AR064424A1 - Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio. - Google Patents
Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio.Info
- Publication number
- AR064424A1 AR064424A1 ARP070105701A ARP070105701A AR064424A1 AR 064424 A1 AR064424 A1 AR 064424A1 AR P070105701 A ARP070105701 A AR P070105701A AR P070105701 A ARP070105701 A AR P070105701A AR 064424 A1 AR064424 A1 AR 064424A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently selected
- halogen
- optionally substituted
- substituents independently
- Prior art date
Links
- 230000000172 allergic effect Effects 0.000 title 1
- 208000010668 atopic eczema Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 210000002345 respiratory system Anatomy 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 22
- 150000002367 halogens Chemical class 0.000 abstract 22
- 125000001424 substituent group Chemical group 0.000 abstract 21
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 16
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 13
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 3
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 229920006395 saturated elastomer Polymers 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87087506P | 2006-12-20 | 2006-12-20 | |
| US97844707P | 2007-10-09 | 2007-10-09 | |
| US99122707P | 2007-11-30 | 2007-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064424A1 true AR064424A1 (es) | 2009-04-01 |
Family
ID=39536783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070105701A AR064424A1 (es) | 2006-12-20 | 2007-12-18 | Derivados sustituidos de 1-oxo-ftalazinas y 1-oxo-pirido-piridazinas,composiciones farmaceuticas que los contienen y usos para prevenir y/o tratar enfermedades inflamatorias y alergicas del tracto respiratorio. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100184770A1 (enExample) |
| EP (1) | EP2091538B1 (enExample) |
| JP (1) | JP2010513393A (enExample) |
| AR (1) | AR064424A1 (enExample) |
| AT (1) | ATE459358T1 (enExample) |
| DE (1) | DE602007005167D1 (enExample) |
| ES (1) | ES2341813T3 (enExample) |
| PE (1) | PE20081657A1 (enExample) |
| TW (1) | TW200831493A (enExample) |
| WO (1) | WO2008074803A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006115221A1 (ja) * | 2005-04-21 | 2006-11-02 | Nippon Shinyaku Co., Ltd. | フタラジノン誘導体及びその医薬 |
| MX347085B (es) * | 2006-12-28 | 2017-04-06 | Abbott Laboratories * | Inhibidores de la poli (adp-ribosa) polimerasa. |
| US8466150B2 (en) | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| ATE525370T1 (de) * | 2007-10-11 | 2011-10-15 | Glaxo Group Ltd | Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten |
| WO2009150101A1 (en) * | 2008-06-09 | 2009-12-17 | Glaxo Group Limited | Pharmaceutical compositions comprising n-[2-((2r)-2-{[4-[(4-chlorophenyl)methyl]-l-oxo-2(ih)-phthalaz inyl]methyl}-l- pyrrolidinyl)ethyl]-4-(methyloxy)butanamide |
| US8969348B2 (en) | 2008-08-13 | 2015-03-03 | Boehringer Ingelheim International Gmbh | Chymase inhibitors |
| WO2012045729A1 (en) | 2010-10-05 | 2012-04-12 | Glaxo Group Limited | Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists |
| WO2012072512A1 (en) | 2010-11-29 | 2012-06-07 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists |
| US8754101B2 (en) | 2011-04-11 | 2014-06-17 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists |
| KR20240013792A (ko) * | 2021-05-27 | 2024-01-30 | 슈뢰딩거, 인크. | 헤테로시클릭 화합물 및 사용 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3677322D1 (de) * | 1985-11-11 | 1991-03-07 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
| DE3634942A1 (de) * | 1985-11-11 | 1987-05-14 | Asta Werke Ag Chem Fab | Neue 4-benzyl-1-(2h)-phthalazinon-derivate |
| CZ199593A3 (en) * | 1992-10-02 | 1994-04-13 | Asta Medica Ag | Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr) |
| DE69912379T2 (de) * | 1998-08-14 | 2004-05-06 | Pfizer Inc. | Antithrombosemittel |
| NZ527424A (en) * | 2001-02-15 | 2005-02-25 | Altana Pharma Ag | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
| TWI347845B (en) * | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
| WO2004082682A1 (en) * | 2003-03-18 | 2004-09-30 | Merck & Co. Inc. | Amino cyclobutylamide modulators of chemokine receptor activity |
| US7595316B2 (en) * | 2003-06-27 | 2009-09-29 | Banyu Pharmaceutical Co., Ltd. | Heteroaryloxy nitrogenous saturated heterocyclic derivative |
| WO2006115221A1 (ja) * | 2005-04-21 | 2006-11-02 | Nippon Shinyaku Co., Ltd. | フタラジノン誘導体及びその医薬 |
| CA2649029A1 (en) * | 2006-04-20 | 2007-11-01 | Glaxo Group Limited | 2-substituted 4-benzylphthalazinone derivatives as histamine h1 and h3 antagonists |
-
2007
- 2007-12-18 WO PCT/EP2007/064140 patent/WO2008074803A2/en not_active Ceased
- 2007-12-18 TW TW096148520A patent/TW200831493A/zh unknown
- 2007-12-18 AT AT07857765T patent/ATE459358T1/de not_active IP Right Cessation
- 2007-12-18 US US12/065,775 patent/US20100184770A1/en not_active Abandoned
- 2007-12-18 EP EP07857765A patent/EP2091538B1/en active Active
- 2007-12-18 AR ARP070105701A patent/AR064424A1/es unknown
- 2007-12-18 DE DE602007005167T patent/DE602007005167D1/de active Active
- 2007-12-18 ES ES07857765T patent/ES2341813T3/es active Active
- 2007-12-18 JP JP2009542033A patent/JP2010513393A/ja active Pending
-
2008
- 2008-01-02 PE PE2008000040A patent/PE20081657A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE459358T1 (de) | 2010-03-15 |
| US20100184770A1 (en) | 2010-07-22 |
| TW200831493A (en) | 2008-08-01 |
| PE20081657A1 (es) | 2008-12-23 |
| JP2010513393A (ja) | 2010-04-30 |
| WO2008074803A2 (en) | 2008-06-26 |
| WO2008074803A3 (en) | 2008-09-18 |
| DE602007005167D1 (de) | 2010-04-15 |
| EP2091538B1 (en) | 2010-03-03 |
| WO2008074803A8 (en) | 2009-05-14 |
| ES2341813T3 (es) | 2010-06-28 |
| EP2091538A2 (en) | 2009-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |