AR058866A1 - Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas - Google Patents
Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulasInfo
- Publication number
- AR058866A1 AR058866A1 ARP060105815A ARP060105815A AR058866A1 AR 058866 A1 AR058866 A1 AR 058866A1 AR P060105815 A ARP060105815 A AR P060105815A AR P060105815 A ARP060105815 A AR P060105815A AR 058866 A1 AR058866 A1 AR 058866A1
- Authority
- AR
- Argentina
- Prior art keywords
- toxic
- pharmaceutical compositions
- nanoparticles
- biocompatible
- biodegradable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/52—Amides or imides
- C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
- C08F220/56—Acrylamide; Methacrylamide
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/04—Anhydrides, e.g. cyclic anhydrides
- C08F222/06—Maleic anhydride
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/10—Esters
- C08F222/12—Esters of phenols or saturated alcohols
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
- C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
- C08F226/10—N-Vinyl-pyrrolidone
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
- C08F222/36—Amides or imides
- C08F222/38—Amides
- C08F222/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
El invento se relaciona con un polímero biocompatible, no biodegradable, y no toxico de la formula (1) que comprende tres unidades monoméricas, seleccionadas de 1-Vinilpirrolidona (VP), N-Isopropilacrilamida (NIPAM), y éster de anhidruro Maleico y Polietilenglicol (MPEG), en union cruzada con un derivado de vinilo bi-funcional, de alta pureza y sustancialmente libre de los respectivos contaminantes monoméricos toxicos, y un proceso para la preparacion del mismo. Asimismo el invento se relaciona a las composiciones farmacéuticas en nanopartículas de drogas o compuestos poco solubles en agua que comprenden el polímero del invento, que resultan seguras, menos toxicas y convenientes para la administracion a pacientes que las necesiten. Asimismo, el invento se relaciona a un método altamente selectivo para la preparacion de composiciones farmacéuticas en nanopartículas de drogas o compuestos poco solubles en agua.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1190KO2005 | 2005-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058866A1 true AR058866A1 (es) | 2008-02-27 |
Family
ID=37845115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060105815A AR058866A1 (es) | 2005-12-28 | 2006-12-27 | Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas |
Country Status (19)
Country | Link |
---|---|
US (2) | US8338562B2 (es) |
EP (2) | EP2172497B1 (es) |
JP (1) | JP2009522251A (es) |
KR (2) | KR20080091158A (es) |
CN (1) | CN101336256B (es) |
AR (1) | AR058866A1 (es) |
AT (1) | ATE529454T1 (es) |
AU (1) | AU2006329554C1 (es) |
BR (1) | BRPI0620745A2 (es) |
CA (1) | CA2635469A1 (es) |
EA (1) | EA017682B1 (es) |
ES (2) | ES2425075T3 (es) |
HK (1) | HK1123814A1 (es) |
IL (1) | IL192423A0 (es) |
MX (1) | MX2008008423A (es) |
MY (1) | MY148575A (es) |
NZ (1) | NZ569372A (es) |
WO (1) | WO2007074476A1 (es) |
ZA (1) | ZA200806548B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101336256B (zh) | 2005-12-28 | 2012-03-28 | 费森尤斯卡比肿瘤学有限公司 | 用于纳米颗粒药物组合物的生物相容的非可生物降解的无毒聚合物 |
JP5420946B2 (ja) * | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | 胆汁酸を含むミノキシジル水性組成物 |
CN101845120B (zh) * | 2010-03-25 | 2011-11-16 | 淮阴师范学院 | 一种温敏和生物可降解性原位凝胶的合成方法 |
US8772355B2 (en) | 2010-11-23 | 2014-07-08 | Howard University | Stealth polymeric particles for delivery of bioactive or diagnostic agents |
US8921429B2 (en) | 2010-11-23 | 2014-12-30 | Howard University | Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization |
PT2782584T (pt) | 2011-11-23 | 2021-09-02 | Therapeuticsmd Inc | Preparações e terapias de substituição para hormonoterapias naturais combinadas |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CN109673621A (zh) * | 2012-06-07 | 2019-04-26 | 保信亚太生物科技(深圳)有限公司 | 用于自体脂肪转移手术的组合物及方法 |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
AU2015264003A1 (en) | 2014-05-22 | 2016-11-17 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2015187947A1 (en) * | 2014-06-04 | 2015-12-10 | Izard Ryan | Methods and compositions for orally dosing postnatal swine |
CN104119475B (zh) * | 2014-06-26 | 2016-06-15 | 中国人民解放军第三○九医院 | 一种表面功能化的微纳米聚合物凝胶粒子及其制备方法 |
CN104119474B (zh) * | 2014-06-26 | 2016-06-15 | 中国人民解放军第三○九医院 | 一种表面功能化的微纳米聚合物空心粒子及其制备方法 |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10176182B2 (en) | 2015-08-31 | 2019-01-08 | International Business Machines Corporation | File deletion in storage devices based on the deletion priority rules |
EP3153227A1 (de) * | 2015-10-07 | 2017-04-12 | Evonik Degussa GmbH | Verfahren zur herstellung von polyalkenameren für verpackungsanwendungen |
KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US636519A (en) | 1899-04-14 | 1899-11-07 | Elisha Gray | Transmission of sound. |
