AR055959A1 - Derivados espiro para la modulacion de actividad de crth2 - Google Patents
Derivados espiro para la modulacion de actividad de crth2Info
- Publication number
- AR055959A1 AR055959A1 ARP060102148A ARP060102148A AR055959A1 AR 055959 A1 AR055959 A1 AR 055959A1 AR P060102148 A ARP060102148 A AR P060102148A AR P060102148 A ARP060102148 A AR P060102148A AR 055959 A1 AR055959 A1 AR 055959A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- heteroaryl
- group
- Prior art date
Links
- 102000009389 Prostaglandin D receptors Human genes 0.000 title 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 hydroxy, amino, aminocarbonyl Chemical group 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 101100439663 Arabidopsis thaliana CHR7 gene Proteins 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- QECVIPBZOPUTRD-UHFFFAOYSA-N N=S(=O)=O Chemical compound N=S(=O)=O QECVIPBZOPUTRD-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 125000003003 spiro group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05104428 | 2005-05-24 | ||
| US68863105P | 2005-06-08 | 2005-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055959A1 true AR055959A1 (es) | 2007-09-12 |
Family
ID=35478408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102148A AR055959A1 (es) | 2005-05-24 | 2006-05-24 | Derivados espiro para la modulacion de actividad de crth2 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8236963B2 (enExample) |
| EP (1) | EP1891075B1 (enExample) |
| JP (1) | JP5567268B2 (enExample) |
| KR (1) | KR101333861B1 (enExample) |
| CN (1) | CN101300259B (enExample) |
| AR (1) | AR055959A1 (enExample) |
| AT (1) | ATE529429T1 (enExample) |
| AU (1) | AU2006251138C1 (enExample) |
| BR (1) | BRPI0610209A2 (enExample) |
| CA (1) | CA2602965C (enExample) |
| DK (1) | DK1891075T3 (enExample) |
| ES (1) | ES2375614T3 (enExample) |
| MX (1) | MX2007014256A (enExample) |
| NZ (1) | NZ562772A (enExample) |
| PL (1) | PL1891075T3 (enExample) |
| PT (1) | PT1891075E (enExample) |
| RU (1) | RU2478639C2 (enExample) |
| UA (1) | UA90145C2 (enExample) |
| WO (1) | WO2006125784A1 (enExample) |
| ZA (1) | ZA200709819B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101500996B (zh) | 2006-08-07 | 2012-07-04 | 埃科特莱茵药品有限公司 | (3-胺基-1,2,3,4-四氢-9h-咔唑-9-基)-乙酸衍生物 |
| CA2766883A1 (en) | 2009-07-15 | 2011-01-20 | Merck Serono S.A. | Tricyclic indole-derived spiro derivatives as crth2 modulators |
| UA107814C2 (uk) | 2009-11-12 | 2015-02-25 | Дзе Ріджентс Оф Дзе Юніверсіті Оф Мічіган | Спірооксіндольні антагоністи мdм2 |
| MX2012010820A (es) | 2010-03-22 | 2012-10-10 | Actelion Pharmaceuticals Ltd | Derivados de 3-(heteroaril-amino)-1, 2, 3, 4-tetrahidro-9h-carbazo l y sus uso como moduladores del receptor de prostaglandina d2. |
| TWI535723B (zh) | 2010-11-12 | 2016-06-01 | 密西根大學董事會 | 螺－吲哚酮ｍｄｍ２拮抗劑 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| WO2012140612A1 (en) | 2011-04-14 | 2012-10-18 | Actelion Pharmaceuticals Ltd | 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators |
| JP2014513699A (ja) | 2011-05-11 | 2014-06-05 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | スピロ−オキシインドールｍｄｍ２アンタゴニスト |
| CN104114169A (zh) | 2011-12-16 | 2014-10-22 | 阿托佩斯治疗有限公司 | 用于治疗嗜酸细胞性食管炎的crth2拮抗剂和质子泵抑制剂的组合物 |
| CN103554118B (zh) * | 2013-10-15 | 2015-08-19 | 华东师范大学 | 四氢呋喃并苯并二氢吡喃多环化合物及其应用 |
| CN103554119B (zh) * | 2013-10-15 | 2015-09-16 | 华东师范大学 | 四氢呋喃并苯并二氢吡喃多环化合物的制备方法 |
| CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
| CN103554121B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用 |
| UA117780C2 (uk) | 2014-03-17 | 2018-09-25 | Ідорсія Фармасьютікалз Лтд | Похідні азаіндолоцтової кислоти та їх застосування як модуляторів рецепторів простагландину d2 |
| RU2016140708A (ru) | 2014-03-18 | 2018-04-18 | Идорсиа Фармасьютиклз Лтд | Производные азаиндол уксусной кислоты и их применение в качестве модуляторов рецептора простагландина d2 |
