ATE459358T1 - 4-benzyl-1(2h)-phthalazinone als h1-rezeptor- antagonisten - Google Patents

4-benzyl-1(2h)-phthalazinone als h1-rezeptor- antagonisten

Info

Publication number
ATE459358T1
ATE459358T1 AT07857765T AT07857765T ATE459358T1 AT E459358 T1 ATE459358 T1 AT E459358T1 AT 07857765 T AT07857765 T AT 07857765T AT 07857765 T AT07857765 T AT 07857765T AT E459358 T1 ATE459358 T1 AT E459358T1
Authority
AT
Austria
Prior art keywords
phthalazinone
benzyl
receptor antagonists
antagonists
receptor
Prior art date
Application number
AT07857765T
Other languages
German (de)
English (en)
Inventor
Paul Martin Gore
Michael Joachim Kranz
Brian Edgar Looker
Sadie Vile
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE459358T1 publication Critical patent/ATE459358T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07857765T 2006-12-20 2007-12-18 4-benzyl-1(2h)-phthalazinone als h1-rezeptor- antagonisten ATE459358T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US87087506P 2006-12-20 2006-12-20
US97844707P 2007-10-09 2007-10-09
US99122707P 2007-11-30 2007-11-30
PCT/EP2007/064140 WO2008074803A2 (en) 2006-12-20 2007-12-18 4-benzyl-l ( 2h) -phthalazinones as h1 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE459358T1 true ATE459358T1 (de) 2010-03-15

Family

ID=39536783

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07857765T ATE459358T1 (de) 2006-12-20 2007-12-18 4-benzyl-1(2h)-phthalazinone als h1-rezeptor- antagonisten

Country Status (10)

Country Link
US (1) US20100184770A1 (enExample)
EP (1) EP2091538B1 (enExample)
JP (1) JP2010513393A (enExample)
AR (1) AR064424A1 (enExample)
AT (1) ATE459358T1 (enExample)
DE (1) DE602007005167D1 (enExample)
ES (1) ES2341813T3 (enExample)
PE (1) PE20081657A1 (enExample)
TW (1) TW200831493A (enExample)
WO (1) WO2008074803A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006115221A1 (ja) * 2005-04-21 2006-11-02 Nippon Shinyaku Co., Ltd. フタラジノン誘導体及びその医薬
MX347085B (es) * 2006-12-28 2017-04-06 Abbott Laboratories * Inhibidores de la poli (adp-ribosa) polimerasa.
US8466150B2 (en) 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
ATE525370T1 (de) * 2007-10-11 2011-10-15 Glaxo Group Ltd Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten
WO2009150101A1 (en) * 2008-06-09 2009-12-17 Glaxo Group Limited Pharmaceutical compositions comprising n-[2-((2r)-2-{[4-[(4-chlorophenyl)methyl]-l-oxo-2(ih)-phthalaz inyl]methyl}-l- pyrrolidinyl)ethyl]-4-(methyloxy)butanamide
US8969348B2 (en) 2008-08-13 2015-03-03 Boehringer Ingelheim International Gmbh Chymase inhibitors
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
US8754101B2 (en) 2011-04-11 2014-06-17 Glaxo Group Limited N-cyclobutyl-imidazopyridine-methylamine as TRPV1 antagonists
KR20240013792A (ko) * 2021-05-27 2024-01-30 슈뢰딩거, 인크. 헤테로시클릭 화합물 및 사용 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677322D1 (de) * 1985-11-11 1991-03-07 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
DE3634942A1 (de) * 1985-11-11 1987-05-14 Asta Werke Ag Chem Fab Neue 4-benzyl-1-(2h)-phthalazinon-derivate
CZ199593A3 (en) * 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
DE69912379T2 (de) * 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
NZ527424A (en) * 2001-02-15 2005-02-25 Altana Pharma Ag Phthalayinone-piperidino-derivatives as PDE4 inhibitors
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
WO2004082682A1 (en) * 2003-03-18 2004-09-30 Merck & Co. Inc. Amino cyclobutylamide modulators of chemokine receptor activity
US7595316B2 (en) * 2003-06-27 2009-09-29 Banyu Pharmaceutical Co., Ltd. Heteroaryloxy nitrogenous saturated heterocyclic derivative
WO2006115221A1 (ja) * 2005-04-21 2006-11-02 Nippon Shinyaku Co., Ltd. フタラジノン誘導体及びその医薬
CA2649029A1 (en) * 2006-04-20 2007-11-01 Glaxo Group Limited 2-substituted 4-benzylphthalazinone derivatives as histamine h1 and h3 antagonists

Also Published As

Publication number Publication date
US20100184770A1 (en) 2010-07-22
TW200831493A (en) 2008-08-01
AR064424A1 (es) 2009-04-01
PE20081657A1 (es) 2008-12-23
JP2010513393A (ja) 2010-04-30
WO2008074803A2 (en) 2008-06-26
WO2008074803A3 (en) 2008-09-18
DE602007005167D1 (de) 2010-04-15
EP2091538B1 (en) 2010-03-03
WO2008074803A8 (en) 2009-05-14
ES2341813T3 (es) 2010-06-28
EP2091538A2 (en) 2009-08-26

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Legal Events

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