JP2517760B2 (ja) | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
US6537579B1 (en) | 1993-02-22 | 2003-03-25 | American Bioscience, Inc. | Compositions and methods for administration of pharmacologically active compounds |
US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US6096331A (en) | 1993-02-22 | 2000-08-01 | Vivorx Pharmaceuticals, Inc. | Methods and compositions useful for administration of chemotherapeutic agents |
US6749868B1 (en) | 1993-02-22 | 2004-06-15 | American Bioscience, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5362478A (en) | 1993-03-26 | 1994-11-08 | Vivorx Pharmaceuticals, Inc. | Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell |
US5874111A (en) | 1997-01-07 | 1999-02-23 | Maitra; Amarnath | Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles |
IT1293823B1 (it) * | 1997-08-05 | 1999-03-10 | Stefano Gasparini | Materiale plastico non tossico avente proprieta' di adsorbenza e assorbenza e relativo procedimento di fabbricazione |
US6403816B1 (en) | 1997-09-30 | 2002-06-11 | Dabur Research Foundation | Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis |
US5830964A (en) * | 1997-12-18 | 1998-11-03 | Isp Investments Inc. | Vinyl pyrrolidone polymers substantially free of vinyl lactam monomers |
US6365191B1 (en) | 1999-02-17 | 2002-04-02 | Dabur Research Foundation | Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof |
IN191203B (es) * | 1999-02-17 | 2003-10-04 | Amarnath Prof Maitra | |
US6617420B2 (en) * | 2000-08-11 | 2003-09-09 | Nippon Shokubai Co., Ltd. | Process for reducing monomer content in N-vinyl compound polymers |
WO2004085712A2 (en) | 2003-03-24 | 2004-10-07 | Penn State Research Foundation | Multi-functional polymeric materials and their uses |
CN101336256B (zh) | 2005-12-28 | 2012-03-28 | 费森尤斯卡比肿瘤学有限公司 | 用于纳米颗粒药物组合物的生物相容的非可生物降解的无毒聚合物 |
RU2492872C2 (ru) * | 2006-10-05 | 2013-09-20 | Дзе Джонс Хопкинс Юниверсити | Вододиспергируемые пероральные, парентеральные и местные композиции для плохо растворимых в воде лекарственных препаратов, включающие улучшающие их свойства полимерные наночастицы |
-
2006
- 2006-12-26 CN CN2006800519727A patent/CN101336256B/zh not_active Expired - Fee Related
- 2006-12-26 ES ES09015722T patent/ES2425075T3/es active Active
- 2006-12-26 MX MX2008008423A patent/MX2008008423A/es active IP Right Grant
- 2006-12-26 AT AT06832316T patent/ATE529454T1/de not_active IP Right Cessation
- 2006-12-26 AU AU2006329554A patent/AU2006329554C1/en not_active Ceased
- 2006-12-26 EP EP09015722.3A patent/EP2172497B1/en not_active Not-in-force
- 2006-12-26 EP EP06832316A patent/EP1971622B1/en not_active Not-in-force
- 2006-12-26 JP JP2008548083A patent/JP2009522251A/ja active Pending
- 2006-12-26 KR KR1020087018210A patent/KR20080091158A/ko not_active Application Discontinuation
- 2006-12-26 WO PCT/IN2006/000504 patent/WO2007074476A1/en active Application Filing
- 2006-12-26 CA CA002635469A patent/CA2635469A1/en not_active Abandoned
- 2006-12-26 ES ES06832316T patent/ES2375740T3/es active Active
- 2006-12-26 NZ NZ569372A patent/NZ569372A/en not_active IP Right Cessation
- 2006-12-26 US US12/159,310 patent/US8338562B2/en not_active Expired - Fee Related
- 2006-12-26 BR BRPI0620745-6A patent/BRPI0620745A2/pt not_active IP Right Cessation
- 2006-12-26 EA EA200801563A patent/EA017682B1/ru not_active IP Right Cessation
- 2006-12-26 KR KR1020137025487A patent/KR20130116954A/ko not_active Application Discontinuation
- 2006-12-26 ZA ZA200806548A patent/ZA200806548B/xx unknown
- 2006-12-26 MY MYPI20082333A patent/MY148575A/en unknown
- 2006-12-27 AR ARP060105815A patent/AR058866A1/es not_active Application Discontinuation
-
2008
- 2008-06-24 IL IL192423A patent/IL192423A0/en unknown
-
2009
- 2009-04-15 HK HK09103495.5A patent/HK1123814A1/xx not_active IP Right Cessation
-
2012
- 2012-10-02 US US13/633,638 patent/US8927023B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2007074476A1 (en) | 2007-07-05 |
AU2006329554C1 (en) | 2013-06-20 |
EP2172497A1 (en) | 2010-04-07 |
CA2635469A1 (en) | 2007-07-05 |
EA017682B1 (ru) | 2013-02-28 |
CN101336256A (zh) | 2008-12-31 |
BRPI0620745A2 (pt) | 2013-02-19 |
US8338562B2 (en) | 2012-12-25 |
ZA200806548B (en) | 2010-02-24 |
EA200801563A1 (ru) | 2009-06-30 |
EP2172497B1 (en) | 2013-05-22 |
JP2009522251A (ja) | 2009-06-11 |
US8927023B2 (en) | 2015-01-06 |
MX2008008423A (es) | 2008-09-23 |
AU2006329554B2 (en) | 2013-01-10 |
US20090318661A1 (en) | 2009-12-24 |
EP1971622A1 (en) | 2008-09-24 |
KR20080091158A (ko) | 2008-10-09 |
EP1971622B1 (en) | 2011-10-19 |
NZ569372A (en) | 2011-10-28 |
HK1123814A1 (en) | 2009-06-26 |
ES2425075T3 (es) | 2013-10-11 |
US20130274211A1 (en) | 2013-10-17 |
IL192423A0 (en) | 2008-12-29 |
ES2375740T3 (es) | 2012-03-05 |
MY148575A (en) | 2013-04-30 |
KR20130116954A (ko) | 2013-10-24 |
ATE529454T1 (de) | 2011-11-15 |
CN101336256B (zh) | 2012-03-28 |
AU2006329554A1 (en) | 2007-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal | ||
FB | Suspension of granting procedure |