AR062775A1 - Composicion farmaceutica capaz de mejorar la actividad de glp -1 en un ser humano y su uso para preparar un medicamento - Google Patents

Composicion farmaceutica capaz de mejorar la actividad de glp -1 en un ser humano y su uso para preparar un medicamento

Info

Publication number
AR062775A1
AR062775A1 ARP070104049A ARP070104049A AR062775A1 AR 062775 A1 AR062775 A1 AR 062775A1 AR P070104049 A ARP070104049 A AR P070104049A AR P070104049 A ARP070104049 A AR P070104049A AR 062775 A1 AR062775 A1 AR 062775A1
Authority
AR
Argentina
Prior art keywords
activity
glp
polypeptide
human
prepare
Prior art date
Application number
ARP070104049A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR062775A1 publication Critical patent/AR062775A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composicion farmacéutica capaz de mejorar la actividad de GLP-1 en un ser humano, que comprende al menos un polipéptido que tiene actividad de GLP-1, en donde dicho polipéptido proporciona una concentracion plasmática máxima de dicho polipéptido de al menos aproximadamente 0,6 nM y un valor de área bajo la curva de dicho polipéptido que es al menos aproximadamente 3,5 nM x día durante el período de una semana cuando es administrado a un ser humano. Uso de dicha composicion para preparar un medicamento util para mejorar la actividad GLP-1. Dicho polipéptido que tiene actividad de GLP-1 comprende al menos un agonista de GLP-1. Al menos un agonista de GLP-1 se selecciona entre el grupo de: hormona incretina y/o fragmento, variante y/o conjugado de la misma, y mimético de incretina y/o fragmento, variante y/o conjugado del mismo.
ARP070104049A 2006-09-13 2007-09-12 Composicion farmaceutica capaz de mejorar la actividad de glp -1 en un ser humano y su uso para preparar un medicamento AR062775A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82547206P 2006-09-13 2006-09-13
US86839106P 2006-12-04 2006-12-04

Publications (1)

Publication Number Publication Date
AR062775A1 true AR062775A1 (es) 2008-12-03

Family

ID=39184534

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104049A AR062775A1 (es) 2006-09-13 2007-09-12 Composicion farmaceutica capaz de mejorar la actividad de glp -1 en un ser humano y su uso para preparar un medicamento

Country Status (25)

Country Link
US (3) US8338369B2 (es)
EP (1) EP2073834B1 (es)
JP (2) JP5524620B2 (es)
KR (1) KR101472601B1 (es)
CN (1) CN103705911A (es)
AR (1) AR062775A1 (es)
AU (1) AU2007296499C1 (es)
BR (1) BRPI0716765A8 (es)
CA (1) CA2662622C (es)
CL (1) CL2007002634A1 (es)
CR (1) CR10684A (es)
EA (1) EA017159B1 (es)
ES (1) ES2442869T3 (es)
IL (1) IL197448A (es)
JO (1) JO2945B1 (es)
MA (1) MA30768B1 (es)
MX (1) MX2009002863A (es)
MY (1) MY149911A (es)
NO (1) NO20091266L (es)
NZ (1) NZ575419A (es)
PE (2) PE20080840A1 (es)
SG (2) SG174770A1 (es)
TW (1) TWI430806B (es)
WO (1) WO2008033888A2 (es)
ZA (1) ZA200901548B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202837B2 (en) 2005-11-04 2012-06-19 Glaxosmithkline Llc Methods for administering hypoglycemic agents
SI2373681T1 (sl) * 2008-12-10 2017-05-31 Glaxosmithkline Llc Corporation Service Company Farmacevtski sestavki albiglutida
JP2013525491A (ja) * 2010-05-04 2013-06-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 心血管障害を治療または予防し心血管保護を提供する方法
PL2651398T3 (pl) 2010-12-16 2018-05-30 Novo Nordisk A/S Stałe kompozycje zawierające agonistę GLP-1 i sól kwasu N-(8-(2-hydroksybenzoilo)amino)kaprylowego
CN103619175B (zh) 2011-04-12 2016-08-17 诺沃—诺迪斯克有限公司 双酰化glp-1衍生物
HRP20231060T1 (hr) 2012-03-22 2023-12-22 Novo Nordisk A/S Pripravci peptida glp-1 i njihova priprava
TR201903918T4 (tr) 2012-03-22 2019-04-22 Novo Nordisk As Bir dağıtım ajanı içeren bileşimler ve bunların hazırlanması.
CN104487056A (zh) 2012-06-20 2015-04-01 诺和诺德A/S（股份有限公司） 包含肽和递送剂的片剂制剂
PL2991671T3 (pl) * 2013-05-02 2019-01-31 Novo Nordisk As Doustne dawkowanie związków glp-1
PE20151770A1 (es) 2013-05-28 2015-12-11 Takeda Pharmaceutical Compuesto peptidico
CN109477094B (zh) 2016-05-24 2022-04-26 武田药品工业株式会社 肽化合物
EP3746111B1 (en) 2018-02-02 2023-07-19 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
AR125086A1 (es) * 2021-03-23 2023-06-07 Lilly Co Eli Composiciones que contienen análogos de incretina y usos de estas

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
DE69739172D1 (de) 1996-08-08 2009-01-29 Amylin Pharmaceuticals Inc Regulation gastrointestinaler beweglichkeit
US6277819B1 (en) * 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
AU764371B2 (en) * 1998-08-28 2003-08-14 Eli Lilly And Company Method for administering insulinotropic peptides
SI1180121T1 (en) * 1999-05-17 2004-04-30 Conjuchem, Inc. Long lasting insulinotropic peptides
US6395767B2 (en) * 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
ES2311560T3 (es) 2000-12-07 2009-02-16 Eli Lilly And Company Proteinas de fusion glp-1.
CN1501809B (zh) 2000-12-13 2012-10-10 伊莱利利公司 应用胰高血糖素样促胰岛肽的长期治疗方案
AU2002308706A1 (en) * 2001-06-01 2002-12-16 Eli Lilly And Company Glp-1 formulations with protracted time action
KR100593348B1 (ko) * 2001-08-23 2006-06-26 일라이 릴리 앤드 캄파니 글루카곤-유사 펩티드-1 유사체
AR036711A1 (es) 2001-10-05 2004-09-29 Bayer Corp Peptidos que actuan como agonistas del receptor del glp-1 y como antagonistas del receptor del glucagon y sus metodos de uso farmacologico
PL377687A1 (pl) 2001-10-18 2006-02-06 Bristol-Myers Squibb Company Środki naśladujące ludzki peptyd glukagonopodobny typu 1 i ich zastosowanie w leczeniu cukrzycy i stanów związanych z cukrzycą
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
PT1463751E (pt) * 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
TW200306202A (en) 2002-01-08 2003-11-16 Lilly Co Eli Extended glucagon-like peptide-1 analogs
KR100918322B1 (ko) * 2003-11-12 2009-09-22 페노믹스 코포레이션 헤테로시클릭 보론산 화합물
JP4697596B2 (ja) * 2004-01-13 2011-06-08 旭硝子株式会社 多層積層体
PL1729795T3 (pl) 2004-02-09 2016-08-31 Human Genome Sciences Inc Białka fuzyjne albuminy
EP1758575A1 (en) * 2004-06-11 2007-03-07 Novo Nordisk A/S Counteracting drug-induced obesity using glp-1 agonists
US8202837B2 (en) * 2005-11-04 2012-06-19 Glaxosmithkline Llc Methods for administering hypoglycemic agents
WO2007139589A1 (en) 2006-05-26 2007-12-06 Bristol-Myers Squibb Company Sustained release glp-1 receptor modulators

Also Published As

Publication number Publication date
BRPI0716765A8 (pt) 2017-02-21
JO2945B1 (en) 2016-03-15
AU2007296499C1 (en) 2013-09-12
IL197448A0 (en) 2011-08-01
SG174770A1 (en) 2011-10-28
MX2009002863A (es) 2009-03-30
CA2662622C (en) 2017-01-17
BRPI0716765A2 (pt) 2013-09-24
JP2010503697A (ja) 2010-02-04
EP2073834A4 (en) 2010-11-03
PE20121528A1 (es) 2012-12-12
MA30768B1 (fr) 2009-10-01
TWI430806B (zh) 2014-03-21
US8338369B2 (en) 2012-12-25
MY149911A (en) 2013-10-31
AU2007296499B2 (en) 2013-05-02
EP2073834A2 (en) 2009-07-01
WO2008033888A3 (en) 2008-10-16
CR10684A (es) 2009-04-28
JP2014148524A (ja) 2014-08-21
SG10201501749WA (en) 2015-05-28
KR101472601B1 (ko) 2014-12-15
JP5753924B2 (ja) 2015-07-22
ES2442869T3 (es) 2014-02-14
IL197448A (en) 2013-06-27
EA200970274A1 (ru) 2009-08-28
US20140066371A1 (en) 2014-03-06
PE20080840A1 (es) 2008-08-27
ZA200901548B (en) 2010-02-24
CA2662622A1 (en) 2008-03-20
CN103705911A (zh) 2014-04-09
JP5524620B2 (ja) 2014-06-18
NO20091266L (no) 2009-06-09
EA017159B1 (ru) 2012-10-30
AU2007296499A1 (en) 2008-03-20
TW200824706A (en) 2008-06-16
KR20090059155A (ko) 2009-06-10
EP2073834B1 (en) 2013-10-23
US20100009910A1 (en) 2010-01-14
NZ575419A (en) 2011-11-25
WO2008033888A2 (en) 2008-03-20
US20130005652A1 (en) 2013-01-03
CL2007002634A1 (es) 2008-05-16

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