AR055741A1 - Sales de adicion de derivado de quinuclidina y composicion farmaceutica - Google Patents
Sales de adicion de derivado de quinuclidina y composicion farmaceuticaInfo
- Publication number
- AR055741A1 AR055741A1 ARP060100801A ARP060100801A AR055741A1 AR 055741 A1 AR055741 A1 AR 055741A1 AR P060100801 A ARP060100801 A AR P060100801A AR P060100801 A ARP060100801 A AR P060100801A AR 055741 A1 AR055741 A1 AR 055741A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- drug
- pharmaceutical composition
- addition salts
- useful
- Prior art date
Links
- UANSQQFYKHHDJM-KRWDZBQOSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]naphthalene-1-carboxamide Chemical compound C1=CC=C2C(C(N[C@@H]3C4CCN(CC4)C3)=O)=CC=CC2=C1 UANSQQFYKHHDJM-KRWDZBQOSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 229940088679 drug related substance Drugs 0.000 abstract 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 abstract 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- WRFYIYOXJWKONR-UHFFFAOYSA-N 4-bromo-2-methoxyaniline Chemical compound COC1=CC(Br)=CC=C1N WRFYIYOXJWKONR-UHFFFAOYSA-N 0.000 abstract 1
- FBOUYBDGKBSUES-FCHUYYIVSA-N [(3r)-1-azabicyclo[2.2.2]octan-3-yl] (1r)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Chemical compound C1([C@@H]2C3=CC=CC=C3CCN2C(O[C@@H]2C3CCN(CC3)C2)=O)=CC=CC=C1 FBOUYBDGKBSUES-FCHUYYIVSA-N 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 abstract 1
- 206010009887 colitis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- CAAULPUQFIIOTL-UHFFFAOYSA-N methyl dihydrogen phosphate Chemical compound COP(O)(O)=O CAAULPUQFIIOTL-UHFFFAOYSA-N 0.000 abstract 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 210000002345 respiratory system Anatomy 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/08—Mydriatics or cycloplegics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se provee una sal de adicion ácida de (-)-(3R)-quinuclidin-3il(1R)-1-fenil-1,2,3,4-tetrahidroisoquinolina-2-carboxilato con un ácido seleccionado del grupo S formado por ácido (-)-(2S,3S)-tartárico, ácido (+)-(2S,3S)-di-O-benzoiltartárico, ácido (+)- (2S,3S)-di-O-(4-metilbenzoil) tartárico, (-)-L-fenilalanina, ácido bencenosulfonico, ácido ciclohexanosulfámico, ácido hidrobromico, ácido naftalina-2-sulfonico, ácido sebácico, ácido (+)-canfor-10-sulfonico, ácido p-toluenosulfonico, ácido etanosulfonico, ácido metansulfonico y metil fosfato, que tiene poca higroscopicidad que afecta el uso de una droga o su sustancia para droga, y es muy util como droga o su sustancia para droga. El compuesto de la presente es util como terapia en enfermedades urologicas, respiratorias y las del tracto digestivo tales como intestino irritable y colitis espástica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005063405 | 2005-03-08 | ||
| JP2005088872A JP3701964B1 (ja) | 2005-03-08 | 2005-03-25 | キヌクリジン誘導体の新規な塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055741A1 true AR055741A1 (es) | 2007-09-05 |
Family
ID=34940702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060100801A AR055741A1 (es) | 2005-03-08 | 2006-03-03 | Sales de adicion de derivado de quinuclidina y composicion farmaceutica |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7176219B2 (es) |
| EP (1) | EP1700858B1 (es) |
| JP (2) | JP3701964B1 (es) |
| KR (1) | KR20070110128A (es) |
| AR (1) | AR055741A1 (es) |
| AT (1) | ATE396992T1 (es) |
| AU (1) | AU2006221451A1 (es) |
| BR (1) | BRPI0608843A2 (es) |
| CA (1) | CA2599872A1 (es) |
| DE (1) | DE602005007176D1 (es) |
| ES (1) | ES2306030T3 (es) |
| IL (1) | IL185470A0 (es) |
| NO (1) | NO20075044L (es) |
| PL (1) | PL1700858T3 (es) |
| PT (1) | PT1700858E (es) |
| RU (1) | RU2007137064A (es) |
| TW (1) | TW200714599A (es) |
| WO (1) | WO2006095671A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100137358A1 (en) * | 1996-11-05 | 2010-06-03 | Dr. Reddy's Laboratories Ltd. | Solifenacin compositions |
| JPWO2006090759A1 (ja) * | 2005-02-25 | 2008-07-24 | アステラス製薬株式会社 | ソリフェナシン含有医薬 |
| JP3701964B1 (ja) | 2005-03-08 | 2005-10-05 | アステラス製薬株式会社 | キヌクリジン誘導体の新規な塩 |
| CZ300692B6 (cs) * | 2006-12-22 | 2009-07-15 | Zentiva, A. S. | Zpusob prípravy solifenacinu |
| RU2495035C2 (ru) * | 2008-01-08 | 2013-10-10 | Мерк Шарп Энд Домэ Лтд | Фармацевтически приемлемые соли 2-{4-[(3s)-пиперидин-3-ил]фенил}-2н-индазол-7-карбоксамида |
| EP3067353B1 (en) | 2008-07-29 | 2017-11-22 | KRKA, D.D., Novo Mesto | A process for the preparation of solifenacin salts and their inclusion into pharmaceutical dosage forms |
| US8278302B2 (en) | 2009-04-08 | 2012-10-02 | Boehringer Ingelheim International Gmbh | Substituted piperidines as CCR3 antagonists |
| UA109290C2 (uk) | 2010-10-07 | 2015-08-10 | Спільні кристали і солі інгібіторів ccr3 | |
| US10213421B2 (en) | 2012-04-04 | 2019-02-26 | Alkahest, Inc. | Pharmaceutical formulations comprising CCR3 antagonists |
| WO2014022139A1 (en) * | 2012-07-31 | 2014-02-06 | University Of Massachusetts Medical School | Methods for identifying agents for treating smooth muscle disorders and compositions thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| GB9600063D0 (en) * | 1996-01-03 | 1996-03-06 | Fujisawa Pharmaceutical Co | Guaridine derivatives |
| JPH107675A (ja) | 1996-06-21 | 1998-01-13 | Yamanouchi Pharmaceut Co Ltd | 新規なイソキノリン誘導体又はその塩 |
| JP2002104968A (ja) | 2000-09-28 | 2002-04-10 | Senju Pharmaceut Co Ltd | 毛様体筋の緊張緩和剤 |
| JP4174673B2 (ja) * | 2001-07-10 | 2008-11-05 | アステラス製薬株式会社 | 間質性膀胱炎治療用医薬組成物 |
| JP3701964B1 (ja) | 2005-03-08 | 2005-10-05 | アステラス製薬株式会社 | キヌクリジン誘導体の新規な塩 |
-
2005
- 2005-03-25 JP JP2005088872A patent/JP3701964B1/ja active Active
- 2005-04-04 PT PT05252102T patent/PT1700858E/pt unknown
- 2005-04-04 PL PL05252102T patent/PL1700858T3/pl unknown
- 2005-04-04 EP EP05252102A patent/EP1700858B1/en not_active Not-in-force
- 2005-04-04 ES ES05252102T patent/ES2306030T3/es active Active
- 2005-04-04 AT AT05252102T patent/ATE396992T1/de not_active IP Right Cessation
- 2005-04-04 DE DE602005007176T patent/DE602005007176D1/de not_active Expired - Fee Related
- 2005-05-13 US US11/128,238 patent/US7176219B2/en not_active Expired - Fee Related
-
2006
- 2006-02-22 TW TW095105953A patent/TW200714599A/zh unknown
- 2006-03-03 AR ARP060100801A patent/AR055741A1/es unknown
- 2006-03-06 BR BRPI0608843-0A patent/BRPI0608843A2/pt not_active Application Discontinuation
- 2006-03-06 RU RU2007137064/04A patent/RU2007137064A/ru not_active Application Discontinuation
- 2006-03-06 JP JP2007507092A patent/JP4605218B2/ja not_active Expired - Fee Related
- 2006-03-06 WO PCT/JP2006/304241 patent/WO2006095671A1/ja active Application Filing
- 2006-03-06 KR KR1020077022738A patent/KR20070110128A/ko not_active Application Discontinuation
- 2006-03-06 AU AU2006221451A patent/AU2006221451A1/en not_active Abandoned
- 2006-03-06 CA CA002599872A patent/CA2599872A1/en not_active Abandoned
-
2007
- 2007-08-23 IL IL185470A patent/IL185470A0/en unknown
- 2007-10-05 NO NO20075044A patent/NO20075044L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL1700858T3 (pl) | 2008-10-31 |
| PT1700858E (pt) | 2008-07-17 |
| JPWO2006095671A1 (ja) | 2008-08-14 |
| EP1700858A1 (en) | 2006-09-13 |
| AU2006221451A1 (en) | 2006-09-14 |
| JP3701964B1 (ja) | 2005-10-05 |
| RU2007137064A (ru) | 2009-04-20 |
| CA2599872A1 (en) | 2006-09-14 |
| ES2306030T3 (es) | 2008-11-01 |
| BRPI0608843A2 (pt) | 2010-02-02 |
| JP4605218B2 (ja) | 2011-01-05 |
| EP1700858B1 (en) | 2008-05-28 |
| WO2006095671A1 (ja) | 2006-09-14 |
| US20060205770A1 (en) | 2006-09-14 |
| ATE396992T1 (de) | 2008-06-15 |
| KR20070110128A (ko) | 2007-11-15 |
| DE602005007176D1 (de) | 2008-07-10 |
| NO20075044L (no) | 2007-12-05 |
| IL185470A0 (en) | 2008-01-06 |
| JP2008308406A (ja) | 2008-12-25 |
| US7176219B2 (en) | 2007-02-13 |
| TW200714599A (en) | 2007-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |