019A (en) | 2008-12-16 |
| CA2679564A1 (en) | 2008-09-12 |
| WO2008109055A3 (en) | 2008-10-30 |
| WO2008109055A8 (en) | 2009-01-08 |
| US20080221201A1 (en) | 2008-09-11 |
| US20100204228A1 (en) | 2010-08-12 |
| WO2008109055A2 (en) | 2008-09-12 |
| EP2137145A2 (en) | 2009-12-30 |
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| FB | Suspension of granting procedure |