AR058866A1 - Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas - Google Patents

Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas

Info

Publication number
AR058866A1
AR058866A1 ARP060105815A ARP060105815A AR058866A1 AR 058866 A1 AR058866 A1 AR 058866A1 AR P060105815 A ARP060105815 A AR P060105815A AR P060105815 A ARP060105815 A AR P060105815A AR 058866 A1 AR058866 A1 AR 058866A1
Authority
AR
Argentina
Prior art keywords
toxic
pharmaceutical compositions
nanoparticles
biocompatible
biodegradable
Prior art date
Application number
ARP060105815A
Other languages
English (en)
Inventor
Rama Mukherjee
Deepak Prusthy
Dhiraj Khattar
Manu Jaggi
Sanjoy Mullick
Anand C Burman
Manoj Kumar Singh
Pawan Kumar Gupta
Mukesh Kumar
Original Assignee
Dabur Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dabur Pharma Ltd filed Critical Dabur Pharma Ltd
Publication of AR058866A1 publication Critical patent/AR058866A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/04—Anhydrides, e.g. cyclic anhydrides
    • C08F222/06—Maleic anhydride
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/12—Esters of phenols or saturated alcohols
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • C08F226/10—N-Vinyl-pyrrolidone
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/36—Amides or imides
    • C08F222/38—Amides
    • C08F222/385—Monomers containing two or more (meth)acrylamide groups, e.g. N,N'-methylenebisacrylamide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

El invento se relaciona con un polímero biocompatible, no biodegradable, y no toxico de la formula (1) que comprende tres unidades monoméricas, seleccionadas de 1-Vinilpirrolidona (VP), N-Isopropilacrilamida (NIPAM), y éster de anhidruro Maleico y Polietilenglicol (MPEG), en union cruzada con un derivado de vinilo bi-funcional, de alta pureza y sustancialmente libre de los respectivos contaminantes monoméricos toxicos, y un proceso para la preparacion del mismo. Asimismo el invento se relaciona a las composiciones farmacéuticas en nanopartículas de drogas o compuestos poco solubles en agua que comprenden el polímero del invento, que resultan seguras, menos toxicas y convenientes para la administracion a pacientes que las necesiten. Asimismo, el invento se relaciona a un método altamente selectivo para la preparacion de composiciones farmacéuticas en nanopartículas de drogas o compuestos poco solubles en agua.
ARP060105815A 2005-12-28 2006-12-27 Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas AR058866A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN1190KO2005 2005-12-28

Publications (1)

Publication Number Publication Date
AR058866A1 true AR058866A1 (es) 2008-02-27

Family

ID=37845115

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105815A AR058866A1 (es) 2005-12-28 2006-12-27 Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas

Country Status (19)

Country Link
US (2) US8338562B2 (es)
EP (2) EP2172497B1 (es)
JP (1) JP2009522251A (es)
KR (2) KR20080091158A (es)
CN (1) CN101336256B (es)
AR (1) AR058866A1 (es)
AT (1) ATE529454T1 (es)
AU (1) AU2006329554C1 (es)
BR (1) BRPI0620745A2 (es)
CA (1) CA2635469A1 (es)
EA (1) EA017682B1 (es)
ES (2) ES2425075T3 (es)
HK (1) HK1123814A1 (es)
IL (1) IL192423A0 (es)
MX (1) MX2008008423A (es)
MY (1) MY148575A (es)
NZ (1) NZ569372A (es)
WO (1) WO2007074476A1 (es)
ZA (1) ZA200806548B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101336256B (zh) 2005-12-28 2012-03-28 费森尤斯卡比肿瘤学有限公司 用于纳米颗粒药物组合物的生物相容的非可生物降解的无毒聚合物
JP5420946B2 (ja) * 2009-03-23 2014-02-19 富士フイルム株式会社 胆汁酸を含むミノキシジル水性組成物
CN101845120B (zh) * 2010-03-25 2011-11-16 淮阴师范学院 一种温敏和生物可降解性原位凝胶的合成方法
US8772355B2 (en) 2010-11-23 2014-07-08 Howard University Stealth polymeric particles for delivery of bioactive or diagnostic agents
US8921429B2 (en) 2010-11-23 2014-12-30 Howard University Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN109673621A (zh) * 2012-06-07 2019-04-26 保信亚太生物科技（深圳）有限公司 用于自体脂肪转移手术的组合物及方法
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2015187947A1 (en) * 2014-06-04 2015-12-10 Izard Ryan Methods and compositions for orally dosing postnatal swine
CN104119475B (zh) * 2014-06-26 2016-06-15 中国人民解放军第三○九医院 一种表面功能化的微纳米聚合物凝胶粒子及其制备方法
CN104119474B (zh) * 2014-06-26 2016-06-15 中国人民解放军第三○九医院 一种表面功能化的微纳米聚合物空心粒子及其制备方法
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10176182B2 (en) 2015-08-31 2019-01-08 International Business Machines Corporation File deletion in storage devices based on the deletion priority rules
EP3153227A1 (de) * 2015-10-07 2017-04-12 Evonik Degussa GmbH Verfahren zur herstellung von polyalkenameren für verpackungsanwendungen
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US636519A (en) 1899-04-14 1899-11-07 Elisha Gray Transmission of sound.
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5874111A (en) 1997-01-07 1999-02-23 Maitra; Amarnath Process for the preparation of highly monodispersed polymeric hydrophilic nanoparticles
IT1293823B1 (it) * 1997-08-05 1999-03-10 Stefano Gasparini Materiale plastico non tossico avente proprieta' di adsorbenza e assorbenza e relativo procedimento di fabbricazione
US6403816B1 (en) 1997-09-30 2002-06-11 Dabur Research Foundation Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
US5830964A (en) * 1997-12-18 1998-11-03 Isp Investments Inc. Vinyl pyrrolidone polymers substantially free of vinyl lactam monomers
US6365191B1 (en) 1999-02-17 2002-04-02 Dabur Research Foundation Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof
IN191203B (es) * 1999-02-17 2003-10-04 Amarnath Prof Maitra
US6617420B2 (en) * 2000-08-11 2003-09-09 Nippon Shokubai Co., Ltd. Process for reducing monomer content in N-vinyl compound polymers
WO2004085712A2 (en) 2003-03-24 2004-10-07 Penn State Research Foundation Multi-functional polymeric materials and their uses
CN101336256B (zh) 2005-12-28 2012-03-28 费森尤斯卡比肿瘤学有限公司 用于纳米颗粒药物组合物的生物相容的非可生物降解的无毒聚合物
RU2492872C2 (ru) * 2006-10-05 2013-09-20 Дзе Джонс Хопкинс Юниверсити Вододиспергируемые пероральные, парентеральные и местные композиции для плохо растворимых в воде лекарственных препаратов, включающие улучшающие их свойства полимерные наночастицы

Also Published As

Publication number Publication date
WO2007074476A1 (en) 2007-07-05
AU2006329554C1 (en) 2013-06-20
EP2172497A1 (en) 2010-04-07
CA2635469A1 (en) 2007-07-05
EA017682B1 (ru) 2013-02-28
CN101336256A (zh) 2008-12-31
BRPI0620745A2 (pt) 2013-02-19
US8338562B2 (en) 2012-12-25
ZA200806548B (en) 2010-02-24
EA200801563A1 (ru) 2009-06-30
EP2172497B1 (en) 2013-05-22
JP2009522251A (ja) 2009-06-11
US8927023B2 (en) 2015-01-06
MX2008008423A (es) 2008-09-23
AU2006329554B2 (en) 2013-01-10
US20090318661A1 (en) 2009-12-24
EP1971622A1 (en) 2008-09-24
KR20080091158A (ko) 2008-10-09
EP1971622B1 (en) 2011-10-19
NZ569372A (en) 2011-10-28
HK1123814A1 (en) 2009-06-26
ES2425075T3 (es) 2013-10-11
US20130274211A1 (en) 2013-10-17
IL192423A0 (en) 2008-12-29
ES2375740T3 (es) 2012-03-05
MY148575A (en) 2013-04-30
KR20130116954A (ko) 2013-10-24
ATE529454T1 (de) 2011-11-15
CN101336256B (zh) 2012-03-28
AU2006329554A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
AR058866A1 (es) Un polimero biocompatible, no biodegradable, no toxico, util para composiciones farmaceuticas en nanoparticulas
Bromberg et al. Effects of polyether-modified poly (acrylic acid) microgels on doxorubicin transport in human intestinal epithelial Caco-2 cell layers
Thiagarajan et al. Charge affects the oral toxicity of poly (amidoamine) dendrimers
JP2015034182A5 (es)
CU20060173A7 (es) Composiciones que comprenden drospirenona dispersada a nivel molecular
ATE405251T1 (de) Zusammensetzungen zur verzögerten abgabe von hydrophoben arzneimitteln und verfahren zu ihrer herstellung
Babazadeh Synthesis and study of controlled release of ibuprofen from the new acrylic type polymers
NO20083573L (no) Amfifile polymerer for opploseliggjoring og malrettet avgivelse av legemidler
BRPI0414017B8 (pt) pró-fármaco polimérico de múltiplos braços, composição farmacêutica e método para a preparação de um pró-fármaco polimérico de múltiplos braços.
WO2005072343A3 (en) Aqueous pharmaceutical compositions 2,6-diisopropylphenol (propofol) and their use
DE602006000381D1 (de) Bioabsorbierbare pharmazeutische Zusammensetzung enthaltend einen PLGA-Copolymer
WO2009020797A3 (en) Polymers for implantable devices exhibiting shape-memory effects
WO2012131104A3 (en) Biodegradable compositions suitable for controlled release
RU2007112777A (ru) Биоматериалы, состоящие из сульфатированной гиалуроновой кислоты и геллана, применяемые для предотвращения спаек в позвоночнике
IN2012DN00407A (es)
EP1567117A4 (en) MATERIALS AND METHODS FOR THE PREVENTION AND TREATMENT OF EPITHELIAL DISORDERS WITH MICROBIAL MEDIATION
Bédouet et al. Synthesis of hydrophilic intra-articular microspheres conjugated to ibuprofen and evaluation of anti-inflammatory activity on articular explants
PT1343530E (pt) Composição farmacêutica oral contendo um copolímero de blocos
MX2022003939A (es) Composicion farmaceutica de estabilidad mejorada.
Naveen et al. A spotlight on thiolated natural polymers and their relevance in mucoadhesive drug delivery system
Nguyen et al. Bioadhesive PAA-PEG-PAA triblock copolymer hydrogels for drug delivery in oral cavity
JP2017186346A (ja) 液状生物学的活性成分の固形製剤を含む非静脈内剤型およびその使用
Constantinou et al. PEG-based methacrylate tetrablock terpolymers: How does the architecture control the gelation?
Bhomia et al. Effect of pressure on the melting point of pluronics in pressurized carbon dioxide
CO5590886A2 (es) Suspension farmaceutica para administracion oral

Legal Events

Date Code Title Description
FA Abandonment or withdrawal
FB Suspension of granting procedure