| KR20170124602A (ko) | 2015-03-13 | 2017-11-10 | 포르마 세라퓨틱스 인크. | Hdac8 억제제로서의 알파-신나미드 화합물 및 조성물 |
| MA42442B1 (fr) | 2015-07-15 | 2019-07-31 | Hoffmann La Roche | Dérivés d'éthynyle comme modulateurs du récepteur métabotropique au glutamate |
| UA123156C2 (uk) | 2015-09-15 | 2021-02-24 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА ФОРМА (S)-2-(8-((5-ХЛОРПІРИМІДИН-2-ІЛ)(МЕТИЛ)АМІНО)-2-ФТОР-6,7,8,9-ТЕТРАГІДРО-5H-ПІРИДО[3,2-b]ІНДОЛ-5-ІЛ)ОЦТОВОЇ КИСЛОТИ, ЇЇ ЗАСТОСУВАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ |
| RU2631856C1 (ru) * | 2016-05-04 | 2017-09-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Чувашский государственный университет имени И.Н. Ульянова" | Способ получения аммонийных солей 3-амино-8-гидрокси-1,6-диоксо-4-циано-2,7-диазаспиро[4.4]нон-3-ен-2-идов |
| MA45665B1 (fr) | 2016-07-18 | 2020-11-30 | Hoffmann La Roche | Dérivés d'éthynyle |
| CN109384787B (zh) * | 2017-08-08 | 2021-04-16 | 沈阳药科大学 | 一种一价银催化的氢化吡啶螺二氢吲哚环的合成方法 |
| CN109369658B (zh) * | 2017-08-08 | 2020-01-31 | 沈阳药科大学 | 一种螺[吡咯烷-3,3`-氧化吲哚]环系的合成方法 |
| CN109384794B (zh) * | 2017-08-08 | 2020-06-19 | 沈阳药科大学 | 质子酸催化的一类四环吲哚骨架的合成方法 |
| KR101857408B1 (ko) * | 2018-02-28 | 2018-05-14 | 경북대학교 산학협력단 | 탈모 예방 또는 치료용 조성물 |
| EP3902805A4 (en) | 2018-12-28 | 2023-03-01 | SPV Therapeutics Inc. | CYCLINE-DEPENDENT KINASE INHIBITORS |
| CN112876488B (zh) * | 2021-02-18 | 2021-12-21 | 苏州大学 | 螺环吲哚啉衍生物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE53102B1 (en) | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
| IE52879B1 (en) * | 1981-05-12 | 1988-03-30 | Ici Plc | Pharmaceutical spiro-hydantoin derivatives |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| IL144897A0 (en) * | 1999-03-12 | 2002-06-30 | Boehringer Ingelheim Pharma | Compounds useful as anti-inflammatory agents |
| SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| GB2388540A (en) * | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
| EA011385B1 (ru) | 2002-10-04 | 2009-02-27 | Миллениум Фармасьютикалз, Инк. | Антагонисты рецептора pgd2 для лечения воспалительных заболеваний |
| WO2004035543A1 (en) | 2002-10-21 | 2004-04-29 | Warner-Lambert Company Llc | Tetrahydroquinoline derivatives as crth2 antagonists |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0301650D0 (sv) | 2003-06-04 | 2003-06-04 | Astrazeneca Ab | Novel compounds |
| SE0301653D0 (sv) | 2003-06-05 | 2003-06-05 | Astrazeneca Ab | Novel compounds |
| US20050038070A1 (en) | 2003-07-09 | 2005-02-17 | Amgen Inc. | Asthma and allergic inflammation modulators |
| WO2005102338A1 (en) | 2004-04-20 | 2005-11-03 | Pfizer Limited | Method of treating neuropathic pain using a crth2 receptor antagonist |
-
2006
- 2006-05-23 MX MX2007014256A patent/MX2007014256A/es active IP Right Grant
- 2006-05-23 PT PT06763238T patent/PT1891075E/pt unknown
- 2006-05-23 NZ NZ562772A patent/NZ562772A/en not_active IP Right Cessation
- 2006-05-23 EP EP06763238A patent/EP1891075B1/en active Active
- 2006-05-23 AU AU2006251138A patent/AU2006251138C1/en not_active Ceased
- 2006-05-23 US US11/919,471 patent/US8236963B2/en not_active Expired - Fee Related
- 2006-05-23 DK DK06763238.0T patent/DK1891075T3/da active
- 2006-05-23 KR KR1020077029797A patent/KR101333861B1/ko not_active Expired - Fee Related
- 2006-05-23 BR BRPI0610209-3A patent/BRPI0610209A2/pt not_active IP Right Cessation
- 2006-05-23 AT AT06763238T patent/ATE529429T1/de active
- 2006-05-23 CA CA2602965A patent/CA2602965C/en not_active Expired - Fee Related
- 2006-05-23 ES ES06763238T patent/ES2375614T3/es active Active
- 2006-05-23 ZA ZA200709819A patent/ZA200709819B/xx unknown
- 2006-05-23 JP JP2008512832A patent/JP5567268B2/ja not_active Expired - Fee Related
- 2006-05-23 CN CN2006800266403A patent/CN101300259B/zh not_active Expired - Fee Related
- 2006-05-23 UA UAA200713923A patent/UA90145C2/ru unknown
- 2006-05-23 RU RU2007147430/04A patent/RU2478639C2/ru not_active IP Right Cessation
- 2006-05-23 PL PL06763238T patent/PL1891075T3/pl unknown
- 2006-05-23 WO PCT/EP2006/062545 patent/WO2006125784A1/en not_active Ceased
- 2006-05-24 AR ARP060102148A patent/AR055959A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007147430A (ru) | 2009-06-27 |
| AU2006251138A1 (en) | 2006-11-30 |
| DK1891075T3 (da) | 2011-12-19 |
| EP1891075B1 (en) | 2011-10-19 |
| JP2008542238A (ja) | 2008-11-27 |
| US20090318486A1 (en) | 2009-12-24 |
| KR20080031191A (ko) | 2008-04-08 |
| RU2478639C2 (ru) | 2013-04-10 |
| KR101333861B1 (ko) | 2013-11-28 |
| EP1891075A1 (en) | 2008-02-27 |
| US8236963B2 (en) | 2012-08-07 |
| AU2006251138B2 (en) | 2012-08-09 |
| CA2602965C (en) | 2013-12-31 |
| CN101300259B (zh) | 2013-08-28 |
| UA90145C2 (ru) | 2010-04-12 |
| BRPI0610209A2 (pt) | 2010-06-01 |
| MX2007014256A (es) | 2008-03-26 |
| WO2006125784A1 (en) | 2006-11-30 |
| CA2602965A1 (en) | 2006-11-30 |
| PL1891075T3 (pl) | 2011-12-30 |
| NZ562772A (en) | 2010-01-29 |
| JP5567268B2 (ja) | 2014-08-06 |
| CN101300259A (zh) | 2008-11-05 |
| ES2375614T3 (es) | 2012-03-02 |
| PT1891075E (pt) | 2011-11-10 |
| ATE529429T1 (de) | 2011-11-15 |
| AU2006251138C1 (en) | 2013-08-29 |
| ZA200709819B (en) | 2009-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR055959A1 (es) | Derivados espiro para la modulacion de actividad de crth2 | |
| ES2512491T3 (es) | Derivados de la piridina pirazolo como inhibidores de la NADPH oxidasa | |
| ECSP055636A (es) | Acidos tienil-hidroxamicos sustituidos, y su uso para tratar enfermedades asociadas con la actividad enzimatica de la histona desacetilasa | |
| AR044078A1 (es) | Dihidroquinazolinas sustituidas | |
| PE20080671A1 (es) | DERIVADOS DE 2-ARIL-6-FENIL-IMIDAZO[1,2-a]PIRIDINAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA | |
| AR054320A1 (es) | Derivados de piridinilo y pirimidinilo sustituidos como moduladores del metabolismo y para tratar trastornos metabolicos. composiciones farmaceuticas | |
| DK1313695T3 (da) | Estere af 5-aminolevulinsyre som fotosensibiliserende midler i fotokemoterapi | |
| CO5721002A2 (es) | Derivados de acido 3-(4-benciloxifenil) propanoico | |
| AR049646A1 (es) | Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados | |
| CR9459A (es) | Derivados benzodioxano y benzodioxolano y usos de los mismos | |
| DK1981874T3 (da) | Aminophenylderivater som nye inhibitorer af histondeacetylase | |
| CO5611110A2 (es) | Mimeticos de glucocorticoides, procedimientos para su preparacion, composiciones farmaceuticas y usos de los mismos | |
| CO6190609A2 (es) | Compuestos de urea policiclicos antibacterianos | |
| NO20073019L (no) | Pyrasolonforbindelser som metabotrope glutamatreseptor-antagonister for behandlingen av nevrotiske og psykiatriske lidelser | |
| AR031627A1 (es) | Activadores heteroaromaticos fusionados de la glucoquinasa | |
| UY28150A1 (es) | Agentes terapeuticos | |
| AR064459A1 (es) | Derivados de sulfonamida | |
| AR066659A1 (es) | Derivados de espiroindolinona | |
| AR063128A1 (es) | Compuestos de aril - indol sustituido y sus usos metabolitosde tipo quinurenina / quinurenina como agentes terapeuticos | |
| DK1412354T3 (da) | Derivater af triazolylimidazopyridin og af triazolylpurinerne, der er egnede som ligander for adenosin A2a?-receptoren og deres anvendelse som medikamenter | |
| AR064521A1 (es) | Activador de glucoquinasa | |
| AR059032A1 (es) | Combinacion de derivados de triazina y sensibilizadores de insulina | |
| NO20076695L (no) | Nye MCHR1-antagonister og deres anvendelse for behandling av MCHR1-medierte tilstander og forstyrrelser | |
| AR059030A1 (es) | Combinacion de derivados de triazina y estimuladores de la secrecion de insulina | |
| AR066604A1 (es) | Derivados de arilamida pirimidona, medicamentos que los contienen y usos terapeuticos para prevenir y/o tratar enfermedades neurodegenerativas fundamentalmente. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |